Patient-Derived Xenografts of Non Small Cell Lung Cancer: Resurgence of an Old Model for Investigation of Modern Concepts of Tailored Therapy and Cancer Stem Cells

Long-Term Engraftment and Expansion of Tumor-Derived Memory T Cells Following the Implantation of Non-Disrupted Pieces of Human Lung Tumor into NOD-scid IL2R null Mice

(2014) M. R. Simpson-Abelson et al.   JOURNAL OF IMMUNOLOGY

Primary human tumor xenografted models (‘tumorgrafts’) for good management of patients with cancer

(2011) Didier Decaudin   ANTI-CANCER DRUGS

The “stem” of chemoresistance

(2011) Giulia Bertolini et al.   CELL CYCLE

Primary resistance to cetuximab in a panel of patient-derived tumour xenograft models: Activation of MET as one mechanism for drug resistance

(2011) Rebekka Krumbach et al.   EUROPEAN JOURNAL OF CANCER

A Pilot Clinical Study of Treatment Guided by Personalized Tumorgrafts in Patients with Advanced Cancer

(2011) M. Hidalgo et al.   MOLECULAR CANCER THERAPEUTICS

ALDH Activity Selectively Defines an Enhanced Tumor-Initiating Cell Population Relative to CD133 Expression in Human Pancreatic Adenocarcinoma

(2011) Michael P. Kim et al.   PLoS One

A Molecularly Annotated Platform of Patient-Derived Xenografts ("Xenopatients") Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

(2011) A. Bertotti et al.   Cancer Discovery

Establishment and characterisation of a new breast cancer xenograft obtained from a woman carrying a germline BRCA2 mutation

(2010) L de Plater et al.   BRITISH JOURNAL OF CANCER

Guidelines for the welfare and use of animals in cancer research

(2010) P Workman et al.   BRITISH JOURNAL OF CANCER

Comparative Profiling of the Novel Epothilone, Sagopilone, in Xenografts Derived from Primary Non-Small Cell Lung Cancer

(2010) S. Hammer et al.   CLINICAL CANCER RESEARCH

Patient-Derived First Generation Xenografts of Non-Small Cell Lung Cancers: Promising Tools for Predicting Drug Responses for Personalized Chemotherapy

(2010) X. Dong et al.   CLINICAL CANCER RESEARCH

The Ability to Form Primary Tumor Xenografts Is Predictive of Increased Risk of Disease Recurrence in Early-Stage Non-Small Cell Lung Cancer

(2010) T. John et al.   CLINICAL CANCER RESEARCH

The challenge of selecting the ‘right’ in vivo oncology pharmacology model

(2010) Brant Firestone   CURRENT OPINION IN PHARMACOLOGY

CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

(2010) Christophe Ginestier et al.   JOURNAL OF CLINICAL INVESTIGATION

Prognostic Significance of Tumorigenic Cells With Mesenchymal Features in Pancreatic Adenocarcinoma

(2010) Zeshaan A. Rasheed et al.   JNCI-Journal of the National Cancer Institute

Genetically modified mice—successes and failures of a widely used technology

(2010) Hayo Castrop   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Animal transgenesis: an overview

(2009) Miguel A. Gama Sosa et al.   Brain Structure & Function

A Primary Xenograft Model of Small-Cell Lung Cancer Reveals Irreversible Changes in Gene Expression Imposed by Culture In vitro

(2009) V. C. Daniel et al.   CANCER RESEARCH

DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency

(2009) Timothy Hoey et al.   Cell Stem Cell

A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development

(2009) A. Jimeno et al.   MOLECULAR CANCER THERAPEUTICS

Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment

(2009) G. Bertolini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Establishment of Patient-Derived Non-Small Cell Lung Cancer Xenografts as Models for the Identification of Predictive Biomarkers

(2008) I. Fichtner et al.   CLINICAL CANCER RESEARCH

Applications and Limitations of Genetically Modified Mouse Models in Drug Discovery and Development

(2008) Jiunn Lin   CURRENT DRUG METABOLISM

Identification of cells initiating human melanomas

(2008) Tobias Schatton et al.   NATURE

Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy

(2008) Scott J. Dylla et al.   PLoS One