Article
Biochemistry & Molecular Biology
Ilona Faustova, Luka Bulatovic, Frida Matiyevskaya, Ervin Valk, Mihkel Ord, Mart Loog
Summary: Cyclin-dependent kinases (CDKs) are regulated by different cyclins throughout the cell cycle, with the NLxxxL docking motif playing a crucial role in the phosphorylation-dependent degradation of the CDK inhibitor Far1 at the G1/S stage in yeast. This motif is specifically recognized by the S-phase CDK (S-CDK) Clb5/6-Cdc28, indicating its importance in controlling cell cycle events. Additionally, the NLxxxL motif governs S-cyclin-specificity in multiple yeast CDK targets, suggesting its significance in fine-tuning cell cycle processes.
Article
Oncology
Guanghui Liu, Hongchao Zhao, Qingqing Ding, Haohao Li, Tao Liu, Hongwei Yang, Yuanhua Liu
Summary: CDK6 plays a critical role in decreasing hyperthermia-induced apoptosis and promoting cell proliferation, with its upregulation potentially being mediated through hyperthermia-induced AKT inhibition. This study suggests that targeting CDK6 may sensitize gastric cancer cells to hyperthermia-based therapy by enhancing apoptosis.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Multidisciplinary Sciences
Kai Furuya, Tao Wu, Ai Orimoto, Eriko Sugano, Hiroshi Tomita, Tohru Kiyono, Takahiro Kurose, Yoshihiro Takai, Tomokazu Fukuda
Summary: The study investigated the expression patterns of immortalized corneal epithelial cells with different genetic modifications, showing that SV40 immortalized cells had a distinct expression pattern from wild-type cells regardless of serum presence, while corneal epithelial cells with combinatorial expression had a pattern closer to that of wild-type cells.
Article
Biotechnology & Applied Microbiology
Mingqing He, Xiaoyan Wang, Zheng Liu, Qiyuan Cui, Ying Chen, Wenqing Geng, Jinzhou Zhu, Jiabing Shen
Summary: This study revealed the mechanism of CDK5 in mediating microglia activity in intracerebral hemorrhage (ICH), which involves direct phosphorylation of DRP1 and subsequent secretion of proinflammatory factors by microglia.
Article
Multidisciplinary Sciences
Hanqiang Deng, Elizabeth Min, Nicolas Baeyens, Brian G. Coon, Rui Hu, Zhen W. Zhuang, Minghao Chen, Billy Huang, Titilayo Afolabi, Georgia Zarkada, Angela Acheampong, Kathleen McEntee, Anne Eichmann, Fang Liu, Bing Su, Michael Simons, Martin A. Schwartz
Summary: This study investigates the sensing of fluid shear stress by endothelial cells. Low shear stress triggers inward remodeling to restore normal levels, while high shear stress is suppressed. The findings suggest that low shear stress activates the Smad2/3 pathway, while high shear stress blocks Smad2/3 nuclear translocation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Ying Zhou, Rishun Fu, Mei Yang, Weihuang Liu, Zan Tong
Summary: Lycopene, a natural carotenoid, inhibits the growth and induces apoptosis in gastric cancer cells. It decreases CCNE1 expression and increases the levels of TP53, making it a potential target therapy reagent for gastric cancer.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jianning Liu, Meng Guo, Xiaotong Fan
Summary: This study reveals the mechanism of gastric epithelial cell death induced by high concentrations of ethanol, showing that necroptosis rather than apoptosis pathway is essential and a novel therapeutic target. Further exploration of the mechanisms of alcoholic gastric diseases could provide potential therapeutic strategies for the treatment of acute alcoholic diseases.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Xiaohui Lv, Honghong Zhou, Kai Hu, Ling Lin, Yongqiang Yang, Longjiang Li, Li Tang, Jiayi Huang, Yi Shen, Rong Jiang, Jingyuan Wan, Li Zhang
Summary: Accumulated evidence suggests that metabolic events play a significant role in the progression of various diseases, including liver injury. In this study, the metabolic status of pyruvate and its pharmacological significance in LPS/D-Gal-induced liver injury were investigated in mice. The findings indicate that the decline of pyruvate induced by LPS/D-Gal exposure may be a novel metabolic mechanism underlying the development of fulminant liver injury, and PKM2 activators or pyruvate derivatives may have potential value for pharmacological intervention.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Reproductive Biology
Sandeep Kumar Parvathareddy, Abdul K. Siraj, Tariq Masoodi, Padmanaban Annaiyappanaidu, Ismail A. Al-Badawi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Summary: Our study shows that the expression of CDK9 in Middle Eastern ethnicity ovarian cancer correlates with markers of advanced disease and serves as a prognostic marker. CDK9 overexpression also identifies a subset of patients with the highest likelihood of recurrence.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jia Liu, Hui Yang, Pak Yan Cheung, Sai Wah Tsao, Liang Lv, Annie L. M. Cheung
Summary: The regulation of cyclin D1 turnover in precancerous cells upon DNA damage remains poorly understood. The study demonstrates a pivotal role of ATM and FBX4 in cyclin D1 proteolysis after DNA damage, suggesting that deregulation of this process may contribute to the carcinogenesis of esophageal squamous cell carcinoma.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Waseem El-Huneidi, Khuloud Bajbouj, Jibran Sualeh Muhammad, Arya Vinod, Jasmin Shafarin, Ghalia Khoder, Mohamed A. Saleh, Jalal Taneera, Eman Abu-Gharbieh
Summary: Carnosic acid inhibits proliferation and survival of human gastric cancer cells in a dose-dependent manner by suppressing the phosphorylation/activation of Akt and mTOR, and enhancing cleavage of PARP as well as downregulating survivin expression.
Article
Fisheries
Chuili Zeng, Wenjun Tao, Bangping Hu, Ming Guo, Chenghua Li
Summary: This study investigated the mechanism of coelomocyte proliferation in Apostichopus japonicus challenged with Vibrio splendidus by knocking out two genes, and found that regulating cell proliferation through increasing the expression level of ll-catenin in the nuclear domain.
Article
Agriculture, Dairy & Animal Science
Gabriela T. Pinheiro Machado, Maria B. Veleirinho, Roberto G. Ferreira, Carine Zuglianello, Elenara Lemos-Senna, Shirley Kuhnen
Summary: This research paper reports that a nanoemulsion of Achyrocline satureioides (macela extract) has a cytoprotective effect on bovine mammary alveolar cells and increases the permeation of flavonoid compounds. This suggests that it could be a promising candidate for bovine mastitis therapy.
JOURNAL OF DAIRY RESEARCH
(2022)
Article
Agriculture, Multidisciplinary
Mengqi Li, Renzhi Lv, Xiaomeng Xu, Qi Ge, Songyi Lin
Summary: T. matsutake peptides attenuate ethanol-induced inflammatory responses and apoptosis by suppressing NF-kappa B signaling activation, thereby enhancing gastric epithelial barrier functions.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Babak Pakbin, Shaghayegh Pishkhan Dibazar, Samaneh Allahyari, Maryam Javadi, Alireza Farasat, Sina Darzi
Summary: The study showed that SBS can reduce cell viability, induce apoptosis, and decrease survivin gene expression in gastric cancer cells, indicating its potential anticancer effects. Additionally, SBS was more efficient in inducing apoptosis in EPG cells compared to RDB cells.
FOOD SCIENCE & NUTRITION
(2021)