Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Drosophila Atg7: Required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis

(2014) Gábor Juhász et al.   Autophagy

Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 inDrosophila

(2014) Péter Nagy et al.   Autophagy

The exon junction complex is required for definition and excision of neighboring introns inDrosophila

(2014) Rippei Hayashi et al.   GENES & DEVELOPMENT

The exon junction complex controls transposable element activity by ensuring faithful splicing of thepiwitranscript

(2014) Colin D. Malone et al.   GENES & DEVELOPMENT

Local caspase activation interacts with Slit-Robo signaling to restrict axonal arborization

(2014) Douglas S. Campbell et al.   JOURNAL OF CELL BIOLOGY

A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

(2014) Aditya Murthy et al.   NATURE

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adenosine Nucleotide Biosynthesis and AMPK Regulate Adult Life Span and Mediate the Longevity Benefit of Caloric Restriction in Flies

(2013) Drew Stenesen et al.   Cell Metabolism

Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion

(2013) Vivek A Rudrapatna et al.   EMBO REPORTS

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The return of the nucleus: transcriptional and epigenetic control of autophagy

(2013) Jens Füllgrabe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

(2013) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila

(2013) Hua Bai et al.   PLoS Genetics

The emerging multiple roles of nuclear Akt

(2012) Alberto M. Martelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Cellular EJC Interactome Reveals Higher-Order mRNP Structure and an EJC-SR Protein Nexus

(2012) Guramrit Singh et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Novel AKT1-GLI3-VMP1 Pathway Mediates KRAS Oncogene-induced Autophagy in Cancer Cells

(2012) Andrea E. Lo Ré et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

(2012) Alejo Efeyan et al.   NATURE

The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex

(2012) Andrea Giovanni Murachelli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Amino acid sensing and regulation of mTORC1

(2012) Lijun Yan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Thefull-of-bacteriagene is required for phagosome maturation during immune defense inDrosophila

(2011) Mohammed Ali Akbar et al.   JOURNAL OF CELL BIOLOGY

Image-based genome-wide siRNA screen identifies selective autophagy factors

(2011) Anthony Orvedahl et al.   NATURE

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis

(2010) J M I Barth et al.   CELL DEATH AND DIFFERENTIATION

Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking

(2010) A. S. Haberman et al.   DEVELOPMENT

A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism inDrosophila melanogasterphotoreceptors

(2010) W. Ryan Williamson et al.   JOURNAL OF CELL BIOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold

(2010) K. K. Singh et al.   RNA

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

FoxO, Autophagy, and Cardiac Remodeling

(2010) Anwarul Ferdous et al.   Journal of Cardiovascular Translational Research

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

(2009) S Luo et al.   CELL DEATH AND DIFFERENTIATION

Autophagy, Not Apoptosis, Is Essential for Midgut Cell Death in Drosophila

(2009) Donna Denton et al.   CURRENT BIOLOGY

TOR-dependent control of autophagy: biting the hand that feeds

(2009) Thomas P Neufeld   CURRENT OPINION IN CELL BIOLOGY

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation

(2009) Patricia Rigou et al.   EMBO JOURNAL

A critical role for AKT activation in protecting cells from ionizing radiation-induced apoptosis and the regulation of acinus gene expression

(2009) Hyung Sun Park et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Activation of Sterol Regulatory Element-binding Protein by the Caspase Drice inDrosophilaLarvae

(2009) Bilal Amarneh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis

(2009) V. M. S. Betin et al.   JOURNAL OF CELL SCIENCE

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

The regulation of aging: does autophagy underlie longevity?

(2009) Tibor Vellai et al.   TRENDS IN CELL BIOLOGY

Serine/Arginine Protein-Specific Kinase 2 Promotes Leukemia Cell Proliferation by Phosphorylating Acinus and Regulating Cyclin A1

(2008) S.-W. Jang et al.   CANCER RESEARCH

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling inDrosophila

(2008) Gábor Juhász et al.   JOURNAL OF CELL BIOLOGY

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

A novel phosphoprotein analysis scheme for assessing changes in premalignant and malignant breast cell lines using 2-D liquid separations, protein microarrays, and tandem mass spectrometry

(2008) Tasneem H. Patwa et al.   Proteomics Clinical Applications