Protein-Protein Interactions: Principles, Techniques, and their Potential Role in New Drug Development

Molecular Modeling of Human Pentameric α7Neuronal Nicotinic Acetylcholine Receptor and Its Interaction with its Agonist and Competitive Antagonist

(2012) Marimuthu Parthiban et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Conserved Water Mediated H-bonding Dynamics of Inhibitor, Cofactor, Asp 364 and Asn 303 in Human IMPDH II

(2012) Hridoy R. Bairagya et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Molecular Modeling Studies of the Interaction BetweenPlasmodium falciparumHslU and HslV Subunits

(2012) Sangeetha Subramaniam et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Structural Rearrangements of Rhodopsin Subunits in a Dimer Complex: a Molecular Dynamics Simulation Study

(2012) Arnau Cordomí et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Investigation of the Effect of Glycosylation on Human Prion Protein by Molecular Dynamics

(2012) Linghao Zhong et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Molecular Dynamics Simulations to Investigate the Aggregation Behaviors of the Aß(17–42) Oligomers

(2012) Jian-Hua Zhao et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Community Structure and Role Analysis in Biological Networks

(2012) Tian Zhu et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Structural Features of the Interfaces in Enzyme-Inhibitor Complexes

(2012) Alexei N. Nekrasov et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

BRCA1/BARD1 E3 Ubiquitin Ligase Can Modify Histones H2A and H2B in the Nucleosome Particle

(2012) Amit Thakar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Conformational and Oligomeric Effects on the Cysteine pKaof Tryparedoxin Peroxidase

(2012) Ye Yuan et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Structure-Based and Ligand-Based Drug Design for HER 2 Receptor

(2012) Hung-Jin Huang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation

(2010) Aaron Klug   Annual Review of Biochemistry

GPCR Interacting Proteins (GIPs) in the Nervous System: Roles in Physiology and Pathologies

(2010) Joël Bockaert et al.   Annual Review of Pharmacology and Toxicology

Influence of flanking sequences on signaling between the activation function AF1 and DNA-binding domain of the glucocorticoid receptor

(2010) R. Kumar et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Errant ensembles: dysfunctional neuronal network dynamics in schizophrenia

(2010) Matt W. Jones   BIOCHEMICAL SOCIETY TRANSACTIONS

Protein binding hot spots and the residue-residue pairing preference: a water exclusion perspective

(2010) Qian Liu et al.   BMC BIOINFORMATICS

Computational approaches for detecting protein complexes from protein interaction networks: a survey

(2010) Xiaoli Li et al.   BMC GENOMICS

Hot-spot mutations in p110α of phosphatidylinositol 3-kinase (PI3K): Differential interactions with the regulatory subunit p85 and with RAS

(2010) Li Zhao et al.   CELL CYCLE

Homodimeric Enzymes as Drug Targets

(2010) D. Cardinale et al.   CURRENT MEDICINAL CHEMISTRY

Functional genomics and networks: new approaches in the extraction of complex gene modules

(2010) Pablo Minguez et al.   Expert Review of Proteomics

Interactions between PrPc and other ligands with the 37-kDa/67-kDa laminin receptor

(2010) Bianca Da Costa Dias   Frontiers in Bioscience-Landmark

Immunological synapse: a multi-protein signalling cellular apparatus for controlling gene expression

(2010) Kartika Padhan et al.   IMMUNOLOGY

N-terminal Domains of DELLA Proteins Are Intrinsically Unstructured in the Absence of Interaction with GID1/Gibberellic Acid Receptors

(2010) Xiaolin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disrupted Transforming Growth Factor-  Signaling in Spinal and Bulbar Muscular Atrophy

(2010) M. Katsuno et al.   JOURNAL OF NEUROSCIENCE

The Current State of Chromatin Immunoprecipitation

(2010) Philippe Collas   MOLECULAR BIOTECHNOLOGY

The protein kingdom extended: Ordered and intrinsically disordered proteins, their folding, supramolecular complex formation, and aggregation

(2010) Konstantin K. Turoverov et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

A Search for Antiamyloidogenic Compounds Based on a Nucleation-Dependent Polymerization Model

(2010) Hironobu NAIKI et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Investigating Homology between Proteins using Energetic Profiles

(2010) James O. Wrabl et al.   PLoS Computational Biology

Physiological and pathophysiological outcomes of the interactions of HMGB1 with cell surface receptors

(2009) Heikki Rauvala et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Nuclear and mitochondrial signalling Akts in cardiomyocytes

(2009) S. Miyamoto et al.   CARDIOVASCULAR RESEARCH

Multivalency-Assisted Control of Intracellular Signaling Pathways: Application for Ubiquitin- Dependent N-End Rule Pathway

(2009) Shashikanth M. Sriram et al.   CHEMISTRY & BIOLOGY

STAT3 as a Central Regulator of Tumor Metastases

(2009) Eswaran Devarajan et al.   CURRENT MOLECULAR MEDICINE

Linking folding and binding

(2009) Peter E Wright et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains

(2009) Jonathan M Wojciak et al.   EMBO JOURNAL

Role for protein–protein interaction databases in human genetics

(2009) Kristine A Pattin et al.   Expert Review of Proteomics

Molecular basis of cytokine signalling - theme and variations

(2009) Walter Sebald et al.   FEBS Journal

Dynamic interactions of proteins in complex networks: a more structured view

(2009) Amelie Stein et al.   FEBS Journal

FRET and mechanobiology

(2009) Yingxiao Wang et al.   Integrative Biology

Yeast Two-Hybrid, a Powerful Tool for Systems Biology

(2009) Anna Brückner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stability of dimeric interface in banana lectin: Insight from molecular dynamics simulations

(2009) Garima Gupta et al.   IUBMB LIFE

A Progesterone Receptor Co-activator (JDP2) Mediates Activity through Interaction with Residues in the Carboxyl-terminal Extension of the DNA Binding Domain

(2009) Krista K. Hill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methods for proteomic analysis of transcription factors

(2009) Daifeng Jiang et al.   JOURNAL OF CHROMATOGRAPHY A

Interaction between Intrinsically Disordered Proteins Frequently Occurs in a Human Protein–Protein Interaction Network

(2009) Kana Shimizu et al.   JOURNAL OF MOLECULAR BIOLOGY

Site-Specific Phosphorylation Induces Functionally Active Conformation in the Intrinsically Disordered N-Terminal Activation Function (AF1) Domain of the Glucocorticoid Receptor

(2009) A. M. S. Garza et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcription Dynamics

(2009) Gordon L. Hager et al.   MOLECULAR CELL

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

Exploiting Amino Acid Composition for Predicting Protein-Protein Interactions

(2009) Sushmita Roy et al.   PLoS One

Protein Dynamism and Evolvability

(2009) N. Tokuriki et al.   SCIENCE

Structural and functional relationships of the steroid hormone receptors’ N-terminal transactivation domain

(2009) Raj Kumar et al.   STEROIDS

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy

(2008) Sanjeev Shangary et al.   Annual Review of Pharmacology and Toxicology

Functional Characterization of the Native NH2-Terminal Transactivation Domain of the Human Androgen Receptor: Binding Kinetics for Interactions with TFIIF and SRC-1a†

(2008) Derek N. Lavery et al.   BIOCHEMISTRY

Detecting and Interfering Protein Interactions: Towards the Control of Biochemical Pathways

(2008) Montse Morell et al.   CURRENT MEDICINAL CHEMISTRY

Two-hybrid technologies in proteomics research

(2008) Bernhard Suter et al.   CURRENT OPINION IN BIOTECHNOLOGY

Protein–protein interactions: from global to local analyses

(2008) WP Kelly et al.   CURRENT OPINION IN BIOTECHNOLOGY

Protein networks in disease

(2008) T. Ideker et al.   GENOME RESEARCH

Genetic interaction between Bardet-Biedl syndrome genes and implications for limb patterning

(2008) Marwan K. Tayeh et al.   HUMAN MOLECULAR GENETICS

A survey of the year 2006 literature on applications of isothermal titration calorimetry

(2008) Oksana Okhrimenko et al.   JOURNAL OF MOLECULAR RECOGNITION

A survey of the year 2007 literature on applications of isothermal titration calorimetry

(2008) Saša Bjelić et al.   JOURNAL OF MOLECULAR RECOGNITION

Role of intrinsically disordered protein regions/domains in transcriptional regulation

(2008) Anna S. Garza et al.   LIFE SCIENCES

Chemical probes for histone-modifying enzymes

(2008) Philip A Cole   Nature Chemical Biology

Signal transduction via unstructured protein conduits

(2008) A Keith Dunker et al.   Nature Chemical Biology

Fluorescent protein FRET pairs for ratiometric imaging of dual biosensors

(2008) Hui-wang Ai et al.   NATURE METHODS

Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors

(2008) M. Ouyang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A robust approach for analyzing a heterogeneous structural ensemble

(2008) David F. Lowry et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

BIOCHEMISTRY: How Do Proteins Interact?

(2008) D. D. Boehr et al.   SCIENCE