Journal
JOURNAL OF BIOMECHANICS
Volume 44, Issue 16, Pages 2790-2794Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2011.08.021
Keywords
Atomic force microscope; Cell apoptosis; Membrane roughness; Oxidative stress
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Funding
- National Science Council Taiwan [NSC 99-2120-M-224-001]
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The morphological change of cellular apoptosis initiates from the change of membrane roughness. In order to identify cellular apoptosis in its early stage, atomic force microscope was adapted to reveal the change of membrane roughness in unprecedented details, providing an image in nanometer-scaled resolution. The mouse monocyte/macrophage cell line RAW 264.7 was the subject studied and subjected to apoptotic induction by hydrogen peroxide. A finding of the qualitative correlation between cell membrane roughness and oxidative stress level is disclosed stating that roughness is increasing with the increasing level of oxidative stress. (C) 2011 Elsevier Ltd. All rights reserved.
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