Article
Chemistry, Physical
Enrico Soldati, Flavy Roseren, Daphne Guenoun, Lucia Mancini, Emilio Catelli, Silvia Prati, Giorgia Sciutto, Jerome Vicente, Stefano Iotti, David Bendahan, Emil Malucelli, Martine Pithioux
Summary: The assessment of subregional bone mineral density is the most commonly used diagnostic index for osteoporosis. In this study, the bone quality in the femoral neck of an osteoporotic patient was characterized using a multiscale and multimodal approach. The results showed abnormalities in the osteocytes lacunae volume, and reduced elastic modulus and hardness in the femoral head and great trochanter.
Review
Endocrinology & Metabolism
Elisabetta Veronica Munari, Myriam Amer, Alessandro Amodeo, Ruggiero Bollino, Silvia Federici, Giovanni Goggi, Luca Giovanelli, Luca Persani, Biagio Cangiano, Marco Bonomi
Summary: The history of diagnosing hypogonadism and hypotestosteronemia illustrates the progress made in understanding these conditions and improving patient well-being. However, there is currently no consistent criteria for diagnosing hypotestosteronemia, and the complications associated with low testosterone levels are still not fully understood. Additionally, conflicting data regarding the severity and clinical relevance of these complications often arise due to insufficient information in studies. Therefore, a complete evaluation of the type and underlying causes of hypogonadism is necessary when researching the effects of low testosterone levels.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Biomedical
Mahmut Pekedis, Firat Ozan, Hasan Yildiz
Summary: The study found that patients with osteopenic fractures have more complex STB structure and higher dynamic strength. The micro structural properties of STB are positively correlated with the macro mechanical properties of AC, which may affect the mechanical performance of cartilage.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Biology
Deyin Kong, Qing Wang, Jiangeng Huang, Zhihui Zhang, Xiebin Wang, Qing Han, Yanbin Shi, Ran Ji, Yiling Li
Summary: This study investigates the mechanical properties and bone reconstruction performance of bionic bone scaffolds, focusing on those that mimic the structural features of natural cancellous bone. The results show that bionic scaffolds with specific structural parameters perform well in bone defect reconstruction and have potential for clinical application.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Urology & Nephrology
Alberto Ferlin, Andrea Garolla, Marco Ghezzi, Riccardo Selice, Pierfrancesco Palego, Nicola Caretta, Antonella Di Mambro, Umberto Valente, Maurizio De Rocco Ponce, Savina Dipresa, Leonardo Sartori, Mario Plebani, Carlo Foresta
Summary: The study found that low sperm count is associated with low testosterone, poor metabolic parameters, and osteoporosis in men. This indicates that a man's semen count is a marker of his overall health.
EUROPEAN UROLOGY FOCUS
(2021)
Review
Endocrinology & Metabolism
Leonardo Bandeira, Barbara C. Silva, John P. Bilezikian
Summary: Osteoporosis, a disease traditionally associated with postmenopausal women, is frequently overlooked, underdiagnosed, and undertreated in men. However, osteoporotic fractures in men are not uncommon and their incidence has been increasing over the years. After a first fracture, men are at higher risk of subsequent fractures and death compared to women. Yet, only a small percentage of men with osteoporosis receive adequate treatment. Secondary causes, such as hypogonadism, excessive alcohol consumption, and chronic use of glucocorticoids, account for up to half of male osteoporosis cases. The diagnosis of osteoporosis in men is based on the use of female databases for DXA scans (T-score = -2.5 in men aged 50 or older). Treatment approaches are similar to those used for postmenopausal osteoporosis, although data on fracture risk reduction in men are less certain due to limited clinical trials.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2022)
Article
Integrative & Complementary Medicine
Hussein F. Sakr, Boudaka Ammar, Amira AlKharusi, I Al-Lawati, Mahmoud AlKhateeb, Basim H. Elesawy
Summary: The study found that resveratrol can correct osteoporosis induced by male hypogonadism in rat models. By restoring the balance between bone formation and bone resorption, resveratrol can improve bone loss.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Orthopedics
Zhentao Ding, Jun Wang, Yanhua Wang, Xiaomeng Zhang, Yong Huan, Dianying Zhang
Summary: A tension screw was designed to mimic tension trabeculae in the new bionic collum femoris preserving (BCFP) short stem for bionic reconstruction and restore the biomechanics of hip joint. The study demonstrated that the BCFP-5 degrees stem minimized the stress shielding effect and showed a more bionic mechanical performance.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Engineering, Biomedical
J. Wooldridge, A. Arduino, L. Zilberti, U. Zanovello, M. Chiampi, V Clementi, O. Bottauscio
Summary: This study assessed clinically relevant factors causing tissue heating through parametric studies, discussing simulations of RF and GC fields and highlighting the highest heating levels in GC fields for large volume implants and large plate areas, and in RF fields driven by the 'antenna effect' in thin, resonant length implants.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Sport Sciences
S. T. U. A. R. T. J. WARDEN, C. H. R. I. S. T. I. A. N. S. WRIGHT, R. O. B. Y. N. K. FUCHS
Summary: Chronic physical activity can enhance trabecular microarchitecture and estimated bone strength. Tennis players demonstrate crossed symmetry, with the leg opposite the racquet arm showing enhanced tibial properties compared with the contralateral leg.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Endocrinology & Metabolism
Chenyu Jiang, Dan Jin, Ming Ni, Yan Zhang, Huishu Yuan
Summary: This study aimed to evaluate the difference in vertebral mechanical properties estimated by finite element analysis (FEA) with different computed tomography (CT) reconstruction kernels and evaluate their accuracy in the screening and classification of osteoporosis. The results showed significant differences in vertebral stiffness and strength between the two reconstruction kernels, but little difference in classifying osteoporosis. Therefore, both kernels seemed to be applicable to CT-FEA screening of osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Mechanical
Martin Lesueur, Manolis Veveakis, Hadrien Rattez
Summary: In this study, a comprehensive parametric study was conducted on the impact of cementation on rock strength for real microstructures of cemented granular materials using direct numerical simulation. The study verified the previously known tendency of rock to strengthen with increasing cementation volume and explored the influence of cement properties on the rock's yield surface.
INTERNATIONAL JOURNAL OF PLASTICITY
(2022)
Article
Computer Science, Interdisciplinary Applications
Fei Song, Yang Liu, Ruisen Fu, Xing Gao, Kamran Iqbal, Dongyue Yang, Yuxuan Liu, Haisheng Yang
Summary: This study investigated the effect of cyclic loading and osteoporosis on screw fixation in osteoporotic patients. The results showed that toggling significantly decreased the strength and stiffness of screw fixation in osteoporotic vertebrae but had no effect in normal vertebrae.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Endocrinology & Metabolism
Vinicius de Paiva Goncalves, Adriana Alicia Cabrera-Ortega, Jhonatan de Souza Carvalho, Dania Ramadan, Luis Carlos Spolidorio
Summary: The study showed that orchiectomy induced osteoporosis in male rats, with testosterone replacement treatment improving femoral fracture strength but not significantly affecting trabecular bone damage.
Article
Mechanics
Robert M. Auenhammer, Lars P. Mikkelsen, Leif E. Asp, Brina J. Blinzler
Summary: This study presents a complete procedure for generating finite element models based on X-ray computer tomography data on the fiber bundle scale for non-crimp fabric reinforced composites. The method includes a fully automated segmentation process and an element-wise material orientation mapping of X-ray computer tomographic data. This methodology combines recent research progress and improvements in image analysis, providing a fast, accurate, and repeatable data transfer and analysis process with a high degree of automation.
COMPOSITE STRUCTURES
(2021)
Article
Biochemistry & Molecular Biology
Ashutosh Parajuli, Shaopeng Pei, Hongbo Zhao, Jerahme R. Martinez, X. Lucas Lu, X. Sherry Liu, Mary C. Farach-Carson, Catherine B. Kirn-Safran, Liyun Wang
Editorial Material
Orthopedics
Tamara Alliston, Kharma C. Foucher, Brenda Frederick, Christopher J. Hernandez, James C. Iatridis, Kenneth M. Kozloff, Karl J. Lewis, X. Sherry Liu, Deana M. Mercer, Ruth Ochia, Robin M. Queen, Clare M. Rimnac, Marjolein C. H. van der Meulen, Jennifer J. Westendorf
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)
Article
Rheumatology
Qing Li, Biao Han, Chao Wang, Wei Tong, Yulong Wei, Wei-Ju Tseng, Li-Hsin Han, X. Sherry Liu, Motomi Enomoto-Iwamoto, Robert L. Mauck, Ling Qin, Renato V. Iozzo, David E. Birk, Lin Han
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Biophysics
Ashley K. Fung, Snehal S. Shetye, Yihan Li, Yilu Zhou, X. Sherry Liu, Louis J. Soslowsky
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2020)
Article
Endocrinology & Metabolism
Yihan Li, Wei-Ju Tseng, Chantal M. J. de Bakker, Hongbo Zhao, Rebecca Chung, X. Sherry Liu
Summary: Postmenopausal osteoporosis is influenced by reduced estrogen levels during menopause, impacting bone remodeling, bone mass, and fracture risk. Peak bone mass and microstructure are important predictors of osteoporosis risk, with thicker trabeculae being associated with lower rates of bone loss in response to estrogen deficiency. Thicker trabeculae are less likely to disconnect or perforate, leading to a lower degree of bone loss.
Article
Medicine, Research & Experimental
Wei Yu, Leilei Zhong, Lutian Yao, Yulong Wei, Tao Gui, Ziqing Li, Hyunsoo Kim, Nicholas Holdreith, Xi Jiang, Wei Tong, Nathaniel Dyment, X. Sherry Liu, Shuying Yang, Yongwon Choi, Jaimo Ahn, Ling Qin
Summary: Our study identified marrow adipogenic lineage precursors (MALPs) as a critical player in controlling bone remodeling during normal bone metabolism and pathological bone loss in a RANKL-dependent fashion.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Orthopedics
B. Han, Q. Li, C. Wang, P. Chandrasekaran, Y. Zhou, L. Qin, X. S. Liu, M. Enomoto-Iwamoto, D. Kong, R. V. Iozzo, D. E. Birk, L. Han
Summary: In post-traumatic osteoarthritis (PTOA), decorin plays a more crucial role than biglycan in regulating cartilage degeneration, while biglycan is more important in regulating subchondral bone structure. The two have distinct activities and modest synergy in the pathogenesis of PTOA.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Engineering, Biomedical
Wenzheng Wang, Wei-Ju Tseng, Hongbo Zhao, Tala Azar, Shaopeng Pei, Xi Jiang, Nathaniel Dyment, Sherry Liu
Summary: The study shows that MBF and RBF have similar contributions to trabecular bone homeostasis, with PTH playing a promoting role in new bone formation. Regardless of the type of bone formation, mineral deposition continues once activated by PTH.
Article
Biology
Yulong Wei, Hao Sun, Tao Gui, Lutian Yao, Leilei Zhong, Wei Yu, Su-Jin Heo, Lin Han, Nathaniel A. Dyment, Xiaowei Sherry Liu, Yejia Zhang, Eiki Koyama, Fanxin Long, Miltiadis H. Zgonis, Robert L. Mauck, Jaimo Ahn, Ling Qin
Summary: Meniscal tears are associated with a high risk of osteoarthritis, with no cure currently available. This study identified Gli1(+) cells as important contributors to meniscus development and repair, showing high progenitor activities under the control of Hh signal. Stimulating these cells or using an Hh agonist can accelerate healing and reduce osteoarthritis symptoms.
Article
Endocrinology & Metabolism
Xiaohan Lai, Rebecca Chung, Yihan Li, Xiaowei Sherry Liu, Liyun Wang
Summary: The study used a multiscale poroelastic modeling technique to investigate the effects of lactation on the physicochemical environment and mechanosensing of osteocytes in murine tibiae. The results showed that lactation-induced LCS expansion and PCM reduction promoted solute transport and osteocyte mechanosensing, while higher loading frequency and sparser PCM enhanced flow-mediated mechanosensing and nutrient transport.
Article
Endocrinology & Metabolism
Yihan Li, Chantal M. J. de Bakker, Xiaohan Lai, Hongbo Zhao, Ashutosh Parajuli, Wei -Ju Tseng, Shaopeng Pei, Tan Meng, Rebecca Chung, Liyun Wang, X. Sherry Liu
Summary: This study demonstrated that maternal bone undergoes improvements in structure in response to dynamic loading, regardless of reproductive status, with lactating rats showing enhanced mechano-responsiveness in both trabecular and cortical bone compartments. Additionally, lactation-induced activities in osteocyte peri-lacunar/canalicular remodeling may lead to increased mechano-responsiveness in maternal bone during lactation. Findings emphasize the importance of weightbearing exercise on maternal bone health during reproduction and postpartum.
Article
Endocrinology & Metabolism
Wei-Ju Tseng, Wonsae Lee, Hongbo Zhao, Yang Liu, Wenzheng Wang, Chantal Mj de Bakker, Yihan Li, Carlos Osuna, Wei Tong, Luqiang Wang, Xiaoyuan Ma, Ling Qin, X. Sherry Liu
Summary: Despite the potent effect of intermittent parathyroid hormone (PTH) treatment on promoting new bone formation, bone mineral density (BMD) rapidly decreases upon discontinuation of PTH administration. The responses to PTH treatment withdrawal vary in intact and estrogen-deficient rats, with the latter experiencing significant bone loss and microarchitecture deterioration. An extended anabolic period is observed in estrogen-deficient rats upon early PTH withdrawal, followed by adverse changes in bone cell activities.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Engineering, Biomedical
Wen Sang, Yihan Li, Jane Guignon, X. Sherry Liu, Ani Ural
Summary: This study examined the structural role of osteocyte lacunae on the mechanical properties of the bone matrix, revealing significant linear relationships between lacunar area, density, size, and orientation with elastic modulus and ultimate strength. Parametric studies also showed strong correlations between elastic modulus and strength with lacunar density, size, and orientation. Additionally, simulations demonstrated that osteocyte lacunae guide crack propagation through local stress concentrations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Shaopeng Pei, Yilu Zhou, Yihan Li, Tala Azar, Wenzheng Wang, Do-Gyoon Kim, X. Sherry Liu
Summary: This review focuses on nanoindentation testing in musculoskeletal research, discussing its application, the factors affecting testing results, and other commonly used techniques for synchronized imaging and colocalized characterization.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Wenzheng Wang, Tala Azar, Wei-Ju Tseng, Shaopeng Pei, Yilu Zhou, Xi Jiang, Nathaniel Dyment, X. Sherry Liu
Summary: This study investigated the temporal response of newly formed bone tissue and preexisting bone tissue to withdrawal from intermittent parathyroid hormone (PTH) treatment in an ovariectomized rat model. The results showed that modeling-based bone formation (MBF) sites had a greater contribution to the extended anabolic effect upon early withdrawal from PTH compared to remodeling-based bone formation (RBF) sites. Furthermore, newly formed bone tissue from MBF had greater resistance to PTH discontinuation-induced bone loss than those from RBF and preexisting bone.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)