Investigation of silent information regulator 1 (Sirt1) agonists from Traditional Chinese Medicine

Molecular Simulation of HER2/neu Degradation by Inhibiting HSP90

(2015) Calvin Yu-Chian Chen et al.   JOURNAL OF THE CHINESE CHEMICAL SOCIETY

SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease

(2013) Yasar Colak et al.   MEDICAL SCIENCE MONITOR

Molecular Docking and Dynamics Simulation, Receptor-based Hypothesis: Application to Identify Novel Sirtuin 2 Inhibitors

(2012) Sugunadevi Sakkiah et al.   Chemical Biology & Drug Design

Can targeting SIRT-1 to treat type 2 diabetes be a good strategy? A review

(2012) Venkat Koushik Pulla et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Blocking the DNA Repair System by Traditional Chinese Medicine?

(2012) Mao-Feng Sun et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Screening from the World's Largest TCM Database Against H1N1 Virus

(2012) Tung-Ti Chang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Search for Novel Remedies to Augment Radiation Resistance of Inhabitants of Fukushima and Chernobyl Disasters: Identifying DNA Repair Protein XRCC4 Inhibitors

(2012) Mao-Feng Sun et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Lose Weight with Traditional Chinese Medicine? Potential Suppression of Fat Mass and Obesity-Associated Protein

(2012) Pei-Chun Chang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

iSMART: An Integrated Cloud Computing Web Server for Traditional Chinese Medicine for Online Virtual Screening,de novoEvolution and Drug Design

(2012) Kai-Wei Chang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Potent Inhibitor Design Against H1N1 Swine Influenza: Structure-based and Molecular Dynamics Analysis for M2 Inhibitors from Traditional Chinese Medicine Database

(2012) Chia-Hui Lin et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Three-in-one agonists for PPAR-α, PPAR-γ, and PPAR-δ from traditional Chinese medicine

(2012) Kuan-Chung Chen et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Traditional Chinese medicine as dual guardians against hypertension and cancer?

(2012) Weng Ieong Tou et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

A Novel Algorithm for Identification of Activated Cryptic 5′ Splice Sites

(2012) Kun-Nan Tsai et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Mechanism of BAG1 repair on Parkinson’s disease-linked DJ1 mutation

(2012) Calvin Yu-Chian Chen   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Are sirtuins viable targets for improving healthspan and lifespan?

(2012) Joseph A. Baur et al.   NATURE REVIEWS DRUG DISCOVERY

In Silico Investigation of Potential Src Kinase Ligands from Traditional Chinese Medicine

(2012) Weng Ieong Tou et al.   PLoS One

Protective roles of SIRT1 in atherosclerosis

(2011) Sokrates Stein et al.   CELL CYCLE

Investigation into Potent Inflammation Inhibitors from Traditional Chinese Medicine

(2011) Kuan-Chung Chen et al.   Chemical Biology & Drug Design

iScreen: world’s first cloud-computing web server for virtual screening and de novo drug design based on TCM database@Taiwan

(2011) Tsung-Ying Tsai et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Topology and dynamics of the interaction between 5-nitroimidazole radiosensitizers and duplex DNA studied by a combination of docking, molecular dynamic simulations and NMR spectroscopy

(2011) Teodorico C. Ramalho et al.   JOURNAL OF MOLECULAR STRUCTURE

Traditional Chinese medicine, a solution for reducing dual stroke risk factors at once?

(2011) Kuan-Chung Chen et al.   Molecular BioSystems

In silico pharmacology suggests ginger extracts may reduce stroke risks

(2011) Tung-Ti Chang et al.   Molecular BioSystems

High performance screening, structural and molecular dynamics analysis to identify H1 inhibitors from TCM Database@Taiwan

(2011) Su-Sen Chang et al.   Molecular BioSystems

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

(2011) Virginia Guarani et al.   NATURE

TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico

(2011) Calvin Yu-Chian Chen   PLoS One

Identifying HER2 Inhibitors from Natural Products Database

(2011) Shun-Chieh Yang et al.   PLoS One

Efficient mapping of ligand migration channel networks in dynamic proteins

(2011) Tu-Liang Lin et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Sirtuins: A Family of Proteins With Implications for Human Performance and Exercise Physiology

(2011) Zekine Lappalainen   Research in Sports Medicine

Stroke prevention by traditional Chinese medicine? A genetic algorithm, support vector machine and molecular dynamics approach

(2011) Kuan-Chung Chen et al.   Soft Matter

Two Birds with One Stone? Possible Dual-Targeting H1N1 Inhibitors from Traditional Chinese Medicine

(2011) Su-Sen Chang et al.   PLoS Computational Biology

Identification of Potent EGFR Inhibitors from TCM Database@Taiwan

(2011) Shun-Chieh Yang et al.   PLoS Computational Biology

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Bioinformatics, chemoinformatics, and pharmainformatics analysis of HER2/HSP90 dual-targeted inhibitors

(2010) Calvin Yu-Chian Chen   Journal of the Taiwan Institute of Chemical Engineers

Current developments of computer-aided drug design

(2010) Hung-Jin Huang et al.   Journal of the Taiwan Institute of Chemical Engineers

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Sirt1's systemic protective roles and its promise as a target in antiaging medicine

(2010) Bor Luen Tang   Translational Research

Sirt1’s Complex Roles in Neuroprotection

(2009) Bor Luen Tang   CELLULAR AND MOLECULAR NEUROBIOLOGY

NAD+, Sirtuins, and Cardiovascular Disease

(2009) Nica Borradaile et al.   CURRENT PHARMACEUTICAL DESIGN

Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity

(2009) Federico Medda et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug design for Influenza A virus subtype H1N1

(2009) Chien-Yu Chen et al.   Journal of the Taiwan Institute of Chemical Engineers