Article
Mathematics, Interdisciplinary Applications
Shahriar Sadatieh, Maryam Dehghani, Mohsen Mohammadi, Reza Boostani
Summary: This paper proposes a nonlinear controller based on extremum-seeking theorem to optimize the amplitude of the limit cycle in order to improve the performance of LVAD. The controller can maintain proper cardiac response and prevent the suction phenomenon effectively. The proposed approach demonstrates superiority over state-of-the-art methods in maintaining cardiac function under various physical activities.
CHAOS SOLITONS & FRACTALS
(2021)
Article
Cardiac & Cardiovascular Systems
Amrut V. Ambardekar, Matthew S. Stratton, Evgenia Dobrinskikh, Kendall S. Hunter, Philip D. Tatman, Madeleine E. Lemieux, Joseph C. Cleveland, Rubin M. Tuder, Mary C. M. Weiser-Evans, Karen S. Moulton, Timothy A. McKinsey
Summary: This study found aortic remodeling and fibrosis after CF-LVAD implantation, which correlated with the duration of support. The fibrosis was partly attributable to the suppression of extracellular matrix-degrading enzyme expression. Further research is needed to investigate the impact of nonphysiological flow patterns on vascular function and the potential benefits of pulsatility modulation on vascular remodeling and long-term outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elisa Dal Canto, Marielle Scheffer, Kirsten Kortekaas, Annet Driessen-Waaijer, Walter J. Paulus, Loek van Heerebeek
Summary: In patients with HFpEF, NP levels can be used to identify different stages of LV remodeling and myocardial tissue composition. This study found that HFpEF patients with high NP levels had worse LV stiffness and left atrial function, indicating advanced stage of HFpEF.
Article
Cardiac & Cardiovascular Systems
Daniel Burkhoff, Veli K. Topkara, Gabriel Sayer, Nir Uriel
Summary: This review provides a comprehensive overview of research into LVAD therapy for heart failure, including the hemodynamic effects of LVAD support and the structural, cellular, and molecular aspects of LVAD-associated reverse remodeling. The review also discusses the synergistic effects of LVAD support with heart failure therapies on clinical outcomes and myocardial biology.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Brent C. Lampert, Jeffrey J. Teuteberg, Jennifer Cowger, Nahush A. Mokadam, Ryan S. Cantor, Raymond L. Benza, Asvin M. Ganapathi, Susan L. Myers, William Hiesinger, Joseph Woo, Francis Pagani, James K. Kirklin, Bryan A. Whitson
Summary: Comparing outcomes of patients implanted with continuous flow LVADs via thoracotomy and sternotomy approaches, it was found that thoracotomy did not reduce right ventricular failure or improve survival, but did result in a shorter postoperative length of stay.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Jiang, Yuan Li, Shan Huang, Pei-Lun Han, Wei-Feng Yan, Han Fang, Zhi-Gang Yang
Summary: In patients with repaired Tetralogy of Fallot, cardiac MRI showed that there was a gradual decrease in right ventricular, left ventricular, and septal strain. The correlation between left ventricular deformation and right ventricular function was strongest in patients with right ventricular heart failure.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Andrea Szucs, Anna Reka Kiss, Zsofia Gregor, Marton Horvath, Attila Toth, Zsofia Dohy, Liliana Erzsebet Szabo, Ferenc Imre Suhai, Bela Merkely, Hajnalka Vago
Summary: For patients with left ventricular noncompaction (LVNC), as the ejection fraction (EF) decreases, both strain values and rotational parameters change, affecting global LV function. LV mechanical dispersion increases significantly in LVNC patients, and there are variations in rotational patterns and degrees.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kenichiro Suzuki, Yasunori Inoue, Kazuo Ogawa, Tomohisa Nagoshi, Kosuke Minai, Takayuki Ogawa, Makoto Kawai, Michihiro Yoshimura
Summary: This study investigated the effects of coronary risk factors on left ventricular size and cardiac function using structure equation modeling. It found that each risk factor directly affected the shape of the heart. Managing risk factors is crucial in reducing the heart failure pandemic, as vascular risk and heart failure risk are likely to evolve simultaneously.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Stefan D. Anker, Randall C. Starling, Muhammad Shahzeb Khan, Tim Friede, Gerasimos Filippatos, JoAnn Lindenfeld, Ralph Stephan von Bardeleben, Andrew J. S. Coats, Javed Butler
Summary: In patients with functional MR and severe LV enlargement, treatment with the Carillon device showed significant improvements in mitral valve function, LV morphology, and functional outcomes compared to GDMT alone. LV dimension should not limit patient eligibility or response to therapy with the Carillon device.
JACC-HEART FAILURE
(2021)
Review
Cardiac & Cardiovascular Systems
Davide Margonato, Francesco Ancona, Giacomo Ingallina, Francesco Melillo, Stefano Stella, Federico Biondi, Antonio Boccellino, Cosmo Godino, Alberto Margonato, Eustachio Agricola
Summary: Tricuspid regurgitation (TR), historically not considered a primary healthcare problem, has recently gained attention from the scientific community. TR can complicate heart failure, most commonly as a functional disease, and its independent prognostic role is still debated. The relationship between TR and LVSD, as well as the potential therapeutic target of TR, remains unclear.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Dominic Emerson, Joanna Chikwe, Pedro Catarino, Mohamed Hassanein, Luqin Deng, Ryan S. Cantor, Amy Roach, Robert Cole, Fardad Esmailian, Jon Kobashigawa, Jaime Moriguchi, James K. Kirklin
Summary: In contemporary practice, elderly patients receiving LVADs showed improved survival, increased functional capacity, enhanced quality of life, and fewer complications compared with younger patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Andreas Leonhard Schober, Carsten Jungbauer, Florian Poschenrieder, Alexander Daniel Schober, Ute Hubauer, Andreas Keyser, Sabine Fredersdorf-Hahn, Kurt Debl, Lars S. Maier, Samuel Sossalla, Stefan Buchner, Ekrem uecer
Summary: LVGFI is a novel marker incorporating total LV structure in the assessment of LV cardiac performance, showing significant prognostic significance in predicting mortality and ICD therapies in high-risk ICD population. Further investigation is needed to evaluate LVGFI compared to ejection fraction in patients with elevated risk for adverse cardiac events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Stefan Frantz, Moritz Jens Hundertmark, Jeanette Schulz-Menger, Frank Michael Bengel, Johann Bauersachs
Summary: Most patients survive acute myocardial infarction, but the prevalence of heart failure is increasing, leading to economic strain on healthcare systems. Pathological changes in the heart significantly impact patient outcomes. Risk factors like diabetes, chronic obstructive pulmonary disease, and female sex can distinctively shape the progression towards heart failure.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Jiangbo Duan, Dandan Yang, Jinshan He, Xuebin Li, Long Wang, Cuncao Wu, Ding Li, Feng Ze, Cuizhen Yuan, Jingliang Zhou, Xu Zhou
Summary: This paper reports the initial clinical experience of using a novel venogram balloon catheter for coronary sinus cannulation and left ventricular lead implantation during cardiac resynchronization therapy. The results demonstrate that this catheter greatly facilitates the procedure and reduces the operation time and fluoroscopy time.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sung-Min Cho, J. Hunter Mehaffey, Susan L. Meyers, Ryan S. Cantor, Randall C. Starling, James K. Kirklin, Jeffrey P. Jacobs, John Kern, Ken Uchino, Leora T. Yarboro
Summary: Comparing two contemporary centrifugal-flow left ventricular assist devices, HM3 is associated with lower hazard of major NAEs compared to HVAD in both early postimplantation period and constant hazard phase.
Article
Materials Science, Multidisciplinary
J. Mojumder, J. S. Choy, S. Leng, L. Zhong, G. S. Kassab, L. C. Lee
Summary: The study revealed a strong correlation between left ventricular growth and changes in fiber stress and sheet-normal stress under pressure overload, suggesting that fiber stress is the predominant mechanical stimulus for left ventricular growth.
EXPERIMENTAL MECHANICS
(2021)
Article
Multidisciplinary Sciences
Nicole Tueni, Jeremy Vizet, Martin Genet, Angelo Pierangelo, Jean-Marc Allain
SCIENTIFIC REPORTS
(2020)
Article
Cardiac & Cardiovascular Systems
Daniel Alexander Castellanos, Katerina Skardova, Abhijit Bhattaru, Ezgi Berberoglu, Gerald Greil, Animesh Tandon, Jeanne Dillenbeck, Barbara Burkhardt, Tarique Hussain, Martin Genet, Radomir Chabiniok
Summary: This study evaluated a novel method for assessing left ventricular torsion in patients after surgical repair of Tetralogy of Fallot (rTOF) as an indicator of systolic dysfunction. The method of equilibrated warping showed good reliability and revealed a high prevalence of torsion loss in rTOF patients. Loss of torsion may be a common finding in these patients and could potentially aid in early detection of heart failure.
PEDIATRIC CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sheikh Mohammad Shavik, Samuel Wall, Joakim Sundnes, Julius M. Guccione, Partho Sengupta, Scott D. Solomon, Daniel Burkhoff, Lik Chuan Lee
Summary: Global longitudinal strain and circumferential strain are reduced in HFpEF patients, suggesting impaired global left ventricular contractility. Research indicates that only a reduction in myocardial contractility and an increase in afterload can simultaneously reproduce the relevant metrics in HFpEF patients.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Gusseva, Tarique Hussain, Camille Hancock Friesen, Philippe Moireau, Animesh Tandon, Cecile Patte, Martin Genet, Keren Hasbani, Gerald Greil, Dominique Chapelle, Radomir Chabiniok
Summary: This study utilized a biomechanical model to evaluate rTOF patients and found that residual RVOTO has a greater impact on cardiac health. Individualized modeling is helpful in predicting the heart's response to percutaneous pulmonary valve replacement.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Computer Science, Artificial Intelligence
Johanna Stimm, Stefano Buoso, Ezgi Berberoglu, Sebastian Kozerke, Martin Genet, Christian T. Stoeck
Summary: The orientation of cardiac myocyte aggregates has a significant impact on cardiac electrophysiology and mechanics. This study demonstrates the feasibility of extracting a low-rank representation of predominant myocyte orientation from high-resolution magnetic resonance imaging and proposes a data-driven, personalized, parametric model for improved accuracy in personalized computational models.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Biophysics
Cecile Patte, Martin Genet, Dominique Chapelle
Summary: This paper introduces a novel poromechanical model of the lungs, which considers the mechanical behavior of the lungs and their interaction with the surrounding environment, and can be applied to studying respiratory mechanisms and clinical applications.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Article
Engineering, Multidisciplinary
Felipe Alvarez-Barrientos, Daniel E. Hurtado, Martin Genet
Summary: In this study, a finite-deformation variational framework was developed for pressure-driven foams. The stress distribution in lung tissue was numerically simulated under different boundary conditions, revealing a strong dependence on kinematic constraints in the spherical alveolar model but not in the image-based alveolar model. Comparison of pressure-driven and deformation-driven models showed a significant shift in hydrostatic stresses but unaffected deviatoric stresses. These findings have implications for lung simulation related to mechanical ventilation and spontaneous breathing.
INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
(2021)
Correction
Cardiac & Cardiovascular Systems
Daniel Alexander Castellanos, Katerina Skardova, Abhijit Bhattaru, Ezgi Berberoglu, Gerald Greil, Animesh Tandon, Jeanne Dillenbeck, Barbara Burkhardt, Tarique Hussain, Martin Genet, Radomir Chabiniok
PEDIATRIC CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ezgi Berberoglu, Christian T. Stoeck, Philippe Moireau, Sebastian Kozerke, Martin Genet
Summary: The study found that radial strain is more sensitive to image resolution and noise, while the quantification of circumferential and longitudinal strains is robust. There is a need for higher-resolution 3D tagged MRI to achieve sufficient accuracy in radial strain quantification.
Article
Geography, Physical
Marion Genet, Anne-Laure Daniau, Florent Mouillot, Vincent Hanquiez, Sabine Schmidt, Valerie David, Muriel Georget, Fatima Abrantes, Pierre Anschutz, Franck Bassinot, Jerome Bonnin, Bernard Dennielou, Frederique Eynaud, David A. Hodell, Thierry Mulder, Filipa Naughton, Linda Rossignol, Polychronis Tzedakis, Maria Fernanda Sanchez-Goni
Summary: Marine microcharcoal records are valuable for understanding changes in biomass burning over multiple glacial cycles, but quantitative reconstructions require calibration studies of the fire-microcharcoal relationship. Analysis of sediment samples from the Iberian margin and Gulf of Cadiz reveals influences of water depth and distance from river mouth on microcharcoal concentrations, as well as a latitudinal variation primarily driven by burnt vegetation types on the adjacent continent.
QUATERNARY SCIENCE REVIEWS
(2021)
Article
Computer Science, Artificial Intelligence
Ezgi Berberoglu, Christian T. Stoeck, Sebastian Kozerke, Martin Genet
Summary: Cardiovascular magnetic resonance (CMR) imaging is the gold standard for assessing left-ventricular (LV) function non-invasively. Previous studies have shown the prognostic value of deformation metrics extracted from regular SSFP CMR images, although they have limitations in detecting myocardial torsion. Tagged CMR allows for the assessment of local myocardial deformation, including torsion, but is limited in quantifying radial strain. To overcome these limitations, a fusion of global shape motion from SSFP images and local deformation from tagged images is proposed. Joint analysis of SSFP and 3DTAG images provides better quantification of LV strain and twist compared to using either data source alone.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Engineering, Biomedical
Nicole Tueni, Jean-Marc Allain, Martin Genet
Summary: Due to structural heterogeneities within the tissue, the myocardium displays orthotropic material behavior. However, the link between microstructure and macroscopic mechanical properties is still unclear. This study aims to investigate the relative role of cardiomyocyte orientation variation and perimysium collagen sheetlet structure in the observed orthotropic symmetry of the myocardium. The results show the importance of sheetlet layers in ensuring the tissue's anisotropic response and suggest further analysis of the size effect in the myocardial tissue shear properties.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Computer Science, Interdisciplinary Applications
Haifeng Wang, Lei Fan, Jenny S. Choy, Ghassan S. Kassab, Lik Chuan Lee
Summary: Capillary transit time is an important factor in gas exchange between the heart and other organs. Researchers have developed a computational framework that can predict the hemodynamics of the entire coronary network and calculate capillary transit time using virtual tracers. The model predictions align with experimental measurements and indicate that coronary artery stenosis leads to longer capillary transit time.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2024)
Article
Computer Science, Interdisciplinary Applications
M. Genet, C. Patte, C. Fetita, P. -Y. Brillet, D. Chapelle
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2020)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)