Article
Cardiac & Cardiovascular Systems
Yuxuan Luo, Nan Jiang, Herman May, Xiang Luo, Anwarul Ferdous, Gabriele G. Schiattarella, Guihao Chen, Qinfeng Li, Chao Li, Beverly A. Rothermel, Dingsheng Jiang, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill
Summary: The study reveals the critical role of ETS2 in cardiac hypertrophy driven by the calcineurin/NFAT pathway, and unveils a previously unknown molecular connection between Erk1/2 activation of ETS2 and the expression of NFAT/ETS2 target genes.
Review
Biology
Christopher J. Gilbert, Jacob Z. Longenecker, Federica Accornero
Summary: Understanding how cardiac cells respond to external stimuli through the ERK1/2 pathway is crucial for maintaining heart health and responding to stress. The review highlights the complexity of upstream and downstream signals involved in ERK1/2-dependent regulation, particularly focusing on cardiomyocyte hypertrophy as an outcome of ERK1/2 activation regulation in the heart.
Article
Pharmacology & Pharmacy
Yan Chen, Junteng Zhou, Zisong Wei, Yue Cheng, Geer Tian, Yue Quan, Qihang Kong, Wenchao Wu, Xiaojing Liu
Summary: Cardiac hypertrophy initially serves as an adaptive response to physiological and pathological stimuli. However, sustained hypertrophy leads to pathological cardiac hypertrophy, cardiac fibrosis, and ultimately heart failure. Recent studies have highlighted the importance of circRNA and its regulation of mRNA in the posttranscriptional regulation of cardiac hypertrophy. This study identifies differentially expressed circRNAs and explores their coexpression with mRNAs and miRNAs, providing potential targets for the treatment of pathological cardiac hypertrophy and fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Bing-yan Liu, Ling Li, Gao-li Liu, Wei Ding, Wen-guang Chang, Tao Xu, Xiao-yu Ji, Xian-xin Zheng, Jing Zhang, Jian-xun Wang
Summary: Baicalein, extracted from Scutellaria baicalensis root, shows protective effect against cardiac hypertrophy by increasing catalase expression and promoting autophagy, which is mediated by direct binding to transcription factor FOXO3a.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Cardiac & Cardiovascular Systems
XiaoQiang Chen, XinTao Li, XiaoYu Wu, Yu Ding, Ya Li, GenQing Zhou, Yong Wei, SongWen Chen, XiaoFeng Lu, Juan Xu, ShaoWen Liu, Jun Li, LiDong Cai
Summary: This study identifies ITGBL1 as an important mediator in fibroblast-cardiomyocyte crosstalk, contributing to cardiac remodeling in heart failure (HF). ITGBL1 promotes fibroblast activation and hypertrophy of cardiomyocytes through signaling pathways, and its knockdown improves cardiac function in a mouse model of HF.
CARDIOVASCULAR RESEARCH
(2023)
Article
Plant Sciences
Linhao Xu, Daqiang He, Yirong Wu, Lishui Shen, Yongmei Wang, Yizhou Xu
Summary: Tanshinone IIA (Tan IIA) shows protective effects against doxorubicin (DOX)-induced heart failure (HF), potentially through activation of the DAXX/MEK/ERK1/2 pathway to suppress apoptosis.
Article
Cardiac & Cardiovascular Systems
Xavier Revelo, Preethy Parthiban, Chen Chen, Fanta Barrow, Gavin Fredrickson, Haiguang Wang, Dogacan Yucel, Adam Herman, Jop H. van Berlo
Summary: This study assessed the role of cardiac immune cells in the early hypertrophy response to cardiac pressure overload and found that cardiac resident macrophages play a key role in stimulating angiogenesis and inhibiting fibrosis in response to cardiac pressure overload.
CIRCULATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Kecheng Tang, Bin Zhong, Qingman Luo, Qiao Liu, Xin Chen, Dayan Cao, Xiaohui Li, Shengqian Yang
Summary: This study demonstrates that phillyrin effectively alleviates catecholamine-induced cardiac hypertrophy and inflammatory response by suppressing the p38 MAPK/ERK1/2 and AKT/NF-xB signaling pathways.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ravi Sonkar, Ryan Berry, Mary N. Latimer, Sumanth D. Prabhu, Martin E. Young, Stuart J. Frank
Summary: Circadian clocks regulate various biological processes, including hormone secretion and target tissue sensitivity. This study found that genetic disruption of the cardiomyocyte circadian clock leads to cardiomyopathy, potentially due to excessive activation of cardiac GH/IGF1 signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ajit Magadum, Neha Singh, Ann Anu Kurian, Mohammad Tofael Kabir Sharkar, Nishat Sultana, Elena Chepurko, Keerat Kaur, Magdalena M. Zak, Yoav Hadas, Djamel Lebeche, Susmita Sahoo, Roger Hajjar, Lior Zangi
Summary: Heart failure remains a major issue globally, with cardiac hypertrophy and fibrosis being key factors. The regulator Pip4k2c, associated with mTORC1, plays a role in these processes. Studies show that deleting Pip4k2c does not affect embryonic cardiac development, but leads to increased rates of CH, CF, and sudden death in adult mice. Upregulating Pip4k2c improves heart function, reverses CH and CF, and enhances survival through inhibiting TGF beta 1 via specific pathways. Loss-and-gain-of-function studies identify Pip4k2c as a potential therapeutic target for CF, CH, and HF, utilizing modRNA as an effective gene therapy approach.
Article
Pharmacology & Pharmacy
Xue Liu, Weina Han, Na An, Na Cao, Tingting Wu, Shuang Yang, Lili Ding, Xiaoli Chen, Chao Chen, Aruhan, Yannan Zhang, Kexin Wang, Lianhuan Suo, Jian Huang, Jinhui Wang, Xin Zhao, Jiuxin Zhu, Yan Zhang, Baofeng Yang
Summary: The novel compound Kanglexin (KLX) showed promising cardioprotective effects by alleviating cardiac dysfunction, hypertrophy, and fibrosis, as well as inhibiting pathological processes in the cardiovascular system. Studies demonstrated its potential therapeutic role in attenuating cardiac fibrosis and dysfunction, offering a new strategy for heart pathological remodeling.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Jiao Ma, Zhechun Hu, Huimin Yue, Yujian Luo, Chao Wang, Xuan Wu, Yan Gu, Lang Wang
Summary: In this study, the researchers found that the metabotropic glutamate receptor 2 (GRM2) is highly expressed in hippocampal dentate granule cells (DGCs) and plays a crucial role in regulating their development and functional integration. Lack of GRM2 leads to developmental defects and impaired cognitive functions in the hippocampus. Interestingly, knocking down GRM2 resulted in the excessive activation of the MEK/ERK1/2 pathway, which was ameliorated by inhibiting MEK.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jemima Seidenberg, Mara Stellato, Amela Hukara, Burkhard Ludewig, Karin Klingel, Oliver Distler, Przemyslaw Blyszczuk, Gabriela Kania
Summary: The study reveals that Fosl-2 regulates autophagy, while the TGF-beta-Fosl-2-autophagy axis controls the differentiation of cardiac fibroblasts. Experimental validation of this mechanism was conducted and confirmed in a mouse model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Xiaocheng Cheng, Liyou Wang, Xuesong Wen, Lei Gao, Guoxing Li, Guanglei Chang, Shu Qin, Dongying Zhang
Summary: The study investigated the role of TNAP in cardiac fibrosis after myocardial infarction, finding that high serum TNAP levels were associated with increased mortality in patients with ischemic heart disease and MI. The findings suggest that TNAP plays a crucial role in cardiac fibrosis by activating the TGF-beta/Smads and ERK1/2 signaling pathways.
Article
Cell Biology
Ya-Ge Jin, Heng Zhou, Di Fan, Yan Che, Zhao-Peng Wang, Sha-Sha Wang, Qi-Zhu Tang
Summary: TMEM173 is involved in cardiac hypertrophy, and its knockout can lead to deterioration of hypertrophy, fibrosis, and cardiac dysfunction. Experimental results suggest that TMEM173 may be a promoter of autophagic flux and could serve as a potential therapeutic target for cardiac hypertrophy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)