MiR-451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC1

Cardiovascular autophagy

(2013) Sergio Lavandero et al.   Autophagy

MTORC1 determines autophagy through ULK1 regulation in skeletal muscle

(2013) Perrine Castets et al.   Autophagy

Enhanced autophagy ameliorates cardiac proteinopathy

(2013) Md. Shenuarin Bhuiyan et al.   JOURNAL OF CLINICAL INVESTIGATION

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

(2013) Michalis Papadakis et al.   NATURE MEDICINE

Fibroblast Growth Factor Receptor 1 Signaling in Adult Cardiomyocytes Increases Contractility and Results in a Hypertrophic Cardiomyopathy

(2013) Sarah N. Cilvik et al.   PLoS One

Reactivation of autophagy amelioratesLMNAcardiomyopathy

(2012) Jason C. Choi et al.   Autophagy

MicroRNA-350 induces pathological heart hypertrophy by repressing both p38 and JNK pathways

(2012) Yuzhi Ge et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Loss of the miR-144/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1

(2012) Xiaohong Wang et al.   CARDIOVASCULAR RESEARCH

MicroRNA-24 regulates cardiac fibrosis after myocardial infarction

(2012) Jue Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MiR-221 promotes cardiac hypertrophy in vitro through the modulation of p27 expression

(2012) Changxin Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hypertrophic cardiomyopathy

(2012) Barry J Maron et al.   LANCET

Ablation of ALCAT1 Mitigates Hypertrophic Cardiomyopathy through Effects on Oxidative Stress and Mitophagy

(2012) X. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy

(2012) Ahmet Ucar et al.   Nature Communications

The PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling

(2011) Christine Schramm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

(2011) Dan Egan et al.   Autophagy

Defective proteolytic systems in Mybpc3-targeted mice with cardiac hypertrophy

(2011) Saskia Schlossarek et al.   BASIC RESEARCH IN CARDIOLOGY

Hypertrophic Cardiomyopathy

(2011) Steve R. Ommen   CURRENT PROBLEMS IN CARDIOLOGY

How do MYBPC3 mutations cause hypertrophic cardiomyopathy?

(2011) Steven Marston et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Inhibition of autophagy in the heart induces age-related cardiomyopathy

(2010) Manabu Taneike et al.   Autophagy

microRNA-451: A conditional switch controlling glioma cell proliferation and migration

(2010) Jakub Godlewski et al.   CELL CYCLE

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

(2010) Denghong Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death

(2010) Xiaowei Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MicroRNA-451 Regulates LKB1/AMPK Signaling and Allows Adaptation to Metabolic Stress in Glioma Cells

(2010) Jakub Godlewski et al.   MOLECULAR CELL

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Loss of Cardiac microRNA-Mediated Regulation Leads to Dilated Cardiomyopathy and Heart Failure

(2009) Prakash K. Rao et al.   CIRCULATION RESEARCH

MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice

(2009) Thomas E. Callis et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy in transition from hypertrophic cardiomyopathy to heart failure

(2009) A. Fidzianska et al.   Microscopy

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

The role of autophagy in the heart

(2008) K Nishida et al.   CELL DEATH AND DIFFERENTIATION

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL