Journal
JOURNAL OF BIOMECHANICS
Volume 46, Issue 16, Pages 2844-2847Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2013.09.002
Keywords
Tendinopathy; Tendon fatigue damage; Tendon extracellular matrix damage; Tendon overuse injury; Automated damage analysis; Edge detection analysis
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Funding
- NIAMS NIH HHS [R01 AR052743] Funding Source: Medline
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The accumulation of sub-rupture tendon fatigue damage in the extracellular matrix, particularly of type I collagen fibrils, is thought to contribute to the development of tendinopathy, a chronic and degenerative pathology of tendons. Quantitative assessment of collagen fibril alignment is paramount to understanding the importance of matrix injury to cellular function and remodeling capabilities. This study presents a novel application of edge detection analysis to calculate local collagen fibril orientation in tendon. This technique incorporates damage segmentation and stratification by severity which will allow future analysis of the direct effect of matrix damage severity on the cellular and molecular response. (C) 2013 Elsevier Ltd. All rights reserved.
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