Article
Oncology
Stefanie Heym, Caroline F. Mohr, Hanna C. Engelbrecht, Bernhard Fleckenstein, Andrea K. Thoma-Kress
Summary: Actin-bundling protein Fascin is upregulated in many types of cancers, including adult T-cell leukemia/lymphoma induced by HTLV-1. Transcriptional induction of Fascin by viral oncoproteins depends on activity of both classical and alternative NF-kappa B signaling. Non-oncogenic Tax-2 can induce Fascin expression to a lesser extent compared to Tax-1, and both Tax-1 and Tax-2 can activate key fragments in the Fascin promoter. Additionally, the activity of alternative NF-kappa B pathway is linked to Fascin induction.
Article
Microbiology
M. Brittany Johnson, Kelli H. H. Furr, Samantha R. R. Suptela, Whitney Leach, Ian Marriott
Summary: Osteoblasts can respond to Staphylococcus aureus infection by producing IFN-beta, which mitigates the infection by inducing ISG expression.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Oncology
Nicolas Ducasa, Daniel Grasso, Paula Benencio, Daniela L. Papademetrio, Mirna Biglione, Fatah Kashanchi, Carolina Berini, Maria Noe Garcia
Summary: HTLV-1, as the etiological agent of ATLL, interacts with host cells through its viral proteins to promote viral replication and T cell transformation by engaging NF-kappa B and autophagy pathways. Additionally, HTLV-1 utilizes the autophagy pathway to achieve its infective goals.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lisa Y. Lawson, Nicole Migotsky, Christopher J. Chermside-Scabbo, John T. Shuster, Kyu Sang Joeng, Roberto Civitelli, Brendan Lee, Matthew J. Silva
Summary: Mechanical loading stimulates bone formation, and the Wnt signaling pathway plays a crucial role in the skeletal response to loading. Specifically, Wnt1 mediates the mechano-adaptive response to loading.
Article
Biotechnology & Applied Microbiology
Yanfeng Han, Dening Pei, Wenjing Li, Bin Luo, Qingsong Jiang
Summary: In this study, it was found that EGCG could suppress the activity of the Hippo/YAP signaling pathway by up-regulating lncRNA TUG1, ultimately improving the inhibitory effect of TNF-alpha on osteoblastic differentiation.
Article
Multidisciplinary Sciences
Tzah Feldman, Akhiad Bercovich, Yoni Moskovitz, Noa Chapal-Ilani, Amanda Mitchell, Jessie J. F. Medeiros, Tamir Biezuner, Nathali Kaushansky, Mark D. Minden, Vikas Gupta, Michael Milyavsky, Zvi Livneh, Amos Tanay, Liran I. Shlush
Summary: Recurrent deletions in myeloid malignancies are found to be generated by PARP1-dependent microhomology-mediated end joining, originating in pre-leukemic stem cells. The association between POLQ-independent MMEJ and clonal hematopoiesis is demonstrated, shedding light on mutational mechanisms in the early stages of leukemia evolution.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Chun-Ling Liang, Weihui Lu, Feifei Qiu, Dan Li, Huazhen Liu, Fang Zheng, Qunfang Zhang, Yuchao Chen, Chuanjian Lu, Bin Li, Zhenhua Dai
Summary: PF can ameliorate lupus nephritis by reducing proteinuria, serum creatinine, anti-dsDNA levels, and renal cellular infiltration, as well as by improving renal immunopathology. It also has the potential to promote Treg differentiation and proliferation mediated by M2 macrophages, suggesting it may be used as a possible treatment for lupus nephritis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Immunology
Chang-hong Li, Zhen-zhen Ma, Lei-lei Jian, Xin-yu Wang, Lin Sun, Xiang-yuan Liu, Zhong-qiang Yao, Jin-xia Zhao
Summary: Iguratimod has been shown to inhibit osteoclast formation and bone resorption by interfering with signaling pathways, preventing bone loss in animal models. It also dampened TNF-alpha-induced osteoclastogenesis and disrupted nuclear translocation, providing promising evidence for its therapeutic application against RA and bone loss prevention.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Ximei Wu, Musaddique Hussain, Shahzada Khurram Syed, Malik Saadullah, Ali M. Alqahtani, Taha Alqahtani, Afaf Aldahish, Mobeen Fatima, Saira Shaukat, Liaqat Hussain, Qurratulain Jamil, Imran Mukhtar, Kashif-Ur-Rehman Khan, Ling-Hui Zeng
Summary: Verapamil has protective effects against acute lung injury, improving the condition by suppressing inflammatory response, oxidative stress, and NF-κB signaling.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Ricardo J. Antonia, Eveliina Karelehto, Kan Toriguchi, Mary Matli, Robert S. Warren, Lawrence M. Pfeffer, David B. Donner
Summary: The study reveals that TNF activates STAT3, which in turn regulates the expression of inflammatory chemokines. Furthermore, Tnfaip3/A20 is identified as a downstream target of STAT3, and it functions to restrict TNF-induced inflammation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Hematology
Wenbin Zhong, Xiuye Cao, Guoping Pan, Qun Niu, Xiaoqin Feng, Mengyang Xu, Mingchuan Li, Yu Huang, Qing Yi, Daoguang Yan
Summary: This study reveals that ORP4L is expressed in ATL cells and plays an important role in the initiation of T-cell leukemogenesis induced by HTLV-1. Loss of miR-31 leads to increased ORP4L expression, which interacts with PI3Kd to promote PI(3,4,5)P3 generation, resulting in AKT hyperactivation, NF-kappa B-dependent p53 inactivation, and pro-oncogene expression.
Article
Environmental Sciences
Lihui Xuan, Jinming Guo, Dexin Xia, Lu Li, Daining Wang, Ying Chang
Summary: This study found that profenofos (PFF) as an environmental pollutant can harm human health through the food chain. Albicanol, a sesquiterpene compound, has been shown to antagonize the toxicity caused by PFF exposure. However, the mechanism of PFF toxicity and the role of Albicanol in regulating immune function, apoptosis, and necroptosis have not been reported. The study revealed that PFF exposure led to mitochondrial damage, increased expression of innate immunity-related factors, and activated TNF/NF-kappa B pathway, while Albicanol countered these effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Milton Roy, Kritarth Singh, Anjali Shinde, Jyoti Singh, Minal Mane, Sawani Bedekar, Yamini Tailor, Dhruv Gohel, Hitesh Vasiyani, Fatema Currim, Rajesh Singh
Summary: The study identified TRIM proteins as potential feedback regulators of the TNF-alpha-induced NF-kappa B pathway. TRIM15 was found to be a late response gene induced by TNF-alpha and inhibits the NF-kappa B pathway in human cell lines. It promotes turnover of K63-linked ubiquitin chains and inhibits the activity of TAK1 and TRIM8, thus regulating the proinflammatory NF-kappa B pathway.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Youn Hye Jo, Go Woon Choi, Mi-Lyang Kim, Kyung Rim Sung
Summary: We characterized the gliosis induced by TRPV4 activation in Muller cells and assessed the modulatory effect of statins. The results showed that statins effectively inhibited Muller cell gliosis and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hye-Youn Cho, Anne E. Jedlicka, Frederick H. Chang, Jacqui Marzec, Alison K. Bauer, Steven R. Kleeberger
Summary: This study identified the time-dependent and TNFR- and NF-kappa B-regulated lung transcriptome changes in response to subacute Ozone exposure. The results provided new insights into the molecular mechanisms regulated by TNFR and NF-kappa B1 in pulmonary subacute O-3 pathogenesis, highlighting the impact on inflammation, redox, cell cycle, and DNA repair processes in the lungs.
