Article
Biology
Kieop Park, Ranjay Jayadev, Sara G. Payne, Isabel W. Kenny-Ganzert, Qiuyi Chi, Daniel S. Costa, William Ramos-Lewis, Siddharthan B. Thendral, David R. Sherwood
Summary: Separate tissues are connected through adjoining basement membranes to fulfill their barrier, exchange, and support functions. The robust and balanced cell adhesion at these connections is essential for withstanding tissue movement. However, the mechanism by which cells achieve synchronized adhesion to connect tissues remains unclear. This study reveals that type IV collagen both fastens the linkage and activates the collagen receptor DDR-2 in the utse and seam tissues, coordinating the strengthening of integrin adhesion through the LET-60/Ras signaling pathway.
Article
Cell Biology
Kedar Ghimire, Atharva Kale, Jennifer Li, Sohel M. Julovi, Philip O'Connell, Shane T. Grey, Wayne J. Hawthorne, Jenny E. Gunton, Natasha M. Rogers
Summary: CD47 is a molecule that regulates insulin secretion and plays an important role in pancreatic beta cells. Its depletion can stimulate insulin secretion and improve insulin sensitivity. Blocking CD47 with drugs can enhance islet transplantation efficiency and restore normal blood glucose levels in diabetic mice.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Eun-Ah Cho, Pingfeng Zhang, Vikas Kumar, Mikhail Kavalchuk, Hao Zhang, Qingqiu Huang, James S. Duncan, Jinhua Wu
Summary: This study revealed that RIAM promotes integrin activation by phosphorylation-based interaction with membrane PIP2, which is facilitated by Src kinase-mediated phosphorylation of specific tyrosine residues in the RIAM PH domain.
Article
Immunology
Max Stevenson, Rency Varghese, Michaeline L. Hebron, Xiaoguang Liu, Nick Ratliff, Amelia Smith, R. Scott Turner, Charbel Moussa
Summary: Treatment with nilotinib in patients with mild-moderate Alzheimer's disease for 12 months can reduce amyloid plaque and cerebrospinal fluid amyloid levels, as well as attenuate hippocampal volume loss. This is achieved by inhibiting DDR-1 gene expression and activity, leading to a reduction in inflammation. Nilotinib may not only clear amyloid and tau but also reduce cerebrovascular fibrosis.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Medicine, General & Internal
Jin-Ju Kim, Judith M. David, Sydney S. Wilbon, Javier Santos, Devang M. Patel, Anis Ahmad, Alla Mitrofanova, Xiaochen Liu, Shamroop K. Mallela, Gloria M. Ducasa, Mengyuan Ge, Alexis J. Sloan, Hassan Al-Ali, Marcia Boulina, Armando J. Mendez, Gabriel N. Contreras, Marco Prunotto, Anjum Sohail, Rafael Fridman, Jeffrey H. Miner, Sandra Merscher, Alessia Fornoni
Summary: DDR1 activation mediated by Col I induces CD36-mediated podocyte lipotoxic injury in Alport Syndrome mice. Ezetimibe interferes with the CD36/DDR1 interaction, thus protecting renal function. Targeting the Col I/DDR1 pathway may represent a new therapeutic strategy for patients with AS and CKD associated with Col4 mutations.
Article
Cardiac & Cardiovascular Systems
Frone Vandewiele, Andy Pironet, Griet Jacobs, Miklos Kecskes, Jorg Wegener, Sara Kerselaers, Lio Hendrikx, Joren Verelst, Koenraad Philippaert, Wouter Oosterlinck, Andrei Segal, Evy Van den Broeck, Silvia Pinto, Silvia G. Priori, Stephan E. Lehnart, Bernd Nilius, Thomas Voets, Rudi Vennekens
Summary: Disturbances of Ca2+ homeostasis in the heart contribute to cardiac arrhythmias, and TRPM4 is a novel target in the prevention and treatment of triggered arrhythmias.
EUROPEAN HEART JOURNAL
(2022)
Article
Oncology
Kaouther Ben Arfi, Christophe Schneider, Amar Bennasroune, Nicole Bouland, Aurore Wolak-Thierry, Guillaume Collin, Cuong Cao Le, Kevin Toussaint, Cathy Hachet, Veronique Lehrter, Stephane Dedieu, Olivier Bouche, Hamid Morjani, Camille Boulagnon-Rombi, Aline Appert-Collin
Summary: This study found that high expression of DDR1 is associated with worse event-free survival in CRC patients, and it may play a role in the invasive properties of colon adenocarcinoma.
Article
Multidisciplinary Sciences
Laura Onuchic, Valeria Padovano, Giorgia Schena, Vanathy Rajendran, Ke Dong, Xiaojian Shi, Raj Pandya, Victoria Rai, Nikolay P. Gresko, Omair Ahmed, TuKiet T. Lam, Weiwei Wang, Hongying Shen, Stefan Somlo, Michael J. Caplan
Summary: In this study, the researchers found that the C-terminal 200 amino acids of PC1 can interact with the mitochondrial enzyme NNT, suppressing cystic disease and preserving renal function. This finding opens up new possibilities for gene therapy strategies for autosomal dominant polycystic kidney disease.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Liang Zhang, Jiawei Hong, Wei Chen, Wei Zhang, Xi Liu, Jiahua Lu, Hong Tang, Zhentao Yang, Ke Zhou, Haiyang Xie, Changku Jia, Donghai Jiang, Shusen Zheng
Summary: This study found that DBF4 was upregulated in hepatocellular carcinoma (HCC) and was an independent prognostic factor for patient survival. The study also revealed that p65 increased DBF4 expression by directly binding to its promoter. DBF4 complexed with CDC7 and bound to the coiled coil domain of STAT3, promoting HCC cell proliferation and tumorigenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Allen Sam Titus, Harikrishnan Venugopal, Mereena George Ushakumary, Mingyi Wang, Randy T. Cowling, Edward G. Lakatta, Shivakumar Kailasam
Summary: The study revealed the crucial role of fibronectin in regulating cardiac fibroblast function, mediated by DDR2 and Integrin-beta 1 signaling pathways. This complex mechanism involves collagen type I and fibronectin interacting with their receptors, offering insights into potential therapeutic targets for myocardial injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Christina C. Rolling, Marcin A. Sowa, Tricia T. T. Wang, MacIntosh Cornwell, Khrystyna Myndzar, Tamar Schwartz, Hanane El Bannoudi, Jill Buyon, Tessa J. Barrett, Jeffrey S. Berger
Summary: Monocyte-platelet aggregates (MPAs) play a role in the intersection of thrombosis and inflammation, and targeting this axis could suppress thromboinflammation. The effect of platelets on monocyte activation and the impact of antiplatelet therapy (APT) on MPA and platelet-induced monocyte activation were analyzed.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cell Biology
Lina M. Gallego-Paez, William J. S. Edwards, Manasa Chanduri, Yanyu Guo, Thijs Koorman, Chieh-Yu Lee, Nina Grexa, Patrick Derksen, Jie Yan, Martin A. Schwartz, Jan Mauer, Benjamin Thomas Goult
Summary: This study identified a previously unannotated cassette exon, referred to as exon 17b, in the TLN1 gene. The presence of this exon alters the function of the TLN1 protein in the mechanosensitive adapter system and affects cell adhesion dynamics and motility. This novel exon is detectable in multiple healthy tissues and significantly enriched in certain cancer subtypes.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Cell Biology
Yahyah Amen, Annmary Paul, Nikolao Tataridas-Pallas, Rhianna Williams, Rachel Wellman, Hannah Chapman, John Labbadia
Summary: The research shows that reducing the activity of a mitochondrial protein can suppress age-related proteostasis collapse in Caenorhabditis elegans, indicating a potential way to maintain protein integrity in aging cells.
Review
Cell Biology
Li Chen, Xiangyi Kong, Yi Fang, Shishir Paunikar, Xiangyu Wang, James A. L. Brown, Emer Bourke, Xingrui Li, Jing Wang
Summary: Discoidin domain receptor tyrosine kinases (DDRs) are a type of receptor tyrosine kinases associated with various diseases, widely expressed in different cell types and involved in signaling pathways, closely related to the development and progression of solid tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Zitong Shi, Kazuko Kaneda-Nakashima, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Shushi Nagamori, Yoshikatsu Kanai
Summary: This study reveals the critical role of LAT1 in cancer metastasis and suggests that LAT1 inhibition may serve as a potential target for anti-metastasis cancer therapy.
SCIENTIFIC REPORTS
(2023)
Article
Pathology
Wan-Chun Chen, Hsi-Hui Lin, Ming-Jer Tang
AMERICAN JOURNAL OF PATHOLOGY
(2015)
Article
Cell Biology
Huei-Fen Jheng, Pei-Jane Tsai, Yi-Lun Chuang, Yi-Ting Shen, Ting-An Tai, Wen-Chung Chen, Chuan-Kai Chou, Li-Chun Ho, Ming-Jer Tang, Kuei-Tai A. Lai, Junne-Ming Sung, Yau-Sheng Tsai
DISEASE MODELS & MECHANISMS
(2015)
Article
Dermatology
Hans I-Chen Harn, Yang-Kao Wang, Chao-Kai Hsu, Yen-Ting Ho, Yi-Wei Huang, Wen-Tai Chiu, Hsi-Hui Lin, Chao-Min Cheng, Ming-Jer Tang
EXPERIMENTAL DERMATOLOGY
(2015)
Article
Cell Biology
Hans I-Chen Harn, Chao-Kai Hsu, Yang-Kao Wang, Yi-Wei Huang, Wen-Tai Chiu, Hsi-Hui Lin, Chao-Min Cheng, Ming-Jer Tang
CELL ADHESION & MIGRATION
(2016)
Correction
Multidisciplinary Sciences
Ya-Ju Chang, Hui-Chun Huang, Yuan-Yu Hsueh, Shao-Wei Wang, Fong-Chin Su, Chih-Han Chang, Ming-Jer Tang, Yi-Shuan Li, Shyh-Hau Wang, Kirk K. Shung, Shu Chien, Chia-Ching Wu
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Hong-Ru Chen, Yi-Chun Yeh, Ching-Yi Liu, Yu-Ting Wu, Fang-Yu Lo, Ming-Jer Tang, Yang-Kao Wang
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Ya-Ju Chang, Hui-Chun Huang, Yuan-Yu Hsueh, Shao-Wei Wang, Fong-Chin Su, Chih-Han Chang, Ming-Jer Tang, Yi-Shuan Li, Shyh-Hau Wang, Kirk K. Shung, Shu Chien, Chia-Ching Wu
SCIENTIFIC REPORTS
(2016)
Review
Dermatology
Hans I-Chen Harn, Rei Ogawa, Chao-Kai Hsu, Michael W. Hughes, Ming-Jer Tang, Cheng-Ming Chuong
EXPERIMENTAL DERMATOLOGY
(2019)
Article
Multidisciplinary Sciences
Yi-Chun Yeh, Jin-Ying Ling, Wan-Chun Chen, Hsi-Hui Lin, Ming-Jer Tang
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Hsiu-Kuan Lin, Hsi-Hui Lin, Yu-Wei Chiou, Ching-Lung Wu, Wen-Tai Chiu, Ming-Jer Tang
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
Review
Dermatology
Chao-Kai Hsu, Hsi-Hui Lin, Hans I-Chen Harn, Michael W. Hughes, Ming-Jer Tang, Chao-Chun Yang
JOURNAL OF DERMATOLOGICAL SCIENCE
(2018)
Article
Dermatology
Chao-Kai Hsu, Hsi-Hui Lin, Hans I-Chen Harn, Rei Ogawa, Yang-Kao Wang, Yen-Ting Ho, Wan-Rung Chen, Yi-Chao Lee, Julia Yu-Yun Lee, Shyh-Jou Shieh, Chao-Min Cheng, John A. McGrath, Ming-Jer Tang
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Letter
Dermatology
Alexandros Onoufriadis, Chao-Kai Hsu, Chrysanthi Ainali, Chuin Ying Ung, Ellie Rashidghamat, Hsing-San Yang, Hsin-Yu Huang, Umar Niazi, Christos Tziotzios, Jui-Chu Yang, Rosamond Nuamah, Ming-Jer Tang, Alka Saxena, Emanuele de Rinaldis, John A. McGrath
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Article
Cell Biology
Wen-Tai Chiu, Heng-Ai Chang, Yi-Hsin Lin, Yu-Shan Lin, Hsiao-Tzu Chang, Hsi-Hui Lin, Soon-Cen Huang, Ming-Jer Tang, Meng-Ru Shen
CELL DEATH DISCOVERY
(2018)
Article
Cell Biology
Chun-Liang Chen, Shu-Chun Chien, Tzeng-Horng Leu, Hans I-Chen Harn, Ming-Jer Tang, Lien-I Hor
JOURNAL OF BIOMEDICAL SCIENCE
(2017)