Article
Biochemistry & Molecular Biology
Balazs Szabo, Balazs Gasz, Laszlo Adam Fazekas, Adam Varga, Levente Kiss-Papai, Orsolya Matolay, Zsofia Rezsabek, Mohammad W. Al-Smadi, Norbert Nemeth
Summary: The maturation of vascular grafts is influenced by blood flow characteristics. This study investigated the remodeling process of arterio-venous fistulas and loop-shaped venous grafts, along with 3D flow simulation. The results demonstrated the importance of blood flow distribution and pressure in vascular remodeling. These findings are valuable for microvascular research and quality control in microsurgical training.
Article
Surgery
Tamer Khafagy, Mohamed S. Abdelgawad, Ahmed Eleshra, Samer Regal, Ehab Saad
Summary: This report describes a surgical technique of converting arterio-venous graft or fistula to arterio-arterial vascular access for treating central venous occlusion. The procedure involves rerouting blood flow through a synthetic graft or vein and can be used for hemodialysis.
ANNALS OF VASCULAR SURGERY
(2021)
Article
Peripheral Vascular Disease
Sekar Natarajan, Jithin Jagan Sebastian
Summary: Upper thigh loop AVG is a reliable option for hemodialysis access, suitable for patients with failed upper limb access or central vein occlusion. Adjunctive procedures are crucial for maintaining patency.
JOURNAL OF VASCULAR ACCESS
(2023)
Article
Urology & Nephrology
Michael Allon, Gary R. Cutter, Carlton J. Young
Summary: This study found that access-related distal ischemia requiring intervention was rare. It was more common in women and patients with peripheral vascular disease or coronary artery disease. In some cases, a subsequent vascular access could be placed with a low likelihood of recurrent distal ischemia.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Urology & Nephrology
Mariana Murea, Carl R. Grey, Charmaine E. Lok
Summary: Shared decision-making (SDM) is important in vascular access planning for hemodialysis patients but is not widely practiced. There is a need to shift from a prescriptive approach to a patient-centered care model in this field.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Michael Allon, Alian Al-Balas, Carlton J. Young, Gary R. Cutter, Timmy Lee
Summary: In CKD patients with an eGFR less than 15 ml/min per 1.73 m2, placement of an AV graft instead of an AV fistula reduces the likelihood of catheter use at the initiation of dialysis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Peripheral Vascular Disease
Yanzhu Lin, Johannes Gahn, Kuheli Banerjee, Gergana Dobreva, Mahak Singhal, Alexandre Dubrac, Roxana Ola
Summary: This study investigates the role of PDGFB in AVM pathogenesis. The results show that disruption of EC Pdgfb-mediated PC recruitment and maintenance leads to capillary enlargement and AVM-like structures. Mechanistically, PDGFB maintains capillary EC size and caliber, limiting hemodynamic changes and regulating EC signaling activation. This study suggests that inducing or activating PDGFB signaling may be a viable therapeutic approach for treating vascular malformations.
Article
Urology & Nephrology
Michael Allon, Alian Al-Balas, Carlton J. Young, Gary R. Cutter, Timmy Lee
Summary: This study compared two strategies for the choice of initial vascular access in hemodialysis patients. The results showed that a more selective approach to arteriovenous fistula (AVF) placement can reduce the frequency of vascular access procedures and the cost of access management.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Chinmay Bhimaji Kulkarni, Patrik Sutphin, Shams Iqbal, Sanjeeva P. Kalva
Summary: Embolotherapy is the primary treatment for PAVMs, but a percentage of cases persist after embolization. Early identification and treatment of persistent PAVMs are crucial for preventing life-threatening complications. Technical challenges arise during repeat embolotherapy due to prior embolic devices and complex angioarchitecture. This article reviews patterns of persistence, factors affecting persistence, endovascular treatment techniques, and outcomes.
ACADEMIC RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yujia Qi, Marcus Roper
Summary: The arrangement and ratio of arterioles and venules in the cerebral cortex can impact the efficiency of energy delivery to neurons, with an optimal ratio balancing size and number of low-flow regions. Changes in vascular conductance can reshape these regions in complex ways, presenting geometric challenges for matching cortical perfusion with neuronal activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Medicine, General & Internal
Mariana Floria, Elena Diana Nafureanu, Diana-Elena Iov, Oana Sirbu, Mihaela Dranga, Anca Ouatu, Daniela Maria Tanase, Oana Bogdana Barboi, Vasile Liviu Drug, Mihail Dan Cobzeanu
Summary: Hereditary hemorrhagic telangiectasia is a rare autosomal dominant vascular disease characterized by mucosal and cutaneous telangiectasia and visceral arteriovenous malformations. Embolization of the afferent arteries of the malformations is the preferred treatment, and routine screening and long-term follow-up are essential.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Chung-Kuan Wu, Chia-Hsun Lin
Summary: The study evaluated the integration of strict vascular access blood flow surveillance with routine clinical monitoring in predicting vascular access stenosis in chronic hemodialysis patients. The results showed that blood flow surveillance models can accurately predict stenosis in arteriovenous fistula patients, improving early detection and treatment of stenosis.
JOURNAL OF NEPHROLOGY
(2023)
Review
Urology & Nephrology
Tushar J. Vachharajani, Jonathan J. Taliercio, Evamaria Anvari
Summary: Hemodialysis remains the most common treatment for kidney failure in the United States, with innovations in vascular access care greatly impacting practice patterns. Endovascular devices for creating arteriovenous fistulas offer a solution to barriers in initiating maintenance hemodialysis, while bioengineered grafts and drug-coated devices show promise in improving vascular access outcomes. The development of innovative techniques for managing central vein stenosis can potentially help patients with exhausted vasculature remain on hemodialysis.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Multidisciplinary Sciences
Fabian Vega-Tapia, Estefania Penaloza, Bernardo J. Krause
Summary: This study showed that the arterial-venous differences of primary endothelial cells from human umbilical artery and vein are preserved in vitro, with differences in nitric oxide- and hypoxia-related genes. The findings were supported by transcriptomic data analysis and functional enrichment analysis, confirming the maintenance of key vascular pathways post-transcriptionally regulated in vitro.
Article
Immunology
Jaya Mary Thomas, Dhakshmi Sasankan, Sumi Surendran, Mathew Abraham, Arumugam Rajavelu, Chandrasekharan C. Kartha
Summary: Through high-throughput RNA sequencing analysis and immunostaining, researchers found deregulated expression of genes related to retinoic acid signaling in AVM nidus and its associated astrocytes. This abnormal expression includes ALDH1A2, a key enzyme in retinoic acid signaling, and CYR61, a regulator of angiogenesis. Abnormal astrocytes associated with AVM nidus were also observed, suggesting a potential trigger for the development of cerebral AVM.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Peripheral Vascular Disease
Simon Helleputte, Bart Spronck, James E. E. Sharman, Luc Van Bortel, Patrick Segers, Patrick Calders, Bruno Lapauw, Tine De Backer
Summary: The central blood pressure values estimated by radial artery tonometry in T1DM patients depend significantly on the method used for calibration of the radial waveforms. Using brachial MAP/DBP calibration resulted in higher central blood pressure compared to using brachial SBP/DBP calibration, indicating the importance of calibration approach for accurate estimation of central blood pressure using noninvasive methods.
JOURNAL OF HYPERTENSION
(2023)
Article
Engineering, Biomedical
Matthias Van Impe, Lisa Caboor, Violette Deleeuw, Margie Olbinado, Julie De Backer, Patrick Sips, Patrick Segers
Summary: This study successfully provides a biomechanical reference for the circulation in adult zebrafish by establishing 3D models of the cardiovascular system. By providing reference values for biomechanical stimuli in wild-type animals and a pipeline for image-based animal-specific computational biomechanical models, this study contributes to a more comprehensive understanding of the role of altered biomechanics and hemodynamics in heritable cardiovascular pathologies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Annette Caenen, Stephanie Bezy, Aniela Petrescu, Annegret Werner, Jens-Uwe Voigt, Jan D'hooge, Patrick Segers
Summary: Shear wave elastography (SWE) is a promising technique for assessing myocardial stiffness non-invasively. The study found that the transmural wave speed gradient can distinguish between intrinsic myocardial stiffening and stiffening caused by increased pressure. This gradient may have potential as a new diagnostic parameter for future clinical studies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Biophysics
Lise Gheysen, Lauranne Maes, Nele Famaey, Patrick Segers
Summary: This study investigates whether pulse wave velocity (PWV) can guide in determining appropriate parameter values for the Gasser-Ogden-Holzapfel (GOH) constitutive model. The results show that PWV80 and PWV110 are complementary measures that can reduce the parameter space in arterial models, particularly for media- and collagen-related parameters.
JOURNAL OF BIOMECHANICS
(2023)
Article
Cardiac & Cardiovascular Systems
Kristian Sorensen, Solveig Fadnes, Luc Mertens, Matthew Henry, Patrick Segers, Lasse Lovstakken, Siri Ann Nyrnes
Summary: This study developed and validated the calculation of intraventricular pressure difference (IVPD) using blood speckle-tracking (BST) in children and investigated its potential role in assessing diastolic function. The results showed that BST is highly feasible and provides information on diastolic suction and early filling in children with heart disease. The IVPD was significantly reduced in children with dilated cardiomyopathies (DCMs) and hypertrophic cardiomyopathies (HCMs) compared to controls.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Physiology
Sandra Sjostrand, Alice Widerstrom, Ingrid Svensson, Patrick Segers, Tobias Erlov, Asa Ryden Ahlgren, Magnus Cinthio
Summary: Longitudinal motion of the carotid arterial wall, as measured with ultrasound, is a promising indicator of vascular health, but its underlying mechanisms are not fully understood. Blood pressure has a strong relation to the antegrade longitudinal displacement in early systole. Tapered geometry and intramural friction between two parts of a vessel wall also influence the longitudinal displacement.
PHYSIOLOGICAL REPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Jordi Alastruey, Peter H. Charlton, Vasiliki Bikia, Birute Paliakaite, Bernhard Hametner, Rosa Maria Bruno, Marijn P. Mulder, Samuel Vennin, Senol Piskin, Ashraf W. Khir, Andrea Guala, Christopher C. Mayer, Jonathan Mynard, Alun D. Hughes, Patrick Segers, Berend E. Westerhof
Summary: Arterial pulse waves (PWs), such as blood pressure and photoplethysmogram (PPG) signals, are rich sources of information for assessing vascular age and identifying individuals at elevated cardiovascular risk. This review explores the possibilities and limitations of reduced-order biophysical models and theoretical and empirical methods for analyzing PW signals and extracting clinically relevant information. Detailed mathematical derivations are provided, demonstrating the relationships between these models and methods. Suggestions for future research are also outlined to fully utilize the potential of modeling and analyzing PW signals for accurate vascular age assessment.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Edward Horton, Bryce Johnson, Mahesh Vidula, Soumya Kondaveety, Srinivas Denduluri, Patrick Segers, Howard C. Herrmann, Julio A. Chirinos
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Biophysics
Lise Gheysen, Lauranne Maes, Nele Famaey, Patrick Segers
Summary: This study developed a computational model to simulate the thickening process of dissected aorta wall, considering the effects of stress and inflammation on elastin and collagen. The results showed that the model with transient inflammation pattern was able to reproduce the clinically observed membrane thickening rates, diameter expansion rates, and adaptations in microstructure.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Marija Smoljkic, Jos Vander Sloten, Patrick Segers, Nele Famaey
Summary: This study provides an estimation method for material parameters in the study of continuous diseases using non-invasively measured human carotid artery data. Both different material models are able to simulate the behavior of the arteries, but the structural model provides more realistic results. Gender has a greater impact on mechanical properties, and there is a stiffening trend in arteries with age, body mass index, and blood pressure, although not strong. Meanwhile, there is a high intersubject variability.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Federico Cane, Lucas Delcour, Alberto Cesare Luigi Redaelli, Patrick Segers, Joris Degroote
Summary: Cardiovascular diseases can lead to chronic pathological conditions, and early diagnosis is crucial for treatment. Image-based patient-specific Computational Fluid Dynamics (CFD) models provide detailed information about cardiac blood flow, supporting clinicians in diagnosis and treatment planning. This study developed a Chimera-based method to build a patient-specific 3D CFD model of the heart, considering the challenges of left ventricle and mitral valve motion. The results suggest that the mitral valve plays a crucial role in intraventricular flow development.
FRONTIERS IN MEDICAL TECHNOLOGY
(2022)
Meeting Abstract
Peripheral Vascular Disease
Simon Helleputte, Bart Spronck, James Sharman, Luc Van Bortel, Patrick Segers, Patrick Calders, Bruno Lapauw, Tine de Backer
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Simon Helleputte, Bart Spronck, James Sharman, Luc Van Bortel, Patrick Segers, Patrick Calders, Bruno Lapauw, Tine de Backer
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Hasan Obeid, Vasiliki Bikia, Catherine Fortier, Mathilde Pare, Patrick Segers, Nikos Stergiopulos, Mohsen Agharazii
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Hasan Obeid, Vasiliki Bikia, Catherine Fortier, Mathilde Pare, Patrick Segers, Nikos Stergiopulos, Mohsen Agharazii
JOURNAL OF HYPERTENSION
(2022)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)