Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 15, Issue -, Pages 1150-1163Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/3667
Keywords
AAV; Adeno-associated virus; alphaviridae; adhesion; Alzheimer's disease; Apoptosis; Cancer; Cell Cycle; Dengue virus; ECM; HIV; human immunodeficiency virus; laminin receptor; lentiviral vectors; LRP/LR; metastasis; prion; PrP; signal transduction; Sindbis virus; Venezuelean Equine Encephalitis virus; Zoonosis; Cell Adhesion; Amyloid; Review
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Funding
- Deutsche Forschungsgemeinschaft (DFG), Germany [WE 2664/2-1]
- National Research Foundation (NRF), Republic of South Africa (RSA)
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The 37-kDa/67 kDa laminin receptor (LRP/LR) represents a multifunctional protein. It is a receptor for viruses such as Dengue Viruses, Alphaviruses and Adeno-associated-Viruses (AAV), as well as the cellular prion protein (PrPc) and infectious prions (PrPSc). The 37-kDa/67-kDa LRP/LR plays furthermore fundamental roles in basic cell biological processes such as cell adhesion and cell growth and acts as a key player in metastatic cancer, affecting invasion, adhesion and apoptotic processes. This review gives fundamental insights into basic cellular processes affected by LRP/LR including signal transduction and cell cycle progression and focuses on pathophysiological implications of the interaction of prion proteins, laminin, viruses and other ligands with LRP/LR affecting the development of highly-prevalent diseases such as cancer, neurodegenerative diseases such as prion disorders and Alzheimer's Disease as well as viral infections. Molecular tools such as LRP/LR specific antibodies and siRNAs targeting LRP expression as possible alternative therapeutics for the treatment of neurodegenerative diseases, metastatic cancer and viral infections are emphasized.
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