Article
Multidisciplinary Sciences
Yu Bai, Tianjun Cao, Oliver Dautermann, Paul Buschbeck, Michael B. Cantrell, Yinjuan Chen, Christopher D. Lein, Xiaohuo Shi, Maxwell A. Ware, Fenghua Yang, Huan Zhang, Lihan Zhang, Graham Peers, Xiaobo Li, Martin Lohr
Summary: Fucoxanthin is a major light-harvesting pigment in ecologically important algae. The biosynthetic pathway of fucoxanthin has been identified by studying knockout mutants of the diatom Phaeodactylum tricornutum. The pathway is more complex than expected and involves the metabolism of diadinoxanthin as a central regulatory hub. The study also reveals the evolution of genes for xanthophyll cycle enzymes and the alternative pathway in brown algae.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Agriculture, Multidisciplinary
Chuying Chen, Xuan Peng, Chunpeng Wan, Yanan Zhang, Zengyu Gan, Jiaoke Zeng, Wenbin Kai, Jinyin Chen
Summary: The study found that treatment with 7-Demethoxytylophorine (DEM) can delay the development of blue mold on harvested Newhall navel orange fruits and provide resistance against the pathogen by activating lignin biosynthesis and maintaining redox balance.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Koyo Honda, Yuki Hitora, Sachiko Tsukamoto
Summary: This study demonstrates that a fungal extract and its derivatives can inhibit cell cycle progression, potentially serving as anticancer agents.
Article
Virology
David D. Dunigan, Irina V. Agarkova, Ahmed Esmael, Sophie Alvarez, James L. Van Etten
Summary: Paramecium bursaria chlorella virus 1 (PBCV-1) faces challenges in DNA replication due to differences in DNA composition and quantity between the virus and host cell. Through reprogramming of the nucleotide biosynthesis pathway, PBCV-1 successfully overcomes these challenges.
Article
Multidisciplinary Sciences
Tao Luo, Peng Xu, Yangyi Zhang, Jessica L. Porter, Marwan Ghanem, Qingyun Liu, Yuan Jiang, Jing Li, Qing Miao, Bijie Hu, Benjamin P. Howden, Janet A. M. Fyfe, Maria Globan, Wencong He, Ping He, Yiting Wang, Houming Liu, Howard E. Takiff, Yanlin Zhao, Xinchun Chen, Qichao Pan, Marcel A. Behr, Timothy P. Stinear, Qian Gao
Summary: A population genomics analysis of Mycobacterium kansasii reveals municipal water as a main source of infection and shows that nearly 80% of infections are due to closely-related strains, forming a main cluster that originated in the 1900s. Bioinformatic analyses suggest that certain genes may have contributed to the pathogen's success and adaptation to the human host.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Jing Shi, Xiang Xu, Pei Yi Liu, Yi Ling Hu, Bo Zhang, Rui Hua Jiao, Ghader Bashiri, Ren Xiang Tan, Hui Ming Ge
Summary: NRPSs are modular enzymes that assemble the peptide backbones of structurally diverse and biologically active natural products in bacteria and fungi using a thiotemplate mechanism. NRPSs-like enzymes activate l-tyrosine molecules to form novel alkaloids such as piperazine, which can be further modified by P450 enzymes into highly strained compounds.
Article
Multidisciplinary Sciences
Stephanie Solier, Sebastian Mueller, Tatiana Caneque, Antoine Versini, Arnaud Mansart, Fabien Sindikubwabo, Leeroy Baron, Laila Emam, Pierre Gestraud, G. Dan Pantos, Vincent Gandon, Christine Gaillet, Ting-Di Wu, Florent Dingli, Damarys Loew, Sylvain Baulande, Sylvere Durand, Valentin Sencio, Cyril Robil, Francois Trottein, David Pericat, Emmanuelle Naeser, Celine Cougoule, Etienne Meunier, Anne-Laure Begue, Helene Salmon, Nicolas Manel, Alain Puisieux, Sarah Watson, Mark A. Dawson, Nicolas Servant, Guido Kroemer, Djillali Annane, Raphael Rodriguez
Summary: Inflammation is a complex physiological process that involves immune cells clearing sources of injury. Excessive inflammation is associated with infection and several diseases. The cell surface glycoprotein CD44 mediates the uptake of metals, including copper, and affects the metabolic and epigenetic states involved in inflammation.
Article
Chemistry, Multidisciplinary
Yanqing Xue, Xiaofeng Wang, Wen Liu
Summary: This study provides a detailed characterization of cypemycin as a D-amino acid-rich linaridin and reveals the unique activities of CypH and CypL in post-translational modifications. These modifications include 16 reactions related to amino acid epimerization, dehydration, and dethiolation. The findings of this study contribute to a better understanding of PTM chemistry and facilitate the exploration of linaridin structural diversity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yanqing Xue, Xiaofeng Wang, Wen Liu
Summary: Through reconstitution in Streptomyces coelicolor, the detailed structural characterization of cypemycin was explored, revealing the versatility of CypH and CypL in catalysis, further advancing our understanding of PTM chemistry.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Xingliang Duan, Sheng Xu, Yuanming Xie, Lun Li, Weicong Qi, Boris Parizot, Yonghong Zhang, Tao Chen, Yi Han, Frank Van Breusegem, Tom Beeckman, Wenbiao Shen, Wei Xuan
Summary: The research shows that light can regulate lateral root formation in plants by activating the HY1 gene, promoting LR branching. HY1 induces the expression of HY5 and HYH, as well as altering the intracellular localization and expression of auxin transporters to stimulate LR branching.
Article
Plant Sciences
Xiaoyan Wang, Fang Xie, Xiaofeng Zhou, Ting Chen, Ye Xue, Wei Wang
Summary: The study shows that 18 beta-Glycyrrhetinic acid has significant antiviral activity against RV SA11 infection in MA104 cells, inducing apoptosis and modulating the cell cycle and expression of proteins related to the Fas/FasL pathway. It may be a promising candidate for the treatment of RV infection.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Microbiology
Kaixin Xiong, Hualing Zhu, Yanyao Li, Mengzhen Ji, Yujia Yan, Xuan Chen, Yaqi Chi, Xueqin Yang, Ling Deng, Xuedong Zhou, Ling Zou, Biao Ren
Summary: The cross-kingdom interactions between Candida albicans and Actinomyces viscosus in root caries are important, and the arginine biosynthesis pathway plays a key role in this interaction. The findings of this study contribute to the treatment of root caries.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Li Meng, Shaoyan Zhang, Xiaoran Bai, Xiaobo Li, Qingji Wang, Li Wang, Wei Wang, Zhuang Li
Summary: In this study, adding leachate of Korshinsk peashrub to the fermentation medium significantly increased the total flavonoid content of Auricularia cornea. Transcriptomic and metabolomic analysis revealed important metabolites and homologous genes in the flavonoid biosynthesis pathway of the edible fungus. This study provides a new avenue for studying flavonoid production regulation in edible fungi.
Article
Plant Sciences
Yao-Pin Lin, Yu-Yen Shen, Yen-Bin Shiu, Yee-Yung Charng, Bernhard Grimm
Summary: This study revealed the importance of chlorophyll in energy harvesting and recycling in plant development. The enzymes CLD1 and CHLG are involved in the dephytylation and rephytylation of chlorophyll, and their interaction with other proteins enables the efficient recycling and utilization of chlorophyll.
Article
Chemistry, Multidisciplinary
Yong-Jiang Wang, Jian-Ping Huang, Tian Tian, Yijun Yan, Yin Chen, Jing Yang, Jianghua Chen, Yu-Cheng Gu, Sheng-Xiong Huang
Summary: This study identifies two key enzymes involved in the biosynthesis of cocaine and reveals the complete pathway for the synthesis of the tropane skeleton. It provides new insights into the metabolic networks of tropane alkaloids in plants and enables the heterologous synthesis of tropane alkaloids in other organisms, with significant implications for pharmaceutical production.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Applied
Rakkhumkaew Numfon
FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL
(2017)
Article
Microbiology
Takeru Matsui, Genki Yoshikawa, Tomoko Mihara, Orawan Chatchawankanphanich, Takeru Kawasaki, Miyako Nakano, Makoto Fujie, Hiroyuki Ogata, Takashi Yamada
FRONTIERS IN MICROBIOLOGY
(2017)
Article
Microbiology
Ahmed Askora, Takeru Kawasaki, Makoto Fujie, Takashi Yamada
FRONTIERS IN MICROBIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Abdelmonim A. Ahmad, Makoto Kawabe, Ahmed Askora, Takeru Kawasaki, Makoto Fujie, Takashi Yamada
Article
Food Science & Technology
Numfon Rakkhumkaew, Chalinan Pengsuk
FOOD SCIENCE AND BIOTECHNOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Numfon Rakkhumkaew, Takeru Kawasaki, Makoto Fujie, Takashi Yamada
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2018)
Article
Virology
Alaaeldin Mohamed Saad, Ahmed Askora, Takeru Kawasaki, Makoto Fujie, Takashi Yamada
ARCHIVES OF VIROLOGY
(2018)
Correction
Virology
Alaaeldin Mohamed Saad, Ahmed Askora, Ahmed Mahrous Soliman, Hirofumi Nariya, Takeru Kawasaki, Makoto Fujie, Tadashi Shimamoto, Takashi Yamada
ARCHIVES OF VIROLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Alaaeldin Mohamed Saad, Ahmed Mahrous Soliman, Takeru Kawasaki, Makoto Fujie, Hirofumi Nariya, Tadashi Shimamoto, Takashi Yamada
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2019)
Article
Biotechnology & Applied Microbiology
Emmanuelle Neumann, Takeru Kawasaki, Gregory Effantin, Leandro F. Estrozi, Orawan Chatchawankanphanich, Takashi Yamada, Guy Schoehn
JOURNAL OF GENERAL VIROLOGY
(2020)
Article
Virology
Takeru Kawasaki, Hisashi Endo, Hiroyuki Ogata, Orawan Chatchawankanphanich, Takashi Yamada
Summary: A novel lytic bacteriophage RP13 was isolated from tomato fields in Thailand, with unique features and heavily modified DNA. The whole genome of RP13 was determined to be 170,942 bp in length with 277 ORFs. Phylogenetic analysis revealed that RP13 is not closely related to any known phages, making it a potential biocontrol agent against bacterial wilt disease caused by R. solanacearum.
ARCHIVES OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ahmed Askora, Takeru Kawasaki, Makoto Fujie, Takashi Yamada
Summary: The study describes the integrative/excisive recombination reactions mediated by phi RSM integrase, showing efficient integration and excision in vitro without the need for additional proteins or high-energy cofactors. This small serine recombinase demonstrated two-way activity in excising a functional phage genome from a prophage fragment, marking a significant advancement in genome engineering applications.
MOLECULAR GENETICS AND GENOMICS
(2021)
Article
Biochemistry & Molecular Biology
Gregory Effantin, Akiko Fujiwara, Takeru Kawasaki, Takashi Yamada, Guy Schoehn
Summary: The phi RSA1 bacteriophage isolated from Ralstonia solanacearum exhibits unique structural characteristics, predominantly composed of a polymer of the gp8 protein, unlike other bacteriophages in terms of stabilization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Proceedings Paper
Horticulture
A. Bhunchoth, N. Phironrit, C. Leksomboon, T. Kawasaki, T. Yamada, O. Chatchawankanphanich
V INTERNATIONAL SYMPOSIUM ON TOMATO DISEASES: PERSPECTIVES AND FUTURE DIRECTIONS IN TOMATO PROTECTION
(2018)