Article
Endocrinology & Metabolism
Jasmin Maria Buelow, Nikolai Renz, Melanie Haffner-Luntzer, Verena Fischer, Astrid Schoppa, Jan Tuckermann, Joerg Koehl, Markus Huber-Lang, Anita Ignatius
Summary: Recent evidence suggests that the complement system may play a role in bone homeostasis and inflammatory bone loss. This study demonstrated that the C5aR1 receptor on osteoblasts is crucial for the development of postmenopausal osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kalpana Patel, S. V. V. S. Ravi Mangu, Shinde Vijay Sukhdeo, Kunal Sharan
Summary: This study investigates the effects of sesamol on bone metabolism. It found that sesamol can promote bone formation but can also lead to bone deterioration in ovariectomized rats. These findings highlight the potential negative impact of sesamol in postmenopausal women.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Engineering, Biomedical
Wei Zhang, Xingzhi Zhou, Weiduo Hou, Erman Chen, Chenyi Ye, Mo Chen, Qian Lu, Xiaohua Yu, Weixu Li
Summary: In this study, a molecular therapeutic strategy mediated by a SIRT-1 agonist was reported to reverse the imbalance in bone homeostasis by regulating osteogenesis and osteoclastogenesis simultaneously. The sustained release of SRT2104 from mineral coated acellular matrix microparticles effectively enhanced osteogenic differentiation and mineralization, while attenuating the formation and function of excessive osteoclasts by integrating multiple vital upstream signals. Animal models also demonstrated the accelerated healing and improved osseointegration of osteoporotic bone defects.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Jung Ha Kim, Kabsun Kim, Inyoung Kim, Semun Seong, Jeong-Tae Koh, Nacksung Kim
Summary: The study found that Ngn1 inhibits the acetylation of NFATc1 and Runx2, leading to the suppression of osteoclast and osteoblast differentiation. Additionally, Ngn1 can also suppress IL-17A-mediated enhancement of osteoclast and osteoblast differentiation. These findings suggest that Ngn1 may serve as a novel therapeutic agent for treating ankylosing spondylitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Takuma Matsubara, Kazuma Yasuda, Kana Mizuta, Hiroka Kawaue, Shoichiro Kokabu
Summary: Osteoclasts and osteoblasts are the key cells regulating bone homeostasis. Imbalance between increased bone resorption by osteoclasts and decreased bone formation by osteoblasts leads to osteoporosis and other metabolic bone diseases. Src has been identified as an essential factor for bone resorption and a suppressor of bone formation. However, developing effective therapies targeting Src is challenging due to its widespread expression and involvement in various biological processes. Understanding the molecular mechanism of Src in bone is crucial for the treatment of bone metabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Vishwa Deepak, Shu-Ting Yang, Ziqing Li, Xinhua Li, Andrew Ng, Ding Xu, Yi-Ping Li, Merry Jo Oursler, Shuying Yang
Summary: This study identifies a negative function of IFT80 in osteoclasts by regulating the stabilization and degradation of Cbl-b and TRAF6, thereby affecting osteoclast formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Pei He, Fei Jiang, Long-Fei Wu, Xu Zhou, Shu-Feng Lei, Fei-Yan Deng
Summary: The variant allele A of phosSNP rs3755955 in the IDUA gene regulates protein phosphorylation, inhibits osteoblast function, and promotes osteoclastic activity. This SNP alters IDUA protein phosphorylation, significantly affects human osteoblastic and osteoclastic gene expression, and influences the growth, differentiation, and activity of osteoblasts and osteoclasts, thereby impacting bone mineral density.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Sung-Ju Lee, Hyun Yang, Seong Cheol Kim, Dong Ryun Gu, Jin Ah Ryuk, Seon-A Jang, Hyunil Ha
Summary: Radix Asteris, a traditional Chinese medicine, has been historically used to treat respiratory conditions. This research reveals its potential in managing osteoporosis by inhibiting osteoclast differentiation and protecting against bone degradation. The study also identifies specific constituents in Radix Asteris that regulate bone and fat metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dong Ryun Gu, Hyun Yang, Seong Cheol Kim, Youn-Hwan Hwang, Hyunil Ha
Summary: Angelica dahurica radix has traditional use in China and Korea for treating headaches, cold-damp pain, and skin diseases. This study found that the water extract of Angelica dahurica radix effectively inhibits osteoclast differentiation and alleviates bone loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kathryn Frost, Amy J. Naylor, Helen M. McGettrick
Summary: Bone remodelling is a dynamically regulated process involving osteoblasts, osteoclasts, and their progenitors. Dysregulation of bone remodelling can lead to disorders like osteoporosis and Paget's disease. The sphingosine-1-phosphate (S1P) signaling pathway has been identified as an important regulator of bone remodelling and inflammatory responses. This review discusses the role of S1P in bone homeostasis and disease, highlighting its potential as a biomarker and therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Andrea Alford, Chris Stephan, Kenneth M. Kozloff, Kurt D. Hankenson
Summary: The trimeric thrombospondin homologs TSP1 and TSP2 play distinct roles in bone physiology, affecting periosteal and endosteal activities, respectively. The absence of both TSP1 and TSP2 results in a unique, sex-specific bone phenotype not observed in single knockouts.
Article
Food Science & Technology
Wen Xiao, Yanyan Wei, Fang Yang, Xiangyi Lu, Shuowen Liu, Yongling Long, Yang Yu
Summary: Cistanche deserticola polysaccharide (CDP) has been shown to prevent and improve osteoporosis by inhibiting osteoclast activity and function. The study demonstrated that CDP can inhibit RANKL-induced osteoclastogenesis and bone resorption, impacting NF-kappa B and MAPKs signaling pathways to prevent NFATc1 activation. These findings suggest that CDP is a potentially safe drug for treating osteoporosis.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Nutrition & Dietetics
Dong Ryun Gu, Hyun Yang, Seong Cheol Kim, Youn-Hwan Hwang, Hyunil Ha
Summary: The study found that the water extract of Piper longum Linn (WEPL) can inhibit osteoclast differentiation and alleviate bone loss in ovariectomized mice. Additionally, phytochemicals in WEPL were identified to have inhibitory effects on osteoclastogenesis and bone loss.
Article
Plant Sciences
Yun Yang, Qiu Wei, Ran An, Hua-mei Zhang, Jia-yuan Shen, Xiao-yan Qin, Xiao-ling Han, Jie Li, Xiao-wei Li, Xiu-mei Gao, Jun He, Hao-ping Mao
Summary: This study aimed to investigate the potential effect of Semen Cuscutae on ovariectomy (OVX)-induced osteoporosis in mice and clarify the exact mechanisms by which Semen Cuscutae exert the anti-osteoporosis effect.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Nan-Nan Sha, Jia-Li Zhang, Christina Chui-Wa Poon, Wen-Xiong Li, Yue Li, Yi-Fei Wang, Wei Shi, Fu-Hui Lin, Wen-Ping Lin, Yong-Jun Wang, Yan Zhang
Summary: In this study, it was found that ANG II and ANG(1-7) had different effects on osteoblasts and osteoclasts under high-glucose conditions, playing different roles in the development of osteoporosis, with ANG(1-7) showing a protective effect against diabetes-induced osteoporosis.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Oncology
Taichi Kamiunten, Hisashi Ideno, Akemi Shimada, Yoshinori Arai, Tatsuo Terashima, Yasuhiro Tomooka, Yoshiki Nakamura, Kazuhisa Nakashima, Hiroshi Kimura, Yoichi Shinkai, Makoto Tachibana, Akira Nifuji
EXPERIMENTAL CELL RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Markus Linder, Manfred Hecking, Elisabeth Glitzner, Karin Zwerina, Martin Holcmann, Latifa Bakiri, Maria Grazia Ruocco, Jan Tuckermann, Georg Schett, Erwin F. Wagner, Maria Sibilia
CELL DEATH AND DIFFERENTIATION
(2018)
Review
Biochemistry & Molecular Biology
Lorenzo Galluzzi, Ilio Vitale, Stuart A. Aaronson, John M. Abrams, Dieter Adam, Patrizia Agostinis, Emad S. Alnemri, Lucia Altucci, Ivano Amelio, David W. Andrews, Margherita Annicchiarico-Petruzzelli, Alexey V. Antonov, Eli Arama, Eric H. Baehrecke, Nickolai A. Barlev, Nicolas G. Bazan, Francesca Bernassola, Mathieu J. M. Bertrand, Katiuscia Bianchi, Mikhail V. Blagosklonny, Klas Blomgren, Christoph Borner, Patricia Boya, Catherine Brenner, Michelangelo Campanella, Eleonora Candi, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K. -M. Chan, Navdeep S. Chandel, Emily H. Cheng, Jerry E. Chipuk, John A. Cidlowski, Aaron Ciechanover, Gerald M. Cohen, Marcus Conrad, Juan R. Cubillos-Ruiz, Peter E. Czabotar, Vincenzo D'Angiolella, Ted M. Dawson, Valina L. Dawson, Vincenzo De laurenzi, Ruggero De Maria, Klaus-Michael Debatin, Ralph J. DeBerardinis, Mohanish Deshmukh, Nicola Di Daniele, Francesco Di Virgilio, Vishva M. Dixit, Scott J. Dixon, Colin S. Duckett, Brian D. Dynlacht, Wafik S. El-Deiry, John W. Elrod, Gian Maria Fimia, Simone Fulda, Ana J. Garcia-Saez, Abhishek D. Garg, Carmen Garrido, Evripidis Gavathiotis, Pierre Golstein, Eyal Gottlieb, Douglas R. Green, Lloyd A. Greene, Hinrich Gronemeyer, Atan Gross, Gyorgy Hajnoczky, J. Marie Hardwick, Isaac S. Harris, Michael O. Hengartner, Claudio Hetz, Hidenori Ichijo, Marja Jaattela, Bertrand Joseph, Philipp J. Jost, Philippe P. Juin, William J. Kaiser, Michael Karin, Thomas Kaufmann, Oliver Kepp, Adi Kimchi, Richard N. Kitsis, Daniel J. Klionsky, Richard A. Knight, Sharad Kumar, Sam W. Lee, John J. Lemasters, Beth Levine, Andreas Linkermann, Stuart A. Lipton, Richard A. Lockshin, Carlos Lopez-Otin, Scott W. Lowe, Tom Luedde, Enrico Lugli, Marion MacFarlane, Frank Madeo, Michal Malewicz, Walter Malorni, Gwenola Manic, Jean-Christophe Marine, Seamus J. Martin, Jean-Claude Martinou, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Sonia Melino, Edward A. Miao, Jeffery D. Molkentin, Ute M. Moll, Cristina Munoz-Pinedo, Shigekazu Nagata, Gabriel Nunez, Andrew Oberst, Moshe Oren, Michael Overholtzer, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M. Penninger, David M. Pereira, Shazib Pervaiz, Marcus E. Peter, Mauro Piacentini, Paolo Pinton, Jochen H. M. Prehn, Hamsa Puthalakath, Gabriel A. Rabinovich, Markus Rehm, Rosario Rizzuto, Cecilia M. P. Rodrigues, David C. Rubinsztein, Thomas Rudel, Kevin M. Ryan, Emre Sayan, Luca Scorrano, Feng Shao, Yufang Shi, John Silke, Hans-Uwe Simon, Antonella Sistigu, Brent R. Stockwell, Andreas Strasser, Gyorgy Szabadkai, Stephen W. G. Tait, Daolin Tang, Nektarios Tavernarakis, Andrew Thorburn, Yoshihide Tsujimoto, Boris Turk, Tom Vanden Berghe, Peter Vandenabeele, Matthew G. Vander Heiden, Andreas Villunger, Herbert W. Virgin, Karen H. Vousden, Domagoj Vucic, Erwin F. Wagner, Henning Walczak, David Wallach, Ying Wang, James A. Wells, Will Wood, Junying Yuan, Zahra Zakeri, Boris Zhivotovsky, Laurence Zitvogel, Gerry Melino, Guido Kroemer
CELL DEATH AND DIFFERENTIATION
(2018)
Article
Endocrinology & Metabolism
Akemi Shimada, Hisashi Ideno, Yoshinori Arai, Koichiro Komatsu, Satoshi Wada, Teruhito Yamashita, Norio Amizuka, Ernst Poschl, Bent Brachvogel, Yoshiki Nakamura, Kazuhisa Nakashima, Hiroaki Mizukami, Yoichi Ezura, Akira Nifuji
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Article
Multidisciplinary Sciences
Masatoshi Fukuda, Tatsuya Yoshizawa, Md Fazlul Karim, Shihab U. Sobuz, Wataru Korogi, Daiki Kobayasi, Hiroki Okanishi, Masayoshi Tasaki, Katsuhiko Ono, Tomohiro Sawa, Yoshifumi Sato, Mami Chirifu, Takeshi Masuda, Teruya Nakamura, Hironori Tanoue, Kazuhisa Nakashima, Yoshihiro Kobashigawa, Hiroshi Morioka, Eva Bober, Sumio Ohtsuki, Yuriko Yamagata, Yukio Ando, Yuichi Oike, Norie Araki, Shu Takeda, Hiroshi Mizuta, Kazuya Yamagata
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Maria Riedel, Martin F. Berthelsen, Latifa Bakiri, Erwin F. Wagner, Martin K. Thomsen
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Biochemistry & Molecular Biology
Yubin Luo, Bettina Groetsch, Nicole Hannemann, Maria Jimenez, Natacha Ipseiz, Ozge Uluckan, Nengyu Lin, Georg Schett, Erwin F. Wagner, Aline Bozec
MOLECULAR AND CELLULAR BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Isidoro Cobo, Paola Martinelli, Marta Flandez, Latifa Bakiri, Mingfeng Zhang, Enrique Carrillo-de-Santa-Pau, Jinping Jia, Victor J. Sanchez-Arevalo Lobo, Diego Megias, Irene Felipe, Natalia del Pozo, Irene Millan, Liv Thommesen, Torunn Bruland, Sara H. Olson, Jill Smith, Kristina Schoonjans, William R. Bamlet, Gloria M. Petersen, Nuria Malats, Laufey T. Amundadottir, Erwin F. Wagner, Francisco X. Real
Article
Medicine, Research & Experimental
Markus Linder, Elisabeth Glitzner, Sriram Srivatsa, Latifa Bakiri, Kazuhiko Matsuoka, Parastoo Shahrouzi, Monika Dumanic, Philipp Novoszel, Thomas Mohr, Oliver Langer, Thomas Wanek, Markus Mitterhauser, Erwin F. Wagner, Maria Sibilia
EMBO MOLECULAR MEDICINE
(2018)
Article
Medicine, Research & Experimental
Nuria Gago-Lopez, Liliana F. Mellor, Diego Megias, Guillermo Martin-Serrano, Ander Izeta, Francisco Jimenez, Erwin F. Wagner
EMBO MOLECULAR MEDICINE
(2019)
Article
Endocrinology & Metabolism
Hisashi Ideno, Kazuhisa Nakashima, Koichiro Komatsu, Ryoko Araki, Masumi Abe, Yoshinori Arai, Hiroshi Kimura, Yoichi Shinkai, Makoto Tachibana, Akira Nifuji
Article
Cell Biology
Kazuhiko Matsuoka, Latifa Bakiri, Lena Wolff, Markus Linder, Amanda Mikels-Vigdal, Ana Patino-Garcia, Fernando Lecanda, Christine Hartmann, Maria Sibilia, Erwin F. Wagner
Article
Biochemistry & Molecular Biology
Maria Riedel, Martin F. Berthelsen, Huiqiang Cai, Jakob Haldrup, Michael Borre, Soren R. Paludan, Henrik Hager, Mikkel H. Vendelbo, Erwin F. Wagner, Latifa Bakiri, Martin K. Thomsen
Summary: This study provides functional evidence that FOS acts as a tumor suppressor in prostate cancer progression, its deficiency leading to increased cell proliferation and oncogenic pathway alterations. Loss of FOS accelerates disease progression through accelerated proliferation and invasiveness, partly through the involvement of JUN.
Article
Biochemistry & Molecular Biology
Philipp Novoszel, Barbara Drobits, Martin Holcmann, Cristiano De Sa Fernandes, Roland Tschismarov, Sophia Derdak, Thomas Decker, Erwin F. Wagner, Maria Sibilia
Summary: The transcription factors c-Jun and JunB are essential for the fate specification and function of CD8 alpha cDC1, playing a key role in controlling the diversification of this subset. Their absence leads to reduced CD8 alpha cDC1 pool and increased resistance to Listeria monocytogenes infection, highlighting their crucial role in maintaining the identity and function of CD8 alpha cDC1.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Dermatology
Nuria Gago-Lopez, Carmen Lagunas Arnal, Juan J. Perez, Erwin F. Wagner
Summary: Topical application of an amygdalin analogue cream on a mouse model of psoriasis showed reduction in disease symptoms, epidermal hyperplasia, and skin inflammation.
EXPERIMENTAL DERMATOLOGY
(2021)