Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 10, Issue 4, Pages 391-396Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2010.06.012
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The predictive value of non-clinical cancer pharmacology models has been poor with many drugs failing in the clinic that previously demonstrated anti-tumor responses in animal models. In the age of targeted drug discovery, the cancer pharmacologist is challenged with improving the translation of these models to a clinical setting. Various model systems currently utilized in preclinical cancer drug discovery are discussed and emphasis is placed on selecting models tailored to interrogate hypothesis-driven scientific questions.
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