Article
Pharmacology & Pharmacy
G. Maccagnano, V Pesce, G. Vicenti, G. Noia, M. Coviello, I Bortone, A. Ziranu, F. Causo, B. Moretti
Summary: This study evaluated the effectiveness of combined drug therapy in lateral fragility femur fractures treated by intramedullary nailing surgery. The results showed that combined drug therapy can lead to increased bone density and positive effects on bone remodeling and absorption processes.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Delphine Farlay, Sebastien Rizzo, Louis-Georges Ste-Marie, Laetitia Michou, Suzanne N. Morin, Shijing Qiu, Pascale Chavassieux, Roland D. Chapurlat, Sudhaker D. Rao, Jacques P. Brown, Georges Boivin
Summary: Bisphosphonates are commonly used drugs for treating osteoporosis, but long-term use may increase the risk of atypical femur fracture. Research found that patients with AFF had higher bone mineralization levels compared to non-AFF patients, potentially due to the accumulation of bisphosphonates in bone mineral affecting the osteocyte cytoskeleton.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Orthopedics
Naoya Inagaki, Takaaki Tanaka, Jun Udaka, Shoshi Akiyama, Tatsuki Matsuoka, Mitsuru Saito
Summary: This study found significant differences in Hounsfield unit (HU) values in different pelvic areas between young and older patients, which could impact load distribution and fracture patterns.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: Bone mineral density (BMD) loss shows greater variability at shorter testing intervals, but this variability diminishes over longer intervals. Using reports of rapid BMD loss as an indication for antifracture medication initiation may not be accurate.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: This study examined medication adherence in women with osteoporosis before and after a fracture. The results show that many women experience a decline in medication adherence after a fracture, which is paradoxical to expectations. Fracture on therapy represents an important opportunity for clinicians to emphasize treatment adherence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Jiangbi Li, Yang Sun, Zhuo Chen, Xiaoping Xie, Feng Gu, Songqi Bi, Tiecheng Yu
Summary: This review examined the effects of bisphosphonates on bone density, fractures, and bone markers in osteopenic older women. The study found that bisphosphonates had significant positive effects on bone density and bone markers, as well as reducing the risk of fractures. However, further research is needed to determine their safety.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Qingmei Li, Jiancheng Yang, Qinghua Tang, Yan Feng, Mingming Pan, Maohong Che, Jie Shi, Yuhong Zeng
Summary: This study evaluated the gender differences in diagnosis and treatment of osteoporosis in fragility fracture patients. The results showed significant differences in bone density measurement, biochemical marker testing, medication treatment, and follow-up between male and female patients.
Article
Endocrinology & Metabolism
Annelies De Mare, Britt Opdebeeck, Ellen Neven, Patrick C. D'Haese, Anja Verhulst
Summary: Sclerostin, a negative regulator of the Wnt/β-catenin signaling pathway, inhibits bone formation and turnover. Depletion or deactivation of sclerostin promotes the development of ectopic calcification, with vascular smooth muscle cells undergoing dedifferentiation playing a central role.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Simone Ciuffi, Francesca Marini, Caterina Fossi, Simone Donati, Francesca Giusti, Annalisa Botta, Laura Masi, Giancarlo Isaia, Claudio Marcocci, Silvia Migliaccio, Salvatore Minisola, Ranuccio Nuti, Umberto Tarantino, Teresa Iantomasi, Maria Luisa Brandi
Summary: This study investigated the expression of circulating microRNAs (miRNAs) in osteoporotic patients using next-generation sequencing (NGS) and droplet digital polymerase chain reaction (ddPCR). The study identified differentially expressed miRNAs, including miR-23a-3p, miR-21-5p, and miR-320a-3p, which could distinguish osteoporotic patients from individuals with normal bone mineral density (BMD). Increased expression of c-miR-320a-3p was specifically associated with fractures, suggesting it as a potential prognostic indicator of fracture risk in osteoporotic patients. These findings need to be further validated in prospective studies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Gregory A. A. Kline, Suzanne N. N. Morin, Lisa M. M. Lix, William D. D. Leslie
Summary: Based on the FLEX study in 2006, a 5-year course of bisphosphonate therapy was found to be sufficient for most women. However, despite the increased risk of atypical femoral fractures associated with long-term use, up to one-third of patients continued to receive bisphosphonate therapy for over 10 years after 2010.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Obstetrics & Gynecology
M. Conradie, T. de Villiers
Summary: Diagnosis of premenopausal osteoporosis should involve a comprehensive evaluation of multiple factors and exclusion of secondary causes. Treatment should include reducing risk factors, advocating a healthy lifestyle, and addressing any secondary causes of bone loss.
Review
Orthopedics
Eleonora Piccirilli, Ida Cariati, Matteo Primavera, Rebecca Triolo, Elena Gasbarra, Umberto Tarantino
Summary: This article reviews the use of fixation augmentation techniques in osteoporotic fractures. The literature review shows that augmentation techniques can improve the stability and strength of implants. However, there are currently no recommendations or consensus on the use of augmentation techniques in osteoporotic fractures.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Endocrinology & Metabolism
Nidhi Gupta, Seth W. Gregory, David R. Deyle, Peter J. Tebben
Summary: The study describes a kindred with a unique phenotype of osteogenesis imperfecta, characterized by the cessation of nontraumatic fractures after the first two years of life in affected family members.
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Angela Lopez-Sainz, Laia Mila, Jose Rodriguez-Palomares, Javier Limeres, Chiara Granato, Lucia La Mura, Ana Sabate, Andrea Guala, Laura Gutierrez, Laura Galian-Gay, Augusto Sao-Aviles, Sergi Bellmunt, Rafael Rodriguez, Hug Cuellar-Calabria, Albert Roque, Ignacio Ferreira-Gonzalez, Artur Evangelista, Gisela Teixido-Tura
Summary: This study revealed that aortic branch aneurysms are present in approximately one-quarter of patients with MFS, are associated with patient age and aortic dilation, and independently predict the need for aortic surgery.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Endocrinology & Metabolism
Frida Igland Nissen, Camilla Andreasen, Tove Tveitan Borgen, Ashild Bjornerem, Ann Kristin Hansen
Summary: This study suggests that cortical bone measurements using clinical CT do not provide substantial added value in fracture risk assessment compared to FN aBMD and FRAX.