Editorial Material
Integrative & Complementary Medicine
Manu Lopus
Summary: Nano-ayurvedic medicine is an emerging field that utilizes nanoparticles functionalized with active principles of potent ayurvedic herbs. These nanoparticles can enhance the efficacy and target-specific delivery of the herbs, making them a potential treatment option for hyperproliferative diseases.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Proceedings Paper
Materials Science, Multidisciplinary
S. Sreelakshmi, P. K. Vineeth, Arun Mohanan, N. V. Ramesh
Summary: Both green-synthesized nanoparticles and Bhasma have potential advantages in treating ailments, being simpler, more efficient, and environmentally friendly compared to chemically synthesized nanoparticles.
MATERIALS TODAY-PROCEEDINGS
(2021)
Review
Biochemistry & Molecular Biology
Rohit Sharma, Prashant Bedarkar, Deepak Timalsina, Anand Chaudhary, Pradeep Kumar Prajapati
Summary: Scholars of ancient Ayurveda showed strong scientific rationality in drug manufacture and therapy. Bhavana is a traditional method that transforms raw material into drugs through levigation or wet grinding, enhancing the physicochemical and biological properties of the drug for quicker and more potent effects. Despite its wide use in Ayurvedic pharmaceutics, there is limited understanding of the fundamental concepts and processes involved in Bhavana.
BIOINORGANIC CHEMISTRY AND APPLICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Xia Zhang, Like Ning, Hongshuai Wu, Suisui Yang, Ziyi Hu, Wenhong Wang, Yuandong Cao, Hongliang Xin, Chaoqun You, Fan Lin
Summary: The aim of this project is to investigate whether the cellulose-based hydrogel via in situ injection can serve as an alternative route for brain delivery of palbociclib (PB) and enhance its anti-glioblastoma (GBM) effect. The formed hydrogel (PB@PH/Cu-CNCs) demonstrated sustained drug retention and controlled release in vivo. Additionally, the PB-loaded hydrogel showed a more potent anti-GBM effect than free PB or drug-free hydrogel in both cultured cells and an orthotopic glioma model.
Review
Integrative & Complementary Medicine
Pankaj Kumar, Remya Jayakumar, Manoj Kumar Dash, Namrata Joshi
Summary: The mass casualties caused by the delta variant and the wave of the newer Omicron variant in India have raised great concern among healthcare officials. The government and healthcare agencies are looking for effective strategies to counter the pandemic, and nanotechnology and drug repurposing are reported as promising approaches. This has led to a search for productive, reliable, cost-effective, and bio-assimilable alternative solutions.
CURRENT TRADITIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Ankush Paladhi, Abhinandan Rej, Debanjan Sarkar, Ranjeet Singh, Sankar Bhattacharyya, Prasanta Kumar Sarkar, Pulak Kanti Kar, Partha Pratim Manna, Sumit Kumar Hira
Summary: This study reports the therapeutic potential of a traditional Ayurvedic herbomineral formulation, Ayu_ND, based on functional nanodiamonds. The treatment showed significant anti-tumor effects in a mouse model, including reducing tumor cell proliferation, inducing apoptosis, and stimulating the immune system.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shashi Saini, Anshul Anand, Abhishek Singh, Baishakhi Mahapatra, Shruti Sirohi, Samer Singh, Rakesh K. K. Singh
Summary: In ancient Indian literature, metallic bhasma, particularly that of gold, is known to have protective and curative properties in various health issues. This study found that gold bhasma has potential in enhancing the immune response against L. donovani antigens. Further research is needed to explore the mechanism and potential of gold bhasma in enhancing vaccine-induced immunity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Yu Zhang, Sheng Ma, Xinming Liu, Yudi Xu, Jiayu Zhao, Xinghui Si, Hongxiang Li, Zichao Huang, Zhenxin Wang, Zhaohui Tang, Wantong Song, Xuesi Chen
Summary: A programmable immune activation nanomedicine (PIAN) is reported in this study, which sequentially finishes multiple steps after intravenous injection and elicits robust antitumor immunity in situ. This innovative approach provides a new framework for designing programmable nanomedicine as an in situ cancer vaccine for cancer immunotherapy.
ADVANCED MATERIALS
(2021)
Article
Multidisciplinary Sciences
Jian Wang, Peirong Xu, Yeyong Zhang, Shuai Han, Gongteng Wang, Hangxiang Wang, Haihan Song, Shufeng Li
Summary: The study develops injectable anticancer nanoassemblies through self-assembly technique, which exhibit tumor-restricted pharmacology and can be self-activated without exogenous stimuli. The anticancer agent cabazitaxel is covalently dimerized to form the prodrug diCTX, which is further coassembled with an ROS generator diDHA. The refined nanoparticles show durable antitumor efficacy in a preclinical model and lower toxicity compared to free drug combinations, suggesting great potential for clinical translation.
Article
Business
Ashish Malik, Vijay Pereira, Pawan Budhwar, Arup Varma, Manlio Del Giudice
Summary: This research is based on a novel Indian multinational enterprise that offers indigenous Ayurvedic care and cure services. The study found that the enterprise formulated and explored innovative treatments and developed sustainable business models by sensing, seizing, and transforming resources. Implications for theory and practice are also discussed.
JOURNAL OF BUSINESS RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Shahriar Sharifi, Nouf N. Mahmoud, Elizabeth Voke, Markita P. Landry, Morteza Mahmoudi
Summary: Understanding the interaction between biological structures and nanoscale technologies is crucial for the development of safe and efficient nanomedicine products. However, the lack of a universal reporting system and standardized methods for nanomaterial characterization has resulted in low reliability and reproducibility in nanomedicine literature. It is necessary to establish a characterization system to support reproducibility of nanoscience data, especially for studies seeking clinical translation. Implementation of standard protocols in experimental laboratories requires long-term planning and collaboration among stakeholders.
NANO-MICRO LETTERS
(2022)
Article
Pharmacology & Pharmacy
Aashish Kumar Netam, Vikas Panka Bhargava, Rambir Singhz, Poonam Sharma
Summary: The study evaluated the physico-chemical characteristics of Swarna Bhasma manufactured by Shree Baidyanath Ayurved Bhawan Pvt. Ltd., revealing high gold content, moderate particle size, and irregular spherical morphology.
JOURNAL OF COMPLEMENTARY MEDICINE RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Catia T. Perciani, Lewis Y. Liu, Lawrence Wood, Sonya A. MacParland
Summary: The use of engineered nanoparticles has shown promise in enhancing vaccine efficacy and host immune responses to viral and tumor antigens. By harnessing the properties of nanoparticles, it may be possible to overcome current obstacles in vaccinology and oncology.
Review
Biochemistry & Molecular Biology
Francesca Roda, Riccardo Caraffi, Silvia Picciolini, Giovanni Tosi, Maria Angela Vandelli, Barbara Ruozi, Marzia Bedoni, Ilaria Ottonelli, Jason Thomas Duskey
Summary: Nanoparticles have potential as a strategy to improve the treatment of glioblastoma by enhancing drug delivery and targeting specific receptors or pathways. This review explores the latest strategies for drug delivery to glioblastoma, with a focus on the importance of surface functionalization for blood-brain barrier crossing and tumor specific targeting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Hui Hu, Nan Yang, Jiahui Sun, Fu Zhou, Rui Gu, Yuan Liu, Li Wang, Xuejiao Song, Ruirui Yun, Xiaochen Dong, Guangfeng Wang
Summary: A multifunctional metal-organic framework (MOF) based photothermal therapy with gene therapy platform has been developed, allowing for photothermal/photoacoustic/fluorescence multimodal imaging and specific release of therapeutic cargos as needed, providing an efficient and safe strategy for cancer theranostics.
