Review
Biotechnology & Applied Microbiology
Matthew Crago, David S. S. Winlaw, Syamak Farajikhah, Fariba Dehghani, Sina Naficy
Summary: Pediatric pulmonary valve replacements (PPVRs) often have suboptimal biocompatibility and durability, leading to repeat operations and burdens for patients and parents. Biofouling and structural discrepancies due to somatic growth are important contributors to clinical failure. This review explores clinical experiences, physiological understandings, and bioengineering technologies to provide insight into the design requirements for next-generation PPVRs.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Hiroyuki Hara, Naoki Kanemitsu, Yuki Hori, Shingo Hirao
Summary: This case report describes a 64-year-old woman with pulmonary artery aneurysm and pulmonary stenosis with a quadricuspid pulmonary valve. Surgical intervention was successful and the patient had an uneventful postoperative course.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Biotechnology & Applied Microbiology
Aroj Bhattarai, Charlotte Anabell May, Manfred Staat, Wojciech Kowalczyk, Thanh Ngoc Tran
Summary: The mechanical behavior of the large intestine beyond the ultimate stress was investigated in this study. It was found that stretching beyond the ultimate stress could impair the tissue microstructure and weaken the functions of the large intestine. The study performed experiments on porcine large intestine and validated the results through numerical simulations, obtaining the hyperelastic characterization of the large intestine.
BIOENGINEERING-BASEL
(2022)
Article
Biophysics
Devin W. Laurence, Shuodao Wang, Rui Xiao, Jin Qian, Arshid Mir, Harold M. Burkhart, Gerhard A. Holzapfel, Chung-Hao Lee
Summary: This study investigates the impact of specimen dimensions on the mechanical behavior of biaxial characterizations. The results show that there are no significant differences in peak equibiaxial stretches across different specimen dimensions, but significant differences exist in the low-tensile modulus of the circumferential tissue direction.
JOURNAL OF BIOMECHANICS
(2023)
Article
Cardiac & Cardiovascular Systems
Parth M. Patel, David Zapata, William Qu, Mia Callahan, Nikita Rao, Michael Kelleman, Kirk R. Kanter, Paul J. Chai, Fawwaz R. Shaw, Subhadra Shashidharan, Joshua M. Rosenblum
Summary: The aim of this study was to identify the incidence and timing of dysfunction and failure of stented bioprosthetic valves in the pulmonary position in congenital heart disease patients. The study found that bovine pericardial valves implanted in older patients (Porcine group: 16-23 years, Pericardial group: 14-33 years) had higher peak gradients, while pericardial valves had a higher incidence of late pulmonary regurgitation. The incidence of valve dysfunction was higher in the pericardial group. Rating: 8 points.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
David W. Sutherland, Aisling McEleney, Matheus de Almeida, Masaki Kajimoto, Giselle Ventura, Brett C. Isenberg, Michael A. Portman, Scott E. Stapleton, Corin Williams
Summary: This study provides anatomical measurements and mechanical properties of porcine cardiovascular tissues, which are crucial for the development of pediatric heart valve replacements. The researchers also developed a novel method to measure tissue stiffness and validated it against a traditional testing method.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Keita Koseki, Sung-Han Yoon, Danon Kaewkes, Ofir Koren, Vivek Patel, Tarun Chakravarty, Mamoo Nakamura, Wen Cheng, Issei Komuro, Raj Makkar
Summary: The study found that CT-derived PAD is a significant prognostic factor in patients undergoing TAVR, and is independently associated with 2-year all-cause mortality.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Materials Science, Composites
Bin Yang, Yingying Shang, Zeliang Yu, Minger Wu, Youji Tao, Jiaxiang Qin
Summary: This article comprehensively investigates the mechanical properties of coated biaxial warp-knitted fabrics, including tensile strength, failure modes, creep elongation, tearing strength, and elastic constants. Experimental data offer a deeper and comprehensive understanding of the performance of these fabrics, which can be conveniently adopted in structural design.
JOURNAL OF REINFORCED PLASTICS AND COMPOSITES
(2022)
Article
Cardiac & Cardiovascular Systems
D. Bos, D. De Wolf, B. Cools, B. Eyskens, J. Hubrechts, D. Boshoff, J. Louw, S. Frerich, B. Ditkowski, F. Rega, B. Meyns, W. Budts, T. Sluysmans, M. Gewillig, R. Heying
Summary: Percutaneous pulmonary valve implantation (PPVI) has shown good hemodynamic results, but infective endocarditis (IE) remains a potential complication. A retrospective analysis of patient records in three Belgian tertiary centers revealed an IE incidence of 2.4% with a clear male predominance. Streptococcal species and Staphylococcus aureus were the main causative organisms in IE cases.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Mechanics
Lanxin Jiang, Shoune Xiao, Bing Yang, Guangwu Yang, Tao Zhu, Mingmeng Wang
Summary: This study proposes a bimodulus constitutive model suitable for two-dimensional braided carbon fiber composites, and investigates the deviation degrees of tensile and compressive moduli under different parameters by experiments and simulations. It provides a new theoretical basis for a deeper understanding of the mechanical properties of such composite materials.
COMPOSITE STRUCTURES
(2021)
Article
Engineering, Biomedical
Ruizhi Wang, Jeffrey M. Mattson, Yanhang Zhang
Summary: This study investigated the mechanical properties of the human descending thoracic aorta with aging and the role of collagen crosslinking. The results showed that the aorta stiffens with aging, especially in the longitudinal direction, leading to altered anisotropy. The constitutive modeling results suggested that excessive collagen crosslinking contributes to aortic stiffening through increased strain energy density.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Austen Hufton, Joshua S. Newman, Stevan S. Pupovac, Allan Mattia, Alan R. Hartman
Summary: This case report describes a rare occurrence of adult pulmonary valve regurgitation following congenital cardiac surgery, which was successfully treated with valve replacement surgery, leading to a favorable outcome without the need for further cardiac surgical interventions.
ANNALS OF THORACIC SURGERY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Alexander K. Reed, Julian A. Villaba, Duke E. Cameron, Jordan P. Bloom
Summary: This article reports a case of a 26-year-old asymptomatic woman with repaired tetralogy of Fallot and a bioprosthetic pulmonary valve, who presented with a large thrombosis occluding her right ventricular outflow tract and main pulmonary arteries. The choice of treatment modality was complicated by the patient's asymptomatic presentation, but a successful intervention was achieved through heparin infusion and surgical thrombectomy.
ANNALS OF THORACIC SURGERY
(2022)
Article
Materials Science, Multidisciplinary
Wei Zhang, Zhikang Zhu, Changyu Zhou, Xiaohua He
Summary: Experimental results show that commercially pure titanium biaxial tensile samples have higher strength than uniaxial samples, with equi-biaxial samples exhibiting the highest strength. Additionally, an increase in strain rate leads to a significant improvement in tensile strength. Fractographic analysis indicates that the shape and size of dimples are dependent on the load ratio and strain rate.
Article
Cardiac & Cardiovascular Systems
Maria Chiara Meucci, Silvia Malara, Steele C. Butcher, Kensuke Hirasawa, Frank van der Kley, Antonella Lombardo, Cristina Aurigemma, Enrico Romagnoli, Carlo Trani, Massimo Massetti, Francesco Burzotta, Jeroen J. Bax, Filippo Crea, Nina Ajmone Marsan, Francesca Graziani
Summary: This study explored the evolution of RV-PA coupling in patients with severe aortic stenosis undergoing TAVR and its prognostic impact. The findings suggest that post-TAVR RV-PA uncoupling is an independent predictor of long-term mortality, regardless of coupling before intervention. Patients with severe uncoupling had the highest risk of death.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Cardiac & Cardiovascular Systems
Rahi S. Alipour S. Symakani, Beatrijs Bartelds, Daphne Merkus, Ad J. J. C. Bogers, Yannick J. H. J. Taverne
Summary: Secondary tricuspid regurgitation (TR) can progress and lead to right ventricular failure and end-organ damage, despite treatment of the underlying disease. Surgical correction, though curative, has historically had poor outcomes due to delayed diagnosis and lack of clear surgical indications. The current guidelines are conservative and show inconsistencies, but there is a trend towards a more aggressive approach and emerging transcatheter options.
CARDIOLOGY IN REVIEW
(2023)
Article
Cardiac & Cardiovascular Systems
Kelly R. Voigt, Arjen L. Gokalp, Grigorios Papageorgiou, Ad J. J. C. Bogers, Johanna J. M. Takkenberg, Mostafa M. Mokhles, Jos A. Bekkers
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Stefan Roest, Marijke H. van der Meulen, Lennie M. Van Osch-Gevers, Ulrike S. Kraemer, Alina A. Constantinescu, Matthijs de Hoog, Ad J. J. C. Bogers, Olivier C. Manintveld, Pieter C. van de Woestijne, Michiel Dalinghaus
Summary: The study examined the outcomes of pediatric heart transplantations in the Netherlands since 1998. The results showed that children who undergo heart transplant have high survival rates up to 10 years post-transplantation, and most patients have excellent functional status despite common complications. However, waiting list mortality remains high, highlighting the limited availability of donors for this vulnerable patient group.
NETHERLANDS HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Wouter Bakhuis, Amir H. Sadeghi, Iris Moes, Alexander P. W. M. Maat, Sabrina Siregar, Ad J. J. C. Bogers, Edris A. F. Mahtab
Summary: This study aimed to investigate the clinical value of using the 3D VR technology, PulmoVR, for preoperative planning. The results showed that VR provided better insight into patient-specific anatomy and offered lung-sparing possibilities, with a 52% change in surgical plans and a 98% rate of radical resection.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cell & Tissue Engineering
Maria J. J. Hagelaars, Laura Rijns, Patricia Y. W. Dankers, Sandra Loerakker, Carlijn V. C. Bouten
Summary: This study reviews the role of microenvironment in the development of renal tubules and provides insights on how this knowledge can be used in biomaterial-based tubular engineering using computational models. Understanding the complex chemical, physical, and mechanical interactions between cells and their microenvironment is crucial for guiding renal tubulogenesis. The study highlights the importance of a reciprocal interaction between understanding and engineering to effectively regenerate kidney tissue function.
TISSUE ENGINEERING PART B-REVIEWS
(2023)
Article
Materials Science, Biomaterials
Elana M. Meijer, Suzanne E. Koch, Christian G. M. van Dijk, Renee G. C. Maas, Ihsan Chrifi, Wojciech Szymczyk, Paul J. Besseling, Lisa Pomp, Vera J. C. H. Koomen, Jan Willem Buikema, Carlijn V. C. Bouten, Marianne C. Verhaar, Anthal I. P. M. Smits, Caroline Cheng
Summary: This study reports the creation of a perfused human macrovessel model using human induced pluripotent stem cell (hiPSC)-derived vascular organoid cells on an electrospun polycaprolactone-bisurea (PCL-BU) 3D scaffold. The cells harvested from the vascular organoids can be cryopreserved and expanded without loss of cell purity and proliferative capacity. The cells show shear stress response and establish a functional barrier that self-restores after a thrombin challenge. The static bioreactor culture results in a biomimetic vascular bi-layer hierarchy under laminar flow.
Article
Chemistry, Multidisciplinary
Laura Rijns, Maria J. J. Hagelaars, Joost J. B. van der Tol, Sandra Loerakker, Carlijn V. C. Bouten, Patricia Y. W. Dankers
Summary: Epithelial cysts and organoids are multicellular hollow structures formed by correctly polarized epithelial cells. Control over the effective ligand concentration in synthetic dynamic supramolecular hydrogels can regulate epithelial polarity in 2D and 3D cultures. The results provide insights on engineering synthetic biomaterials for cell and organoid culture.
ADVANCED MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Jelle P. G. van der Ven, Marie Gunthel, Eva van den Bosch, Vivian P. Kamphuis, Nicolaas A. Blom, Johannes Breur, Rolf M. F. Berger, Ad J. J. C. Bogers, Laurens Koopman, Arend D. J. Ten Harkel, Vincent Christoffels, Willem A. Helbing
Summary: This study aims to characterize the response to perioperative injury in patients undergoing repair or pulmonary valve replacement for tetralogy of Fallot. The results show that there are differences in ventricular function and immune response after surgery between patients undergoing repair and those undergoing pulmonary valve replacement.
Article
Engineering, Biomedical
Tom C. L. Bracco Gartner, Ye Wang, Laurynas Leiteris, Iris van Adrichem, Judith Marsman, Marie Jose Goumans, Carlijn V. C. Bouten, Joost P. G. Sluijter, Jaap M. J. den Toonder, Willem J. L. Suyker, Jesper Hjortnaes
Summary: Cardiac fibroblasts in the ever-beating human heart remain quiescent due to the antifibrotic effect of cyclic strain conditions revealed by a novel platform for studying cardiac fibrosis-on-a-chip. This study provides insights into the mechanosensitive pathways and genes involved in the fibrogenic process, which can contribute to the development of new therapies against cardiac fibrosis.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Ethics
Anne-Floor J. de Kanter, Karin R. Jongsma, Carlijn V. C. Bouten, Annelien L. Bredenoord
Summary: Innovations in the field of Regenerative Medicine may soon allow for the replacement and re-growth of healthy tissues after injury or disease. One promising innovation is a regenerative valve implant, made from 'smart' and 'lifelike' materials, that can stimulate the re-growth of a healthy heart valve. However, the ethical implications and conceptual understanding of these materials are still unclear.
SCIENCE AND ENGINEERING ETHICS
(2023)
Article
Multidisciplinary Sciences
Janine Grolleman, Nicole C. A. van Engeland, Minahil Raza, Sepinoud Azimi, Vito Conte, Cecilia M. Sahlgren, Carlijn V. C. Bouten
Summary: Recent experimental evidence suggests that vimentin, an intermediate filament protein, plays a role in regulating cellular mechanical homeostasis. Vimentin-expressing cells adapt their cellular morphology and mechanics to changes in microenvironment stiffness, while vimentin-depleted cells lose this ability on short timescales but regain it on longer timescales. Additionally, vimentin-depleted cells compensate for the loss of vimentin by increasing collagen matrix synthesis and crosslinking.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Maaike Bril, Aref Saberi, Ignasi Jorba, Mark C. van Turnhout, Cecilia M. Sahlgren, Carlijn V. C. Bouten, Albert P. H. J. Schenning, Nicholas A. Kurniawan
Summary: This study presents a dynamic, cell-compatible, and reconfigurable hydrogel-based platform that allows reversible micrometer-scale changes in surface topography of the cellular environment using blue light stimulation. By investigating fibroblast response to controlled geometry actuations, the study reveals that fibroblasts reorganize their nucleus and focal adhesions in response to recurring topographical changes. This dynamic conditioning is associated with long-term maintenance of focal adhesions and epigenetic modifications.
Article
Cardiac & Cardiovascular Systems
J. P. G. van der Ven, V. P. Kamphuis, E. van den Bosch, D. Gnanam, C. Terol, A. J. J. C. Bogers, J. M. P. J. Breur, R. M. F. Berger, N. A. Blom, A. D. J. ten Harkel, L. Koopman, W. A. Helbing
Summary: This study aimed to explore the biological processes related to impaired ventricular function and recovery following Fontan palliations using a biomarker panel, as well as to describe changes in ventricular function across the Fontan palliation. Observational study was conducted in patients undergoing partial or total cavo-pulmonary connection surgeries. The results showed that the single ventricular longitudinal strain temporarily decreased in partial cavo-pulmonary connection patients, but not in total cavo-pulmonary connection patients. Several biomarkers were associated with post-operative stress and adaptation, but none were related to the outcome.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Cardiac & Cardiovascular Systems
Maximiliaan L. Notenboom, Reda Rhellab, Jonathan R. G. Etnel, Nova van den Bogerd, Kevin M. Veen, Yannick J. H. J. Taverne, Willem A. Helbing, Pieter C. van de Woestijne, Ad J. J. C. Bogers, Johanna J. M. Takkenberg
Summary: This study supports the use of aortic valve repair in clinical decision-making for children with aortic valve disease by compiling available evidence. The study found that long-term outcomes after pediatric aortic valve repair for stenosis are satisfactory and depend on the age at surgery.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wiebe G. Knol, Annemarie M. den Harder, Linda M. de Heer, Kalman Benke, Pal Maurovich-Horvat, Tim Leiner, Bela Merkely, Gabriel P. Krestin, Ad J. J. C. Bogers, Ricardo P. J. Budde
Summary: Routine CT-screening increases the rate of incidental findings, primarily by identifying more pulmonary findings requiring follow-up. Incidental findings are more prevalent in patients with a history of smoking, and preoperative CT may increase the yield of identifying lung cancer in these patients. Incidental findings, but not specifically the use of routine CT, are associated with delay of surgery.
EUROPEAN RADIOLOGY
(2023)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)
