Key roles of histone methyltransferase and demethylase in leukemogenesis

BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells

(2010) A. Rizo et al.   BLOOD

BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia

(2010) J. C. van Galen et al.   BLOOD

Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera

(2010) F. Perna et al.   BLOOD

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

(2010) Gorica Nikoloski et al.   NATURE GENETICS

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

(2010) Thomas Ernst et al.   NATURE GENETICS

Identification of Two Critically Deleted Regions within Chromosome Segment 7q35-q36 in EVI1 Deregulated Myeloid Leukemia Cell Lines

(2010) An De Weer et al.   PLoS One

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells

(2009) W. Fiskus et al.   BLOOD

Mutations of polycomb-associated geneASXL1in myelodysplastic syndromes and chronic myelomonocytic leukaemia

(2009) Véronique Gelsi-Boyer et al.   BRITISH JOURNAL OF HAEMATOLOGY

The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation

(2009) H. Boukarabila et al.   GENES & DEVELOPMENT

Alteration of enhancer of polycomb 1 at 10p11.2 is one of the genetic events leading to development of adult T-cell leukemia/lymphoma

(2009) Shingo Nakahata et al.   GENES CHROMOSOMES & CANCER

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

(2009) Gang G. Wang et al.   NATURE

Mutation inTET2in Myeloid Cancers

(2009) François Delhommeau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells

(2009) M Shimabe et al.   ONCOGENE

LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis

(2009) X. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BMI-1 expression is enhanced through transcriptional and posttranscriptional regulation during the progression of chronic myeloid leukemia

(2008) Joyeeta Bhattacharyya et al.   ANNALS OF HEMATOLOGY

Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation

(2008) Christine Dierks et al.   CANCER CELL

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

(2008) Andrei V. Krivtsov et al.   CANCER CELL

Evi-1 Is a Critical Regulator for Hematopoietic Stem Cells and Transformed Leukemic Cells

(2008) Susumu Goyama et al.   Cell Stem Cell

Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemia

(2008) Lykke Grubach et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a

(2008) Dominik Spensberger et al.   FEBS LETTERS

Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2

(2008) D. Pasini et al.   GENES & DEVELOPMENT

EVI1 recruits the histone methyltransferase SUV39H1 for transcription repression

(2008) Francesca Cattaneo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY