Article
Immunology
Anil K. Singh, Mahamudul Haque, Bhanupriya Madarampalli, Yuanyuan Shi, Benjamin J. Wildman, Abdul Basit, Sadik A. Khuder, Bhagwat Prasad, Quamarul Hassan, Salahuddin Ahmed, Madhu M. Ouseph
Summary: IL-6 trans-signaling induces molecular reprogramming of RASFs to osteoclast-like cells through the activation of transcription factor Ets2, leading to increased expression of osteoclast-specific proteins and markers of invasive phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Emily J. Strong, Jia Wang, Tony W. Ng, Steven A. Porcelli, Sunhee Lee
Summary: Tuberculosis is a significant global infectious disease caused by Mycobacterium tuberculosis infection of the lungs. The PPE51 protein of Mtb inhibits autophagy by suppressing TLR2 signaling, allowing the bacteria to evade immune responses.
Article
Multidisciplinary Sciences
Carolina Manosalva, Pablo Alarcon, John Quiroga, Stefanie Teuber, Maria D. Carretta, Hedie Bustamante, Rodrigo Lopez-Munoz, Maria A. Hidalgo, Rafael A. Burgos
Summary: Lameness in dairy cattle can be caused by infectious or noninfectious agents, with joint lesions being the second most common cause. Fibroblast-like synoviocytes (FLS) play a key role in joint diseases and the expression of proinflammatory mediators. Tumor necrosis factor-alpha (TNF-alpha) is a potent proinflammatory cytokine that increases the expression of proinflammatory cytokines in bovine FLS (bFLS). This study found that TNF-alpha induces metabolic reprogramming in bFLS, favoring glycolysis, and increasing the expression of IL-6, IL-8, IL-1 beta, and COX-2/PGE2.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Piero Ruscitti, Vasiliki Liakouli, Noemi Panzera, Adriano Angelucci, Onorina Berardicurti, Elena Di Nino, Luca Navarini, Marta Vomero, Francesco Ursini, Daniele Mauro, Vincenza Dolo, Francesco Ciccia, Roberto Giacomelli, Paola Cipriani
Summary: This study found that the expression of markers of myofibroblast differentiation in the synovial tissue of rheumatoid arthritis patients was significantly higher than in healthy controls, and that TGF-beta and IL-6 stimulation promoted the expression of these markers; tofacitinib may have a role in reducing the expression of these markers.
Article
Biology
Cristina Almeida-Santiago, Juan Carlos Quevedo-Abeledo, Maria Vanesa Hernandez-Hernandez, Antonia de Vera-Gonzalez, Alejandra Gonzalez-Delgado, Miguel Angel Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to analyze the linear correlation between IL-1ra and IL-6 in patients with rheumatoid arthritis (RA) and their relationship with disease's inflammatory activity. IL-6 and IL-1ra levels were measured in 407 RA patients. No correlation was found between serum levels of IL-6 and IL-1ra. However, both cytokines were positively associated with disease activity and acute phase reactants. After controlling for covariates, disease activity scores were more strongly associated with IL-1ra compared to IL-6.
Article
Cell Biology
Shachi Pranjal Vyas, Rajeshwar Nath Srivastava, Ritobrata Goswami
Summary: This study investigated the TLR2 signaling pathway in Th9 cells and its regulation by calcitriol. The findings suggest that TLR2 signals via IL-33/ST2 in Th9 cells, and calcitriol can attenuate TLR2 signaling. Low serum vitamin D3 levels are associated with increased IL-9 and TLR2 expression as well as disease severity in rheumatoid arthritis patients.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Immunology
Regina Sakalyte, Jaroslav Denkovskij, Eiva Bernotiene, Sigita Stropuviene, Silvija Ona Mikulenaite, Giedrius Kvederas, Narunas Porvaneckas, Vytautas Tutkus, Algirdas Venalis, Irena Butrimiene
Summary: This study investigated the expression and secretion of activated rheumatoid arthritis synovial fibroblasts and their correlation with rheumatoid arthritis and other forms of arthritis. The results showed that NLRP3 was associated with inflammatory activation, and vitamin D may have a protective effect on inflammatory responses. Inflammatory responses may also be age-related.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zhen-Yi Long, Yi-Feng Zhou, Hao Yuan, Ya-Meng Peng, Si-Xian Wu, Fang Peng
Summary: The study revealed that the levels of IgG4 and IL-21 in the serum increased with disease progression in collagen-induced arthritis (CIA) rats, and the expression of IgG4 and IL-21 receptors in the ankle joint was significantly higher in the CIA model group. These proteins were closely related to the pathological score, indicating that IL-21 may promote rheumatoid arthritis development by regulating IgG4 content.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Medicine, General & Internal
Yun Guan, Zhimin Zeng
Summary: Tuberculosis infection following total elbow arthroplasty, though rare, can be challenging to diagnose due to nonspecific symptoms. Timely diagnosis and treatment are essential for controlling infection and preserving the prosthesis.
Review
Biochemistry & Molecular Biology
Ruifeng Chen, Xuan Wang, Zilin Li, Yumei Dai, Wenya Du, Lixian Wu
Summary: Toll-like receptor 2 (TLR2) is important in tuberculosis development. However, the association between TLR2 polymorphisms and tuberculosis susceptibility has not been explored. This study systematically searched relevant databases and included 37 studies, involving 6 polymorphisms and a total of 9,474 cases and 10,295 controls. The results showed that only the TLR2 rs5743708 polymorphism was significantly associated with a higher tuberculosis risk, while other TLR2 polymorphisms were not associated with tuberculosis susceptibility.
Article
Chemistry, Multidisciplinary
Naibo Feng, Li Liang, Mengtian Fan, Yu Du, Cheng Chen, Rong Jiang, Dongsheng Yu, Yuyou Yang, Mengying Zhang, Lin Deng, Xingyue Li, Nana Geng, Menglin Xian, Qizhong Qin, Xiaoli Li, Qiaoyan Tan, Fengtao Luo, Fangzhou Song, Huabing Qi, Yangli Xie, Fengjin Guo
Summary: The study investigates the use of siRNA drugs targeting the ERN1 gene for the treatment of autoimmune inflammatory diseases. The developed nanodrug delivery system demonstrates efficient targeting and therapeutic effects in mouse models of arthritis and inflammatory bowel disease.
Article
Immunology
Rodolfo Soria-Castro, Angel R. Alfaro-Doblado, Gloria Rodriguez-Lopez, Marcia Campillo-Navarro, Yatsiri G. Meneses-Preza, Adrian Galan-Salinas, Violeta Alvarez-Jimenez, Juan C. Yam-Puc, Rosario Munguia-Fuentes, Adriana Dominguez-Flores, Sergio Estrada-Parra, Sonia M. Perez-Tapia, Alma D. Chavez-Blanco, Rommel Chacon-Salinas
Summary: The study found that MC infected with L.m were able to clear the bacterial load and responded by degranulating and producing various cytokines. TLR2 was shown to mediate some MC activation pathways during L.m infection, particularly those related to IL-6 and IL-13 production. Interestingly, p38 activation depended on TLR2, but not ERK or NF-kappa B activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anais Mariscal, Carlos Zamora, Cesar Diaz-Torne, Ma Angels Ortiz, Juan Jose de Agustin, Delia Reina, Paula Estrada, Patricia Moya, Hector Corominas, Silvia Vidal
Summary: The binding of platelets to monocytes is increased in rheumatoid arthritis, and this interaction is modulated by IL-6 blockage. After treatment, the percentage of CD14+PLT+ increases in patients who achieve remission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Bilal Ahmad Wani, Faheem Shehjar, Sonaullah Shah, Ajaz Koul, Adfar Yusuf, Muzamil Farooq, Mohmad Iqbal Mir, Rajni Singh, Dil Afroze
Summary: Based on the analysis of gene polymorphisms in extrapulmonary tuberculosis patients of the ethnic Kashmiri population, TLR-4 (Thr/Ile) and TLR-2 (Del/Del) were identified as significant risk factors for extrapulmonary tuberculosis predisposition.
MICROBIAL PATHOGENESIS
(2021)
Review
Immunology
Stefan Rose-John, Brendan J. Jenkins, Christoph Garbers, Jens M. Moll, Juergen Scheller
Summary: This review discusses the discovery of the IL-6 trans-signalling pathway and the development of biologics that specifically inhibit this pathway. Targeting IL-6 trans-signalling can decrease disease-promoting activities of IL-6 without blocking its protective actions.
NATURE REVIEWS IMMUNOLOGY
(2023)