Bhavana, an Ayurvedic Pharmaceutical Method and a Versatile Drug Delivery Platform to Prepare Potentiated Micro-Nano-Sized Drugs: Core Concept and Its Current Relevance

Scholars of ancient Ayurveda (Indian system of medicine) were extremely reasonable and had strong scientific rationality in fundamental concepts, which are also applied to drug manufacture and therapy. Bhavana is a unique traditional method of transformation of raw material/substances into the drug by levigation or wet grinding of powdered drugs with juice/decoction/solution of plant, animal, or mineral origin. This method adds the unique capability of affecting the physicochemical and biological properties of a drug, making the drug quicker, augmented, and persistent action with minimal dose. Despite the fact that Bhavana has a wide range of applications in Ayurvedic pharmaceutics, there is only a limited amount of knowledge of its fundamental notions. A comprehensive review was performed on the core concepts of Bhavana, alongside its possible pharmacotherapeutic effects and relevance in drug development, by probing Ayurvedic claims in light of published pharmaceutical, analytical, and pharmacological reports. Various processes, such as thermo- and photochemistry, physicochemical reactions, and mechanic chemical changes, appear to occur during Bhavana.

Automated summary

Scholars of ancient Ayurveda showed strong scientific rationality in drug manufacture and therapy. Bhavana is a traditional method that transforms raw material into drugs through levigation or wet grinding, enhancing the physicochemical and biological properties of the drug for quicker and more potent effects. Despite its wide use in Ayurvedic pharmaceutics, there is limited understanding of the fundamental concepts and processes involved in Bhavana.