Inhibition of Cathepsin K Increases Modeling-Based Bone Formation, and Improves Cortical Dimension and Strength in Adult Ovariectomized Monkeys

Effects of minodronic acid and alendronate on bone remodeling, microdamage accumulation, degree of mineralization and bone mechanical properties in ovariectomized cynomolgus monkeys

(2013) Yoshiki Yamagami et al.   BONE

Effects of Odanacatib on Bone Mineralization Density Distribution in Thoracic Spine and Femora of Ovariectomized Adult Rhesus Monkeys: A Quantitative Backscattered Electron Imaging Study

(2012) Nadja Fratzl-Zelman et al.   CALCIFIED TISSUE INTERNATIONAL

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Are Women with Thicker Cortices in the Femoral Shaft at Higher Risk of Subtrochanteric/Diaphyseal Fractures? The Study of Osteoporotic Fractures

(2012) Nicola Napoli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The effects of the cathepsin K inhibitor odanacatib on osteoclastic bone resorption and vesicular trafficking

(2011) P. Leung et al.   BONE

Decreased bone remodeling and porosity are associated with improved bone strength in ovariectomized cynomolgus monkeys treated with denosumab, a fully human RANKL antibody

(2011) Paul J. Kostenuik et al.   BONE

Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys

(2011) Michael S. Ominsky et al.   BONE

Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys

(2011) Patricia J Masarachia et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey

(2011) Tara Cusick et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys

(2011) C. Jerome et al.   OSTEOPOROSIS INTERNATIONAL

Denosumab and bisphosphonates: Different mechanisms of action and effects

(2010) Roland Baron et al.   BONE

Resorption is not essential for the stimulation of bone growth by hPTH-(1-34) in rats in vivo

(2010) J. M. Hock et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cathepsin K inhibitors prevent bone loss in estrogen-deficient rabbits

(2010) Brenda L Pennypacker et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Treatment with a Potent Cathepsin K Inhibitor Preserves Cortical and Trabecular Bone Mass in Ovariectomized Monkeys

(2009) G. B. Stroup et al.   CALCIFIED TISSUE INTERNATIONAL

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

(2008) Jacques Yves Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS