Tanshinone IIA inhibits breast cancer stem cells growth in vitro and in vivo through attenuation of IL-6/STAT3/NF-kB signaling pathways

Anti-nociceptive effects of Tanshinone IIA (TIIA) in a rat model of complete Freund's adjuvant (CFA)-induced inflammatory pain

(2012) Shukai Sun et al.   BRAIN RESEARCH BULLETIN

Interleukin-6 signaling pathway in targeted therapy for cancer

(2012) Yuqi Guo et al.   CANCER TREATMENT REVIEWS

Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells

(2012) A Papi et al.   CELL DEATH AND DIFFERENTIATION

Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-κB signaling pathways

(2012) Bilal Bin Hafeez et al.   INTERNATIONAL JOURNAL OF CANCER

Tanshinone IIA Prevents Uric Acid Nephropathy in Rats through NF-κB Inhibition

(2012) Xinlin Wu et al.   PLANTA MEDICA

Nonadhesive Culture System as a Model of Rapid Sphere Formation with Cancer Stem Cell Properties

(2012) Su-Feng Chen et al.   PLoS One

Tanshinones Inhibit the Growth of Breast Cancer Cells through Epigenetic Modification of Aurora A Expression and Function

(2012) Yi Gong et al.   PLoS One

Tanshinone IIA Attenuates the Inflammatory Response and Apoptosis after Traumatic Injury of the Spinal Cord in Adult Rats

(2012) Xin Yin et al.   PLoS One

Phosphosulindac (OXT-328) Selectively Targets Breast Cancer Stem Cells In Vitro and in Human Breast Cancer Xenografts

(2012) Caihua Zhu et al.   STEM CELLS

Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation

(2012) Suowen Xu et al.   Translational Research

Disulfiram modulated ROS–MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties

(2011) N C Yip et al.   BRITISH JOURNAL OF CANCER

The Unholy Trinity: Inflammation, Cytokines, and STAT3 Shape The Cancer Microenvironment

(2011) Ning Li et al.   CANCER CELL

Regulation of Cancer Stem Cells by Cytokine Networks: Attacking Cancer's Inflammatory Roots

(2011) H. Korkaya et al.   CLINICAL CANCER RESEARCH

Amelioration of atherosclerosis by tanshinone IIA in hyperlipidemic rabbits through attenuation of oxidative stress

(2011) Wenying Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Caffeic Acid Phenethyl Ester (CAPE) derived from propolis, a honeybee product, inhibits growth of breast cancer stem cells

(2011) Coral O. Omene et al.   INVESTIGATIONAL NEW DRUGS

Breast cancer stem cells, cytokine networks, and the tumor microenvironment

(2011) Hasan Korkaya et al.   JOURNAL OF CLINICAL INVESTIGATION

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/β-catenin pathway

(2011) Weiru Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

NF-κB and STAT3 cooperatively induce IL6 in starved cancer cells

(2011) S Yoon et al.   ONCOGENE

Response of Estrogen Receptor-Positive Breast Cancer Tumorspheres to Antiestrogen Treatments

(2011) Ada Ao et al.   PLoS One

Breast cancer screening in developing countries

(2011) Indraneel Mittra   PREVENTIVE MEDICINE

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

(2011) D. Iliopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro models

(2011) Jennie Powell Mather   STEM CELLS

Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-κB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia

(2010) Lina Wang et al.   BRAIN RESEARCH

Bitter Melon (Momordica charantia) Extract Inhibits Breast Cancer Cell Proliferation by Modulating Cell Cycle Regulatory Genes and Promotes Apoptosis

(2010) R. B. Ray et al.   CANCER RESEARCH

The Canonical NF- B Pathway Governs Mammary Tumorigenesis in Transgenic Mice and Tumor Stem Cell Expansion

(2010) M. Liu et al.   CANCER RESEARCH

Mammosphere-forming cells from breast cancer cell lines as a tool for the identification of CSC-like- and early progenitor-targeting drugs

(2010) Mario Cioce et al.   CELL CYCLE

Inflammatory signaling pathways in self-renewing breast cancer stem cells

(2010) Kunihiko Hinohara et al.   CURRENT OPINION IN PHARMACOLOGY

Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells

(2009) M Murohashi et al.   BRITISH JOURNAL OF CANCER

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

Tanshinone IIA: a potent, natural anti-carcinogenic agent for the management of systemic malignancies

(2009) Shailendra Kapoor   Chinese Journal of Integrative Medicine

Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice

(2009) C.-H. Tsai et al.   CLINICAL CANCER RESEARCH

The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS

(2009) Guan-Wei Fan et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression

(2009) Z.H. Ren et al.   PHYTOMEDICINE