Keratins and disease at a glance

The Mechanical Behavior of Mutant K14-R125P Keratin Bundles and Networks in NEB-1 Keratinocytes

(2012) Daniel R. Beriault et al.   PLoS One

Gene expression analysis of an epidermolysis bullosa simplex Dowling-Meara cell line by subtractive hybridization: recapitulation of cellular differentiation, migration and wound healing

(2011) Martin Wagner et al.   EXPERIMENTAL DERMATOLOGY

Keratin disorders: from gene to therapy

(2011) W. H. I. McLean et al.   HUMAN MOLECULAR GENETICS

Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia

(2011) Reinhard Windoffer et al.   JOURNAL OF CELL BIOLOGY

Development of Allele-Specific Therapeutic siRNA for Keratin 5 Mutations in Epidermolysis Bullosa Simplex

(2011) Sarah D. Atkinson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Chemical Chaperones Protect Epidermolysis Bullosa Simplex Keratinocytes from Heat Stress–Induced Keratin Aggregation: Involvement of Heat Shock Proteins and MAP Kinases

(2011) Jean Christopher Chamcheu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Statins Downregulate K6a Promoter Activity: A Possible Therapeutic Avenue for Pachyonychia Congenita

(2011) Yiwei Zhao et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Vimentin organization modulates the formation of lamellipodia

(2011) Brian T. Helfand et al.   MOLECULAR BIOLOGY OF THE CELL

Development of Allele-Specific Therapeutic siRNA in Meesmann Epithelial Corneal Dystrophy

(2011) Haihui Liao et al.   PLoS One

The ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation

(2010) Stefanie Löffek et al.   HUMAN MUTATION

Keratin Hypersumoylation Alters Filament Dynamics and Is a Marker for Human Liver Disease and Keratin Mutation

(2010) Natasha T. Snider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-GlcNAcylation Determines the Solubility, Filament Organization, and Stability of Keratins 8 and 18

(2010) Budnar Srikanth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A guide to super-resolution fluorescence microscopy

(2010) Lothar Schermelleh et al.   JOURNAL OF CELL BIOLOGY

Cytoskeletal keratin glycosylation protects epithelial tissue from injury

(2010) Nam-On Ku et al.   NATURE CELL BIOLOGY

Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin

(2010) Daryle DePianto et al.   NATURE GENETICS

Keratins in health and cancer: more than mere epithelial cell markers

(2010) V Karantza   ONCOGENE

Intermediate filaments take the heat as stress proteins

(2010) D.M. Toivola et al.   TRENDS IN CELL BIOLOGY

Severe keratin 5 and 14 mutations induce down-regulation of junction proteins in keratinocytes

(2009) Mirjana Liovic et al.   EXPERIMENTAL CELL RESEARCH

Insights into the mechanical properties of epithelial cells: the effects of shear stress on the assembly and remodeling of keratin intermediate filaments

(2009) Eric W. Flitney et al.   FASEB JOURNAL

Mitochondrial reactive oxygen species are required for hypoxia-induced degradation of keratin intermediate filaments

(2009) Ni Na et al.   FASEB JOURNAL

Plectin Isoform-dependent Regulation of Keratin-Integrin α6β4 Anchorage via Ca2+/Calmodulin

(2009) Julius Kostan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Self-organization of keratin intermediate filaments into cross-linked networks

(2009) Chang-Hun Lee et al.   JOURNAL OF CELL BIOLOGY

Introducing intermediate filaments: from discovery to disease

(2009) John E. Eriksson et al.   JOURNAL OF CLINICAL INVESTIGATION

Toward unraveling the complexity of simple epithelial keratins in human disease

(2009) M. Bishr Omary et al.   JOURNAL OF CLINICAL INVESTIGATION

ERK Involvement in Resistance to Apoptosis in Keratinocytes with Mutant Keratin

(2009) David Russell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Shear Stress Induced Reorganization of the Keratin Intermediate Filament Network Requires Phosphorylation by Protein Kinase C ζ

(2009) Sivaraj Sivaramakrishnan et al.   MOLECULAR BIOLOGY OF THE CELL

First-in-human Mutation-targeted siRNA Phase Ib Trial of an Inherited Skin Disorder

(2009) Sancy A Leachman et al.   MOLECULAR THERAPY

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Actin-dependent dynamics of keratin filament precursors

(2009) Anne Kölsch et al.   CELL MOTILITY AND THE CYTOSKELETON

Plectin deficiency affects precursor formation and dynamics of vimentin networks

(2008) Radovan Spurny et al.   EXPERIMENTAL CELL RESEARCH

Ubiquitin-Proteasome-mediated Degradation of Keratin Intermediate Filaments in Mechanically Stimulated A549 Cells

(2008) Ariel Jaitovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Intermediate Filament Network in Cultured Human Keratinocytes Is Remarkably Extensible and Resilient

(2008) Douglas Fudge et al.   PLoS One

Mutation in keratin 18 induces mitochondrial fragmentation in liver-derived epithelial cells

(2007) Hiroto Kumemura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases

(2007) Ildiko Szeverenyi et al.   HUMAN MUTATION