Article
Multidisciplinary Sciences
Stephen C. Balmert, Zohreh Gholizadeh Ghozloujeh, Cara Donahue Carey, Lian H. Williams, Jiying Zhang, Preeti Shahi, Maher Amer, Tina L. Sumpter, Geza Erdos, Emrullah Korkmaz, Louis D. Falo Jr
Summary: This study presents a dissolvable microarray patch (MAP) vaccine that targets the skin microenvironment for needle-free immunization. The vaccine induces strong immune responses and generates antibodies and cellular immunity systemically and in the respiratory mucosa. It demonstrates high neutralizing capacity, long-term protection, and stability without refrigeration.
Review
Immunology
Ye Zheng, Xiaoyu Ma, Shouchang Feng, Hongtao Zhu, Xin Chen, Xingjiang Yu, Kai Shu, Suojun Zhang
Summary: Glioblastoma (GBM), the most malignant subtype of glioma, is resistant to traditional therapies and immunotherapies. Dendritic cell vaccine (DCV) has shown potential as a therapeutic method, but there are challenges to its use.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Agriculture, Multidisciplinary
Haitham G. Abo-Al-Ela
Summary: RNAi is a natural mechanism used to silence specific genes and has been extensively studied and applied in aquaculture, particularly in shrimp. Despite limitations, RNAi methods show potential in therapeutic agents and studying biological functions.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Medicine, General & Internal
Moqbel Ali Moqbel Redhwan, M. G. Hariprasad, Suman Samaddar, Sumaia Abdulbari Ahmed Ali Hard, Vidyabhushan Yadav, Apurbo Mukherjee, Rahul Kumar
Summary: This review examines the clinical trials on siRNA published in the last 5 years to understand its benefits, pharmacokinetics, and safety. So far, 55 clinical studies have been conducted on siRNA, showing its effectiveness and safety in treating various diseases. However, there are limitations and uncertainties, such as cellular uptake, precise targeting, and elimination from the body.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Chemistry, Organic
Marta Papis, Camilla Loro, Michele Penso, Gianluigi Broggini, Francesca Foschi
Summary: The synthesis of modified morpholino monomers was achieved through condensation reactions under Lewis acid conditions, utilizing a simple and efficient method to access diversified optically pure morpholino monomers with high yields and anomeric ratios.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Chemistry, Multidisciplinary
Hongze Ren, Wencong Jia, Yujie Xie, Meihua Yu, Yu Chen
Summary: Vaccines with innovative adjuvants, such as nanotechnology adjuvants in COVID-19 mRNA vaccines, are offering new strategies to combat diseases and enhance immune responses. The modulation of physicochemical properties of nanoplatforms elevates the capability of adjuvants, allowing the development of vaccines against challenging infections and cancer. This review focuses on the progress of nanotechnology adjuvants in cancer treatment and infectious disease prevention.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Engineering, Biomedical
Yan-Wei Wu, Wan-Yu Wang, Yu-Hung Chen
Summary: This study demonstrates that a positively charged nanocomplex can drive the Th1 immune response and modulate dendritic cell differentiation. The surface charge and size of the nanocomplex were found to affect the immune response. Furthermore, vaccination with the positively charged nanocomplex was shown to increase specific antibody and memory T-cell responses.
MATERIALS TODAY BIO
(2022)
Article
Biology
Yuexin Wang, Hui Yang, Anna Jia, Yufei Wang, Qiuli Yang, Yingjie Dong, Yueru Hou, Yejin Cao, Lin Dong, Yujing Bi, Guangwei Liu
Summary: Dendritic cells (DCs) are important in anti-tumor immunity, and the mechanical sensor Piezo1 plays a role in regulating the differentiation of T(H)1 and T-reg cells in response to mechanical stiffness or inflammatory signals. Genetic deletion of Piezo1 in DCs inhibits T(H)1 cell generation and promotes T-reg cell development, leading to cancer growth. Mechanistically, Piezo1-deficient DCs regulate the secretion of cytokines TGF beta 1 and IL-12, affecting the activity of TGF beta R2-p-Smad3 and IL-12R beta 2-p-STAT4, and influencing the differentiation of T-reg and T(H)1 cells. Additionally, Piezo1 integrates metabolic and signaling pathways to orchestrate T(H)1 and T-reg lineage commitment through IL-12 and TGF beta 1 derived from DCs. Our studies provide critical insight into the role of DC-based mechanical regulation in directing T cell lineage commitment in tumor microenvironments.
Review
Cell Biology
Hara Kang, Yun Ji Ga, Soo Hyun Kim, Young Hoon Cho, Jung Won Kim, Chaeyeon Kim, Jung-Yong Yeh
Summary: RNA has become a revolutionary tool in battling emerging infectious diseases, particularly in response to the COVID-19 pandemic. RNAi therapeutics have shown potential in reducing disease-associated genes, and nucleic acid-based therapies have emerged as alternative treatments. However, there are obstacles to overcome in the use of siRNA-based antiviral therapies, including off-target effects and drug resistance.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Microbiology
Xinting Wang, Chunyan Zhang, Shuhe Wang, Rasheduzzaman Rashu, Rony Thomas, Jie Yang, Xi Yang
Summary: The study demonstrates the important role of SND1 in host defense against intracellular bacterial infection, particularly in promoting Th1/17 immunity and inhibiting Treg cell expansion through modulation of DC function. The deficiency of SND1 leads to altered phenotype and function of dendritic cells, resulting in delayed bacterial clearance and more severe disease in chlamydial lung infection.
Article
Multidisciplinary Sciences
Yukihiro Hiramatsu, Takashi Nishida, Dendi Krisna Nugraha, Mayuko Osada-Oka, Daisuke Nakane, Katsumi Imada, Yasuhiko Horiguchi
Summary: A bacterial small RNA called Bpr4 was found to contribute to Bordetella pertussis infection by up-regulating the expression of a major adhesin called filamentous hemagglutinin (FHA) posttranscriptionally. Bpr4 up-regulation was triggered by interference with flagellar rotation, leading to activation of a diguanylate cyclase and subsequent up-regulation of Bpr4.
Review
Plant Sciences
William Conrad Ledford, Alessandro Silvestri, Valentina Fiorilli, Ronelle Roth, Ignacio Rubio-Somoza, Luisa Lanfranco
Summary: Arbuscular mycorrhizal (AM) symbiosis is a mutualistic interaction between fungi and land plants, involving nutrient exchange. The development of AM is tightly regulated and involves molecular communication, fungal accommodation, and symbiotic function activation. Small RNAs (sRNAs) from both the host and AM fungi contribute to the transcriptional reprogramming of AM fungus colonized cells, playing important roles in gene expression regulation and symbiosis control.
Review
Plant Sciences
Yunjia Tang, Xiaoning Yan, Chenxian Gu, Xiaofeng Yuan
Summary: This article reviews the systematic processes of sRNA biogenesis, trafficking, and the underlying mechanisms of its functions in plant genomes. sRNAs can move within plants, be transferred to plant pathogens via extracellular vesicles, and be transferred to mammals through food. They function at target sites through various mechanisms.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Cell Biology
Lingfeng Yu, Gentao Fan, Qingyan Wang, Yan Zhu, Hao Zhu, Jiang Chang, Zhen Wang, Shoubin Zhan, Xianming Hua, Diankun She, Jianhao Huang, Yicun Wang, Jianning Zhao, Chen-Yu Zhang, Xi Chen, Guangxin Zhou
Summary: This study presents a synthetic biological strategy for efficient in vivo delivery of VEGFR2 siRNA by remolding the host liver with genetic circuits. The results show that this strategy is superior to the positive medicine in terms of therapeutic efficacy and toxic adverse effects, providing a feasible therapeutic solution for lung metastatic OS.
CELL DEATH & DISEASE
(2023)
Article
Plant Sciences
Niccolo' Miotti, Natalia Sukhikh, Nathalie Laboureau, Paola Casati, Mikhail M. Pooggin
Summary: This study characterized the virome and antiviral RNA interference (RNAi) in different hemp varieties, and identified several viruses. Different sizes of sRNAs may be involved in different RNAi pathways, providing clues for further research on hemp diseases.
Article
Clinical Neurology
Jun Takei, Toshihide Tanaka, Yohei Yamamoto, Keisuke Hatano, Diasuke Ichinose, Fumiaki Maruyama, Satoru Tochigi, Yuzuru Hasegawa, Yuichi Murayama
Summary: The study found that the group with high hematoma density had the highest VEGF concentration, while the recurrence rate of CSDH was highest in the separated group with low hematoma density. There was a significant correlation between VEGF concentration and CT classification, indicating a predictive value of VEGF concentration in the natural history of chronic subdural hematoma.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Clinical Neurology
Toshihide Tanaka, Jun Takei, Akihiko Teshigawara, Yohei Yamamoto, Yasuharu Akasaki, Yuzuru Hasegawa, Yuichi Murayama
Summary: The study indicated that surgery for brain metastatic tumors near the optic radiation could improve hemianopsia in some patients. Factors such as tumor location, resection rate, and postoperative Karnofsky performance scale score had an impact on visual field improvement.
WORLD NEUROSURGERY
(2021)
Review
Medicine, General & Internal
Michiyasu Fuga, Toshihide Tanaka, Ryo Nogami, Rintaro Tachi, Akihiko Teshigawara, Toshihiro Ishibashi, Yuzuru Hasegawa, Yuichi Murayama
Summary: This study presents a case of delayed subdural hematoma caused by posterior cerebral artery aneurysm, which was successfully treated with parent artery occlusion resulting in a good outcome for the patient.
AMERICAN JOURNAL OF CASE REPORTS
(2021)
Article
Clinical Neurology
Michiyasu Fuga, Toshihide Tanaka, Koreaki Irie, Ikki Kajiwara, Rintaro Tachi, Akihiko Teshigawara, Toshihiro Ishibashi, Yuzuru Hasegawa, Yuichi Murayama
Summary: This retrospective study analyzed 301 unruptured aneurysms and found that RROC class 3 and aneurysm volume were independent predictors of recanalization. Cases with RROC class 3 or high aneurysm volume may have a higher risk of recanalization and should be closely monitored during coil embolization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Editorial Material
Immunology
Loredana Albonici, Sara Labiano Alminana, Toshihide Tanaka, Roberto Bei
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jun Takei, Nei Fukasawa, Toshihide Tanaka, Yohei Yamamoto, Ryota Tamura, Hikaru Sasaki, Yasuharu Akasaki, Yuko Kamata, Mutsunori Murahashi, Masayuki Shimoda, Yuichi Murayama
Summary: A pseudo-papillary structure was observed in recurrent GBM after anti-vascular endothelial growth factor therapy. Bev may enhance tumor oxygenation, inhibit stemness, and correlate with neuroimaging response during treatment. FOXM1 could serve as a survival biomarker in the context of Bev therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Neurosciences
Michiyasu Fuga, Toshihide Tanaka, Rintaro Tachi, Kyoichi Tomoto, Ryoto Wachi, Akihiko Teshigawara, Toshihiro Ishibashi, Yuzuru Hasegawa, Yuichi Murayama
Summary: This study aimed to assess the associations between thromboelastography 6s (TEG6s) measurements and postoperative ischemic complications in patients with unruptured intracranial aneurysms (UIAs) treated by coil embolization. The results showed that MAADP and ADP% can serve as reliable parameters to predict postoperative ischemic complications after coil embolization of UIAs.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Clinical Neurology
Michiyasu Fuga, Toshihide Tanaka, Rintaro Tachi, Ryoto Wachi, Akihiko Teshigawara, Toshihiro Ishibashi, Yuzuru Hasegawa, Yuichi Murayama
Summary: This study describes the use of a novel 3-Fr guiding sheath for aneurysm embolization via transradial access in patients with narrow radial arteries. The procedure was successful and complications were avoided.
INTERVENTIONAL NEURORADIOLOGY
(2022)
Article
Neuroimaging
Michiyasu Fuga, Toshihide Tanaka, Rintaro Tachi, Kyoichi Tomoto, Shun Okawa, Akihiko Teshigawara, Toshihiro Ishibashi, Yuzuru Hasegawa, Yuichi Murayama
Summary: The study aimed to compare the efficacy and complications of transradial approach (TRA) and transfemoral approach (TFA) in coil embolization of unruptured intracranial aneurysms (UIAs). Results showed that coil embolization via TRA can reduce the risk of minor access site complications (ASCs) without increasing the risk of non-ASCs compared with conventional TFA, and achieve comparable results in terms of efficacy and fluoroscopy time.
NEURORADIOLOGY JOURNAL
(2023)
Article
Clinical Neurology
M. Fuga, T. Tanaka, R. Tachi, S. Yamana, K. Irie, I. Kajiwara, A. Teshigawara, T. Ishibashi, Y. Hasegawa, Y. Murayama
Summary: A retrospective study on 396 patients who underwent neurointervention for cerebral aneurysms found that contrast injection from an intradural artery and retreatment of recurrent aneurysms were major risk factors for contrast-induced encephalopathy.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Oncology
Jun Takei, Yuko Kamata, Toshihide Tanaka, Nei Fukasawa, Kazutaka Gomisawa, Mari Satake, Ryosuke Mori, Yohei Yamamoto, Tomoya Suzuki, Ayaka Oda, Mutsunori Murahashi, Takahiro Fukuda, Masayuki Shimoda, Yuichi Murayama, Yasuharu Akasaki
Summary: This study investigated the prognostic factors in patients receiving tumor-fused dendritic cell (TFDC) immunotherapy for glioblastoma (GBM). It found that TFDC immunotherapy showed clinical activity against GBM, especially in patients with O-6-methylguanine-DNA methyltransferase (MGMT) unmethylated tumors, with a 5-year survival rate of 33%.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Clinical Neurology
Michiyasu Fuga, Toshihide Tanaka, Rintaro Tachi, Koreaki Irie, Ikki Kajiwara, Akihiko Teshigawara, Toshihiro Ishibashi, Yuzuru Hasegawa, Yuichi Murayama
Summary: Stenting into the fetal posterior cerebral artery (fPCA) can provide effective embolization and prevent recanalization for aneurysms with fPCA incorporated into the aneurysm. This study found that the stenting group achieved significantly higher complete occlusion rate and packing density compared to the non-stenting group, with no major complications observed. Therefore, fPCA stent-assisted coil embolization can be considered as an alternative treatment for fPCA aneurysms.
INTERVENTIONAL NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Michiyasu Fuga, Toshihide Tanaka, Rintaro Tachi, Kyoichi Tomoto, Kenta Kazami, Akihiko Teshigawara, Toshihiro Ishibashi, Yuzuru Hasegawa, Yuichi Murayama
Summary: This study aimed to explore the risk factors for radial artery occlusion (RAO) after coil embolization of unruptured intracranial aneurysms (UIAs) via transradial access (TRA). The results showed that radial artery size and radial artery spasm were independent predictors of subsequent RAO. Prophylaxis against radial artery spasm and limiting neurointervention via TRA to patients with radial artery larger than 2.5 mm in diameter may reduce the risk of postoperative RAO.
INTERVENTIONAL NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Tomoya Suzuki, Jun Takei, Nei Fukasawa, Kenta Suzuki, Daisuke Ogawa, Yohei Yamamoto, Yasuharu Akasaki, Yuichi Murayama, Masayuki Shimoda, Keisuke Miyake, Toshihide Tanaka
Summary: This study compared the expressions of carbonic anhydrase 9 (CA9) and Forkhead box M1 (FOXM1) in glioblastoma (GBM) during bevacizumab (Bev) therapy. The results showed that FMISO-PET effectively visualized the oxygenation of tumor microenvironment (TME) after Bev treatment. Increased FMISO accumulation at the time of recurrence, even under Bev treatment, suggests that FMISO-PET might be useful for monitoring the duration of Bev efficacy by reflecting tumor oxygenation.
WORLD NEUROSURGERY
(2023)
Article
Oncology
Jun Takei, Toshihide Tanaka, Akihiko Teshigawara, Satoru Tochigi, Yuzuru Hasegawa, Yuichi Murayama
Summary: Malignant progression of meningioma is rare, but possible even after initial treatment of low-grade tumors without adjuvant radiotherapy. The expression levels of proliferation markers and macrophages increase in recurrent and malignant meningiomas, suggesting potential for predicting malignant progression. A multidisciplinary approach including radiation and targeted therapy is crucial for managing recurrent and malignant meningiomas.
TRANSLATIONAL CANCER RESEARCH
(2021)
