Article
Biotechnology & Applied Microbiology
Tobias Winkler, Louisa Bell, Alwina Bender, Adam Trepczynski, Georg N. Duda, Alexander J. D. Baur, Philipp Damm
Summary: This study assessed the status of periarticular muscles in long-term follow-up after TKA and found that fatty infiltration reduction may lead to increased tibio-femoral joint contact forces. Functional muscle recovery after surgery is important for reducing joint loads and improving long-term outcomes of TKA.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Adam Trepczynski, Philippe Moewis, Philipp Damm, Pascal Schutz, Jorn Dymke, Hagen Hommel, William R. Taylor, Georg N. Duda
Summary: In total knee arthroplasty, static alignment in frontal radiographs does not accurately predict dynamic motion and load distribution, while the external knee adduction moment shows strong correlations with medial force and mediolateral force distribution.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Gisela Sole, Todd Pataky, Niels Hammer, Peter Lamb
Summary: The study examined the effects of wearing a knee sleeve on ground reaction forces and knee joint power during a step-down hop task after anterior cruciate ligament reconstruction. The results showed that wearing a knee sleeve increased knee joint power during the task but had inconsistent effects on ground reaction forces.
Article
Engineering, Biomedical
Jia Yu, Yulian Xia, Chaochao Zhou, Tsungyuan Tsai, Sophia Li, Timothy Foster, Hany Bedair, Guoan Li
Summary: This study aimed to develop and validate a new concept of flexion axis by calculating points on femoral condyles that maintain constant heights during knee flexion. The results showed that these points form a medial-lateral flexion axis called the iso-height axis (IHA). The IHA exhibited minimal changes in proximal-distal translations and varus-valgus rotations along the flexion path, suggesting interesting clinical implications for knee surgeries.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Orthopedics
Timothy A. Burkhart, Takashi Hoshino, Lachlan M. Batty, Alexandra Blokker, Philip P. Roessler, Rajeshwar Sidhu, Maria Drangova, David W. Holdsworth, Ivailo Petrov, Ryan Degen, Alan M. Getgood
Summary: Through studying ACL reconstruction, it is found that at time-zero biomechanical environment, similar graft strains and knee kinematics were achieved using rectangular femoral tunnel (RFT) and cylindrical femoral tunnel (CFT) for ACL reconstruction, indicating both techniques are equally effective in restoring native knee kinematics.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2021)
Article
Engineering, Mechanical
Laura Bartsoen, Matthias G. R. Faes, Michael Skipper Andersen, Roel Wirix-Speetjens, David Moens, Ilse Jonkers, Jos Vander Sloten
Summary: The objective of this study is to estimate the correlated ligament material properties and attachment sites in a non-linear knee model based on kinematic data. Results showed significant variability in ligament properties and interdependence between reference strain and attachment sites.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2023)
Article
Medicine, General & Internal
Malin Ciba, Eva-Maria Winkelmeyer, Justus Schock, Philipp Schad, Niklas Kotowski, Teresa Nolte, Lena Marie Wollschlaeger, Matthias Knobe, Andreas Prescher, Christiane Kuhl, Daniel Truhn, Sven Nebelung
Summary: This study utilized valgus stress MRI combined with sophisticated image post-processing to simulate medial collateral ligament injury in human cadaveric knee joints, aiming to evaluate joint stability by measuring the degree of joint opening. The results showed that the medial compartment gradually opened as loading and injury increased, especially anteriorly.
Article
Engineering, Multidisciplinary
Wei Liang, Wei Wu, Wei Chen, Lei Ren, Kunyang Wang, Zhihui Qian, Luquan Ren
Summary: This study fabricated a bioinspired robotic knee based on a kinematic model of the human knee, in order to reveal the relationship between the meniscus, ligaments, and their stability. The results showed that a smooth rolling-sliding motion could be achieved with the addition of menisci and compatible ligaments, and that joint stiffness could be adjusted by changing the springs and activation lengths of ligament fibers.
BIOINSPIRATION & BIOMIMETICS
(2022)
Article
Orthopedics
Megan C. Graham, Kelsey A. Reeves, Darren L. Johnson, Brian Noehren
Summary: The study aims to evaluate the relationship between quadriceps strength, joint power, and the percentage contribution of specific joints to total limb power during the propulsive phase of jumping after ACL reconstruction. It also establishes a quadriceps strength cutoff value for predicting knee joint power characteristics similar to healthy participants.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2023)
Article
Orthopedics
Joachim Grifka, Clemens Baier, Guenther Maderbacher
Summary: The study found that using anatomical landmarks for femoral component rotation did not balance the flexion gap as well as navigation, with deviations of up to 6 degrees observed. The authors recommend optimizing flexion gap balancing using ligament balancing technique, and advocate for the use of navigational devices to ensure neutral leg alignment.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2021)
Review
Orthopedics
L. Rao, W. R. Taylor, N. Horn, R. List, S. Preiss, P. Schuetz
Summary: This study aimed to investigate the association between kinematic and kinetic parameters assessed during passive clinical tests and functional activities of daily living and poor functionality and underlying deficits after total knee replacement. The study identified several biomechanical parameters that showed promise for supporting decision making in total knee arthroplasty.
Article
Biology
Liming Shu, Ko Yamamoto, Reina Yoshizaki, Jiang Yao, Takashi Sato, Naohiko Sugita
Summary: This study used a subject-specific musculoskeletal model and a high-accuracy intact finite element knee model to evaluate the kinematics and mechanics of an intact knee joint during the gait cycle. The results showed that internal rotation and parallel anterior translation are important movements for the normal function of the knee joint. Furthermore, the majority of the joint load is borne by the cartilage-cartilage contact, and there is significant contact pressure on the patellofemoral joint. These findings provide important theoretical foundations for the treatment of knee joint diseases and the design of knee prostheses.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Orthopedics
Kelsey Neal, Jack R. Williams, Abdulmajeed Alfayyadh, Jacob J. Capin, Ashutosh Khandha, Kurt Manal, Lynn Snyder-Mackler, Thomas S. Buchanan
Summary: Gait alterations after anterior cruciate ligament reconstruction (ACLR) are commonly reported and have been linked to posttraumatic osteoarthritis development. This study aimed to analyze knee gait biomechanical variables at 3 and 6 months after ACLR and to study the progression of interlimb asymmetry between the two time points. The results showed that the involved limb had smaller knee joint angles, moments, extensor forces, and medial compartment forces compared to the uninvolved limb.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Computer Science, Artificial Intelligence
Shawanee' Patrick, Namita Anil Kumar, Woolim Hong, Pilwon Hur
Summary: This study investigates the impact of toe-joint stiffness on walking with a powered transfemoral prosthesis for amputees. The study finds that lower stiffness reduces push-off assistance and results in compensatory movements, while higher stiffness increases power generation on the prosthetic side.
FRONTIERS IN NEUROROBOTICS
(2022)
Article
Orthopedics
Alberto Grassi, Piero Agostinone, Stefano Di Paolo, Gian Andrea Lucidi, Luca Macchiarola, Marco Bontempi, Gregorio Marchiori, Laura Bragonzoni, Stefano Zaffagnini
Summary: The study used MRI and RSA to analyze knee position at the time of bone bruise in patients, finding that these positions deviated from the normal biomechanics of flexion-extension of the knee joint.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Chemistry, Multidisciplinary
Gilda Durastanti, Claudio Belvedere, Miriana Ruggeri, Davide Maria Donati, Benedetta Spazzoli, Alberto Leardini
Summary: Limb salvage procedures in orthopaedic oncology have become more common with recent advancements in medical imaging, biomechanical modeling, and additive manufacturing. However, surgical reconstruction with metal implants after tumor resection in the pelvis remains challenging due to the complexity of anatomical structures involved. This study aims to provide a consistent procedure to guide surgeons and bioengineers in the design of proper implants.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Elena Campagnoli, Sorin Siegler, Maria Ruiz, Alberto Leardini, Claudio Belvedere
Summary: This study compared the effect of different MRI modalities on the mechanical behavior of a dynamic model of the ankle complex by evaluating the ligament origin and insertion site definitions. The results showed significant differences in ligament attachment sites between the 1.5 T and 3.0 T MRI modalities, with the 3.0 T MRI mapping being more consistent with the anatomical dissection. The load-displacement curves showed similar mechanical behaviors between the three mappings, but the 3.0 T MRI mapping was closer to the results obtained from dissection in the frontal plane.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Paolo Caravaggi, Alessandro Zomparelli, Giulia Rogati, Massimiliano Baleani, Roberta Fognani, Franco Cevolini, Cristina Fanciullo, Arianna Cinquepalmi, Giada Lullini, Lisa Berti, Alberto Leardini
Summary: This paper reports the overall procedure for designing and manufacturing a novel custom PD-AFO using 3D scanning and manufacturing technologies. The study found that the custom PD-AFO provided better ankle dorsiflexion, faster walking speed, and higher comfort compared to the off-the-shelf PD-AFO. This novel PD-AFO offers a valid, custom solution for drop-foot patients not satisfied with standard orthotics.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Claudio Belvedere, Maurizio Ortolani, Emanuela Marcelli, Barbara Bortolani, Katsiaryna Matsiushevich, Stefano Durante, Laura Cercenelli, Alberto Leardini
Summary: This study reports the performance of five commercial software packages for bone shape reconstruction. The time to import and create the model, the number of triangles, and the STL file size were evaluated. The results show that these commercial packages perform well in these aspects and are superior to the previously analyzed freeware packages.
APPLIED SCIENCES-BASEL
(2022)
Review
Medicine, General & Internal
Stefano Zaffagnini, Giacomo Dal Fabbro, Claudio Belvedere, Alberto Leardini, Silvio Caravelli, Gian Andrea Lucidi, Piero Agostinone, Massimiliano Mosca, Maria Pia Neri, Alberto Grassi
Summary: Customized devices play an important role in the accuracy of high tibial osteotomy. Previous studies have shown that custom-made cutting guides are the most commonly used customized instruments. Our pilot case results demonstrate that personalized HTO using a new 3D-printed customized system can achieve satisfactory alignment and clinical outcomes at one-year follow-up.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Claudio Belvedere, Maurizio Ortolani, Alberto Leardini, Michele Cappuccio, Luca Amendola, Federico De Iure
Summary: Three-dimensional (3D)-printed anatomical models of the bones are valuable tools in complex surgeries, aiding in pre-operative planning and improving visibility of anatomical structures. This study reports on the use of virtual and 3D-printed cervical spine models for a patient with severe deformity, demonstrating their efficacy in personalized complex surgeries.
APPLIED SCIENCES-BASEL
(2022)
Article
Biophysics
Claudio Belvedere, Alisdair Macleod, Alberto Leardini, Alberto Grassi, Giacomo Dal Fabbro, Stefano Zaffagnini, Harinderjit Singh Gill
Summary: High Tibial Osteotomy is a surgical procedure used to correct misalignment in varus knees and prevent end-stage osteoarthritis. A new 3D printed system has been developed for personalized surgery, which includes pre-surgical planning and custom fixation plates. This system allows for accurate correction and reduced surgical time, with an average discrepancy of 1.2 degrees between planned and achieved alignment and a 30% reduction in surgical time.
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
(2023)
Article
Orthopedics
Michele Conconi, Alessandro Pompili, Nicola Sancisi, Stefano Durante, Alberto Leardini, Claudio Belvedere
Summary: This study provides a quantitative and systematic description of the kinematics of all bones in the foot, considering different foot orientations and weightbearing conditions. The results show that certain bones in the foot move more during pronation than flexion. Weightbearing significantly increases the range of motion of almost all the bones. These findings contribute to a deeper understanding of foot behavior and can inform the development of better treatment and medical devices, as well as new biomechanical models of the foot.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Gamze Arin-Bal, Volga Bayrakci-Tunay, Maria Grazia Benedetti, Alberto Leardini, Federico Vismara, Claudio Belvedere
Summary: This scoping review presents evidence on new technologies used to assess patients with patellofemoral pain (PFP). The review found that innovative technologies, such as medical imaging and advanced gait analysis, are widely used in PFP, often in combination for comprehensive biomechanical studies. It emphasizes the importance of utilizing modern technology to design more effective prevention campaigns and personalized rehabilitation programs.
APPLIED SCIENCES-BASEL
(2023)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)