Article
Biochemistry & Molecular Biology
Bin Wan, Seok-Jun Hong, Richard A. I. Bethlehem, Dorothea L. Floris, Boris C. Bernhardt, Sofie L. Valk
Summary: Autism is a neurodevelopmental condition characterized by atypical sensory-perceptual functions, language deficits, and socio-cognitive impairments. Previous research has shown that individuals with autism exhibit subtle alterations in brain structure asymmetry and reduced functional activation laterality compared to non-autistic individuals. However, whether these functional asymmetries reflect altered intrinsic systematic organization in autism is still unclear.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Joo Young Lee, Yong-Ho Choi, Jong Ho Cha, Ji Young Lee, Young-Jun Lee, Bo-Hyun Kim, Il-Kewon Kim, Jong-Min Lee, Hyun Ju Lee
Summary: The study found altered lateralization of fronto-limbic neural circuitry in preterm infants, indicating potential involvement in the early development of social-emotional disorders.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Tingting Liu, Zhiyong Zhao, Yuqing You, Fusheng Gao, Ying Lv, Mingyan Li, Chai Ji, Can Lai, Hongxi Zhang, Dan Wu
Summary: This study aimed to investigate the developmental trajectory of structural connectivity in preterm-born infants and explore the potential function correlation associated with network properties. The findings revealed a unique developmental pattern of structural networks in early infancy, with enhanced efficiency and small-worldness, and a significant correlation between local efficiency and late language comprehension.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Ersin Ersoezlue, Robert Perneczky, Maia Tato, Julia Utecht, Carolin Kurz, Jan Hackert, Selim Guersel, Lena Burow, Gabriele Koller, Sophia Stoecklein, Daniel Keeser, Boris Papazov, Marie Totzke, Tommaso Ballarini, Frederic Brosseron, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Wenzel Glanz, John Dylan Haynes, Michael T. Heneka, Daniel Janowitz, Ingo Kilimann, Luca Kleineidam, Christoph Laske, Franziska Maier, Matthias H. Munk, Oliver Peters, Josef Priller, Alfredo Ramirez, Sandra Roeske, Nina Roy, Klaus Scheffler, Anja Schneider, Bjorn H. Schott, Annika Spottke, Eike J. Spruth, Stefan Teipel, Chantal Unterfeld, Michael Wagner, Xiao Wang, Jens Wiltfang, Steffen Wolfsgruber, Renat Yakupov, Emrah Duezel, Frank Jessen, Boris-Stephan Rauchmann
Summary: Cognitive reserve (CR) explains inter-individual differences in the impact of neurodegenerative burden on cognitive functioning. This study explored the associations between residual CR markers (CRM) and intrinsic network connectivity (INC) in Alzheimer's disease neuropathological continuum. The results showed that INC was positively associated with CRM in the default mode network (DMN), and CRM was positively associated with the anti-correlation between memory-related regions in the frontoparietal network (FPN) and DMN in ADN and A+T/N+.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Psychology, Developmental
Sonja J. Fenske, Janelle Liu, Haitao Chen, Marcio A. Diniz, Rebecca L. Stephens, Emil Cornea, John H. Gilmore, Wei Gao
Summary: This study investigated sex differences in functional connectivity using resting-state fMRI and heatmap analysis in a large cohort of infants and adults. The findings revealed sex differences in functional connectivity in infancy, which were associated with language, executive function, and intelligence in later childhood. These results provide insights into the effects of sex on neurodevelopmental trajectories and lay a foundation for understanding sex differences in health and disease.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2023)
Article
Neurosciences
Siqi Cai, Zhifeng Shi, Chunxiang Jiang, Kai Wang, Liang Chen, Lin Ai, Lijuan Zhang
Summary: The study found that functional remodeling in the contralesional hemisphere is highly predictive of the malignant grade of glioma, showing significant hemispheric specificity. This suggests that functional features in the contralesional hemisphere may serve as efficient predictors for glioma aggressiveness.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Eleftherios Kavroulakis, Nicholas J. Simos, Thomas G. Maris, Ioannis Zaganas, Simeon Panagiotakis, Efrosini Papadaki
Summary: This study found age-related changes in intrinsic functional brain connectivity and hemodynamics in adulthood, with a greater reduction in connectivity and increased hemodynamic lead in frontal regions, while the effects were influenced by concurrent subclinical depression symptoms.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Shunshun Cui, Ping Jiang, Yan Cheng, Huanhuan Cai, Jiajia Zhu, Yongqiang Yu
Summary: Previous literature has shown that there are sex differences in behavioral inhibition and its neural substrates. This study aimed to investigate whether there are sex-dependent associations between behavioral inhibition and resting-state brain function, and how they are modulated by molecular mechanisms. The authors used resting-state functional MRI data to compute functional connectivity density (FCD) and examined its associations with behavioral inhibition ability in a large cohort of healthy young adults. They found a significant negative correlation between behavioral inhibition and FCD in the left superior parietal lobule in females but not in males. Further analyses revealed that the neural correlates of behavioral inhibition were associated with gene expression and neurotransmitter atlases, particularly those related to the cerebral cortex and the serotonergic system. These findings provide important insights into the molecular mechanisms underlying the female-specific neural substrates of behavioral inhibition, and shed light on the contribution of biological sex to variation in behavioral inhibition and its related disease risk.
Article
Neurosciences
Xi Yu, Silvina L. Ferradal, Danielle D. Sliva, Jade Dunstan, Clarisa Carruthers, Joseph Sanfilippo, Jennifer Zuk, Lilla Zollei, Emma Boyd, Borjan Gagoski, Yangming Ou, P. Ellen Grant, Nadine Gaab
Summary: Functional connectivity techniques can delineate brain organization in infancy, with early functional networks potentially influencing language and foundational literacy skills by 6.5 years old.
Article
Neuroimaging
Maria E. Barnes-Davis, Stephanie L. Merhar, Scott K. Holland, Nehal A. Parikh, Darren S. Kadis
Summary: This study found delays in language development among children born extremely preterm, but also noted the presence of hyperconnectivity in functional connectivity which was positively correlated with language performance.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Haotian Xin, Hongwei Wen, Mengmeng Feng, Yian Gao, Chaofan Sui, Nan Zhang, Changhu Liang, Lingfei Guo
Summary: This study aimed to investigate alterations in functional brain networks in patients with cerebral small vessel disease (CSVD) and assess the relationship between functional impairment and topological network changes. The results showed that patients with CSVD and cerebral microbleeds (CMBs) exhibited disrupted balance between local specialization and global integration in the functional connectivity networks, as well as altered nodal betweenness centrality in certain brain regions. These findings contribute to our understanding of the pathophysiological mechanisms underlying CSVD.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Eirini Messaritaki, Sonya Foley, Simona Schiavi, Lorenzo Magazzini, Bethany Routley, Derek K. Jones, Krish D. Singh
Summary: The study investigates the relationship between brain structure and function using microstructural MRI and resting-state MEG data. The shortest-path-length algorithm is found to be better at predicting functional connectivity patterns, with streamline count and myelination leading to the highest correlations between predicted and observed functional connectivity.
NETWORK NEUROSCIENCE
(2021)
Article
Neurosciences
Xiyong Dai, Jianlong Zhang, Lei Gao, Jinming Yu, Yuanchun Li, Baoguo Du, Xiangyi Huang, Haibo Zhang
Summary: Middle-aged male alcoholic subjects exhibited significant reductions in interhemispheric and intrahemispheric functional coherence, indicating possible degeneration of system/network integration, particularly in domains related to default mode, language processing, and salience integration.
Article
Neurosciences
Sebastian C. Schneider, Stephan Kaczmarz, Jens Goettler, Jan Kufer, Benedikt Zott, Josef Priller, Michael Kallmayer, Claus Zimmer, Christian Sorg, Christine Preibisch
Summary: This study investigates and compares different hemodynamic-vascular processes and their impact on BOLD-FC in healthy controls and patients with ICAS. The results suggest that systemic perfusion delays have a stronger influence on BOLD-FC than impairments in local neurovascular coupling.
Article
Biochemistry & Molecular Biology
Nguyen Thanh Nhu, David Yen-Ting Chen, Jiunn-Horng Kang
Summary: This study compared the accuracy of network rs-FC and brain structural features in identifying FM using a machine learning approach. The results showed that the rs-FC ML model outperformed the structural ML model in distinguishing FM patients from pain-free controls, and the combined rs-FC and structural ML model performed the best. Several rs-FC features in the final ML model were found to correlate with FM's clinical data.
Article
Statistics & Probability
Kuang-Yao Lee, Dingjue Ji, Lexin Li, Todd Constable, Hongyu Zhao
Summary: Graphical modeling of multivariate functional data is important in various applications. In this article, we propose a new conditional graphical model that takes into account the effects of external variables on graph structure, and introduce new linear operators to extend existing methods.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2023)
Article
Neurosciences
Wenjing Luo, R. Todd Constable
Summary: Research on the human connectome has great clinical potential, with significant connectivity information contained within each node that varies across task-induced states and subjects. Changes within nodes may play a substantial role in brain connectivity studies, potentially accounting for a significant fraction of the observed variance.
Article
Psychiatry
Anjali Sankar, Dustin Scheinost, Danielle A. Goldman, Rebecca Drachman, Lejla Colic, Luca M. Villa, Jihoon A. Kim, Yarani Gonzalez, Imani Marcelo, Mei Shinomiya, Brian Pittman, Cheryl M. Lacadie, Maria A. Oquendo, R. Todd Constable, Hilary P. Blumberg
Summary: This study used a whole brain graph-theoretical approach to identify hubs of functional connectivity associated with suicide attempts in individuals with Bipolar Disorder (BD). The results showed that individuals with prior suicide attempts had lower functional connectivity in the bilateral ventromedial prefrontal cortex and right anterior insula compared to those with no prior attempts and healthy volunteers. The hubs of dysfunction were associated with altered connectivity to other brain regions and with measures of suicidal ideation, hopelessness, and attempt lethality. These findings suggest that targeting these hubs may be important for reducing suicide risk in individuals with BD.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Neurosciences
Corey Horien, Dorothea L. Floris, Abigail S. Greene, Stephanie Noble, Max Rolison, Link Tejavibulya, David O'Connor, James C. McPartland, Dustin Scheinost, Katarzyna Chawarska, Evelyn M. R. Lake, R. Todd Constable
Summary: This article reviews the use of predictive modeling in understanding autism through measures of functional connectivity and symptoms, and discusses how different frameworks can improve our understanding of the neural basis of complex symptoms. The article highlights the need to consider factors such as data decay and sampling biases in study interpretation, and suggests exciting future directions for predictive modeling in autism.
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Endocrinology & Metabolism
Jelani Deajon-Jackson, Elizabeth Sanchez Rangel, Cheryl Lacadie, Abigail S. Greene, Renata Belfort-Deaguiar, Todd Constable, Douglas L. Rothman, Janice J. Hwang
Article
Neurosciences
Pratheek S. Bobba, Clara F. Weber, Adrian Mak, Ali Mozayan, Ajay Malhotra, Kevin N. Sheth, Sarah N. Taylor, Arastoo Vossough, Patricia Ellen Grant, Dustin Scheinost, Robert Todd Constable, Laura R. Ment, Seyedmehdi Payabvash
Summary: In this study, the researchers characterized the age-related changes in diffusion metrics in neonatal brains. They found a rapid decrease in diffusivity metrics in cerebral/cerebellar white matter and vermis within the first few weeks of neonatal age, likely due to myelination. Prematurity and low gestational age at birth may also result in lasting delay in myelination of the corpus callosum and cellularity of the cerebral cortex.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Phan Q. Duy, Stefan C. Weise, Claudia Marini, Xiao-Jun Li, Dan Liang, Peter J. Dahl, Shaojie Ma, Ana Spajic, Weilai Dong, Jane Juusola, Emre Kiziltug, Adam J. Kundishora, Sunil Koundal, Maysam Z. Pedram, Lucia A. Torres-Fernandez, Kristian Haendler, Elena De Domenico, Matthias Becker, Thomas Ulas, Stefan A. Juranek, Elisa Cuevas, Le Thi Hao, Bettina Jux, Andre M. M. Sousa, Fuchen Liu, Suel-Kee Kim, Mingfeng Li, Yiying Yang, Yutaka Takeo, Alvaro Duque, Carol Nelson-Williams, Yonghyun Ha, Kartiga Selvaganesan, Stephanie M. Robert, Amrita K. Singh, Garrett Allington, Charuta G. Furey, Andrew T. Timberlake, Benjamin C. Reeves, Hannah Smith, Ashley Dunbar, Tyrone DeSpenza, June Goto, Arnaud Marlier, Andres Moreno-De-Luca, Xin Yu, William E. Butler, Bob S. Carter, Evelyn M. R. Lake, R. Todd Constable, Pasko Rakic, Haifan Lin, Engin Deniz, Helene Benveniste, Nikhil S. Malvankar, Juvianee Estrada-Veras, Christopher A. Walsh, Seth L. Alper, Joachim L. Schultze, Katrin Paeschke, Angelika Doetzlhofer, F. Gregory Wulczyn, Sheng Chih Jin, Richard P. Lifton, Nenad Sestan, Waldemar Kolanus, Kristopher T. Kahle
Summary: This study reveals a neuroprogenitor-based genetic subtype of human hydrocephalus with defective neurogenesis and altered brain-fluid biomechanics. By analyzing genomic and transcriptomic data of 483 patients with congenital hydrocephalus, the study identifies a group of risk genes that converge in embryonic neuroepithelial stem cells. Mutations in these genes lead to premature neuroepithelial cell differentiation and reduced neurogenesis, resulting in the development of hydrocephalus. This research highlights the importance of precisely regulated neuroepithelial cell fate for normal brain-CSF biomechanics and provides insights into the genetic mechanisms behind hydrocephalus.
NATURE NEUROSCIENCE
(2022)
Article
Psychology, Biological
Kwangsun Yoo, Monica D. Rosenberg, Young Hye Kwon, Qi Lin, Emily W. Avery, Dustin Sheinost, R. Todd Constable, Marvin M. Chun
Summary: This study introduces a model that predicts a person's overall attentional functioning using functional magnetic resonance imaging data and demonstrates its generalization across multiple datasets.
NATURE HUMAN BEHAVIOUR
(2022)
Article
Neurosciences
Kwangsun Yoo, Monica D. Rosenberg, Young Hye Kwon, Dustin Scheinost, R. Todd Constable, Marvin M. Chun
Summary: This study presents a novel method that models the brain's functional reorganization in response to specific task goals. The method accurately generates task-related connectomes from task-free connectomes and amplifies behaviorally relevant individual differences. Additionally, the study reveals how the brain reorganizes between different cognitive states.
Article
Clinical Neurology
Lejla Colic, Alexis Clark, Anjali Sankar, Durga J. Rathi, Danielle A. Goldman, Jihoon A. Kim, Luca M. Villa, E. Kale Edmiston, Elizabeth T. C. Lippard, Brian Pittman, R. Todd Constable, Carolyn M. Mazure, Hilary P. Blumberg
Summary: This study investigated the relationships among gender, childhood maltreatment, hippocampus and prefrontal gray matter structure, and clinical features in bipolar disorder (BD). The findings demonstrated significant gender-related effects of childhood maltreatment on frontotemporal structure and clinical features of BD, providing novel perspectives on the gendered effects of childhood maltreatment in BD.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
John Bero, Yang Li, Aviral Kumar, Colin Humphries, Snehesh Nag, Heungyeol Lee, Woo Young Ahn, Sowon Hahn, Robert Todd Constable, Hackjin Kim, Daeyeol Lee
Summary: This study examined the interaction between myelination, cortical thickness, and resting-state functional connectivity in children aged 10 to 15. The results showed higher correlations among these measures in sensory-motor cortical areas compared to association cortical areas. These correlations were stable and not influenced by age-related changes in each measure, and regional variations reflected the hierarchy of cortical information processing.
HUMAN BRAIN MAPPING
(2023)
Meeting Abstract
Clinical Neurology
Ece Eldem, Shubham Misra, Terence Quinn, Lucas Driskell, Alice Perez, Carmen Carrion, Todd Constable, Joseph Schindler, Yize Zhao, Jason Sico, Jason D. Hinman, Heather Allore, Swathi Kiran, Jubin Abutalebi, Jean-Marie Annoni, Nishant K. Mishra
Article
Chemistry, Multidisciplinary
Sandeep K. Mishra, Peter Herman, Michael Crair, R. Todd Constable, John J. Walsh, Adil Akif, Justus V. Verhagen, Fahmeed Hyder
Summary: In this study, magnetic protein nanoparticles (MPNPs) with fluorescent dye (f-MPNPs) were successfully synthesized for optical cerebrovascular imaging without losing the properties of positive magnetic resonance imaging (MRI) contrast. In vivo experiments on mice showed that f-MPNPs provided detailed microvascular contrast enhancement with fast clearance and no toxic effects.
Article
Multidisciplinary Sciences
Abigail S. Greene, Xilin Shen, Stephanie Noble, Corey Horien, C. Alice Hahn, Jagriti Arora, Fuyuze Tokoglu, Marisa N. Spann, Carmen Carrion, Daniel S. Barron, Gerard Sanacora, Vinod H. Srihari, Scott W. Woods, Dustin Scheinost, R. Todd Constable
Summary: Individual differences in brain functional organization manifest a range of traits, symptoms, and behaviors. Predictive models linking brain activity to phenotype highlight the failure of models in different individuals, showing reliable and phenotype-specific failures that generalize across datasets.
Article
Clinical Neurology
Mubbahsir Sheikh, Mohamad Koubeissi, R. Todd Constable, Dennis D. Spencer, Rafeed Alkawadri
Summary: This is the first known case of profound illusionary time dilation caused by electrical cortical stimulation. The study found that stimulation of certain brain regions can alter time perception. This finding may have potential benefits for conditions involving impaired time perception.
EPILEPTIC DISORDERS
(2022)