Article
Chemistry, Multidisciplinary
Jin-yi Liu, Wei-qi Fu, Xiang-jin Zheng, Wan Li, Li-wen Ren, Jin-hua Wang, Cui Yang, Guan-hua Du
Summary: Avasimibe demonstrated potent anticancer effects on human glioblastoma cells by inhibiting proliferation, inducing apoptosis, and regulating multiple signaling pathways. The drug showed promising potential as a chemotherapy treatment for glioblastoma.
ACTA PHARMACOLOGICA SINICA
(2021)
Review
Cell Biology
Luiz H. C. Assis, Debora Andrade-Silva, Mark E. Shiburah, Beatriz C. D. de Oliveira, Stephany C. Paiva, Bryan E. Abuchery, Yete G. Ferri, Veronica S. Fontes, Leilane S. de Oliveira, Marcelo S. da Silva, Maria Isabel N. Cano
Summary: Leishmaniases, neglected tropical diseases caused by over 20 species of Leishmania parasites, continue to impact millions of people, especially those with low incomes. Molecular biology research, particularly on telomeres, plays a vital role in understanding parasite maintenance and its impact on the cell cycle.
Article
Chemistry, Multidisciplinary
Li-wen Ren, Wan Li, Xiang-jin Zheng, Jin-yi Liu, Yi-hui Yang, Sha Li, Sen Zhang, Wei-qi Fu, Bin Xiao, Jin-hua Wang, Guan-hua Du
Summary: Analysis of hub genes in GBM revealed benzimidazoles as potential anti-GBM agents, with in vivo studies showing their efficacy in suppressing tumor growth.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Chemistry, Physical
Peihua Li, Shiming Pu, Chao Lin, Liu He, Hongxia Zhao, Cheng Yang, Ziqi Guo, Shisan Xu, Zuping Zhou
Summary: Curcumin exhibits anti-colon cancer properties by inhibiting cell proliferation and inducing apoptosis through p53-mediated mechanisms.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Biochemistry & Molecular Biology
Anastasia I. I. Palamarchuk, Elena I. I. Kovalenko, Maria A. A. Streltsova
Summary: TERT, as a core component of telomerase, is not only responsible for lengthening telomeres, but also involved in multiple signaling pathways with various intracellular localizations and functions. Upregulation of TERT expression and increased telomerase activity in cancer and somatic cells are associated with improved survival and persistence.
Article
Biochemistry & Molecular Biology
Konstantinos Gousias, Theocharis Theocharous, Matthias Simon
Summary: Glioblastoma, a common malignant brain tumor, exhibits rapid growth and infiltration. It takes advantage of the patients' biological capacities to maintain its excessive proliferation and invasion, primarily through disrupting cell cycle regulation and apoptosis mechanisms. Molecular targeting therapies have been developed for glioblastoma, and promising therapeutic agents that induce cell cycle arrest and apoptosis are being studied.
Article
Biochemistry & Molecular Biology
Narissara Namwan, Gulsiri Senawong, Chanokbhorn Phaosiri, Pakit Kumboonma, La-Or Somsakeesit, Arunta Samankul, Chadaporn Leerat, Thanaset Senawong
Summary: The curcumin derivative CU17 shows potential in inhibiting the growth of lung cancer cells, while exhibiting less toxicity to non-cancer cells. CU17 inhibits HDAC activity, induces cell cycle arrest and apoptosis, and down-regulates expression of certain proteins associated with cancer growth in lung cancer cells.
Article
Oncology
Xuehua Zhang, Leilei Zhao, Jinlong Xiao, Yudi Wang, Yunmeng Li, Chaoqun Zhu, He Zhang, Yurui Zhang, Xiao Zhu, Yucui Dong
Summary: 5-Demethylnobiletin, an active ingredient in citrus polymethoxyflavones, was found to inhibit the proliferation of various tumor cells. This study explored its anti-tumor effect on glioblastoma and its molecular mechanisms. The results showed that 5-Demethylnobiletin significantly inhibited the viability, migration, and invasion of glioblastoma cells. It induced cell cycle arrest at the G0/G1 phase and apoptosis by regulating various proteins and inhibiting specific signaling pathways. The in vivo model also confirmed its inhibitory effect on U87-MG cell growth. Therefore, 5-Demethylnobiletin holds promise as a potential glioblastoma treatment drug.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Salman Ahmed, Muhammad Mohtasheemul Hasan, Michael Aschner, Hamed Mirzaei, Waqas Alam, Syed Muhammad Mukarram Shah, Haroon Khan
Summary: Glioblastoma multiforme is the most common primary malignant brain tumor, with poor prognosis and limited treatment options. Marine peptides have shown potential as safe therapeutic agents for glioblastoma through various pathways.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Muhammad Azizan Samad, Mohd Zuwairi Saiman, Nazia Abdul Majid, Saiful Anuar Karsani, Jamilah Syafawati Yaacob
Summary: This study found that berberine can decrease telomerase activity and level in HCT 116 cells, which subsequently inhibits the proliferative ability of the cells.
Article
Pharmacology & Pharmacy
Jiayun Xu, Shanshan Sun, Wei Zhang, Jianhong Dong, Changgang Huang, Xin Wang, Mengxian Jia, Hao Yang, Yongjie Wang, Yuanyuan Jiang, Liying Cao, Zhihui Huang
Summary: Irigenin inhibits the proliferation, induces apoptosis, and inhibits migration of GBM cells by suppressing YAP/β-catenin signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tai-Hsin Tsai, Kuan-Ting Lee, Yi-Chiang Hsu
Summary: Cucurbitacin I (JSI-124) derived from Cucurbitaceae has the potential to induce apoptosis and cell cycle arrest in glioblastoma multiforme (GBM) cells. JSI-124 effectively reduced cell viability in GBM cells, leading to apoptosis and cell cycle arrest.
Article
Multidisciplinary Sciences
Francisco J. Sanchez-Rivera, Jeremy Ryan, Yadira M. Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M. Feldser, Michael T. Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony Letai, Tyler Jacks
Summary: The level of mitochondrial apoptotic priming is a critical determinant of cell fate upon p53 reactivation, with cells having high initial priming tending to undergo apoptosis and cells with low priming tending to survive and arrest in the cell cycle. Manipulating the priming levels through BCL-2 or BCL-XL expression or inhibition can affect the outcome of p53 restoration, highlighting mitochondrial apoptotic priming as a key factor in determining cell fate. Moreover, less primed cells can be forced into apoptotic cell fate following p53 activation using p53-independent drugs that increase apoptotic priming.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Tai-Hsin Tsai, Yu-Feng Su, Cheng-Yu Tsai, Chieh-Hsin Wu, Kuan-Ting Lee, Yi-Chiang Hsu
Summary: RTA dh404 is a novel synthetic oleanolic acid derivative with various properties and therapeutic effects on cancers. It reduces glioma cell viability and induces apoptosis, autophagy, and cell cycle arrest in glioblastoma cells. These effects are mediated by the regulation of associated genes, indicating the potential of RTA dh404 as a drug candidate for glioblastoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Farid Qoorchi Moheb Seraj, Niloofar Heravi-Faz, Arash Soltani, Seyed Sajad Ahmadi, Fatemeh Shahbeiki, Amir Talebpour, Amir R. Afshari, Gordon A. Ferns, Afsane Bahrami
Summary: Thymol exhibited potential cytotoxic activities on U-87 cells, possibly through increased apoptosis, generation of reactive oxygen species, and cell cycle arrest. Combination therapy of thymol and temozolomide synergistically enhanced cytotoxic effects.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Multidisciplinary Sciences
Deepika Kandilya, Sukanya Shyamasundar, Dhiraj Kumar Singh, Avijit Banik, Manoor Prakash Hande, Walter Stunkel, Yap Seng Chong, S. Thameem Dheen
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Yongqiang Luo, Ramya Viswanathan, Manoor Prakash Hande, Amos Hong Pheng Loh, Lih Feng Cheow
Article
Biotechnology & Applied Microbiology
Varsha Hande, Keith Teo, Prarthana Srikanth, Jane See Mei Wong, Swaminathan Sethu, Wilner Martinez-Lopez, Manoor Prakash Hande
Summary: Acetaldehyde (AA) has been classified as a probable human carcinogen due to its ability to cause tumors following inhalation or alcohol consumption. Individuals with deficiencies in the enzymes that are involved in the metabolism of AA are more susceptible to its toxicity. Studies have shown that AA induces DNA damage and cytogenetic abnormalities.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2021)
Review
Health Care Sciences & Services
Volodymyr Vinnikov, Manoor Prakash Hande, Ruth Wilkins, Andrzej Wojcik, Eduardo Zubizarreta, Oleg Belyakov
JOURNAL OF PERSONALIZED MEDICINE
(2020)
Article
Biology
Eric Gregoire, Joan Francesc Barquinero, Gaetan Gruel, Mohamedamine Benadjaoud, Juan S. Martinez, Christina Beinke, Adayabalam Balajee, Philip Beukes, William F. Blakely, Inmaculada Dominguez, Pham Ngoc Duy, Octavia Monteiro Gil, Inci Guclu, Kamile Guogyte, Savina Petrova Hadjidekova, Valeria Hadjidekova, Prakash Hande, Seongjae Jang, Katalin Lumniczky, Roberta Meschini, Mirta Milic, Alegria Montoro, Jayne Moquet, Mercedes Moreno, Farrah N. Norton, Ursula Oestreicher, Jelena Pajic, Laure Sabatier, Sylwester Sommer, Antonella Testa, Georgia Terzoudi, Marco Valente, Perumal Venkatachalam, Anne Vral, Ruth C. Wilkins, Andrzej Wojcik, Demetre Zafiropoulos, Ulrike Kulka
Summary: In the event of a mass-casualty radiological incident, networking and inter-laboratory comparisons are crucial for ensuring consistent results in biological dosimetry laboratories. While significant harmonization efforts have been made at the European level, challenges remain with the statistical tools and diversity in dose-effect curves highlighted by this study.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Biology
Varsha Hande, Karthik Prathaban, M. Prakash Hande
Summary: The seminar-style educational module on Radiation and Society at Tembusu College, NUS aimed to equip students with analytical tools to assess evidence on nuclear energy and societal perceptions of radiation, with interactive sessions covering topics like historical dimensions, radiation science, and societal impacts. The post-course survey revealed students perceived nuclear energy as safe and reliable but preferred renewable energy, indicating the effectiveness of the sessions in raising awareness.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Editorial Material
Biology
Veena Kumari Hande, Manoor Prakash Hande
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Shivam Rai, A. R. S. Badarinath, Alex George, Sneha Sitaraman, Sudha Anandt, Anand Moses, Radha Saraswathy, Stephen Charles Bronson, K. Thirumal Babu, M. Prakash Hande
Summary: This study aimed to investigate the relationship between telomere shortening and age-related diseases (such as type 2 diabetes and idiopathic dilated cardiomyopathy) in a south Indian population. The results showed a negative correlation between telomere length and age, diabetes, and idiopathic dilated cardiomyopathy. The study supports the usefulness of telomere length measurements as a marker for age-related diseases.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2022)
Article
Biotechnology & Applied Microbiology
Grace Kah Mun Low, Aloysius Poh Leong Ting, Edwin Dan Zhihao Fok, Kalpana Gopalakrishnan, Dimphy Zeegers, Aik Kia Khaw, Manikandan Jayapal, Wilner Martinez-Lopez, M. Prakash Hande
Summary: The Xeroderma Pigmentosum D (XPD) protein plays a crucial role in the repair of oxidative DNA damage and telomere maintenance. Primary fibroblasts derived from patients with Xeroderma Pigmentosum D showed increased susceptibility, reduced repair capacity, and telomeric loss when exposed to oxidative stress. Gene expression profiling revealed alterations in genes involved in transcription, nucleotide metabolism, and cellular processes.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2022)
Article
Biotechnology & Applied Microbiology
Gavin Yong-Quan Ng, Varsha Hande, Min Hui Ong, Beverly Wen-Xin Wong, Zachary Wai-Loon Loh, Wei D. Ho, Lionel B. Handison, Ian Ming-Sheng P. Tan, David Y. Fann, Thiruma Arumugam, M. Prakash Hande
Summary: Telomeres play a critical role in maintaining cellular fate and are closely related to ageing and age-associated diseases. Dietary habits and interventions may promote healthy ageing, but further research is needed to establish the link between dietary intervention and telomere maintenance.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2022)
Article
Geriatrics & Gerontology
Gavin Yong-Quan Ng, Dominic Paul Lee Kok Sheng, Han-Gyu Bae, Sung Wook Kang, David Yang-Wei Fann, Jinsu Park, Joonki Kim, Asfa Alli-Shaik, Jeongmi Lee, Eunae Kim, Sunyoung Park, Jeung-Whan Han, Vardan Karamyan, Eitan Okun, Thameem Dheen, Manoor Prakash Hande, Raghu Vemuganti, Karthik Mallilankaraman, Lina H. K. Lim, Brian K. Kennedy, Grant R. Drummond, Christopher G. Sobey, Jayantha Gunaratne, Mark P. Mattson, Roger Sik-Yin Foo, Dong-Gyu Jo, Thiruma V. Arumugam
Summary: Intermittent fasting can modulate H3K9 trimethylation in the cerebellum and trigger transcriptomic changes associated with metabolic processes. Part of the epigenomic and transcriptomic modulations induced by IF can be preserved for at least 3 months post-IF, but termination of IF results in a loss of H3K9 trimethylation regulation of the transcriptome.
Biographical-Item
Biotechnology & Applied Microbiology
Manoor Prakash Hande
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2022)
Article
Biotechnology & Applied Microbiology
Abhik Chakraborty, Souvick Roy, Manoor Prakash Hande, Birendranath Banerjee
Summary: The study aimed to elucidate the genomic instability among couples experiencing unexplained recurrent pregnancy loss. It was found that individuals with unexplained recurrent pregnancy loss exhibited higher levels of intracellular oxidative stress and basal genomic instability compared to fertile controls. This study highlights the role of genomic instability in cases of unexplained recurrent pregnancy loss.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2023)
Biographical-Item
Biology
M. Prakash Hande, Hiroo Nakajima
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Meeting Abstract
Environmental Sciences
N. G. Gavin, Thiruma Arumugam, Prakash Hande
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2022)