Article
Cardiac & Cardiovascular Systems
Alexander C. Egbe, Jae K. Oh, Patricia A. Pellikka
Summary: Patients with repaired coarctation of aorta (COA) and aortic stenosis (AS) have higher left ventricular global pressure load, more advanced cardiac remodeling, and higher incidence of cardiovascular events compared to non-COA patients with similar AS severity. Valvulo-arterial impedance (Zva) could be used for risk stratification in timing of aortic valve replacement for these patients.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Biotechnology & Applied Microbiology
Giulia Comunale, Luigi Di Micco, Daniela Paola Boso, Francesca Maria Susin, Paolo Peruzzo
Summary: The choice of material and geometry for aortic replicas significantly affects the dynamics of the aorta, with the parametric geometry exhibiting a similar strain field to the patient-specific model with biological tissue. The flow velocity distribution is greatly influenced by local geometry, but plays a minor role in the arch's helicity.
BIOENGINEERING-BASEL
(2021)
Article
Engineering, Multidisciplinary
Dandan Ma, Yong Wang, Mueed Azhar, Ansgar Adler, Michael Steinmetz, Martin Uecker
Summary: The study presents a framework for personalized stent intervention in CoA by combining image-based prediction of aortic geometry and CFD prediction of hemodynamics to select optimal stent.
ENGINEERING APPLICATIONS OF COMPUTATIONAL FLUID MECHANICS
(2022)
Article
Biochemistry & Molecular Biology
Arash Ghorbannia, Mehdi Maadooliat, Ronald K. K. Woods, Said H. H. Audi, Brandon J. J. Tefft, Claudio Chiastra, El Sayed H. Ibrahim, John F. F. LaDisa
Summary: This study successfully established a growth and remodeling (G & R) model based on empirical measurements from a rabbit model of CoA, which can predict the arterial changes leading to hypertension precursors. The predicted results from the model were found to be in excellent agreement with the observed patterns. This research provides a validated computational tool for predicting persistent arterial dysfunction and identifying revised severity-duration thresholds for CoA.
Article
Cardiac & Cardiovascular Systems
Pim van Ooij, Emile S. Farag, Carmen P. S. Blanken, Aart J. Nederveen, Maarten Groenink, R. Nils Planken, S. Matthijs Boekholdt
Summary: This study demonstrates a fully quantitative and three-dimensional approach to map and quantify abnormal velocity and wall shear stress in patients with bicuspid aortic valve, providing new insights for hemodynamic characterization in BAV disease. Abnormal velocity and WSS in the ascending aorta are moderately correlated with vorticity scores, while abnormal velocity and WSS in the proximal descending aorta are higher in patients with repaired coarctation.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Article
Cardiac & Cardiovascular Systems
Lee Hafen, William P. Shutze, Srinivasa Potluri, John J. Squiers, J. Michael DiMaio, William T. Brinkman
Summary: The study retrospectively reviewed 24 adult patients treated for aortic coarctation, showing a high procedural success rate with no significant mortality, and significant improvement in post-procedure hypertension status with some patients no longer requiring blood pressure medications. Management of these patients may present complex problems due to complications of prior open or endovascular repair.
ANNALS OF CARDIOTHORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Vahid Goodarzi Ardakani, Harshinee Goordoyal, Maria Victoria Ordonez, Froso Sophocleous, Stephanie Curtis, Radwa Bedair, Massimo Caputo, Alberto Gambaruto, Giovanni Biglino
Summary: This study used computational simulations to analyze the relationship between aortic shape and hemodynamic parameters. The results showed that even small alterations in aortic morphology can impact key hemodynamic indices, which may explain phenomena such as persistent hypertension in the absence of any clinically significant narrowing. The findings suggest that the geometry of the aortic arch may be a contributing factor to cardiovascular events in patients with aortic coarctation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Surgery
Duanduan Chen, Shichao Liang, Zhenfeng Li, Yuqian Mei, Huiwu Dong, Yihao Ma, Jing Zhao, Shangdong Xu, Jun Zheng, Jiang Xiong
Summary: This study proposed a mock circulation loop that integrated Windkessel element and patient-specific silicone aortic phantoms to reproduce aortic flow environment in vitro. By altering boundary conditions, this mock circulation loop could mimic normal resting and left-sided heart failure conditions, quantifying the flow rates and pressure statuses of aortic branches.
JOURNAL OF ENDOVASCULAR THERAPY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aylin Demir, Stephanie Wiesemann, Jennifer Erley, Sebastian Schmitter, Ralf Felix Trauzeddel, Burkert Pieske, Jochen Hansmann, Sebastian Kelle, Jeanette Schulz-Menger
Summary: The study investigated the inter-vendor comparability of aortic hemodynamic parameters derived from 4D Flow MR, as well as assessed the repeatability of scan-rescan and intra- and interobserver reproducibility. Results showed significant differences between scanners of different vendors, but good reproducibility and consistency within and between observers.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ozden Kilinc, Stanley Chu, Justin Baraboo, Elizabeth K. Weiss, Joshua Engel, Anthony Maroun, Daniel Giese, Ning Jin, Kelvin Chow, Xiaoming Bi, Rachel Davids, Christopher Mehta, S. Chris Malaisrie, Andrew Hoel, James Carr, Michael Markl, Bradley D. Allen
Summary: This study aimed to investigate the performance of compressed sensing (CS) accelerated 4D Flow MRI in evaluating aortic hemodynamics in type B aortic dissection (TBAD). The results showed that CS-accelerated 4D Flow MRI has potential for clinical utilization with shorter scan times in TBAD. There were similar hemodynamic trends between acceleration types, but CS-acceleration impacted kinetic energy, forward flow, reverse flow, and stasis more in the false lumen.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Surgery
Amer Heider, David Gordon, Dawn M. Coleman, Jonathan L. Eliason, Santhi K. Ganesh, James C. Stanley
Summary: This study aimed to investigate the histologic characteristics of pediatric abdominal aortic narrowings and evaluate its relevance to clinical practice. The results showed that intimal fibroplasia is a common pathology in abdominal aortic coarctation and hypoplasia.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Peripheral Vascular Disease
Marta Kantauskaite, Guenter Fuerst, Peter Minko, Gerald Antoch, Lars Christian Rump, Sebastian Alexander Potthoff
Summary: The present case report describes a rare presentation of aortic coarctation in a 38-year-old man with well-controlled arterial hypertension, minimal change glomerulonephritis, and colitis ulcerosa. The workup included renal duplex sonography and CT angiography, which confirmed the diagnosis and guided the treatment with percutaneous transluminal angioplasty and stent implantation. The patient's blood pressure normalized and renal perfusion improved after the procedure. This case highlights the importance of evaluating for secondary hypertension and thoroughly investigating acute renal failure in young patients.
JOURNAL OF HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Alexander C. Egbe, William R. Miranda, Jason H. Anderson, Patricia A. Pellikka, Elizabeth H. Stephens, Kartik Andi, Omar Abozied, Heidi M. Connolly
Summary: This study compared left ventricular remodeling and clinical outcomes in adults with repaired coarctation of aorta (COA) and aortic regurgitation (AR) to those without COA. The results showed that patients with COA had higher left ventricular mass index and E/e ' before aortic valve replacement, and less regression of left ventricular mass index and E/e ' after the surgery.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mitch J. F. G. Ramaekers, Bouke P. Adriaans, Joe F. Juffermans, Hans C. van Assen, Sebastiaan C. A. M. Bekkers, Arthur J. H. A. Scholte, Sasa Kenjeres, Hildo J. Lamb, Joachim E. Wildberger, Jos J. M. Westenberg, Simon Schalla
Summary: The study found that patients with degenerative TAA have decreased flow vorticity and helicity, which may cause disturbances in physiological flow patterns. This altered distribution of wall shear stress could potentially be a contributing factor to vessel wall remodeling and aneurysm formation.
INVESTIGATIVE RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yan Gu, Qianqian Li, Rui Lin, Wenxi Jiang, Xue Wang, Gengxu Zhou, Junwu Su, Xiangming Fan, Pei Gao, Mei Jin, Yuan Wang, Jie Du
Summary: This study developed a risk model for predicting postoperative risk in pediatric patients with coarctation of aorta, using daily clinical data. The model exhibited significant improvement in performance compared to existing risk assessment tools.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Philip C. Wiener, Evan J. Friend, Ruchika Bhargav, Kirthi Radhakrishnan, Lyes Kadem, Gregg S. Pressman
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2020)
Article
Engineering, Biomedical
Amanda Mikhail, Giuseppe Di Labbio, Ahmed Darwish, Lyes Kadem
MEDICAL ENGINEERING & PHYSICS
(2020)
Article
Cardiac & Cardiovascular Systems
Ahmed Darwish, Giuseppe Di Labbio, Wael Saleh, Lyes Kadem
Summary: This in vitro study investigated the flow dynamics downstream of healthy and dysfunctional bileaflet mechanical heart valves using particle image velocimetry measurements. The results suggest that proper orthogonal decomposition can differentiate between healthy and dysfunctional cases effectively.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Philip C. Wiener, Ahmed Darwish, Evan Friend, Lyes Kadem, Gregg S. Pressman
Summary: Comparing hemodynamics and viscous energy dissipation in 3D printed mitral valves replicating normal valves and those with severe mitral annular calcification (MAC), the study found that MAC patients had slightly increased transmitral gradients but markedly increased VED during exercise, potentially contributing to exercise intolerance and exertional dyspnea.
Correction
Physics, Fluids & Plasmas
Giuseppe Di Labbio, Jerome Vetel, Lyes Kadem
PHYSICAL REVIEW FLUIDS
(2021)
Article
Cardiac & Cardiovascular Systems
M. Asaadi, W. Mawad, A. Djebbari, Z. Keshavardz-Motamed, N. Dahdah, L. Kadem
Summary: The optimal timing for management of pediatric patients with moderate aortic valve disease remains unknown. A new evaluative parameter of LV performance, LVSW efficiency, may offer a promising avenue for future stratification of mixed aortic valve disease for optimal timing of management and intervention. Patients with moderate aortic valve disease have significantly reduced LV performance and may require careful myocardial assessment for timely intervention.
PEDIATRIC CARDIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hana Sheitt, Hansuk Kim, Stephen Wilton, James A. White, Julio Garcia
Summary: This study demonstrates the clinical relevance of 4D flow-derived LA stasis mapping in evaluating left atrial recovery in patients with atrial fibrillation. It reveals a reduction in left atrial stasis following successful pulmonary vein ablation, with control subjects showing significantly lower stasis compared to pre-ablation patients. The findings highlight the importance of assessing left atrial stasis maps for evaluating the impact of pulmonary vein ablation on left atrial function.
APPLIED SCIENCES-BASEL
(2021)
Letter
Mechanics
Shahrzad Norouzi, Arnaud Le Floc'h, Giuseppe Di Labbio, Lyes Kadem
Summary: By optimizing experimental AAA flow models, this study proposes a method to assess AAA severity based on underlying flow, with simplified models capturing relevant pathological flow features for a more comprehensive clinical evaluation.
Article
Cardiac & Cardiovascular Systems
Reza Sadeghi, Benjamin Tomka, Seyedvahid Khodaei, Julio Garcia, Javier Ganame, Zahra Keshavarz-Motamed
Summary: The study showed that COA and mixed valvular diseases interacted to worsen abnormal blood flow dynamics and increase disease progression. Additionally, the presence of valvular diseases in patients led to increased workload, highlighting the importance of considering both COA severity and mixed valvular diseases in patient evaluation and treatment planning.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Ahmed Darwish, Shahrzad Norouzi, Lyes Kadem
Summary: Identification of coherent structures in cardiovascular flows is crucial in understanding blood transport and mixing. Graph-based approaches have been used to describe fluid transport between Lagrangian trajectories. Local graph measures reveal fluid regions of high mixing, while spectral clustering extracts flow coherent sets for further analysis.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2022)
Article
Engineering, Mechanical
Reza Sadeghi, Nadav Gasner, Seyedvahid Khodaei, Julio Garcia, Zahra Keshavarz-Motamed
Summary: The optimal course of intervention for patients with coexisting coarctation of the aorta (COA) and mixed valvular disease (MVD) is uncertain. This study developed a computational-mechanics framework to investigate the impact of COA and MVD on aortic fluid dynamics. The results suggest that the presence and severity of MVD should be considered in the evaluation of risks in patients with COA.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Feham Peer-Zada, Dima Hamze, Julio Garcia
Summary: The study found that overweight and obese patients have an increase in cardiac fat, especially in epicardial and pericardial adipose tissue, and are more likely to experience decreased cardiac function. Although BMI does not significantly affect AF recurrence, overweight patients have slightly higher recurrence rates compared to obese patients.
APPLIED SCIENCES-BASEL
(2023)
Article
Mechanics
Giuseppe Di Labbio, Jean-Luc Thiffeault, Lyes Kadem
Summary: The flow patterns in the heart, especially in relation to health and disease, have attracted a lot of attention. Modern fluid dynamics analyses explain how inefficient flow patterns can lead to adverse effects. However, translating these analyses into the clinical setting remains difficult. In this experiment, the concept of using braids of random and sparse particle trajectories is proposed and demonstrated as an intuitive and practical description of cardiovascular flows. The study also reveals the highly effective blood mixing properties of a healthy flow pattern in a left ventricle model, which can be compared to diseased flow models to evaluate energetic efficiency.
Article
Physics, Fluids & Plasmas
Ghassan Maraouch, Lyes Kadem
Summary: The formation of vortex rings at valve leaflets during ventricular inflow has been studied with different annulus angles for the mitral valve. In the unhealthy case, circulation was reversed and energy dissipation was highest in the slightly angled case. The healthy case resulted in the least amount of stasis and was most effective in minimizing particle residence time.
Letter
Cardiac & Cardiovascular Systems
Philip C. Wiener, Evan J. Friend, Gregg S. Pressman, Ruchika Bhargav, Kirthi Radhakrishnan, Lyes Kadem
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2021)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)