Selective tyrosine kinase inhibition of insulin-like growth factor-1 receptor inhibits human and mouse breast cancer-induced bone cell activity, bone remodeling, and osteolysis

Small Interfering RNA Targeted to IGF-IR Delays Tumor Growth and Induces Proinflammatory Cytokines in a Mouse Breast Cancer Model

(2012) Tiphanie Durfort et al.   PLoS One

Insulin-like growth factor receptor (IGF-1R) in breast cancer subtypes

(2011) Rinat Yerushalmi et al.   BREAST CANCER RESEARCH AND TREATMENT

PI3K/Akt and MAPK/ERK1/2 signaling pathways are involved in IGF-1-induced VEGF-C upregulation in breast cancer

(2011) Chenfang Zhu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The insulin-like growth factor-I receptor as an oncogene

(2011) Haim Werner et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Defining the pathway to insulin-like growth factor system targeting in cancer

(2010) Steven A. Rosenzweig et al.   BIOCHEMICAL PHARMACOLOGY

Osteoblasts are a major source of inflammatory cytokines in the tumor microenvironment of bone metastatic breast cancer

(2010) Karen M. Bussard et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer pain

(2010) C. Geis et al.   NEUROSCIENCE

Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor

(2009) Mark J Mulvihill et al.   Future Medicinal Chemistry

Paracrine Overexpression of Insulin-Like Growth Factor-1 Enhances Mammary Tumorigenesis in Vivo

(2008) Krisztina Kovács de Ostrovich et al.   AMERICAN JOURNAL OF PATHOLOGY

IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts

(2008) Manando Nakasaki et al.   BONE

Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival

(2008) J. H. Law et al.   CANCER RESEARCH

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

(2008) Jinhua Wu et al.   EMBO JOURNAL

Growth Hormone, Insulin-Like Growth Factors, and the Skeleton

(2008) Andrea Giustina et al.   ENDOCRINE REVIEWS

Resveratrol inhibits migration and invasion of human breast-cancer cells

(2008) Feng-Yao Tang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Insulin-like growth factor-I and bone: lessons from mice and men

(2008) Masanobu Kawai et al.   PEDIATRIC NEPHROLOGY