Journal
CURRENT PROBLEMS IN CARDIOLOGY
Volume 36, Issue 11, Pages 409-453Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.cpcardiol.2011.06.001
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Hypertrophic cardiomyopathy is a fascinating disease of marked heterogeneity. Hypertrophic cardiomyopathy was originally characterized by massive myocardial hypertrophy in the absence of known etiology, a dynamic left ventricular outflow obstruction, and increased risk of sudden death. It is now well accepted that multiple mutations in genes encoding for the cardiac sarcomere are responsible for the disease. Complex morphologic and pathophysiologic differences, disparate natural history studies, and novel treatment strategies underscore the challenge to the practicing cardiologist when faced with the management of the hypertrophic cardiomyopathy patient. (Curr Probl Cardiol 2011;36:409-453.)
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