Three-in-one agonists for PPAR-α, PPAR-γ, and PPAR-δ from traditional Chinese medicine

Molecular Simulation of HER2/neu Degradation by Inhibiting HSP90

(2015) Calvin Yu-Chian Chen et al.   JOURNAL OF THE CHINESE CHEMICAL SOCIETY

Virtual Screening and Drug Design for PDE-5 Receptor from Traditional Chinese Medicine Database

(2012) Calvin Yu-Chian Chen   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Docking Simulation and Competitive Experiments Validate the Interaction Between the 2,5-Xylidine Inhibitor andRigidoporus lignosusLaccase

(2012) Maria Teresa Cambria et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Molecular Docking Studies to Map the Binding Site of Squalene Synthase Inhibitors on Dehydrosqualene Synthase ofStaphylococcus Aureus

(2012) Amandeep Kaur Kahlon et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Key Features for Designing Phosphodiesterase-5 Inhibitors

(2012) Tung-Ti Chang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

A Novel Strategy for Designing the Selective PPAR Agonist by the “Sum of Activity” Model

(2012) Hung-Jin Huang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Molecular Dynamics Simulation Study of the Interaction of Piscidin 1 with DPPC Bilayers: Structure-Activity Relationship

(2012) Faramarz Mehrnejad et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Study on Interaction of DNA from Calf Thymus with 1,10-phenanthrolinehexyldithiocarbamatopalladium(II) nitrate as Potential Antitumor Agent

(2012) H. Mansouri-Torshizi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Compounds of the 1,5-di(4-R-phenyl)-3-selenopentanediones-1,5 series interaction with the BasidiomyceteLentinula edodes, lectins: Computations and Experiment

(2012) Alexei N. Pankratov et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Using Computer-aided Drug Design and Medicinal Chemistry Strategies in the Fight Against Diabetes

(2012) Evandro P. Semighini et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Screening from the World's Largest TCM Database Against H1N1 Virus

(2012) Tung-Ti Chang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Design of New Chemotherapeutics Against the Deadly Anthrax Disease. Docking and Molecular Dynamics studies of Inhibitors Containing Pyrrolidine and Riboamidrazone Rings on Nucleoside Hydrolase fromBacillus anthracis

(2012) Ana P. Guimarães et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Search for Novel Remedies to Augment Radiation Resistance of Inhabitants of Fukushima and Chernobyl Disasters: Identifying DNA Repair Protein XRCC4 Inhibitors

(2012) Mao-Feng Sun et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Lose Weight with Traditional Chinese Medicine? Potential Suppression of Fat Mass and Obesity-Associated Protein

(2012) Pei-Chun Chang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Docking Studies on the Binding of Quinoline Derivatives and Hematin toPlasmodium FalciparumLactate Dehydrogenase

(2012) Wilian A. Cortopassi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Pharmacophore Modeling and Hybrid Virtual Screening for the Discovery of Novel IκB Kinase 2 (IKK2) Inhibitors

(2012) Huan-Zhang Xie et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Potent Inhibitor Design Against H1N1 Swine Influenza: Structure-based and Molecular Dynamics Analysis for M2 Inhibitors from Traditional Chinese Medicine Database

(2012) Chia-Hui Lin et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Investigation into Potent Inflammation Inhibitors from Traditional Chinese Medicine

(2011) Kuan-Chung Chen et al.   Chemical Biology & Drug Design

Protective effect of antrosterol from Antrodia camphorata submerged whole broth against carbon tetrachloride-induced acute liver injury in mice

(2011) Guan-Jhong Huang et al.   FOOD CHEMISTRY

Analgesic Effects and Mechanisms of Anti-inflammation of Taraxeren-3-one from Diospyros maritima in Mice

(2011) Tien-Ning Chang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Participate in Anti-inflammatory Activity of Imperatorin from Glehnia littoralis

(2011) Guan-Jhong Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Traditional Chinese medicine, a solution for reducing dual stroke risk factors at once?

(2011) Kuan-Chung Chen et al.   Molecular BioSystems

In silico pharmacology suggests ginger extracts may reduce stroke risks

(2011) Tung-Ti Chang et al.   Molecular BioSystems

High performance screening, structural and molecular dynamics analysis to identify H1 inhibitors from TCM Database@Taiwan

(2011) Su-Sen Chang et al.   Molecular BioSystems

TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico

(2011) Calvin Yu-Chian Chen   PLoS One

Efficient mapping of ligand migration channel networks in dynamic proteins

(2011) Tu-Liang Lin et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Stroke prevention by traditional Chinese medicine? A genetic algorithm, support vector machine and molecular dynamics approach

(2011) Kuan-Chung Chen et al.   Soft Matter

Two Birds with One Stone? Possible Dual-Targeting H1N1 Inhibitors from Traditional Chinese Medicine

(2011) Su-Sen Chang et al.   PLoS Computational Biology

Identification of Potent EGFR Inhibitors from TCM Database@Taiwan

(2011) Shun-Chieh Yang et al.   PLoS Computational Biology

Discovery of a novel selective PPARγ modulator from (−)-Cercosporamide derivatives

(2010) Akihiro Furukawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of an Oxybenzylglycine Based Peroxisome Proliferator Activated Receptor α Selective Agonist 2-((3-((2-(4-Chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic Acid (BMS-687453)

(2010) Jun Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Insights into designing the dual-targeted HER2/HSP90 inhibitors

(2010) Chien-Yu Chen et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Bioinformatics, chemoinformatics, and pharmainformatics analysis of HER2/HSP90 dual-targeted inhibitors

(2010) Calvin Yu-Chian Chen   Journal of the Taiwan Institute of Chemical Engineers

7-Chloroarctinone-b as a new selective PPARγ antagonist potently blocks adipocyte differentiation

(2009) Yong-tao Li et al.   ACTA PHARMACOLOGICA SINICA

Discovery of potent inhibitors for phosphodiesterase 5 by virtual screening and pharmacophore analysis

(2009) Chien-yu Chen et al.   ACTA PHARMACOLOGICA SINICA

Peroxisome proliferator-activated receptor translational research and clinical experience

(2009) Wayman Wendell Cheatham   AMERICAN JOURNAL OF CLINICAL NUTRITION

Fatty Acid Synthesis and PPARα Hand in Hand

(2009) Nicolas Rotman et al.   CHEMISTRY & BIOLOGY

Ligand-Activated Peroxisome Proliferator–Activated Receptor-γ Protects Against Ischemic Cerebral Infarction and Neuronal Apoptosis by 14-3-3ε Upregulation

(2009) Jui-Sheng Wu et al.   CIRCULATION

Computational screening and design of traditional Chinese medicine (TCM) to block phosphodiesterase-5

(2009) Calvin Yu-Chian Chen   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Pharmacoinformatics approach for mPGES-1 in anti-inflammation by 3D-QSAR pharmacophore mapping

(2009) Calvin Yu-Chian Chen   Journal of the Taiwan Institute of Chemical Engineers

De novo design of novel selective COX-2 inhibitors: From virtual screening to pharmacophore analysis

(2009) Calvin Yu-Chian Chen   Journal of the Taiwan Institute of Chemical Engineers

Chemoinformatics and pharmacoinformatics approach for exploring the GABA-A agonist from Chinese herb suanzaoren

(2009) Calvin Yu-Chian Chen   Journal of the Taiwan Institute of Chemical Engineers

Drug design for Influenza A virus subtype H1N1

(2009) Chien-Yu Chen et al.   Journal of the Taiwan Institute of Chemical Engineers

PPAR-β/δ agonists for Type 2 diabetes and dyslipidemia: an adopted orphan still looking for a home

(2008) Andrew N Billin   EXPERT OPINION ON INVESTIGATIONAL DRUGS

T2384, a Novel Antidiabetic Agent with Unique Peroxisome Proliferator-activated Receptor γ Binding Properties

(2008) Yang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

(2008) D. R. Artis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARδ is pro-tumorigenic in a mouse model of COX-2-induced mammary cancer

(2008) Mallika Ghosh et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS