Nuclear factor-κB in glioblastoma: insights into regulators and targeted therapy

Decoy Receptor DcR1 Is Induced in a p50/Bcl3-Dependent Manner and Attenuates the Efficacy of Temozolomide

(2015) N. M. Mansour et al.   CANCER RESEARCH

S-phase-dependent p50/NF-кB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability

(2015) Clayton D Crawley et al.   CELL CYCLE

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

Constitutive Activation of Signal Transducer and Activator of Transcription 3 (STAT3) and Nuclear Factor κB Signaling in Glioblastoma Cancer Stem Cells Regulates the Notch Pathway

(2013) Jo Meagan Garner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Frequency of NFKBIA deletions is low in glioblastomas and skewed in glioblastoma neurospheres

(2013) Monica Patanè et al.   Molecular Cancer

The NF-κB RelB Protein Is an Oncogenic Driver of Mesenchymal Glioma

(2013) Dong Whan Lee et al.   PLoS One

Opposing Effect of EGFRWT on EGFRvIII-Mediated NF-κB Activation with RIP1 as a Cell Death Switch

(2013) Vineshkumar Thidil Puliyappadamba et al.   Cell Reports

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets

(2012) Libing Song et al.   JOURNAL OF CLINICAL INVESTIGATION

BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets

(2012) Jaehwi Lee et al.   MEDIATORS OF INFLAMMATION

Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-κB activation

(2012) Tao Tao et al.   MOLECULAR BIOLOGY OF THE CELL

EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis

(2012) Weiwei Yang et al.   MOLECULAR CELL

MiR-218 sensitizes glioma cells to apoptosis and inhibits tumorigenicity by regulating ECOP-mediated suppression of NF-κB activity

(2012) Hongping Xia et al.   NEURO-ONCOLOGY

DNA damage-induced cytotoxicity is mediated by the cooperative interaction of phospho-NF-κB p50 and a single nucleotide in the κB-site

(2012) Clayton D. Crawley et al.   NUCLEIC ACIDS RESEARCH

Essential role of cooperative NF-κB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma

(2012) D Kesanakurti et al.   ONCOGENE

Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF- B network

(2012) K. M. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Targeting inflammation-induced transcription factor activation: an open frontier for glioma therapy

(2011) Ellora Sen   DRUG DISCOVERY TODAY

Knockdown of cyclin D1 inhibits proliferation, induces apoptosis, and attenuates the invasive capacity of human glioblastoma cells

(2011) JunYu Wang et al.   JOURNAL OF NEURO-ONCOLOGY

The nonsteroidal anti-inflammatory drug celecoxib suppresses the growth and induces apoptosis of human glioblastoma cells via the NF-κB pathway

(2011) Gangadhara Reddy Sareddy et al.   JOURNAL OF NEURO-ONCOLOGY

Effect of Brain- and Tumor-Derived Connective Tissue Growth Factor on Glioma Invasion

(2011) Lincoln A. Edwards et al.   JNCI-Journal of the National Cancer Institute

Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage

(2011) Daniel R. Premkumar et al.   MOLECULAR CARCINOGENESIS

p50 (NF-κB1) Is an Effector Protein in the Cytotoxic Response to DNA Methylation Damage

(2011) Adam M. Schmitt et al.   MOLECULAR CELL

Return to homeostasis: downregulation of NF-κB responses

(2011) Jürgen Ruland   NATURE IMMUNOLOGY

Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: a north central cancer treatment group study

(2011) B. B. Friday et al.   NEURO-ONCOLOGY

Antitumor effect of dehydroxymethylepoxyquinomicin, a small molecule inhibitor of nuclear factor- B, on glioblastoma

(2011) T. Fukushima et al.   NEURO-ONCOLOGY

EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway

(2011) R Bonavia et al.   ONCOGENE

Blockade of the NFκB pathway drives differentiating glioblastoma-initiating cells into senescence both in vitro and in vivo

(2011) L Nogueira et al.   ONCOGENE

Oncogenic EGFR Signaling Activates an mTORC2-NF- B Pathway That Promotes Chemotherapy Resistance

(2011) K. Tanaka et al.   Cancer Discovery

miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-β

(2010) Libing Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NFκB inhibitors induce cell death in glioblastomas

(2010) Alfeu Zanotto-Filho et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of cyclin D1 gene expression: Figure 1

(2010) Ini-Isabée Witzel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

NFκB/p53 crosstalk—a promising new therapeutic target

(2010) Günter Schneider et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Non-canonical NF-κB signaling pathway

(2010) Shao-Cong Sun   CELL RESEARCH

Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma

(2010) Surasak Phuphanich et al.   JOURNAL OF NEURO-ONCOLOGY

NFKBIADeletion in Glioblastomas

(2010) Markus Bredel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of Sulfasalazine for the treatment of progressing malignant gliomas in adults

(2009) Pierre A Robe et al.   BMC CANCER

The Receptor Interacting Protein 1 Inhibits p53 Induction through NF- B Activation and Confers a Worse Prognosis in Glioblastoma

(2009) S. Park et al.   CANCER RESEARCH

Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma

(2009) Etienne Meylan et al.   NATURE

The prolyl isomerase Pin1 regulates the NF-κB signaling pathway and interleukin-8 expression in glioblastoma

(2009) G P Atkinson et al.   ONCOGENE

The NF-κB-independent functions of IKK subunits in immunity and cancer

(2009) Alain Chariot   TRENDS IN CELL BIOLOGY

Signaling to NF- B: Regulation by Ubiquitination

(2009) I. E. Wertz et al.   Cold Spring Harbor Perspectives in Biology

NF- B as a Critical Link Between Inflammation and Cancer

(2009) M. Karin   Cold Spring Harbor Perspectives in Biology

Glioma cells on the run – the migratory transcriptome of 10 human glioma cell lines

(2008) Tim Demuth et al.   BMC GENOMICS

Molecular Basis of Nuclear Factor- B Activation by Astrocyte Elevated Gene-1

(2008) D. Sarkar et al.   CANCER RESEARCH

Induction of a pro-apoptotic ATM–NF-κB pathway and its repression by ATR in response to replication stress

(2008) Zhao-Hui Wu et al.   EMBO JOURNAL

Phase I Trial Using Proteasome Inhibitor Bortezomib and Concurrent Temozolomide and Radiotherapy for Central Nervous System Malignancies

(2008) Gregory J. Kubicek et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Inactivation of NF-κB Components by Covalent Binding of (−)-Dehydroxymethylepoxyquinomicin to Specific Cysteine Residues

(2008) Mizuki Yamamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults

(2008) Santosh Kesari et al.   NEURO-ONCOLOGY

Proteasome Inhibitor-Induced Apoptosis of Glioma Cells Involves the Processing of Multiple Caspases and Cytochrome c Release

(2003) Bettina Wagenknecht et al.   JOURNAL OF NEUROCHEMISTRY