Article
Multidisciplinary Sciences
Alexander Scholz, Jeff DeFalco, Yvonne Leung, Iraz T. Aydin, Cathrin J. Czupalla, Wei Cao, Daniel Santos, Nikhil Vad, Shaun M. Lippow, Gilson Baia, Michael Harbell, Judevin Sapugay, Danhui Zhang, Dai-Chen Wu, Erin Wechsler, Anne Z. Ye, Jenny W. Wu, Xiao Peng, John Vivian, Hargita Kaplan, Rodney Collins, Ngan Nguyen, Mark Whidden, Dongkyoon Kim, Carl Millward, Jonathan Benjamin, Norman M. Greenberg, Tito A. Serafini, Daniel E. Emerling, Lawrence Steinman, William H. Robinson, Amy Manning-Bog
Summary: ATRC-101 is an immunotherapy targeting a tumor-specific RNP complex to activate immune responses for treating solid tumors. Preclinical models demonstrate that ATRC-101 can effectively inhibit tumor growth and induce immune memory upon rechallenge with fresh tumor cells in cured mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Deyao Shi, Shidai Mu, Feifei Pu, Jianxiang Liu, Binlong Zhong, Binwu Hu, Na Ni, Hao Wang, Hue H. Luu, Rex C. Haydon, Le Shen, Zhicai Zhang, Tong-Chuan He, Zengwu Shao
Summary: In this study, we investigated the potential association of alterations in DNA methylation and immune-related gene transcription with changes in the tumor microenvironment and prognosis of osteosarcoma (OS). We found that immune-related DNA methylation patterns have a significant impact on the prognosis and tumor microenvironment characteristics of OS.
MOLECULAR ONCOLOGY
(2022)
Review
Oncology
Marit M. Melssen, Natasha D. Sheybani, Katie M. Leick, Craig L. Slingluff Jr
Summary: Increased immune cell infiltration into tumors is associated with improved patient survival and predicts response to immune therapies. Thus, identification of factors that determine the extent of immune infiltration is crucial, so that methods to intervene on these targets can be developed.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Immunology
Mengjie Liang, Xingzhou Wang, Daming Cai, Wenxian Guan, Xiaofei Shen
Summary: Tissue-resident memory T cells (Trm) are a specific subgroup of T cells that reside in tissues and are the most abundant memory T cell population in various tissues. They can be activated locally by infection or tumor cells and rapidly eliminate them to restore local immunostasis in gastrointestinal tissues. It has been found that tissue-resident memory T cells have great potential to combat gastrointestinal tumors, making them promising immune markers for immunotherapy and potential targets for cell therapy. This review comprehensively explores the role of tissue-resident memory T cells in gastrointestinal tumors and discusses their future prospects in immunotherapy, aiming to provide insights for clinical applications.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ailton Sousa-Junior, Chun-Ting Yang, Preethi Korangath, Robert Ivkov, Andris Bakuzis
Summary: This article explores the feasibility of targeted delivery of therapeutic agents to tumors in cancer nanomedicine and proposes a mathematical model to describe the interactions between nanoparticles and immune cells as well as the tumor retention process. The study finds that tumor-associated macrophages play a crucial role in tumor retention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Artur Mezheyeuski, Patrick Micke, Alfonso Martin-Bernabe, Max Backman, Ina Hrynchyk, Klara Hammarstrom, Simon Strom, Joakim Ekstrom, Per-Henrik Edqvist, Magnus Sundstrom, Fredrik Ponten, Karin Leandersson, Bengt Glimelius, Tobias Sjoblom
Summary: This study provides a detailed overview of the immune landscape of colorectal cancer by analyzing immune cell subsets in different tumor regions, revealing 'inflamed' and 'desert' groups among therapy-naive patients. Additionally, it identifies the impact of specific immune cell types on survival outcomes in different stages of colon cancer and highlights the repopulation of the immune infiltrate in rectal tumors post radiation.
Article
Biochemical Research Methods
Zicheng Zhang, Siqi Bao, Congcong Yan, Ping Hou, Meng Zhou, Jie Sun
Summary: This study provides an overview of the interaction between tumor-infiltrating immune cells and the tumor microenvironment, data sources, computational methods and software tools for inferring the composition of immune cells in the TME, and discusses future challenges and perspectives for more accurate quantitative analysis of immune cell infiltration in the future.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Immunology
Wen-shan Li, Qing-qing Zhang, Qiao Li, Shang-yu Liu, Guo-qiang Yuan, Ya-wen Pan
Summary: The imbalance of immune response is crucial in disease development, including glioblastoma. Understanding how the innate immune system detects tumors and pathogens is essential. This review emphasizes the similarity in RNA and DNA sensing mechanisms in the innate immunity of both tumors and pathogens, with the aim of enhancing the anti-tumor innate immune response and exploring new targets to improve the response to conventional tumor therapy and immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Siyuan Liu, Linan Ren, Xue Gao, Mengjin Hao, Guixia Wang
Summary: Intracranial germ cell tumors (IGCTs) are clinically rare, more common in children and adolescents, and with a higher incidence in Asia than in Western countries. The occurrence of IGCTs may be related to factors such as chromosomal instability, changes in the MAPK and/or PI3K pathways, and DNA hypomethylation in pure germ cell tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yoshinobu Ichiki, Takashi Fukuyama, Mari Ueno, Yoshiro Kanasaki, Hidenori Goto, Mai Takahashi, Shuji Mikami, Noritada Kobayashi, Kozo Nakanishi, Shinichi Hayashi, Tsuyoshi Ishida
Summary: This study found that the change of CD103+ CD39+ CD8+ cells after administration may predict the efficacy of immune checkpoint inhibitors (ICIs).
TRANSLATIONAL LUNG CANCER RESEARCH
(2022)
Article
Immunology
Yanzhu Chen, Zhishang Meng, Lin Zhang, Feng Liu
Summary: This study identifies CD2 as a potential biomarker in the tumor microenvironment of breast cancer, with high expression associated with longer survival and significant correlation with immune-related pathways. It may serve as a complementary approach to improve clinical outcome prediction for breast cancer patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Clinical Neurology
Cordelia Dunai, Ceryce Collie, Benedict D. Michael
Summary: Neurological complications are common in COVID-19 patients caused by SARS-CoV-2, but the mechanisms and treatments are not well understood. The immune system plays a critical role in these complications, but dysregulation can also lead to pathology.
FRONTIERS IN NEUROLOGY
(2022)
Review
Immunology
Pei-Yu Chen, Wen-Fei Wei, Hong-Zhen Wu, Liang-Sheng Fan, Wei Wang
Summary: CAFs are important and heterogeneous components of the tumor extracellular matrix, with different origins and biomarkers, playing a role in immune regulation of the tumor microenvironment and exerting immunosuppressive functions through various mechanisms. Inhibition of CAFs and targeted therapy against CAFs offer new adjuvant means for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Jessica M. Keilson, Hannah M. Knochelmann, Chrystal M. Paulos, Ragini R. Kudchadkar, Michael C. Lowe
Summary: This article discusses the importance of immunotherapy in cancer treatment and presents successful cases of PD-1 and CTLA-4 blockade therapy, as well as biomarkers of therapeutic response. Additionally, it also examines novel targets in Phase III clinical trials and innovations aimed at improving outcomes in therapy-resistant solid tumors.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Editorial Material
Multidisciplinary Sciences
Mark A. Travis, Chiara Romagnani
Summary: Active control of the immune system is necessary to prevent inflammatory bowel disease. Cell populations that promote the generation of immunosuppressive regulatory T cells in the gut have been identified.