Article
Behavioral Sciences
Sarah B. Beamish, Karyn M. Frick
Summary: Sex steroid hormones such as 17 beta-estradiol play critical roles in the modulation of hippocampal synaptic plasticity and memory formation. The mechanisms through which 17 beta-estradiol regulates memory formation are not fully understood. This article provides an overview of the receptor and signaling mechanisms involved in the regulation of hippocampal 17 beta-estradiol and protein degradation mediated by the ubiquitin proteasome system (UPS) in both males and females. The article suggests that further study is needed to examine the contributions of ubiquitin-mediated protein degradation in regulating the effects of sex steroid hormones on cognition.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Kumar Krishna-K, Thomas Behnisch, Sreedharan Sajikumar
Summary: Alzheimer's disease (AD) is characterized by deficits in memory and cognitive functions, which are partly due to decreased activity-dependent synaptic plasticity. This study shows that inhibition of proteasome-mediated protein degradation can restore impaired synaptic plasticity in an AD-like mouse model. The ubiquitin-proteasome system (UPS) plays a critical role in protein turnover and synaptic function. Dysfunction of UPS is implicated in inadequate proteostasis and synaptic malfunction in AD.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Behavioral Sciences
Joep Titulaer, Carl Bjorkholm, Kristin Feltmann, Torun Malmlof, Devesh Mishra, Carolina Bengtsson Gonzales, Bjorn Schilstrom, Asa Konradsson-Geuken
Summary: The study suggests that increased release of dopamine and norepinephrine in the rat ventral hippocampus plays a crucial role in recognition memory and signaling novelty. In a novel object recognition test, rats' responses to a new object led to increased dopamine and norepinephrine release in the ventral hippocampus, potentially aiding in the formation of long-term memory.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Kellie S. Gross, Randie L. Alf, Tiffany R. Polzin, Karyn M. Frick
Summary: The study found that 17β-estradiol enhances memory consolidation by regulating hippocampal TrkB signaling rather than mBDNF expression. This suggests that modulation of TrkB signaling by 17β-estradiol is essential for its beneficial effects on memory consolidation, providing further insights into how TrkB/BDNF signaling is regulated by 17β-estradiol in the hippocampus.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marco Rinaudo, Francesca Natale, Francesco La Greca, Matteo Spinelli, Antonella Farsetti, Fabiola Paciello, Salvatore Fusco, Claudio Grassi
Summary: This study found that male mice are more susceptible to memory loss induced by retroactive interference than females. Estrogen signaling involving estrogen receptor alpha activation in the dorsal hippocampus mediates the resistance of female mice to retroactive interference. Female mice showed higher phosphorylation levels of ERK1/2 in the hippocampus following retroactive interference. Inhibition of ERK1/2 made female mice more prone to retroactive interference.
Article
Psychiatry
Emily E. Noble, Christine A. Olson, Elizabeth Davis, Linda Tsan, Yen-Wei Chen, Ruth Schade, Clarissa Liu, Andrea Suarez, Roshonda B. Jones, Claire de la Serre, Xia Yang, Elaine Y. Hsiao, Scott E. Kanoski
Summary: Research indicates that excessive early life consumption of sugar negatively impacts memory function in rats during adulthood, affecting hippocampal-dependent memory function and altering the gut microbiome, including the abundance of specific Parabacteroides species. Enrichment of these bacterial taxa during adolescence impairs hippocampal-dependent memory in adulthood, while early life sugar consumption and Parabacteroides microbial enrichment lead to alterations in gene expression related to intracellular kinase, neurotransmitter signaling, metabolic function, neurodegenerative disease, and dopaminergic signaling pathways.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Kellie S. Gross, Carnita M. Lincoln, McKenna M. Anderson, Grace E. Geiger, Karyn M. Frick
Summary: In the hippocampus, the potent estrogen 17 beta-estradiol (E-2) regulates hippocampal plasticity and memory. Research has shown that E-2 can modulate the activity of matrix metalloproteinase-9 (MMP-9) in the hippocampus, which in turn affects memory consolidation. These findings provide the first evidence of E-2 regulation of MMP-9 in hippocampal memory.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhenlin Ouyang, Fang Zheng, Li Zhu, Jan Felix, Di Wu, Ke Wu, Irina Gutsche, Yi Wu, Peter M. Hwang, Junjun She, Yurong Wen
Summary: This study demonstrates the importance of the N-terminal intrinsically disordered tail in AdeR for upregulating adeABC expression, and the necessity of AdeS assembling into a hexameric state for its full histidine kinase activity.
Article
Neurosciences
David A. Cinalli, Sarah J. Cohen, Mariah Calubag, Goksu Oz, Lylybell Zhou, Robert W. Stackman
Summary: This study used the DREADDs method to investigate the effects of CA1 pyramidal neurons in the hippocampus on the retrieval of long-term memory for nonspatial and spatial information in mice. The results showed that the inhibition of CA1 neuronal activity significantly impaired the memory retrieval in mice. These findings support the use of mice as a model system to study the neurobiological mechanisms of human episodic memory.
Article
Endocrinology & Metabolism
Cheryl A. Frye, Vincent F. Lembo, Alicia A. Walf
Summary: The study found that progesterone can enhance cognitive performance in male mice by increasing allopregnanolone concentrations, BDNF levels, and GABA(A) activity. These effects may be independent of traditional progestin receptors' trophic actions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Anuck Sawangjit, Maximilian Harkotte, Carlos N. Oyanedel, Niels Niethard, Jan Born, Marion Inostroza
Summary: Memory consolidation is promoted by both sleep and wakefulness, but their effects on hippocampal and nonhippocampal representations differ. Sleep consolidation involves event-context binding, while wake consolidation tends to strengthen context-independent representations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Kartikeya Vijayasimha, Marilyn Vo Tran, Amy L. Leestemaker-Palmer, Brian P. Dolan
Summary: The study demonstrates that fusion of NEDD8 to a protein of interest leads to rapid degradation, depending on functional ubiquitin-conjugation system. However, the inhibitor of the E1 activating enzyme for NEDD8 failed to prevent degradation of other destabilized substrates.
Article
Biochemistry & Molecular Biology
Beatriz G. Muratori, Claudia R. Zamberlam, Thais B. Mendes, Bruno H. N. Nozima, Janete M. Cerutti, Suzete M. Cerutti
Summary: The study demonstrates that EGb treatment before acquisition of object recognition memory promotes the persistence of long-term memory by upregulating BDNF expression in a dose- and session-dependent manner, leading to improved performance of animals in memory tests.
Article
Geriatrics & Gerontology
Natalia Lopez-Gonzalez del Rey, Tiziano Balzano, Lucia Martin-Rodriguez, Constanza Salinas-Rebolledo, Ines Trigo-Damas, Alejandro Rojas-Fernandez, Lydia Alvarez-Erviti, Javier Blesa
Summary: Proteinaceous inclusions known as LBs are used as a pathological hallmark for PD, with early deposits in the OB and amygdala containing insoluble alpha-synuclein and other ubiquitinated proteins. Injecting lactacystin into the OB and amygdala of mice did not result in significant differences in neuronal numbers, alpha-synuclein expression, or dopaminergic integrity, indicating that long-term injections in extra nigrostriatal regions may not mimic the spreading aspects of PD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Martina Canatelli-Mallat, Priscila Chiavellini, Marianne Lehmann, Rodolfo Gustavo Goya, Gustavo Ramon Morel
Summary: Ageing is associated with impaired recognition memory. This study aimed to evaluate the ability of female rats at different ages to retain long-term recognition memory. The results showed that spatial discrimination capacity could be affected earlier than feature discrimination capacity. Furthermore, neurogenesis depletion in the Dentate Gyrus and microglial disruption in the perirhinal cortex were associated with memory deficits.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Barbara Paranhos Coelho, Mariana Maier Gaelzer, Fernanda dos Santos Petry, Juliana Bender Hoppe, Vera Maria Treis Trindade, Christianne G. Salbego, Fatima T. C. R. Guma
Article
Oncology
Luis Carlos Moreira Antunes, Andre Cartell, Caroline Brunetto de Farias, Renato Marchiori Bakos, Rafael Roesler, Gilberto Schwartsmann
Article
Pharmacology & Pharmacy
Amanda Thomaz, Kelly de Vargas Pinheiro, Barbara Kunzler Souza, Lauro Gregianin, Algemir L. Brunetto, Andre T. Brunetto, Caroline Brunetto de Farias, Mariane da Cunha Jaeger, Vijay Ramaswamy, Carolina Nor, Michael D. Taylor, Rafael Roesler
FRONTIERS IN PHARMACOLOGY
(2019)
Letter
Oncology
R. Roesler
CLINICAL & TRANSLATIONAL ONCOLOGY
(2019)
Article
Neurosciences
Vanise Hallas Uberti, Betania Souza de Freitas, Patricia Molz, Elke Bromberg, Nadja Schroeder
MOLECULAR NEUROBIOLOGY
(2020)
Article
Chemistry, Medicinal
Fernanda dos Santos Petry, Barbara Paranhos Coelho, Mariana Maier Gaelzer, Fernando Kreutz, Fatima Theresinha Costa Rodrigues Guma, Christianne Gazzana Salbego, Vera Maria Treis Trindade
PHYTOTHERAPY RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Fernanda dos Santos Petry, Juliana Bender Hoppe, Caroline Peres Klein, Bernardo Gindri dos Santos, Regis Mateus Hozer, Felippo Bifi, Cristiane Matte, Christianne Gazzana Salbego, Vera Maria Treis Trindade
Summary: This study evaluated the protective effect of genistein against Aβ(1-42)-induced cognitive impairment and elucidated some possible mechanisms involved in its neuroprotective effects in the hippocampus, including attenuation of synaptotoxicity, prevention of Tau hyperphosphorylation, and inactivation of ERK.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Flavia Bittencourt Brasil, Renata Cristina Bertolini Gobbo, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Fernanda dos Santos Petry, Marcos Roberto de Oliveira
Summary: The study demonstrates that SFN protects mitochondria of MG-challenged cells by stimulating the Nrf2/gamma-GCL/GSH axis, leading to increased synthesis of GSH and prevention of OXPHOS dysfunction and mitochondrial redox impairment.
NEUROCHEMICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Patricia Molz, Betania Souza de Freitas, Vanise Hallas Uberti, Kesiane Mayra da Costa, Luiza Wilges Kist, Mauricio Reis Bogo, Nadja Schroder
Summary: The study found that supplementing with LA during adulthood combined with supplementation later in life can reverse age-induced cognitive dysfunction and mitochondrial DNA deletions, whereas using LA treatment only at old age has a lesser effect.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Rafael Roesler, Barbara Kunzler Souza, Gustavo R. Isolan
Summary: Meningioma is the most common type of intracranial tumor in adults, and novel prognostic biomarkers are urgently needed to guide tumor stratification and clinical prognosis. Molecular and cellular alterations in Meningioma tumors over recent years provide a rational basis for identifying biomarkers and therapeutic targets. The role of receptor tyrosine kinases as oncogenes, including those in the ErbB family, has been well established, suggesting their potential as biomarkers and therapeutic targets in Meningioma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Barbara Kunzler Souza, Natalia Hogetop Freire, Mariane Jaeger, Caroline Brunetto de Farias, Algemir L. Brunetto, Andre T. Brunetto, Rafael Roesler
Summary: G9a, a histone methyltransferase, is overexpressed in several cancer types, and inhibitors have potential as anticancer agents. Evidence suggests changes in G9a activity are involved in brain tumor development, especially in GBM and MB, as well as NB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Fernanda dos Santos Petry, Juliana Bender Hoppe, Caroline Peres Klein, Bernardo Gindri dos Santos, Regis Mateus Hozer, Christianne Gazzana Salbego, Vera Maria Treis Trindade
Summary: This study investigated the effects of A beta toxicity and genistein treatment on the lipid composition in the frontal cortex of rats. The results showed that A beta infusion led to a decrease in ganglioside concentration, while genistein treatment prevented this decrease. However, phospholipid and cholesterol contents did not show significant differences.
NEUROLOGICAL RESEARCH
(2022)
Review
Neurosciences
Jose Afonso Correa da Silva, Nadja Schroeder
Summary: It is believed that neurological diseases caused by degenerative conditions may have abnormal influx of Ca2+ through glutamate receptors. In addition to the NMDAR, AMPARs can also mediate neurotoxic Ca2+ influx, especially when the GluA2 subunit is absent or disrupted. The increase of Ca2+-permeable AMPA receptors (CP-AMPARs) is associated with behavioral changes and various neurodegenerative, neuroinflammatory, and neurotoxic conditions, suggesting a potential role in the emergence and evolution of central nervous system (CNS) pathological conditions. This article summarizes and discusses studies on changes in the composition of AMPARs and their effects, aiming to understand the therapeutic potential of CP-AMPAR in neurological diseases.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Cell Biology
Mariana Ilha, Leo A. Meira Martins, Ketlen da Silveira Moraes, Camila K. Dias, Marcos P. Thome, Fernanda Petry, Francieli Rohden, Radovan Borojevic, Vera M. T. Trindade, Fabio Klamt, Florencia Barbe-Tuana, Guido Lenz, Fatima C. R. Guma
Summary: This study demonstrates that Cav-1 may modulate mitochondrial function and structural reorganization in hepatic stellate cell activation, making it a potential candidate marker for chronic liver diseases and a molecular target for therapeutic intervention.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Clinical Neurology
Cristiano Schaffer Aguzzoli, Petronilla Battista, Rafi Hadad, Yuri Ferreira Felloni Borges, Lucas Porcello Schilling, Bruce L. Miller
Summary: This case presentation involves a 24-year-old man with early-onset bvFTD, rapid progression, and severe cognitive and functional impairment. Genetic testing revealed a variant of uncertain significance (VUS) mutation in the FUS gene.
