Review
Medicine, General & Internal
Haider Al-Waeli, Ana Paula Reboucas, Alaa Mansour, Martin Morris, Faleh Tamimi, Belinda Nicolau
Summary: This study conducted a systematic review and meta-analysis on the effects of NSAID administration after bone fracture in animal models. The results indicate that NSAIDs can decrease the biomechanical properties of healing bones, with variations observed in different sites, sex, and assessment times.
SYSTEMATIC REVIEWS
(2021)
Review
Medicine, General & Internal
Nattawat Klomjit, Patompong Ungprasert
Summary: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed drugs that inhibit COX enzyme, affecting prostaglandin production and causing various renal complications. AKI from NSAIDs is usually reversible after discontinuation, emphasizing the importance of avoiding NSAIDs in high-risk patients.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Cell Biology
Tess A. Leathers, Crystal D. Rogers
Summary: Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the activity of cyclooxygenase isoenzymes, which drive tissue inflammation pathways, making them a class of analgesics. However, caution should be exercised during pregnancy as these drugs increase the risk of developmental defects. In this review, the roles of cyclooxygenase signaling pathway components throughout pregnancy are characterized, and the effects of perturbation of this pathway on embryonic development are discussed.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Medicine, General & Internal
Caroline M. P. G. van Durme, Mihir D. Wechalekar, Robert B. M. Landewe, Jordi Pardo Pardo, Sheila Cyril, Desiree van der Heijde, Rachelle Buchbinder
Summary: The study showed that NSAIDs were effective in relieving pain in acute gout compared to placebo within 24 hours. However, their impact on inflammation, function, and adverse events was limited. Data also indicated that non-selective NSAIDs and COXIBs had similar benefits in terms of pain relief, function, inflammation, and treatment success, with the former potentially leading to more withdrawals due to adverse events and total adverse events. Systemic glucocorticoids and NSAIDs were found to have similar efficacy in pain relief and treatment, with NSAIDs possibly leading to more total adverse events.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Review
Pharmacology & Pharmacy
Hongjin Lai, Yi Liu, Juan Wu, Jie Cai, Hui Jie, Yuyang Xu, Senyi Deng
Summary: Inflammatory processes play a crucial role in innate immunity and tumor development in various malignancies. Targeting inflammation with pharmacotherapies, such as non-steroidal anti-inflammatory drugs (NSAIDs), has the potential to reduce the risk of carcinogenesis and enhance the effectiveness of anti-cancer treatments. However, the pharmacogenomic variability of NSAIDs can greatly impact their pharmacokinetics and therapeutic outcomes in cancer patients. Thus, a comprehensive understanding of the pharmacogenomic characteristics of NSAIDs and cancer-related inflammation is important for developing new strategies in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mandeep Kaur, Hafiz Muzzammel Rehman, Gurmeet Kaur, Amandeep Kaur, Manisha Bansal
Summary: A new series of linker-based derivatives of non-steroidal anti-inflammatory drugs were synthesized and characterized. The study focused on understanding the switch in the anti-inflammatory and anticancer activity of compounds 8 and 10 through in-silico and in-vitro studies. The molecular docking study showed the importance of hetero atoms and proper alignment in the binding pocket for bioactivity. Compound 8 exhibited better inhibitory activity against the COX-2 target site, possibly due to the presence of 1,3-dicarbonyl interactions, whereas compound 10 showed increased potency towards anticancer activity. In-vitro assays confirmed the results obtained from the in-silico study.
BIOORGANIC CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Igor Jose dos Santos Nascimento, Thiago Mendonca de Aquino, Edeildo Ferreira da Silva Junior
Summary: Inflammation is a natural reaction to external stimuli, but if exaggerated, it can cause severe physiopathological damage. Recent studies have shown that inhibiting mPGES-1 has potential for developing anti-inflammatory drugs, and computer-aided drug design methods are increasingly used for this purpose.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Environmental Sciences
Shane R. de Solla, Laura E. King, Eve A. M. Gilroy
Summary: Abnormally thin eggshells can reduce avian reproductive success and have caused population declines. Non-steroidal anti-inflammatory drugs (NSAIDs) may impair eggshell development, and their effects have been observed in scavenging birds. The study discusses the environmental exposure to NSAIDs, the process of eggshell formation, and the mechanisms by which NSAIDs affect eggshell thickness. It highlights the potential hazard of NSAIDs in the environment for wild bird reproduction.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Green & Sustainable Science & Technology
Thiago Lopes da Silva, Camila Stefanne Dias Costa, Meuris Gurgel Carlos da Silva, Melissa Gurgel Adeodato Vieira
Summary: This article provides detailed information about the properties of anti-inflammatory drugs found in water and effluents, the latest results on the concentration of these compounds in different aquatic environments, the main characteristics of AOP, and the recent achievements in oxidation processes aimed at degrading NSAIDs.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Abeer J. J. Ayoub, Ghewa A. A. El-Achkar, Sandra E. E. Ghayad, Layal Hariss, Razan H. H. Haidar, Leen M. M. Antar, Zahraa I. I. Mallah, Bassam Badran, Rene Gree, Ali Hachem, Eva Hamade, Aida Habib
Summary: The benzofuran and dihydrobenzofuran derivatives have been found to effectively inhibit inflammation and tumor growth in macrophages and colorectal adenocarcinoma cells. Six of these compounds showed anti-inflammatory effects by suppressing the expression of inflammatory genes and reducing the secretion of inflammatory mediators. Two compounds with fluorine, bromine, and ester or carboxylic acid groups also inhibited tumor cell proliferation and induced apoptosis. These findings suggest that these derivatives have potential applications in the treatment of chronic inflammation and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Daniil V. Spector, Kirill G. Pavlov, Roman A. Akasov, Alexander N. Vaneev, Alexander S. Erofeev, Petr V. Gorelkin, Vita N. Nikitina, Elena V. Lopatukhina, Alevtina S. Semkina, Kseniya Yu. Vlasova, Dmitrii A. Skvortsov, Vitaly A. Roznyatovsky, Nikolay V. Ul'yanovskiy, Ilya I. Pikovskoi, Sergey A. Sypalov, Anastasiia S. Garanina, Stepan S. Vodopyanov, Maxim A. Abakumov, Yulia L. Volodina, Alina A. Markova, Albina S. Petrova, Dmitrii M. Mazur, Dmitry A. Sakharov, Nikolay V. Zyk, Elena K. Beloglazkina, Alexander G. Majouga, Olga O. Krasnovskaya
Summary: In this study, a series of novel Pt(IV) prodrugs with nonsteroidal anti-inflammatory drugs were designed and synthesized. By tuning the drug lipophilicity via variation of the axial ligands, the most potent Pt(IV) prodrug was obtained, showing enhanced cellular accumulation and cytotoxicity. The prodrugs exhibited superior antiproliferative activity compared to cisplatin and overcame tumor cell line resistance.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Genetics & Heredity
Hoang Kim Tu Trinh, Le Duy Pham, Kieu Minh Le, Hae-Sim Park
Summary: Non-steroidal anti-inflammatory drugs (NSAIDs) are the main cause of drug hypersensitivity reactions worldwide, with diverse clinical phenotypes that can be classified into cross-reactive or selective responses. Genetic and epigenetic backgrounds play important roles in NSAID-induced hypersensitivity reactions.
FRONTIERS IN GENETICS
(2021)
Review
Medicine, Research & Experimental
Jeffery S. Staab, Alexander L. Kolb, Ryan E. Tomlinson, Paola Divieti Pajevic, Ronald W. Matheny, Julie M. Hughes
Summary: There is mounting evidence suggesting that NSAIDs may inhibit new bone formation and increase risk of stress fractures, particularly in physically active populations like endurance athletes and military recruits. However, human trials evaluating the effects of NSAIDs on exercise and bone adaptation have been inconclusive. Further research is needed to address knowledge gaps and support guidelines for at-risk populations.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Review
Oncology
Farzana Y. Zaman, Suzanne G. Orchard, Andrew Haydon, John R. Zalcberg
Summary: Aspirin has been shown to play a beneficial role in preventing CRC, while non-aspirin NSAIDs have also been studied and found to potentially decrease CRC incidence in certain high-risk subgroups. However, the use of non-aspirin NSAIDs may come with increased risks of toxicity. Further studies are needed to establish the associations between concurrent aspirin and non-aspirin NSAID use, and CRC-related outcomes.
BRITISH JOURNAL OF CANCER
(2022)
Article
Chemistry, Physical
Abdessamad Y. A. Kaassis, Wafa T. Al-Jamal, Margarita Strimaite, Maja Severic, Gareth R. Williams
Summary: Two novel biocompatible hydroxy double salts (HDS), MgZn-Cl and FeZn-Cl, were found to successfully intercalate diclofenac, ibuprofen, and valproate. Drug release studies showed that the solubility of the drug ions controls the fate of the HDS in an acidic environment, with valproate intercalates dissolving completely at pH 1.0 within two hours. The HDS were also found to be biocompatible and stable upon storage for 5 years in vitro.
APPLIED CLAY SCIENCE
(2022)
Article
Endocrinology & Metabolism
Cody McGrath, Jeyantt S. Sankaran, Negin Misaghian-Xanthos, Buer Sen, Zhihui Xie, Martin A. Styner, Xiaopeng Zong, Janet Rubin, Maya Styner
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Cell & Tissue Engineering
Jeyantt S. Sankaran, Buer Sen, Annel Dudakovic, Christopher R. Paradise, Tony Perdue, Zhihui Xie, Cody McGrath, Maya Styner, Joshua Newberg, Gunes Uzer, Andre J. van Wijnen, Janet Rubin
Article
Endocrinology & Metabolism
Buer Sen, Christopher R. Paradise, Zhihui Xie, Jeyantt Sankaran, Gunes Uzer, Maya Styner, Mark Meyer, Amel Dudakovic, Andre J. van Wijnen, Janet Rubin
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Review
Endocrinology & Metabolism
Sarah E. Little-Letsinger, Gabriel M. Pagnotti, Cody McGrath, Maya Styner
CURRENT OSTEOPOROSIS REPORTS
(2020)
Article
Dentistry, Oral Surgery & Medicine
J. T. Marchesan, K. Moss, T. Morelli, F. R. Teles, K. Divaris, M. Styner, A. A. Ribeiro, J. Webster-Cyriaque, J. Beck
Summary: This study analyzed data from 1,450 adult participants in the ARIC study and found that men and African Americans had higher systemic antibody levels against most microorganisms, while healthy individuals had low levels of biofilm bacteria and serum IgG levels. Additionally, individuals in different PPC classifications showed distinct microbial profiles.
JOURNAL OF DENTAL RESEARCH
(2021)
Review
Cell Biology
Sarah E. Little-Letsinger, Janet Rubin, Brian Diekman, Clinton T. Rubin, Cody McGrath, Gabriel M. Pagnotti, Eric L. Klett, Maya Styner
Summary: Aging induces changes in the bone structure and strength, which exacerbate common aging-related diseases such as osteoporosis and osteoarthritis. This article examines the cellular hallmarks of aging in relation to bone and the marrow microenvironment, and explores how these factors contribute to various age-related disruptions in different cell types. Cellular senescence, stem cell exhaustion, mitochondrial dysfunction, epigenetic changes, and alterations in intracellular communication are recognized as central pathways in aging. The article highlights the importance of understanding cellular and tissue crosstalk in bone, cartilage, and the bone marrow niche, and proposes exercise-based interventions as potential strategies to counteract the effects of aging on the skeleton. Regular exercise has been shown to increase bone mass and delay the onset or progression of osteoporosis and osteoarthritis. Further research is needed to uncover how cellular indicators of aging manifest in bone and the marrow niche, and how altered cellular and tissue crosstalk contribute to disease progression and the development of targeted therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Buer Sen, Zhihui Xie, Sean Howard, Maya Styner, Andre J. van Wijnen, Gunes Uzer, Janet Rubin
Summary: Mesenchymal stem cells respond differently to dynamic and static forces, with dynamic force promoting nuclear translocation of beta-catenin and actin re-structuring, while static force increases nuclear levels of YAP1.
Article
Endocrinology & Metabolism
Cody McGrath, Sarah E. Little-Letsinger, Jeyantt Srinivas Sankaran, Buer Sen, Zhihui Xie, Martin A. Styner, Xiaopeng Zong, Weiqin Chen, Janet Rubin, Eric L. Klett, Rosalind A. Coleman, Maya Styner
Summary: Exercise has positive effects on skeletal health in lipodystrophy, a condition characterized by lack of white adipose tissue. A mouse model with SEIPIN deficiency showed improvements in trabecular bone density through exercise, despite differences in bone marrow adipose tissue between knockout and wild type mice.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, Research & Experimental
Janet Rubin, Maya Styner
Summary: All organisms respond to physical forces and exist within a physical space. In higher organisms, the skeleton is crucial for mobility and survival. The skeleton has evolved to adapt to different physical stresses in order to support its function. This article explores how cells responsible for remodeling the skeletal structure respond to mechanical forces and how these forces affect cellular structure. It also discusses the effects of these forces on the balance between bone-forming osteoblasts and adipocytes. The article emphasizes the importance of understanding these mechanisms for intelligent exercise prescription.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Medicine, General & Internal
Sadia Ejaz, Neeharika Nandam, Susan Maygarden, Maya Styner
Summary: This article presents two cases of extra-adrenal paragangliomas (PGLs) and highlights the possible hereditary basis of PGLs, which can occur in non-European populations. It discusses the different anatomical sites of PGLs in the two cases and suggests the need for further investigation into environmental and genetic factors that may predispose certain populations to PGLs.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Meeting Abstract
Endocrinology & Metabolism
Sarah Little-Letsinger, Cody McGrath, M. C. Ramage, Janet Rubin, Martin A. Styner, Zhihui Xie, Buer Sen, Brian Diekman, Maya Styner
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Buer Sen, Zhihui Xie, Sean Howard, Maya Styner, Gunes Uzer, Andre van Wijnen, Janet Rubin
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Janet Rubin, Rebecca J. Cleveland, Alexander Padovano, David Hu, Maya Styner, James Sanders
Summary: The study found that the prevalence of lumbar scoliosis and osteoporosis increases with age. However, there was no association between the incidence of lumbar scoliosis and femoral neck bone density.
JOURNAL OF THE ENDOCRINE SOCIETY
(2021)
Article
Endocrinology & Metabolism
Neeharika Nandam, Sadia Ejaz, William Ahrens, Maya Styner
Summary: This article presents a case of tumor-induced osteomalacia (TIO) in a 45-year-old man, who showed significant improvement in physical function and pain relief after surgical resection. The importance of establishing a robust clinical diagnosis of TIO, excluding other entities, and avoiding pitfalls in the interpretation of laboratory testing should be emphasized.
Article
Endocrinology & Metabolism
Zhihui Xie, Cody McGrath, Jeyantt Sankaran, Maya Styner, Sarah Little-Letsinger, Amel Dudakovic, Andre J. van Wijnen, Janet Rubin, Buer Sen
Summary: The study demonstrates that the selective estrogen receptor modulator Tamoxifen (TAM) can significantly increase bone volume in mice, even at very low doses, with a dose-dependent effect.
