Article
Chemistry, Medicinal
Yulia Desheva, Nadezhda Petkova, Tatiana Smolonogina, Svetlana Donina, Alexey Go
Summary: The study evaluated humoral immunity to influenza neuraminidase (NA) and found that antibodies to NA can serve as an additional criterion for assessing the immunogenicity of influenza vaccines. The antibody levels in middle-aged patients differ among different NA subtypes, which may have implications for vaccine strategies. Older people have higher antibody positivity rates to archival influenza virus subtypes, which needs to be considered in vaccine design.
Review
Virology
Kaito A. Nagashima, Jarrod J. Mousa
Summary: Influenza virus is a highly mutable respiratory pathogen causing significant disease annually. Despite efforts to improve vaccine effectiveness against circulating strains, limitations exist, and research into broader neutralizing antibodies has shown progress.
Article
Virology
Nada Abbadi, Jarrod J. Mousa
Summary: Neuraminidase (NA) is an important surface protein on influenza virions, playing a crucial role in the viral life cycle and being a target of the immune system. Vaccines currently focus on the hemagglutinin (HA) protein, but NA-specific antibodies have shown promise in reducing infection severity. This review summarizes the characteristics of NA, NA-specific antibodies, NA inhibition mechanism, and recent developments in NA-based influenza vaccines.
Article
Oncology
Melissa Bersanelli, Diana Giannarelli, Ugo De Giorgi, Sandro Pignata, Massimo Di Maio, Alberto Clemente, Elena Verzoni, Raffaele Giusti, Marilena Di Napoli, Giuseppe Aprile, Paola Ermacora, Annamaria Catino, Vieri Scotti, Francesca Mazzoni, Pamela Francesca Guglielmini, Antonello Veccia, Marco Maruzzo, Ernesto Rossi, Francesco Grossi, Chiara Casadei, Corrado Ficorella, Vincenzo Montesarchio, Francesco Verderame, Mimma Rizzo, Giorgia Guaitoli, Lucia Fratino, Caterina Accettura, Manlio Mencoboni, Fable Zustovich, Cinzia Baldessari, Saverio Cinieri, Andrea Camerini, Letizia Laera, Mariella Soraru, Paolo Andrea Zucali, Valentina Guadalupi, Francesco Leonardi, Marcello Tiseo, Michele Tognetto, Francesco Di Costanzo, Carmine Pinto, Giorgia Negrini, Antonio Russo, Maria R. Migliorino, Marco Filetti, Sebastiano Buti
Summary: The study shows that influenza vaccination in patients with advanced cancer receiving immunotherapy can reduce the incidence of influenza-like illness, decrease ILI complications, and improve survival rates.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Chemistry, Medicinal
Yulia Desheva, Igor Losev, Nadezhda Petkova, Polina Kudar, Svetlana Donina, Andrey Mamontov, Chih-Hsuan Tsai, Yu-Chan Chao
Summary: This study investigated the antigenic properties of neuraminidase (NA) in A/H7N9 influenza viruses, finding that the antibodies induced by different A/H7N9 vaccines did not inhibit the NA of each other. In addition, monoclonal antibodies targeting a specific H7N9 strain showed partial cross-protection against a drift variant of H7N9 in mice.
Article
Immunology
Wei Wang, Esmeralda Alvarado-Facundo, Russell Vassell, Limone Collins, Rhonda E. Colombo, Anuradha Ganesan, Casey Geaney, David Hrncir, Tahaniyat Lalani, Ana Elizabeth Markelz, Ryan C. Maves, Bruce McClenathan, Katrin Mende, Stephanie A. Richard, Christina Schofield, Srihari Seshadri, Christina Spooner, Gregory C. Utz, Tyler E. Warkentien, Min Levine, Christian L. Coles, Timothy H. Burgess, Maryna Eichelberger, Carol D. Weiss
Summary: This study found that egg- and cell-derived influenza vaccines in the 2018-2019 season elicited similar neutralizing antibody titers and response rates against A(H3N2) viruses, while rHA vaccine generated the strongest response. All vaccines boosted titers to HA with egg-adaptive substitutions, but showed poor neutralization against wild-type viruses.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Maarten Swart, Harmjan Kuipers, Fin Milder, Mandy Jongeneelen, Tina Ritschel, Jeroen Tolboom, Leacky Muchene, Joan van der Lubbe, Ana Izquierdo Gil, Daniel Veldman, Jeroen Huizingh, Johan Verspuij, Sonja Schmit-Tillemans, Sven Blokland, Martijn de Man, Ramon Roozendaal, Christopher B. Fox, Hanneke Schuitemaker, Martinus Capelle, Johannes P. M. Langedijk, Roland Zahn, Boerries Brandenburg
Summary: The stability and manufacturability of a subunit vaccine antigen were further optimized, and the potency with different adjuvants was evaluated. It was found that a vaccine formulation with aluminum hydroxide or specific ratio of SLA-LSQ induced broad neutralizing antibodies after the second immunization. The study provided insights into potential adjuvant formulations for an H1 stem-based vaccine.
Article
Immunology
Kailey Hughes, Donald B. Middleton, Mary Patricia Nowalk, Goundappa K. Balasubramani, Emily T. Martin, Manjusha Gaglani, H. Keipp Talbot, Manish M. Patel, Jill M. Ferdinands, Richard K. Zimmerman, Fernanda P. Silveira
Summary: This study evaluated the vaccine effectiveness against influenza hospitalization among immunocompromised adults during the 2017-2018 influenza season. The results showed that while immunocompromised adults had a higher vaccination rate, their protection against influenza was lower, with a vaccine effectiveness of 33% in the overall adult population. Further research is needed to assess vaccine effectiveness among different immunocompromising conditions and explore ways to improve effectiveness for immunocompromised individuals.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Andrew Tung Yep, Yasu Takeuchi, Othmar G. Engelhardt, Simon E. Hufton
Summary: Influenza virus poses challenges due to its antigenic variability, but there are conserved epitopes that could be targeted for therapeutic development. Single domain antibodies, with their preference for specific epitopes, small size, flexibility, and stability, are well-suited to address these vulnerabilities and provide robust therapeutics for controlling influenza.
Article
Microbiology
Jenna J. Guthmiller, Henry A. Utset, Carole Henry, Lei Li, Nai-Ying Zheng, Weina Sun, Marcos Costa Vieira, Seth Zost, Min Huang, Scott E. Hensley, Sarah Cobey, Peter Palese, Patrick C. Wilson
Summary: Seasonal influenza virus vaccines produced in eggs can induce antibody responses against egg-associated antigens, which have specific antibody features and may impact the host immune response.
Article
Immunology
Vitoria Paixao, Ewin B. Almeida, Jonatas B. Amaral, Tamaris Roseira, Fernanda R. Monteiro, Roberta Foster, Adriane Sperandio, Marcelo Rossi, Gislene R. Amirato, Carlos A. F. Santos, Renier S. Pires, Fabyano B. Leal, Edison L. Durigon, Danielle B. L. Oliveira, Rodolfo P. Vieira, Mauro Vaisberg, Juliana M. B. Santos, Andre L. L. Bachi
Summary: The study showed that L-glutamine supplementation can modulate the cytokine profile in saliva and increase levels of secretory immunoglobulin A, both total and specific to the influenza virus vaccine, in physically active elderly subjects.
Article
Immunology
Raquel Giacomelli Cao, Lisa Christian, Zhaohui Xu, Lisa Jaramillo, Bennett Smith, Erik A. Karlsson, Stacey Schultz-Cherry, Asuncion Mejias, Octavio Ramilo
Summary: Influenza vaccination in pregnant women led to upregulation of interferon-stimulated genes on day 1 and plasma cell genes on day 7, which were significantly correlated with increased antibody titers. Compared to non-vaccinated women, those vaccinated during the previous influenza season showed more frequent significant correlations between ISGs and antibody titers.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Constantina Boikos, Lauren Fischer, Dan O'Brien, Joe Vasey, Gregg C. Sylvester, James A. Mansi
Summary: This study estimated the relative vaccine effectiveness (rVE) of cell-propagated inactivated quadrivalent influenza vaccine (ccIIV4) versus egg-derived inactivated quadrivalent influenza vaccine (eIIV4) in preventing influenza-related medical encounters in the 2018-2019 US season. The results showed a statistically significantly greater reduction in influenza-related medical encounters in individuals vaccinated with ccIIV4 compared to eIIV4, supporting ccIIV4 as a potentially more effective public health measure against influenza.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Immunology
Rina Fajri Nuwarda, Abdulsalam Abdullah Alharbi, Veysel Kayser
Summary: Influenza is a major public health concern, and vaccines are an effective method for prevention and control. New vaccine platforms and advancements in vaccine manufacturing processes are being explored to improve effectiveness and stability.
Article
Multidisciplinary Sciences
Daniel Ellis, Julia Lederhofer, Oliver J. Acton, Yaroslav Tsybovsky, Sally Kephart, Christina Yap, Rebecca A. Gillespie, Adrian Creanga, Audrey Olshefsky, Tyler Stephens, Deleah Pettie, Michael Murphy, Claire Sydeman, Maggie Ahlrichs, Sidney Chan, Andrew J. Borst, Young-Jun Park, Kelly K. Lee, Barney S. Graham, David Veesler, Neil P. King, Masaru Kanekiyo
Summary: This study reveals the conformational stability of influenza virus neuraminidase (NA) and demonstrates how recombinant NA antigens can be strengthened through structure-based design.
NATURE COMMUNICATIONS
(2022)