APPL1 regulates basal NF-κB activity by stabilizing NIK

Lymphotoxin- 1 2 and LIGHT Induce Classical and Noncanonical NF- B-Dependent Proinflammatory Gene Expression in Vascular Endothelial Cells

(2014) L. A. Madge et al.   JOURNAL OF IMMUNOLOGY

Tumor necrosis factor receptor cross-talk

(2011) Petrus J. W. Naudé et al.   FEBS Journal

TNFR1-induced activation of the classical NF-κB pathway

(2011) Harald Wajant et al.   FEBS Journal

Biochemical Characterization of APPL Endosomes: The Role of Annexin A2 in APPL Membrane Recruitment

(2011) Anna Urbanska et al.   TRAFFIC

Non-canonical NF-κB signaling pathway

(2010) Shao-Cong Sun   CELL RESEARCH

A single NFκB system for both canonical and non-canonical signaling

(2010) Vincent Feng-Sheng Shih et al.   CELL RESEARCH

NF-κB inducing kinase: A key regulator in the immune system and in cancer

(2010) Yee Mon Thu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex

(2009) Magdalena Banach-Orlowska et al.   BIOCHEMICAL JOURNAL

A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes

(2009) Roberto Zoncu et al.   CELL

APPL1 Potentiates Insulin-Mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice

(2009) Kenneth K.Y. Cheng et al.   Cell Metabolism

Appl1Is Dispensable for Mouse Development, and Loss of Appl1 Has Growth Factor-selective Effects on Akt Signaling in Murine Embryonic Fibroblasts

(2009) Yinfei Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endosomal Adaptor Proteins APPL1 and APPL2 Are Novel Activators of β-Catenin/TCF-mediated Transcription

(2009) Sajid Rashid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adiponectin Activates AMP-activated Protein Kinase in Muscle Cells via APPL1/LKB1-dependent and Phospholipase C/Ca2+/Ca2+/Calmodulin-dependent Protein Kinase Kinase-dependent Pathways

(2009) Lijun Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis

(2009) Beata Pyrzynska et al.   Molecular Oncology

Nuclear Trafficking and Functions of Endocytic Proteins Implicated in Oncogenesis

(2009) Joana Borlido et al.   TRAFFIC

APPL1: role in adiponectin signaling and beyond

(2008) Sathyaseelan S. Deepa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development

(2008) Annette Schenck et al.   CELL

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Resistance in Human Obesity

(2008) Leonie Heilbronn et al.   CURRENT PHARMACEUTICAL DESIGN

Adiponectin Blocks Interleukin-18-mediated Endothelial Cell Death via APPL1-dependent AMP-activated Protein Kinase (AMPK) Activation and IKK/NF-κB/PTEN Suppression

(2008) Bysani Chandrasekar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY

Control of canonical NF- B activation through the NIK-IKK complex pathway

(2008) B. Zarnegar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights into NF-κB regulation and function

(2008) Shao-Cong Sun et al.   TRENDS IN IMMUNOLOGY