Hyperactive Transforming Growth Factor-β1 Signaling Potentiates Skeletal Defects in a Neurofibromatosis Type 1 Mouse Model

A controlled register-based study of 460 neurofibromatosis 1 patients: Increased fracture risk in children and adults over 41 years of age

(2012) Eetu Heervä et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Is double inactivation of the Nf1 gene responsible for the development of congenital pseudarthrosis of the tibia associated with NF1?

(2012) Sang Min Lee et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Identification of MicroRNAs Inhibiting TGF-β-Induced IL-11 Production in Bone Metastatic Breast Cancer Cells

(2012) Sirkku Pollari et al.   PLoS One

Multiple increased osteoclast functions in individuals with neurofibromatosis type 1

(2011) David A. Stevenson et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Expanding the skeletal phenotype of Loeys-Dietz syndrome

(2011) Sérgio B. Sousa et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Primary osteopathy of vertebrae in a neurofibromatosis type 1 murine model

(2011) Wei Zhang et al.   BONE

Osteoclasts derived from patients with neurofibromatosis 1 (NF1) display insensitivity to bisphosphonates in vitro

(2011) Eetu Heervä et al.   BONE

Mice lacking Nf1 in osteochondroprogenitor cells display skeletal dysplasia similar to patients with neurofibromatosis type I

(2011) Weixi Wang et al.   HUMAN MOLECULAR GENETICS

Low bone mass and high material bone density in two patients with Loeys-Dietz syndrome caused by transforming growth factor beta receptor 2 mutations

(2011) I Mouna Ben Amor et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Haploinsufficient Hematopoietic Microenvironment Is Critical to the Pathological Fracture Repair in Murine Models of Neurofibromatosis Type 1

(2011) Xiaohua Wu et al.   PLoS One

Germline TGF-β receptor mutations and skeletal fragility: A report on two patients with Loeys-Dietz syndrome

(2010) Salman Kirmani et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Osteoclasts in neurofibromatosis type 1 display enhanced resorption capacity, aberrant morphology, and resistance to serum deprivation

(2010) Eetu Heervä et al.   BONE

Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2

(2010) S. Lieu et al.   Disease Models & Mechanisms

The bone mineral status of patients with marfan syndrome

(2010) Lynn Kohlmeier et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of TGF-β signaling by 1D11 antibody treatment increases bone mass and quality in vivo

(2010) James R Edwards et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Local low-dose lovastatin delivery improves the bone-healing defect caused by Nf1 loss of function in osteoblasts

(2010) Weixi Wang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone

(2010) Jeffry S Nyman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Matrix Metalloproteinases That Associate With and Cleave Bone Morphogenetic Protein-2 In Vitro Are Elevated in Hypertrophic Fracture Nonunion Tissue

(2010) Marc Fajardo et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

TGF-β1 As Possible Link between Loss of Bone Mineral Density and Chronic Inflammation

(2010) Sabrina Ehnert et al.   PLoS One

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Pharmacologic Inhibition of the TGF-β Type I Receptor Kinase Has Anabolic and Anti-Catabolic Effects on Bone

(2009) Khalid S. Mohammad et al.   PLoS One

Bone health and fracture rate in individuals with neurofibromatosis 1 (NF1)

(2008) T Tucker et al.   JOURNAL OF MEDICAL GENETICS

Models of tibial fracture healing in normal and Nf1‐deficient mice

(2008) Aaron Schindeler et al.   JOURNAL OF ORTHOPAEDIC RESEARCH