Article
Biochemistry & Molecular Biology
Taisuke Yamauchi, Megumi Miyabe, Nobuhisa Nakamura, Mizuho Ito, Takeo Sekiya, Saki Kanada, Rina Hoshino, Tatsuaki Matsubara, Ken Miyazawa, Shigemi Goto, Keiko Naruse
Summary: This study investigated the effects of glucose-dependent insulinotropic polypeptide (GIP) on force-induced bone remodeling during orthodontic tooth movement. The results suggest that GIP promotes osteoblast formation and suppresses osteoclasts in force-induced bone remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Yukun Jiang, Yuzhe Guan, Yuanchen Lan, Shuo Chen, Tiancheng Li, Shujuan Zou, Zhiai Hu, Qingsong Ye
Summary: The Piezo1 channel plays a critical role in mediating bone formation and osteoclastic activities during orthodontic tooth movement, particularly on the tension side. Inhibition of Piezo1 function leads to reduced expression of osteogenesis-associated transcription factors and disruptions in bone remodeling processes.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sinan Sen, Ralf Erber
Summary: During orthodontic tooth movement, neuronal guidance molecules (NGMs), particularly Semaphorins, ephrins, and Eph receptors, have been identified to play important roles in bone remodeling. However, research on the functions of NGMs during orthodontic tooth movement is currently limited, and further studies are needed to fully understand their significance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Ruojing Liu, Li Huang, Xiaoyue Xiao, Yuzhe Guan, Yukun Jiang, Xing Yin, Shujuan Zou, Qingsong Ye
Summary: Corticotomy is an effective method to accelerate orthodontic tooth movement by promoting bone turnover and tissue remodeling. In a mouse model study, it was found that corticotomy can accelerate tooth movement by promoting osteogenic and proliferative activity, and eliminating root resorption through upregulating the Wnt signal pathway.
Review
Dentistry, Oral Surgery & Medicine
S. Chaushu, Y. Klein, O. Mandelboim, Y. Barenholz, O. Fleissig
Summary: The review critically summarizes the immune processes involved in orthodontic tooth movement (OTM) inflammation and provides insights into the relationship between classical inflammation and clinical OTM phases. Recent studies highlight the existence of a typical innate immune response in OTM, with partial resolution observed in the lag phase. Future studies are needed to further uncover cellular and molecular immune targets for developing strategies to control OTM through modulation of the inflammatory process.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Cell Biology
Mingrui Zhai, Shuyue Cui, Lan Li, Chen Cheng, Zijie Zhang, Jiani Liu, Fulan Wei
Summary: Lactate can respond to mechanical stimulus during orthodontic tooth movement and has an impact on the alveolar bone remodeling. The regulatory effects of lactate are mediated by histone lactylation. Lactate is a critical modulator for alveolar bone remodeling during orthodontics.
Article
Dentistry, Oral Surgery & Medicine
Yugui Du, Kai Yang
Summary: Objective: This study aimed to investigate the role of Piezo1 in alveolar bone remodeling during orthodontic tooth movement (OTM). The results suggest that Piezo1 plays a crucial role in alveolar bone remodeling during OTM, and the Wnt/Ca2+ signaling pathway may be involved in this process.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Engineering, Biomedical
Delong Jiao, Jing Wang, Wenting Yu, Ke Zhang, Ning Zhang, Lingyan Cao, Xinquan Jiang, Yuxing Bai
Summary: This study evaluated the use of biocompatible gelatin reduced graphene oxide (GOG) to accelerate orthodontic tooth movement. The in vivo experiments on a mouse model showed that GOG injection promoted bone resorption and neovascularization, resulting in accelerated tooth movement. In vitro experiments demonstrated the good biocompatibility of GOG in bone marrow stromal stem cells (BMSCs) and confirmed that GOG injection did not affect the survival and life of animals. Furthermore, the study found that GOG-stimulated BMSCs regulated osteoclastogenesis and angiogenesis, with the PERK pathway playing an important role.
BIOACTIVE MATERIALS
(2022)
Review
Medicine, Research & Experimental
Yuming Chen, Chao Zhang
Summary: Orthodontic tooth movement relies on the remodeling process in periodontium, which is regulated by noncoding RNAs. These ncRNAs play a role in maintaining periodontal homeostasis and transducing mechanical load to modulate intracellular genes. They are involved in different biological processes throughout orthodontic tooth movement, such as cell proliferation, differentiation, autophagy, inflammation, immune, and neurovascular responses.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Jie Zhou, Yanlin Zhu, Dongqing Ai, Mengjiao Zhou, Han Li, Yiru Fu, Jinlin Song
Summary: Low-intensity pulsed ultrasound (LIPUS) can improve orthodontic tooth movement and alveolar bone remodeling by promoting the interaction between osteoblasts and osteoclasts, thus enhancing the effectiveness of orthodontic treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biology
Hyeran Helen Jeon, Jessica Kang, Jiahui (Madelaine) Li, Douglas Kim, Gongsheng Yuan, Nicolette Almer, Min Liu, Shuying Yang
Summary: The effects of IFT80 deletion in osteocytes on orthodontic and physiological bone remodeling were investigated, and it was found that the deletion did not significantly impact these processes.
Article
Immunology
Yehuda Klein, Offir Levin-Talmor, Jaime Garber Berkstein, Sharon Wald, Yaron Meirow, Avi Maimon, Avi Leibovich, Yechezkel Barenholz, David Polak, Stella Chaushu
Summary: The study investigated the role of RvD1 in acute and prolonged sterile inflammation and bone remodeling, and found that RvD1 significantly inhibited bone remodeling and reduced inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sharmin Sultana, Norma Ab Rahman, Siti Lailatul Akmar Zainuddin, Basaruddin Ahmad
Summary: This clinical trial compared the time required to complete the levelling and alignment stage in severe maxillary malocclusion cases with premolar extraction using the flapless piezocision procedure. The study found that the piezocision group had a significantly shorter time to complete the levelling and alignment stage compared to the control group. The piezocision group also experienced greater reduction in irregularity index and faster alignment rate.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Sinan Sen, Christopher J. Lux, Ralf Erber
Summary: Mechanical forces can regulate the expression of Semaphorin 3A, its receptors, and Osterix, affecting bone cell differentiation and remodeling during orthodontic therapy. Semaphorin 3A enhances osteogenic marker gene expression in osteoblasts potentially through pathways involving Rac1GTPase and beta-catenin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Qian Wang, Jie Zhang, Guang Yao, Wenhao Lou, Tianyao Zhang, Zihan Zhang, Maowen Xie, Xingyi Gan, Taisong Pan, Min Gao, Zhihe Zhao, Hulin Zhang, Jun Wang, Yuan Lin
Summary: This study proposes an occlusion-activated electromechanical synergistic dental aligner that can convert occlusal energy into a piezo-excited alternating electric field to accelerate orthodontic tooth movement. Experimental results show significant orthodontic effects in young and aged rats, leading to improved orthodontic efficiency. This work has great potential for personalized and effective treatment for malocclusions, greatly reducing the suffering of the long orthodontic course.
Article
Dentistry, Oral Surgery & Medicine
Lucas Cardinal, Gabriela da Rosa Zimermann, Fausto Medeiros Mendes, Ildeu Andrade, Dauro Douglas Oliveira, Gladys Cristina Dominguez
Summary: This study evaluated the effects of rapid maxillary expansion on buccal bone thickness and dehiscence in patients with unilateral cleft lip and palate. The results showed that rapid maxillary expansion led to a decrease in posterior buccal bone volume.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2022)
Article
Immunology
Thiago Vinicius Avila, Zelia Menezes-Garcia, Raquel Duque do Nascimento Arifa, Frederico Marianetti Soriani, Alexandre de Magalhaes Vieira Machado, Mauro Martins Teixeira, Caio Tavares Fagundes, Daniele G. Souza
Summary: Cancer chemotherapy and radiotherapy can cause mucositis, with stem cell damage and inflammation in the gastrointestinal tract. This study found that circulating free CpG-DNA increases during chemotherapy and that TLR9 activation is crucial for the transcription of NLRP3 inflammasome and the release of IL-1 beta, playing a central role in the development of intestinal mucositis induced by irinotecan. Antagonizing TLR9 may be a new therapeutic approach for limiting irinotecan-induced intestinal inflammation.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Article
Biochemistry & Molecular Biology
Daiane Boff, Remo Castro Russo, Helena Crijns, Vivian Louise Soares de Oliveira, Matheus Silverio Mattos, Pedro Elias Marques, Gustavo Batista Menezes, Angelica Thomaz Vieira, Mauro Martins Teixeira, Paul Proost, Flavio Almeida Amaral
Summary: This study tested the anti-inflammatory effect of CXCL9(74-103) in Klebsiella pneumoniae-induced pneumonia. The treatment with CXCL9(74-103) reduced neutrophil migration, decreased the production of IL-1 beta, and improved lung function in infected mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Michelle A. A. Sugimoto, Luiza O. O. Perucci, Luciana P. P. Tavares, Mauro M. M. Teixeira, Lirlandia P. Sousa
Summary: COVID-19 is a multisystem disease associated with an imbalance between the coagulation and fibrinolytic systems. The dysregulation of fibrinolysis contributes to thrombosis risk and exacerbated inflammation in severe cases. Understanding the interplay between fibrinolysis and inflammation resolution is crucial for managing COVID-19.
CURRENT DRUG TARGETS
(2022)
Article
Biochemistry & Molecular Biology
Vivian Louise Soares de Oliveira, Emilie Pollenus, Nele Berghmans, Celso Martins Queiroz-Junior, Marfa Blanter, Matheus Silverio Mattos, Mauro Martins Teixeira, Paul Proost, Philippe E. Van den Steen, Flavio Almeida Amaral, Sofie Struyf
Summary: In a murine model of ARDS, the absence of CCR2 leads to increased pulmonary leukocytes, enhanced neutrophil influx, and decreased monocyte and interstitial macrophage numbers. However, the time needed to control inflammation was comparable between CCR2(+/+) and CCR2(-/-) mice. Interestingly, CCR2(-/-) mice showed higher numbers and increased proliferation of alveolar macrophages, which had a more pronounced M2 profile.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Thiago Henrique Caldeira Oliveira, Vincent Vanheule, Sofie Vandendriessche, Fariba Poosti, Mauro Martins Teixeira, Paul Proost, Mieke Gouwy, Pedro Elias Marques
Summary: The study suggests that interfering with chemokine function using a peptide called MIG30 can disrupt neutrophil recruitment to the injured liver during ischemia-reperfusion injury (IRI). Mice treated with MIG30 showed significantly lower liver injury and dysfunction, as well as reduced levels of chemokines and proinflammatory cytokines. This indicates that MIG30 holds promise as a potential treatment strategy for liver IRI and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Dermatology
Maria Cecilia Campos Canesso, Puebla Cassini-Vieira, Camila Francisco Moreira, Suzanne Luong, Milene Alvarenga Rachid, Flaviano Santos Martins, Mauro Martins Teixeira, Angelica Thomas Vieira, Charles Reay Mackay, Luciola Silva Barcelos
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Nutrition & Dietetics
Debora Romualdo Lacerda, Albena Nunes-Silva, Ana Leticia Malheiros Silveira, Katia Anunciacao Costa, Debora Fernandes Rodrigues, Michele Macedo Moraes, Vanessa Pinho, Gustavo Batista Menezes, Mauro Martins Teixeira, Samuel Penna Wanner, Danusa Dias Soares, Adaliene Versiani Matos Ferreira
Summary: This study investigated the effect of acute exercise on the inflammatory response in adipose tissue of lean and obese mice. Acute exercise enhanced the levels of IL-6 and tumor necrosis factor-a in the adipose tissue of lean mice, while no changes were observed in proinflammatory cytokines in obese mice. However, the levels of IL-13, IL-4, and IL-10 were increased in obese mice after exercise. These findings suggest that acute exercise promotes an inflammatory response in adipose tissue of lean mice, but elicits an anti-inflammatory response in adipose tissue of obese mice.
Article
Immunology
Andrew Bacon, Mauro Teixeira, Vivian Costa, Peter Bone, Jennifer Simmons, Jeffrey Drew
Summary: Here we developed a thermally stable, orally administered Zika vaccine using engineered AdHu5. This vaccine, formulated with a mix of sugars and modified amino acids and protected by an enteric coated capsule, induced immune responses and reduced viral counts in mice and non-human primates. It has advantages over current vaccines that require cold storage and parenteral administration.
Review
Virology
Rosangela Santos Pereira, Francoise Camila Pereira Santos, Priscilla Rodrigues Valadares Campana, Vivian Vasconcelos Costa, Rodrigo Maia de Padua, Daniele G. Souza, Mauro Martins Teixeira, Fernao Castro Braga
Summary: This article reviews studies on the anti-ZIKV activity of natural products (NPs) and derivatives from 1997 to 2022. The majority of the studies used NPs from plants (82.4%) or semisynthetic/synthetic derivatives, followed by fungi (3.1%), bacteria (7.6%), animals (1.2%), and marine organisms (1.9%). Different classes of NPs, such as polyphenols, triterpenes, alkaloids, and steroids, have been reported to exhibit anti-ZIKV activity. NPs mainly act at the stages of viral adsorption and internalization, and some compounds show high selectivity index values. However, further research is needed to understand their mechanisms of action and evaluate their safety and efficacy in animal models.
Article
Immunology
Maria Elena Romero-Ibarguengoitia, Diego Rivera-Salinas, Riccardo Sarti, Riccardo Levi, Maximiliano Mollura, Arnulfo Garza-Silva, Andrea Rivera-Cavazos, Yodira Guadalupe Hernandez-Ruiz, Irene Antonieta Barco-Flores, Arnulfo Gonzalez-Cantu, Miguel Angel Sanz-Sanchez, Milton Henriques Guimaraes Junior, Chiara Pozzi, Riccardo Barbieri, Devany Paola Morales-Rodriguez, Mauro Martins Texeira, Maria Rescigno
Summary: This study evaluated the real-life efficacy of six different vaccines against SARS-CoV-2 and found that mRNA vaccines had the highest antibody levels during follow-up. Infection before vaccination and after complete vaccination scheme correlated with higher antibody titers. The CoronaVac vaccine was found to lower the risk of infection in the presence of certain comorbidities.
Editorial Material
Microbiology
Andre Talvani, Mauro Martins Teixeira
Article
Nutrition & Dietetics
Katia Anunciacao Costa, Marina Chaves de Oliveira, Leticia Maria de Souza Cordeiro, Cynthia Honorato Val, Fabiana Simao Machado, Simone Odilia Antunes Fernandes, Valbert Nascimento Cardoso, Mauro Martins Teixeira, Ana Leticia Malheiros Silveira, Adaliene Versiani Matos Ferreira
Summary: This study aims to evaluate the effects of a high-refined carbohydrate (HC) diet on small intestine changes. Male BALB/c mice were fed an HC diet for 8 weeks, and it was found that although there were no significant differences in body weight gain, mice fed the HC diet exhibited adiposity and metabolic alterations. However, there were no significant changes observed in intestinal integrity, tight junction protein expression, intestinal permeability, and bacterial translocation.
Article
Dentistry, Oral Surgery & Medicine
Eduardo Murad Villoria, Bernardo Quiroga Souki, Flavio Lucena Antunes, Marina Araujo Leite Assis, Ildeu Andrade Junior, Dauro Douglas Oliveira, Rodrigo Villamarim Soares
Summary: The aim of this study was to analyze the craniofacial morphology of unilateral cleft lip and palate (UCLP) patients at two stages of skeletal maturation using 3D analysis. Cone-beam computed tomography scans were collected from 52 UCLP patients and 15 craniofacial landmarks were identified for measurement. The results showed that pubertal patients had greater maxillary retrusion and posterior cranial base length, as well as increased upper facial height.
BRAZILIAN ORAL RESEARCH
(2023)
Article
Respiratory System
Andrea L. Bastos, Gilda A. Ferreira, Marcelo Mamede, Eliane V. Mancuzo, Mauro M. Teixeira, Flavia P. S. T. Santos, Cid S. Ferreira, Ricardo A. Correa
Summary: This study investigated the correlation of HRCT findings with pulmonary metabolic activity in patients with SSc-associated ILD by using F-18-FDG PET/CT and inflammatory markers. The results showed that there was a correlation between HRCT patterns and metabolic activity. Furthermore, higher levels of inflammatory markers were found in SSc patients compared to controls. The study also highlighted the importance of fibroblast activity in areas with ground-glass opacity on HRCT scans.
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2022)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)
