Review
Biochemistry & Molecular Biology
Ewa Baczynska, Katarzyna Karolina Pels, Subhadip Basu, Jakub Wlodarczyk, Blazej Ruszczycki
Summary: This article reviews experimental approaches designed to assess quantitative features of dendritic spines under physiological stimuli and in pathological conditions. By comparing various methodological pipelines and systematically summarizing the methodology and results of relevant experiments, the focus is on quantitative data regarding the number of animals, cells, dendritic spines, types of studied parameters, size of observed changes, and their statistical significance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Edita Bulovaite, Zhen Qiu, Maximilian Kratschke, Adrianna Zgraj, David G. Fricker, Eleanor J. Tuck, Ragini Gokhale, Babis Koniaris, Shekib A. Jami, Paula Merino-Serrais, Elodie Husi, Lorena Mendive-Tapia, Marc Vendrell, Thomas J. O'Dell, Javier DeFelipe, Noboru H. Komiyama, Anthony Holtmaat, Erik Fransen, Seth G. N. Grant
Summary: This study quantified the lifetime of endogenous PSD95 in synapses and generated the Protein Lifetime Synaptome Atlas. It found that protein lifetime in synapses varies with age, brain regions, and memory duration, and that it increases in mouse models of autism and schizophrenia.
Article
Engineering, Multidisciplinary
YuWei Cao, Chun Shen, Hu Qiu, WanLin Guo
Summary: Dendritic spines receive synaptic inputs and play a crucial role in initiating dendritic NMDA spikes and action potentials. The number and morphology of spines constantly change during learning and memory processes. This study investigates the influence of spine number and morphology on dendritic NMDA spikes and reveals that the threshold number of spines differs between distal and proximal dendrites due to differences in impedance. Additionally, the presence of more AMPA receptors on spines leads to larger NMDA spikes. The findings highlight the importance of the dynamic distribution of spine number and morphology in neurodegenerative diseases.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2023)
Article
Neurosciences
Courtney K. Walker, Kelsey M. Greathouse, Benjamin D. Boros, Emily H. Poovey, Kelsey R. Clearman, Raksha Ramdas, Hamad M. Muhammad, Jeremy H. Herskowitz
Summary: This study combined cell and biochemical analyses of the Tau P301S mouse line (PS19) and observed changes in synaptic tau protein levels and dendritic spine morphology in response to age and hyperphosphorylated tau accumulation. The research revealed brain region-specific alterations in dendritic spine density and morphology in PS19 mice, indicating a possible spine remodeling in response to tau accumulation and age.
Review
Anatomy & Morphology
Simon Granak, Cyril Hoschl, Saak V. Ovsepian
Summary: General anesthesia, considered a medical miracle, enables life-saving interventions without pain sensation and traumatic memories. However, the mechanisms of how it induces a coma-like state are not fully understood. Research shows that even brief exposure to general anesthesia can have lasting effects on brain plasticity, cognition, mood, and social behavior.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Immunology
Liuyue Yang, Weihua Ding, Yuanlin Dong, Cynthia Chen, Yanru Zeng, Zhangjie Jiang, Shuyuan Gan, Zerong You, Yilin Zhao, Yiying Zhang, Xinghua Ren, Shiyu Wang, Jiajia Dai, Zhong Chen, Shengmei Zhu, Lucy Chen, Shiqian Shen, Jianren Mao, Zhongcong Xie
Summary: This study found that electroacupuncture at specific acupoints could attenuate both surgical pain and delirium-like behavior in mice. Mechanistically, mice with incision-induced surgical pain and delirium-like behavior showed gut microbiota imbalance, microglia activation, and dendritic spine elimination. The electroacupuncture treatment restored gut microbiota balance, prevented microglia activation, and reversed dendritic spine elimination. These findings suggest a potential gut-brain interactive mechanism underlying surgical pain-induced delirium and provide a possible therapeutic approach in preventing and treating postoperative delirium.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Md. Shamim Hossain, Shiro Mawatari, Takehiko Fujino
Summary: Plasmalogens (Pls) can enhance brain-derived neurotrophic factor expression, promote neurogenesis in the hippocampus, and improve learning and memory in mice. Pls regulates memory-related gene expression through signaling pathways and transcription factor recruitment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Shaorong Ma, Yi Zuo
Summary: Synapses are crucial for neuronal communication and play a role in learning and memory through activity-dependent modifications. Recent advances in high-resolution imaging techniques have allowed researchers to monitor and manipulate the structure and function of synapses both in vitro and in vivo.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Alicia Hernandez-Vivanco, Nuria Cano-Adamuz, Alberto Sanchez-Aguilera, Alba Gonzalez-Alonso, Alberto Rodriguez-Fernandez, Inigo Azcoitia, Liset Menendez de la Prida, Pablo Mendez
Summary: Using a combination of molecular, genetic, functional and behavioural tools, this study describes the impact of brain synthesized estrogen on inhibitory neuronal function, network oscillations and hippocampal dependent memory.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Qiaoyun Wu, Chenchen Cai, Xinwang Ying, Yujun Zheng, Jiaying Yu, Xiaoxue Gu, Wenzhan Tu, Xinfa Lou, Guanhu Yang, Ming Li, Songhe Jiang
Summary: Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic pain. Electroacupuncture (EA) has a beneficial effect on the treatment of neuropathic pain, but the specific mechanism remains unclear.
BIOLOGICAL RESEARCH
(2023)
Article
Neurosciences
Li Cheng, Yanfang Su, Kaining Zhi, Yaru Xie, Chun Zhang, Xianfang Meng
Summary: This study reveals the essential role of MAD2B in regulating learning and memory. Conditional knockout of MAD2B improves the learning and memory abilities in mice and increases the number of neurons in the hippocampus and cerebral cortex.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Junyang Wang, Jiewei Liu, Shiwu Li, Xiaoyan Li, Jinfeng Yang, Xinglun Dang, Changgai Mu, Yifan Li, Kaiqin Li, Jiao Li, Rui Chen, Yixing Liu, Di Huang, Zhijun Zhang, Xiong-Jian Luo
Summary: Genome-wide association studies have identified 10q24.32 as a robust schizophrenia risk locus. Researchers have discovered a regulatory variant, rs10786700, that disrupts binding of transcription factors at 10q24.32 and have uncovered the biological mechanism underlying the association between rs10786700 and schizophrenia.
Article
Behavioral Sciences
Deepika Patel, Shobha Anilkumar, Sumantra Chattarji, Sietse F. de Boer, Bauke Buwalda
Summary: This study compared the apical dendritic spine density of neurons in rats that were repeatedly winning or losing social conflicts. The results showed that repeated defeat had atrophic effects on the hippocampal and prefrontal regions, while winners exhibited a surprising reduction in hippocampal spine density.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Immunology
Qian Zhang, Xuetao Cao
Summary: The innate immune response is a rapid and precise reaction to pathogens, aiming to efficiently eliminate them while avoiding excessive inflammation. The epiregulome, shaped by epigenetic factors, gives innate immune cells specialized phenotypes and functions, contributing to the resolution of inflammatory responses.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
Article
Biochemistry & Molecular Biology
Anna Di Maio, Arianna De Rosa, Silvia Pelucchi, Martina Garofalo, Benedetta Marciano, Tommaso Nuzzo, Fabrizio Gardoni, Andrea M. Isidori, Monica Di Luca, Francesco Errico, Andrea De Bartolomeis, Elena Marcello, Alessandro Usiello
Summary: This study examined mRNA and protein expression of key spine shaping proteins in the brains of schizophrenia patients and found altered expression of CAP2 and DLG1 genes in different brain regions, suggesting their potential involvement in synaptic dysfunction associated with psychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
L. Saba, M. T. Viscomi, S. Caioli, A. Pignataro, E. Bisicchia, M. Pieri, M. Molinari, M. Ammassari-Teule, C. Zona
Article
Neurosciences
Antonella Borreca, Katia Gironi, Giusy Amadoro, Martine Ammassari-Teule
MOLECULAR NEUROBIOLOGY
(2016)
Article
Neurosciences
Chiara Schepisi, Annabella Pignataro, Salvatore Simone Doronzio, Sonia Piccinin, Caterina Ferraina, Silvia Di Prisco, Marco Feligioni, Anna Pittaluga, Nicola Biagio Mercuri, Martine Ammassari-Teule, Robert Nistico, Paolo Nencini
PSYCHOPHARMACOLOGY
(2016)
Article
Cell Biology
Francesca Gabanella, Cinzia Pisani, Antonella Borreca, Stefano Farioli-Vecchioli, Maria Teresa Ciotti, Tiziano Ingegnere, Annalisa Onori, Martine Ammassari-Teule, Nicoletta Corbi, Nadia Canu, Lucia Monaco, Claudio Passananti, Maria Grazia Di Certo
JOURNAL OF CELL SCIENCE
(2016)
Article
Oncology
Cinzia Pisani, Annalisa Onori, Francesca Gabanella, Francesca Delle Monache, Antonella Borreca, Martine Ammassari-Teule, Maurizio Fanciulli, Maria Grazia Di Certo, Claudio Passananti, Nicoletta Corbi
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2016)
Article
Neurosciences
Roberta Antonelli, Roberto De Filippo, Silvia Middei, Stefka Stancheva, Beatrice Pastore, Martine Ammassari-Teule, Andrea Barberis, Enrico Cherubini, Paola Zacchi
JOURNAL OF NEUROSCIENCE
(2016)
Article
Oncology
Eleonora Vannini, Francesco Olimpico, Silvia Middei, Martine Ammassari-Teule, Erik L. de Graaf, Liam McDonnell, Gudula Schmidt, Alessia Fabbri, Carla Fiorentini, Laura Baroncelli, Mario Costa, Matteo Caleo
Review
Behavioral Sciences
Martine Ammassari-Teule
NEUROBIOLOGY OF LEARNING AND MEMORY
(2016)
Article
Multidisciplinary Sciences
Victor Briz, Leonardo Restivo, Emanuela Pasciuto, Konrad Juczewski, Valentina Mercaldo, Adrian C. Lo, Pieter Baatsen, Natalia V. Gounko, Antonella Borreca, Tiziana Girardi, Rossella Luca, Julie Nys, Rogier B. Poorthuis, Huibert D. Mansvelder, Gilberto Fisone, Martine Ammassari-Teule, Lutgarde Arckens, Patrik Krieger, Rhiannon Meredith, Claudia Bagni
NATURE COMMUNICATIONS
(2017)
Article
Neurosciences
A. Borreca, V. Latina, V. Corsetti, S. Middei, S. Piccinin, F. Della Valle, R. Bussani, M. Ammassari-Teule, R. Nistico, P. Calissano, G. Amadoro
MOLECULAR NEUROBIOLOGY
(2018)
Article
Neurosciences
Annalisa Nobili, Paraskevi Krashia, Alberto Cordella, Livia La Barbera, Maria Concetta Dell'Acqua, Angela Caruso, Annabella Pignataro, Ramona Marino, Francesca Sciarra, Filippo Biamonte, Maria Luisa Scattoni, Martine Ammassari-Teule, Francesco Cecconi, Nicola Berretta, Flavio Keller, Nicola Biagio Mercuri, Marcello D'Amelio
MOLECULAR NEUROBIOLOGY
(2018)
Article
Neurosciences
Alberto Cordella, Paraskevi Krashia, Annalisa Nobili, Annabella Pignataro, Livia La Barbera, Maria Teresa Viscomi, Alessandro Valzania, Flavio Keller, Martine Ammassari-Teule, Nicola Biagio Mercuri, Nicola Berretta, Marcello D'Amelio
NEUROBIOLOGY OF DISEASE
(2018)
Article
Multidisciplinary Sciences
Chiara Criscuolo, Veronica Fontebasso, Silvia Middei, Martina Stazi, Martine Ammassari-Teule, Shirley ShiDu Yan, Nicola Origlia
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Annabelle Pignataro, Giovanni Meli, Roberto Pagano, Veronica Fontebasso, Roberta Battistella, Giulia Conforto, Martine Ammassari-Teule, Silvia Middei
BIOLOGICAL PSYCHIATRY
(2019)
Article
Anatomy & Morphology
Annabella Pignataro, Roberto Pagano, Giorgia Guarneri, Silvia Middei, Martine Ammassari-Teule
BRAIN STRUCTURE & FUNCTION
(2017)