Article
Orthopedics
Zakary Wankier, Carolyn Taylor, Alex Drew, Erik Kubiak, Jayant Agarwal, Sarina Sinclair
Summary: This study utilized CT imaging and three-dimensional modeling techniques to analyze bone remodeling around a percutaneous osseointegrated implant in transfemoral amputees. Results showed increases in cortical bone area and thickness around the implant at 52 weeks postoperatively, with minimal changes in medullary canal parameters.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Engineering, Biomedical
Armin Omidvar Ghaziani, Reza Soheilifard, Sara Kowsar
Summary: Osseointegrated trans-femoral fixations have been utilized as an alternative to conventional sockets, however, the dissimilarity in mechanical properties has led to issues in bone adaptation. This study proposes fixations made of functionally graded materials (FGMs) and reveals significant advantages over conventionally used Titanium fixtures. The direction of gradation in FGMs plays a crucial role in bone remodeling behavior, with radial FGMs with low-stiffness outer layers showing improved bone adaptation.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Maohua Chen, Menghuan Li, Xijiao Ren, Fei Zhou, Yanan Li, Lu Tan, Zhong Luo, Kaiyong Cai, Yan Hu
Summary: A nanoengineered composite coating was developed to improve the in situ osseointegration of a Ti implant for osteoporotic fracture repair. The coating inhibited STING in endothelial cells to stimulate the formation of Type H vessels. Galvanotaxis recruited endothelial cells and mesenchymal stem cells to the implant surface, where released narigenin upregulated eNOS in recruited endothelial cells under ROS stimulation, leading to enhanced local angiogenesis. Coordinately released DNFzns abolished STING expression in endothelial cells to transform the newly formed vessels into Type H vessels, thereby promoting the osseointegration of Ti implants.
Article
Orthopedics
Robin Atallah, David Reetz, Nico Verdonschot, Marinus de Kleuver, Jan Paul M. Frolke, Ruud A. Leijendekkers
Summary: This study compared two groups of patients with transfemoral amputation treated with different surgical techniques and implant designs, and found that changes to treatment can reduce the incidence of soft tissue infections and stoma-related complications. However, the use of a shallower stoma and titanium implant was associated with an increased risk of surgical site infections before stoma creation. Serious complications such as deep implant infection were rare in both groups during the 2-year follow-up period.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Yingying Sun, Jinying Xu, Shuang Lv, Ziran Xu, Lisha Li, Yan Li, Yulin Li
Summary: Percutaneous osseointegrated prostheses have improved the quality of life for amputees, but maintenance remains challenging. Bone resorption and component breakage are major problems. A novel osseointegration implant was designed by changing the bone-implant contact area. The study found that the external implant induced intramedullary bone regeneration and increased cortical bone density.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Nicholas L. Deep, Brian J. Johnson, Emily Kay-Rivest, Matthew L. Carlson, David R. Friedmann, Colin L. W. Driscoll, J. Thomas Roland, Daniel Jethanamest
Summary: This report provides details on modifications made to the OSIA bone conduction hearing implant surgery to minimize wound complications.
Article
Neurosciences
Slawomir Winiarski, Alicja Rutkowska-Kucharska, Mateusz Kowal
Summary: The study utilized the Symmetry Function to evaluate gait asymmetries in patients with unilateral trans-femoral amputation, with significant side deviations observed in the pelvis and hip joints throughout the gait cycle.
Article
Otorhinolaryngology
Tiffany Peng Hwa, Garrett Locketz, Michael J. Ruckenstein
Summary: The study reported the experience of using a novel minimally invasive surgical technique for implantation of a fully implantable active bone conduction implant, showing that the minimally invasive approach had potential benefits of shorter operative time, low risk for intra- and postoperative complications, and rapid healing.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Review
Orthopedics
Chiara Bregoli, Carlo Alberto Biffi, Kavin Morellato, Emanuele Gruppioni, Matteo Primavera, Michele Rampoldi, Mario Lando, Roberto Adani, Ausonio Tuissi
Summary: Digital trauma amputations and digital agenesis significantly affect the functionality and appearance of the hand. Autologous reconstruction is the most effective treatment, but for patients who cannot undergo microsurgery or transplantation, osseointegrated finger prostheses offer a promising alternative.
ORTHOPAEDIC SURGERY
(2022)
Article
Multidisciplinary Sciences
Ting Zhou, Jirapa Wongpairojpanich, Maytha Sareethammanuwat, Charukrit Lilakhunakon, Borvornwut Buranawat
Summary: This study analyzed the effects of single posterior implant restorations on bite force redistribution, showing that implant-supported prostheses had lower bite force compared to natural teeth initially, but increased over time to reach similar levels. Both unilateral and bilateral missing teeth restorations significantly improved bite force, with a greater discrepancy in bite force observed in subjects with bilateral defects.
Article
Biophysics
Basil Mathai, Santanu Dhara, Sanjay Gupta
Summary: This study aimed to develop an orthotropic bone remodelling algorithm for evaluating peri-prosthetic bone adaptation in uncemented implanted femur. The orthotropic directionality, based on principal stress directions, was found to be consistent with trabecular orientation. Despite reasonable agreement in peri-prosthetic bone density distributions, there were quantitative differences between the isotropic and orthotropic models.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Biophysics
Basil Mathai, Santanu Dhara, Sanjay Gupta
Summary: This study aimed to develop an orthotropic bone remodelling algorithm for evaluation of peri-prosthetic bone adaptation in the uncemented implanted femur. The algorithm was tested on intact femur models to verify predicted results, and compared with an isotropic formulation. Results showed differences in bone directionality and density predictions between the two models, highlighting the influences of bone orthotropy and mechanical stimulus in the adaptation process.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Engineering, Biomedical
Bastian Welke, Christof Hurschler, Michael Schwarze, Eike Jakubowitz, Horst -Heinrich Aschoff, Marcus Oergel
Summary: This cross-sectional study compared the gait performance and quality of life between patients treated with bone-anchored prosthesis systems and those treated with conventional socket-suspended prostheses. The results showed no significant differences in quality of life, daily mobility, and gait performance between the two groups, with the only notable difference being a wider step width in the socket-suspended group. The study suggests that the individual capabilities, rather than the type of treatment, play a more significant role in determining functional capabilities and perceived quality of life for patients.
CLINICAL BIOMECHANICS
(2023)
Article
Rehabilitation
Brecca M. M. Gaffney, Hope C. Davis-Wilson, Mohamed E. Awad, James Tracy, Danielle H. Melton, Guy Lev, Jason W. Stoneback, Cory L. Christiansen
Summary: This study evaluated the effect of lower-limb prosthesis osseointegration on physical activity, showing that participants increased daily steps, stepping time, average step cadence, and maximum cadence per walking bout one year following osseointegration compared to before.
DISABILITY AND REHABILITATION
(2023)
Article
Orthopedics
Benjamin W. Hoyt, Alex E. Lundy, DesRaj M. Clark, Donald Colantonio, Scott M. Tintle, Benjamin K. Potter
Summary: The study found a strong correlation between CT HU and DEXA T-score, which decreased with longer intervals between the two scans. By analyzing HUs thresholds, low BMD and osteoporosis can be accurately identified.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2021)
Article
Engineering, Biomedical
Thomas Anijs, Sanne Eemers, Yukihide Minoda, David Wolfson, Nico Verdonschot, Dennis Janssen
Summary: This study validated postoperative bone response using finite element analysis and strain-adaptive remodeling theory in total knee arthroplasty. Similar trends were observed in bone remodeling between computational and clinical data in proximal regions, but large differences were found in distal regions. Further research is recommended to optimize bone remodeling distal to the tibial baseplate.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Orthopedics
Robin Atallah, David Reetz, Nico Verdonschot, Marinus de Kleuver, Jan Paul M. Frolke, Ruud A. Leijendekkers
Summary: This study compared two groups of patients with transfemoral amputation treated with different surgical techniques and implant designs, and found that changes to treatment can reduce the incidence of soft tissue infections and stoma-related complications. However, the use of a shallower stoma and titanium implant was associated with an increased risk of surgical site infections before stoma creation. Serious complications such as deep implant infection were rare in both groups during the 2-year follow-up period.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Review
Engineering, Biomedical
Vera G. M. Kooiman, Eline S. van Staveren, Ruud A. Leijendekkers, Jaap H. Buurke, Nico Verdonschot, Erik C. Prinsen, Vivian Weerdesteyn
Summary: This review examines the characteristics, protocols, aims, and outcome measures used during prosthesis prototype testing on individuals with a transfemoral amputation. The results indicate significant variations in research protocols and outcome measures, highlighting the need for a core set of reported characteristics, testing protocols, and outcome measures to evaluate prosthetic developments.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Article
Orthopedics
T. G. van Tienen, B. van Minnen, K. C. Defoort, P. J. Emans, S. A. W. van de Groes, N. Verdonschot, L. M. Jutten, R. W. E. Pikaart, P. J. C. Heesterbeek
Summary: This study evaluated the effects of a polycarbonate anatomical meniscus prosthesis system on knee pain in patients with post-meniscectomy pain syndrome, and found that the prosthesis led to impaired knee function and had serious adverse events. However, one patient showed improvement with the prosthesis still in place.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Multidisciplinary Sciences
Athra Malki, Gijsbertus Verkerke, Rienk Dekker, Juha Hijmans
Summary: This study aims to determine the factors perceived as important for the use of therapeutic footwear by different groups of persons with diabetes mellitus and loss of protective sensation. The results showed that comfort and fit, stability/balance, and usability were ranked in the top three factors in all groups.
Article
Clinical Neurology
Justin V. C. Lemans, Sebastiaan P. J. Wijdicks, Gerrit Overweg, Edsko E. G. Hekman, Tom. P. C. Schlosser, Rene M. Castelein, Gijsbertus J. Verkerke, Moyo C. Kruyt
Summary: The Double Spring Reduction (DSR) system effectively corrects adolescent idiopathic scoliosis by applying continuous correction through two different elements.
Article
Neurosciences
Vera Kooiman, Lisanne Haket, Nico Verdonschot, Ruud Leijendekkers, Vivian Weerdesteyn
Summary: Comparative analysis between satisfied transfemoral socket-suspended prosthesis (SSP) users, satisfied transfemoral bone-anchored prosthesis (BAP) users, and able-bodied individuals (AB) revealed that SSP users had higher oxygen consumption and trunk dynamics compared to AB during walking. BAP users had intermediate results between SSP users and AB, but no significant differences were found. Greater trunk excursions were associated with higher oxygen consumption, while a higher degree of pistoning in SSP users was related to larger trunk dynamics. These findings suggest that evaluating CoM and trunk dynamics, as well as pistoning, could help determine the suitability of BAP for SSP users and potentially benefit a larger population.
Review
Orthopedics
Carl W. Imhauser, Andrew P. Baumann, Xiangyi (Cheryl) Liu, Jeffrey E. Bischoff, Nico Verdonschot, Benjamin J. Fregly, Shady S. Elmasry, Neda N. Abdollahi, Donald R. Hume, Nynke B. Rooks, Marco T. -Y. Schneider, William Zaylor, Thor F. Besier, Jason P. Halloran, Kevin B. Shelburne, Ahmet Erdemir
Summary: Stakeholders in the modeling and simulation community organized a workshop to discuss efforts to address irreproducibility focusing on the knee joint. Representatives from academia, industry, and regulatory bodies highlighted the need for reproducibility standards and open collaboration. Survey results showed strong support for increasing emphasis on computational modeling and identified individual laboratories and journals as key players in ensuring reproducible research. Thought leaders stressed the importance of data sharing and the credibility of computational models in advancing knee modeling and simulation.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Navid Soltanihafshejani, Thom Bitter, Nico Verdonschot, Dennis Janssen
Summary: This study used finite element analysis (FEA) to simulate the effects of postoperative bone density changes on the failure of tibial total knee arthroplasty (TKA) due to bone resorption. The results showed that postoperative bone loss significantly increased the risk of TKA loosening, especially in patients with poor bone quality. Additionally, the study examined the probability of medial or lateral subsidence of the implant and aimed to improve clinical implications.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Hans Dunning, S. A. W. van de Groes, C. F. Buckens, Mathias Prokop, Nico Verdonschot, Dennis Janssen
Summary: This study establishes normative knee kinematics of 100 healthy subjects using a fully automatic workflow, which can be used in clinics. The dynamic CT scans provide valuable information on the angles, rotation, and displacement of the knee joint during flexion and extension.
Article
Biotechnology & Applied Microbiology
Periklis Tzanetis, Rene Fluit, Kevin de Souza, Seonaid Robertson, Bart Koopman, Nico Verdonschot
Summary: Robotic-assisted total knee arthroplasty can achieve accurate implantation. This study demonstrates the feasibility of reproducing pre-diseased kinematics and ligament strains to optimize the position of knee components. By using a patient-specific musculoskeletal model and an optimization algorithm, the deviations between pre-diseased and post-operative kinematics and ligament strains were significantly reduced, providing valuable information for the pre-planning of robotic-assisted surgery.
BIOENGINEERING-BASEL
(2023)
Article
Chemistry, Analytical
Ce Zhang, Charlotte Christina Roossien, Gijsbertus Jacob Verkerke, Han Houdijk, Juha M. Hijmans, Christian Greve
Summary: This study aimed to establish the biomechanical profile of neck and trunk postures and neck and lumbar joint loads during open surgery. The results showed that there were significant flexion angles in neck and trunk postures and higher joint loads in neck and lumbar regions. This provides important insights for designing effective exoskeleton devices.
Article
Materials Science, Coatings & Films
P. Farjam, M. Luckabauer, E. G. de Vries, V. R. Rangel, E. E. G. Hekman, G. J. Verkerke, J. Rouwkema
Summary: Long-term fixation of orthopaedic implants can be enhanced by depositing bioactive bone-like coatings on the implants. This study identified the optimal parameters for depositing osteo-conductive Calcium Phosphate (CaP) coatings on PolyCarbonate-Urethane (PCU) foils. The deposited CaP coatings demonstrated high stability and did not affect cell viability or proliferation, while enhancing cell-mediated calcium deposition. This presents a promising method for integrating PCU implants onto bone.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Athra Malki, Laurens van Kouwenhove, Gijsbertus J. Verkerke, Rienk Dekker, Juha M. Hijmans
Summary: Rocker shoes can reduce the occurrence of diabetic foot ulcers but may increase pressure on the heel. This study found that a heel rocker midsole with distal apex position, small rocker radius, and large apex angle can mitigate the negative effects on proximal heel pressure. However, rocker shoes alone cannot effectively reduce pressure in the midheel and distal heel regions. Other footwear options are needed for reducing pressure in these areas.
Article
Orthopedics
Branco S. van Minnen, Albert J. van der Veen, Sebastiaan A. W. van de Groes, Nico J. J. Verdonschot, Tony G. van Tienen
Summary: The study aimed to investigate whether a flexible medial meniscus prosthesis is capable of sharing loads with the direct tibiofemoral cartilage contact and its effect on tibial pressure distribution after total meniscectomy. The second-generation prosthesis was found to share loads with the direct tibiofemoral contact and significantly reduce pressure on the medial tibial cartilage. These findings suggest that the prosthesis has the potential to relieve post-meniscectomy pain symptoms.
JOURNAL OF EXPERIMENTAL ORTHOPAEDICS
(2022)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)
