Article
Endocrinology & Metabolism
Fjola Johannesdottir, Melissa S. Putman, Sherri-Ann M. Burnett-Bowie, Joel S. Finkelstein, Elaine W. Yu, Mary L. Bouxsein
Summary: The study found that postmenopausal Black women have similar rates of bone loss compared to White women, with lower weight women experiencing greater declines in bone density and microstructure at the radius. Women who lost weight during the follow-up period had higher rates of bone loss, particularly at the tibia, while higher baseline total body fat mass was protective against bone loss.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Xiaolin Ni, Yiming Feng, Wenmin Guan, Yue Chi, Xiang Li, Yiyi Gong, Nan Zhao, Qianqian Pang, Wei Yu, Huanwen Wu, Li Huo, Yong Liu, Jin Jin, Xi Zhou, Wei Lv, Lian Zhou, Yu Xia, Wei Liu, Ruizhi Jiajue, Ou Wang, Mei Li, Xiaoping Xing, Seiji Fukumoto, Yan Jiang, Weibo Xia
Summary: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive production of fibroblast growth factor 23 (FGF23) by a tumor. This study evaluated the bone microarchitecture in TIO patients using high-resolution peripheral quantitative computed tomography (HR-pQCT) and trabecular bone score (TBS) and found that TIO patients had impaired bone microstructure in the peripheral skeleton. HR-pQCT parameters and TBS showed promising advantages for assessing bone impairment in TIO patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Julian Stuerznickel, Felix N. Schmidt, Hannah S. Schaefer, Frank Timo Beil, Karl-Heinz Frosch, Carsten Schlickewei, Michael Amling, Alexej Barg, Tim Rolvien
Summary: This study demonstrates that age, female sex, and osteoporosis have severe negative effects on distal fibula bone mineralization and microarchitecture, with cortical microarchitecture declining with age in both sexes. There are moderate positive associations between distal tibial and fibular microarchitecture.
Article
Endocrinology & Metabolism
L. Wang, K. Chen, L. Duan, X. Ke, F. Gong, H. Pan, H. Yang, H. Zhu, W. Xia
Summary: This study evaluated bone microarchitecture parameters using high-resolution peripheral quantitative computed tomography (HR-pQCT) in prolactinoma patients and compared them with healthy controls. The results showed that many bone microarchitecture parameters were impaired in prolactinoma patients, and this impairment was more prominent in patients with higher prolactin levels.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Ko Chiba, Naoki Iwamoto, Kounosuke Watanabe, Kazuteru Shiraishi, Kengo Saito, Naoki Okubo, Atsushi Kawakami, Makoto Osaki
Summary: This study investigated the effect of denosumab on bone mineral density (BMD) and bone microarchitecture in patients with rheumatoid arthritis (RA) treated with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs). The results suggest that denosumab can increase BMD and improve bone microarchitecture.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Endocrinology & Metabolism
Shingo Ota, Ko Chiba, Narihiro Okazaki, Akihiko Yonekura, Masato Tomita, Makoto Osaki
Summary: An advanced method using HR-pQCT was developed to analyze the cortical bone microarchitecture of the distal radius. The study found that cortical bone density and thickness decreased while cortical porosity increased with age. The thinning of cortical bone was particularly pronounced in the dorsal and palmar regions.
JOURNAL OF BONE AND MINERAL METABOLISM
(2022)
Article
Orthopedics
Carsten Schlickewei, Conradin Schweizer, Klaus Pueschel, Benjamin Ondruschka, Holger Kleinertz, Alexej Barg, Tim Rolvien, Julian Stuerznickel
Summary: This study examines the effects of age, sex, and subregion on the bone microarchitecture and strength of the distal fibula. Results show that cortical parameters increase and trabecular parameters decrease from distal to proximal. Age is primarily associated with a cortical decrease in all subregions for women, while men also exhibit age-associated decreases in certain parameters. The stiffness and failure load are highest in the type C subregion for both genders. A critical age-related decline in bone strength parameters is observed in the type B subregion for women, providing an explanation for the increased incidence of low-traumatic type B fractures in the elderly.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
E. H. S. Koy, A. Amouzougan, E. Biver, R. Chapurlat, T. Chevalley, S. L. Ferrari, A. Fouilloux, H. Locrelle, H. Marotte, M. Normand, R. Rizzoli, L. Vico, T. Thomas
Summary: This study presents reference values of HR-pQCT measurements in a Franco-Swiss female cohort at the distal radius and tibia sites, considering specific age bounds. Microarchitectural parameters start to decline before the age of 30, with the optimal bone profile observed between the ages of 22 to 27 in this population.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Qian Li, Zhen Zhao, Bo Wu, Qianqian Pang, Lijia Cui, Li Zhang, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Yingying Hu, Wei Yu, Xunwu Meng, Ruizhi Jiajue, Weibo Xia
Summary: Camurati-Engelmann disease is a rare skeletal dysplasia caused by mutations in the TGFB1 gene. This study conducted a retrospective review of CED patients in Beijing, China and characterized various clinical features, bone microstructure, and strength using HR-pQCT. The study revealed typical manifestations of CED and showed alterations in bone density, microstructure, and strength in CED patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
M. S. A. M. Bevers, A. M. Daniels, B. van Rietbergen, P. P. M. M. Geusens, S. M. J. van Kuijk, S. Sassen, S. Kaarsemaker, P. F. W. Hannemann, M. Poeze, H. M. J. Janzing, J. P. van den Bergh, C. E. Wyers
Summary: By utilizing high-resolution peripheral quantitative computed tomography, this study examined changes in bone density, microstructure, and strength during the healing of conservatively-treated scaphoid fractures. The findings indicated a substantial decrease in bone density, trabecular thickness, and failure load during the initial 6 weeks of healing, followed by stabilization or increase in these parameters. However, at 26 weeks, these parameters had not returned to baseline levels.
Article
Endocrinology & Metabolism
Nicklas Hojgaard-hessellund Rasmussen, Jakob Dal, Annika Vestergaard Kvist, Joop P. van den Bergh, Morten Hasselstrom Jensen, Peter Vestergaard
Summary: This study compared the bone mineral density, bone strength, and bone microarchitecture of individuals with type 1 diabetes and type 2 diabetes to those without diabetes. The results showed that individuals with type 1 diabetes had lower bone density, while those with type 2 diabetes had higher bone density. Both groups showed favorable bone microarchitecture and strength parameters at the tibia and radius.
Article
Endocrinology & Metabolism
Aleksandar Cirovic, Jelena Jadzic, Danica Djukic, Danijela Djonic, Vladimir Zivkovic, Slobodan Nikolic, Marija Djuric, Petar Milovanovic
Summary: Individuals with type 2 diabetes have an increased risk of hip fracture, but the cause of this elevated risk is not clear. This study found that individuals with type 2 diabetes had higher cortical porosity and lower cortical thickness in the superolateral femoral neck, and there were significant differences in trabecular microarchitectural parameters. The control group had higher cortical and trabecular bone microhardness. The deteriorated cortical microarchitecture in the superolateral femoral neck cannot be detected by standard DXA measurement.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Wenting Qi, Yan Jiang, Wei Liu, Yue Chi, Ruizhi Jiajue, Qianqian Pang, Ou Wang, Mei Li, Xiaoping Xing, Wei Yu, Weibo Xia
Summary: Obesity is associated with improved areal bone mineral density, bone geometry, and bone microarchitecture in postmenopausal Chinese women. Except for a lower level of osteocalcin, no significant differences in bone turnover markers were found among the groups.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Nathan J. Neeteson, Bryce A. Besler, Danielle E. Whittier, Steven K. Boyd
Summary: High-resolution peripheral quantitative computed tomography (HR-pQCT) is an emerging in vivo imaging modality for quantification of bone microarchitecture. However, the current standard protocol for HR-pQCT image segmentation is laborious and introduces biases into research data. In this study, a fully automated algorithm for HR-pQCT image segmentation was proposed and validated, which significantly improved precision for several outputs.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Saghi Sadoughi, Courtney Pasco, Gabby B. Joseph, Po-Hung Wu, Anne L. Schafer, Galateia J. Kazakia
Summary: This study found that patients undergoing RYGB surgery experienced significant increases in cortical porosity in the midcortical and periosteal layers of the tibia and radius at 12 months postoperatively, suggesting that the mechanism driving this increase is not primarily endosteal trabecularization.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ashutosh Parajuli, Shaopeng Pei, Hongbo Zhao, Jerahme R. Martinez, X. Lucas Lu, X. Sherry Liu, Mary C. Farach-Carson, Catherine B. Kirn-Safran, Liyun Wang
Editorial Material
Orthopedics
Tamara Alliston, Kharma C. Foucher, Brenda Frederick, Christopher J. Hernandez, James C. Iatridis, Kenneth M. Kozloff, Karl J. Lewis, X. Sherry Liu, Deana M. Mercer, Ruth Ochia, Robin M. Queen, Clare M. Rimnac, Marjolein C. H. van der Meulen, Jennifer J. Westendorf
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)
Article
Rheumatology
Qing Li, Biao Han, Chao Wang, Wei Tong, Yulong Wei, Wei-Ju Tseng, Li-Hsin Han, X. Sherry Liu, Motomi Enomoto-Iwamoto, Robert L. Mauck, Ling Qin, Renato V. Iozzo, David E. Birk, Lin Han
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Biophysics
Ashley K. Fung, Snehal S. Shetye, Yihan Li, Yilu Zhou, X. Sherry Liu, Louis J. Soslowsky
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2020)
Article
Endocrinology & Metabolism
Yihan Li, Wei-Ju Tseng, Chantal M. J. de Bakker, Hongbo Zhao, Rebecca Chung, X. Sherry Liu
Summary: Postmenopausal osteoporosis is influenced by reduced estrogen levels during menopause, impacting bone remodeling, bone mass, and fracture risk. Peak bone mass and microstructure are important predictors of osteoporosis risk, with thicker trabeculae being associated with lower rates of bone loss in response to estrogen deficiency. Thicker trabeculae are less likely to disconnect or perforate, leading to a lower degree of bone loss.
Article
Medicine, Research & Experimental
Wei Yu, Leilei Zhong, Lutian Yao, Yulong Wei, Tao Gui, Ziqing Li, Hyunsoo Kim, Nicholas Holdreith, Xi Jiang, Wei Tong, Nathaniel Dyment, X. Sherry Liu, Shuying Yang, Yongwon Choi, Jaimo Ahn, Ling Qin
Summary: Our study identified marrow adipogenic lineage precursors (MALPs) as a critical player in controlling bone remodeling during normal bone metabolism and pathological bone loss in a RANKL-dependent fashion.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Orthopedics
B. Han, Q. Li, C. Wang, P. Chandrasekaran, Y. Zhou, L. Qin, X. S. Liu, M. Enomoto-Iwamoto, D. Kong, R. V. Iozzo, D. E. Birk, L. Han
Summary: In post-traumatic osteoarthritis (PTOA), decorin plays a more crucial role than biglycan in regulating cartilage degeneration, while biglycan is more important in regulating subchondral bone structure. The two have distinct activities and modest synergy in the pathogenesis of PTOA.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Engineering, Biomedical
Wenzheng Wang, Wei-Ju Tseng, Hongbo Zhao, Tala Azar, Shaopeng Pei, Xi Jiang, Nathaniel Dyment, Sherry Liu
Summary: The study shows that MBF and RBF have similar contributions to trabecular bone homeostasis, with PTH playing a promoting role in new bone formation. Regardless of the type of bone formation, mineral deposition continues once activated by PTH.
Article
Biology
Yulong Wei, Hao Sun, Tao Gui, Lutian Yao, Leilei Zhong, Wei Yu, Su-Jin Heo, Lin Han, Nathaniel A. Dyment, Xiaowei Sherry Liu, Yejia Zhang, Eiki Koyama, Fanxin Long, Miltiadis H. Zgonis, Robert L. Mauck, Jaimo Ahn, Ling Qin
Summary: Meniscal tears are associated with a high risk of osteoarthritis, with no cure currently available. This study identified Gli1(+) cells as important contributors to meniscus development and repair, showing high progenitor activities under the control of Hh signal. Stimulating these cells or using an Hh agonist can accelerate healing and reduce osteoarthritis symptoms.
Article
Endocrinology & Metabolism
Xiaohan Lai, Rebecca Chung, Yihan Li, Xiaowei Sherry Liu, Liyun Wang
Summary: The study used a multiscale poroelastic modeling technique to investigate the effects of lactation on the physicochemical environment and mechanosensing of osteocytes in murine tibiae. The results showed that lactation-induced LCS expansion and PCM reduction promoted solute transport and osteocyte mechanosensing, while higher loading frequency and sparser PCM enhanced flow-mediated mechanosensing and nutrient transport.
Article
Endocrinology & Metabolism
Yihan Li, Chantal M. J. de Bakker, Xiaohan Lai, Hongbo Zhao, Ashutosh Parajuli, Wei -Ju Tseng, Shaopeng Pei, Tan Meng, Rebecca Chung, Liyun Wang, X. Sherry Liu
Summary: This study demonstrated that maternal bone undergoes improvements in structure in response to dynamic loading, regardless of reproductive status, with lactating rats showing enhanced mechano-responsiveness in both trabecular and cortical bone compartments. Additionally, lactation-induced activities in osteocyte peri-lacunar/canalicular remodeling may lead to increased mechano-responsiveness in maternal bone during lactation. Findings emphasize the importance of weightbearing exercise on maternal bone health during reproduction and postpartum.
Article
Endocrinology & Metabolism
Wei-Ju Tseng, Wonsae Lee, Hongbo Zhao, Yang Liu, Wenzheng Wang, Chantal Mj de Bakker, Yihan Li, Carlos Osuna, Wei Tong, Luqiang Wang, Xiaoyuan Ma, Ling Qin, X. Sherry Liu
Summary: Despite the potent effect of intermittent parathyroid hormone (PTH) treatment on promoting new bone formation, bone mineral density (BMD) rapidly decreases upon discontinuation of PTH administration. The responses to PTH treatment withdrawal vary in intact and estrogen-deficient rats, with the latter experiencing significant bone loss and microarchitecture deterioration. An extended anabolic period is observed in estrogen-deficient rats upon early PTH withdrawal, followed by adverse changes in bone cell activities.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Engineering, Biomedical
Wen Sang, Yihan Li, Jane Guignon, X. Sherry Liu, Ani Ural
Summary: This study examined the structural role of osteocyte lacunae on the mechanical properties of the bone matrix, revealing significant linear relationships between lacunar area, density, size, and orientation with elastic modulus and ultimate strength. Parametric studies also showed strong correlations between elastic modulus and strength with lacunar density, size, and orientation. Additionally, simulations demonstrated that osteocyte lacunae guide crack propagation through local stress concentrations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Shaopeng Pei, Yilu Zhou, Yihan Li, Tala Azar, Wenzheng Wang, Do-Gyoon Kim, X. Sherry Liu
Summary: This review focuses on nanoindentation testing in musculoskeletal research, discussing its application, the factors affecting testing results, and other commonly used techniques for synchronized imaging and colocalized characterization.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Wenzheng Wang, Tala Azar, Wei-Ju Tseng, Shaopeng Pei, Yilu Zhou, Xi Jiang, Nathaniel Dyment, X. Sherry Liu
Summary: This study investigated the temporal response of newly formed bone tissue and preexisting bone tissue to withdrawal from intermittent parathyroid hormone (PTH) treatment in an ovariectomized rat model. The results showed that modeling-based bone formation (MBF) sites had a greater contribution to the extended anabolic effect upon early withdrawal from PTH compared to remodeling-based bone formation (RBF) sites. Furthermore, newly formed bone tissue from MBF had greater resistance to PTH discontinuation-induced bone loss than those from RBF and preexisting bone.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)