Effects of Odanacatib on Bone Mineralization Density Distribution in Thoracic Spine and Femora of Ovariectomized Adult Rhesus Monkeys: A Quantitative Backscattered Electron Imaging Study

The effects of the cathepsin K inhibitor odanacatib on osteoclastic bone resorption and vesicular trafficking

(2011) P. Leung et al.   BONE

Osteoclast Activity and Subtypes as a Function of Physiology and Pathology—Implications for Future Treatments of Osteoporosis

(2011) K. Henriksen et al.   ENDOCRINE REVIEWS

Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: The OCEAN study

(2011) Richard Eastell et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys

(2011) Patricia J Masarachia et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey

(2011) Tara Cusick et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Reduced cortical bone compositional heterogeneity with bisphosphonate treatment in postmenopausal women with intertrochanteric and subtrochanteric fractures

(2011) Eve Donnelly et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys

(2011) C. Jerome et al.   OSTEOPOROSIS INTERNATIONAL

Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption - implications for osteoclast quality

(2010) Anita V Neutzsky-Wulff et al.   BMC MUSCULOSKELETAL DISORDERS

The Cathepsin K Inhibitor Odanacatib Suppresses Bone Resorption in Women With Breast Cancer and Established Bone Metastases: Results of a 4-Week, Double-Blind, Randomized, Controlled Trial

(2010) Anders Bonde Jensen et al.   Clinical Breast Cancer

Future of anticathepsin K drugs: dual therapy for skeletal disease and atherosclerosis?

(2010) Izabela Podgorski   Future Medicinal Chemistry

Cathepsin K inhibitors prevent bone loss in estrogen-deficient rabbits

(2010) Brenda L Pennypacker et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Odanacatib in the treatment of postmenopausal women with low bone mineral density: Three-year continued therapy and resolution of effect

(2010) John A Eisman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis

(2010) J.J. McDougall et al.   OSTEOARTHRITIS AND CARTILAGE

Bisphosphonate treatment modifies canine bone mineral and matrix properties and their heterogeneity

(2009) Samuel Gourion-Arsiquaud et al.   BONE

Effect of the Cathepsin K Inhibitor Odanacatib on Bone Resorption Biomarkers in Healthy Postmenopausal Women: Two Double-Blind, Randomized, Placebo-Controlled Phase I Studies

(2009) S A Stoch et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: qBEI and sSAXS data from the fracture intervention trial long-term extension (FLEX)

(2009) P Roschger et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoclasts secrete non-bone derived signals that induce bone formation

(2008) Morten A. Karsdal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

(2008) Jacques Yves Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bone density, strength, and formation in adult cathepsin K (−/−) mice

(2008) B. Pennypacker et al.   BONE

Effect of Temporal Changes in Bone Turnover on the Bone Mineralization Density Distribution: A Computer Simulation Study

(2008) Davide Ruffoni et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts

(2007) Karen Fuller et al.   BONE

Bone mineralization density distribution in health and disease

(2007) P. Roschger et al.   BONE