Article
Orthopedics
Amelie Poilliot, Max Hans-Peter Gay-Dujak, Magdalena Muller-Gerbl
Summary: This study assessed the mineralization and microstructure of the subchondral endplates and trabecular bone in the cervical vertebrae using computed tomography osteoabsorptiometry and micro-computed tomography. The results showed that the highest mineralization was found in the dorsal-caudal region of the C4 vertebra. Based on these findings, it is recommended to position orthopedic implants dorsally with screws anchored in the dorsal-caudal region.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Medicine, General & Internal
Kun Li, Yucheng Ji, Jun Shi, Shaojie Zhang, Haoyu Song, Peng Wang, Chunying Ma, Yansong Zhang, Yexing Dang, Yuan Ma, Xing Wang, Zhijun Li
Summary: This study measured and analyzed the microstructures and morphometric parameters of the cervical facet using high-resolution 3D micro-computed tomography. It revealed that the cervical facet has complicated 3D microstructures and inhomogeneities, and correct identification and evaluation of its microstructure can help in the diagnosis of orthopedic disease and predict early phases of fracture risk.
Article
Medicine, General & Internal
Hiroaki Hasegawa, Nobuhito Nango, Masafumi Machida
Summary: This study aimed to validate the use of QDCT scanner for evaluating trabecular structure in the diagnosis of osteoporosis. Statistical analysis and linear regression were performed on micro-CT and QDCT images, and evidence was found that QDCT can contribute to the evaluation of bone fragility.
Article
Engineering, Multidisciplinary
Ee Lian Lim, Wei Cheong Ngeow, Kathreena Kadir, Murali Naidu
Summary: This study aimed to determine the microstructures of bone harvested from different sites of the maxilla. The bone characteristics from the zygomatic buttress, anterior maxillary sinus wall, anterior nasal spine, and anterior palate were identified as the microarchitecture standard for developing new bone graft materials for use in the maxilla.
Article
Orthopedics
A. Nakasone, Y. Guang, A. Wise, L. Kim, J. Babbin, S. Rathod, A. J. Mitchell, L. C. Gerstenfeld, E. F. Morgan
Summary: This study used various analysis methods to investigate the characteristics and influencing factors of subchondral bone cysts (SBCs) in the hip joint, and found that SBCs were associated with abnormalities in bone density and cartilage thickness.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Orthopedics
S. C. Mastbergen, A. Ooms, T. D. Turmezei, J. W. MacKay, R. J. Van Heerwaarden, S. Spruijt, F. P. J. G. Lafeber, M. P. Jansen
Summary: Knee joint distraction treatment can partially normalize subchondral bone in the first two years after treatment, as indicated by the thinning of the subchondral cortical bone plate and decrease in subchondral trabecular bone density.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Biochemistry & Molecular Biology
Marissa Chatterjee, Fernanda Faot, Cassia Correa, Jente Kerckhofs, Katleen Vandamme
Summary: The study revealed that ovariectomy-induced osteoporosis only affects specific jaw bone regions, which can be prevented by bisphosphonate treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Riccardo Levi, Federico Garoli, Massimiliano Battaglia, Dario A. A. Rizzo, Maximilliano Mollura, Giovanni Savini, Marco Riva, Massimo Tomei, Alessandro Ortolina, Maurizio Fornari, Saurabh Rohatgi, Giovanni Angelotti, Victor Savevski, Gherardo Mazziotti, Riccardo Barbieri, Marco Grimaldi, Letterio S. Politi
Summary: This study aimed to evaluate the accuracy of machine learning in identifying physiological changes related to subjects' sex and age through analysis of radiomics features from lumbar vertebral CT images, and to determine its generalizability across different scanners. Spherical volumes-of-interest (VOIs) were annotated in the center of the vertebral body for each lumbar vertebra in 233 subjects who had undergone lumbar CT on 3 different scanners, and radiomics features from each VOI were evaluated. Machine learning models were used to identify subjects' sex and age, and a voting model was computed to combine predictions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dan Jin, Han Zheng, Qingqing Zhao, Chunjie Wang, Mengze Zhang, Huishu Yuan
Summary: The study proposes a deep learning-based image enhancement approach to generate high-resolution micro-CT-like images from MDCT. The pix2pixHD model outperformed two control methods in enhancing MDCT images. Subjective assessments showed that the pix2pixHD-derived micro-CT-like images had similar contrast and shadow to micro-CT images but lower noise, sharpness, and trabecular bone texture.
Article
Materials Science, Composites
Arturo Mendoza, Roger Trullo, Yanneck Wielhorski
Summary: In this research, a novel and fully automated method for extracting yarn geometrical features in woven composites is proposed, aiming to achieve direct parametrization of textile reinforcement. By using two deep neural network architectures (U-Net and Mask R-CNN), the method is accurate and robust for performing yarn instance segmentation on CT images, as demonstrated by quantitative and qualitative analyses.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Tae-Hyun Kim, Dong-Yul Lee, Seok-Ki Jung
Summary: This study measured the bone mineral density of specific regions of the maxilla, mandible, and first cervical vertebra using the Hounsfield unit and trabecular microstructure pattern analysis. Results showed the distribution characteristics of trabecular bone in different sites.
APPLIED SCIENCES-BASEL
(2021)
Review
Endocrinology & Metabolism
Weiwei Chen, Min Mao, Jin Fang, Yikai Xie, Yongjun Rui
Summary: Diabetes mellitus is associated with an increased risk of fracture, possibly due to bone intrinsic and extrinsic factors that contribute to bone strength damage. Traditional bone mineral density measurement methods may underestimate fracture risk in diabetes. Assessment tools and noninvasive examination methods can improve the prediction ability of fracture risk.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Hao Xu, Marie-Helene Lafage-Proust, Lamia Bouazza, Sandra Geraci, Philippe Clezardin, Bernard Roche, Francoise Peyrin, Max Langer
Summary: This study used synchrotron radiation microcomputed tomography (SR-mu CT) to investigate the effect of anti-angiogenic drugs on bone metastasis. The results suggest that combined anti-angiogenic drug treatment can reduce bone resorption at an early stage and affect bone microvascular structure at a later stage.
Article
Dentistry, Oral Surgery & Medicine
Mira Huefner, Nicole Rauch, Beryl Schwarz-Herzke, Ivonne Jeanette Knorr, Martin Sager, Dieter Drescher, Kathrin Becker
Summary: The study found that peri-implant vessel thickness and density were associated with force magnitude in the early loading phase, but this effect diminished after 8 weeks of loading.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Engineering, Biomedical
Emily Brooke Long, Meir Max Barak, Victoria Jane Frost
Summary: This study found that acute exposure to S. aureus does not significantly decrease trabecular bone stiffness or yield in the context of a deer tibia model. These results may have clinical value in assessing fracture risks for osteomyelitis or other patients whose cultures test positive for S. aureus.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Cardiac & Cardiovascular Systems
Pedro Morais, Yiting Fan, Sandro Queiros, Jan D'hooge, Alex Pui-Wai Lee, Joao L. Vilaca
Summary: This study evaluated the feasibility and accuracy of a novel software tool for automated 3D analysis of the left atrial appendage (LAA) using 3D transesophageal echocardiographic data. The results showed that the automated software accurately determined the LAA size and had higher reproducibility and faster analysis compared to traditional 2D echocardiography.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Article
Dentistry, Oral Surgery & Medicine
E. De Moor, S. E. F. Huys, G. H. van Lenthe, M. Y. Mommaerts, J. Vander Sloten
Summary: The study evaluated an additively manufactured subperiosteal jaw implant as an alternative solution for edentulous patients with severe bone loss. Finite-element analysis was used to perform a biomechanical evaluation, and the results showed that the implant performed safely under average occlusion forces for a predicted implantation period of 15 years. However, increased stresses and potential fatigue were observed in cases of severe bone atrophy.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Orthopedics
Amelie Sas, Esther Tanck, Hazem Wafa, Yvette van der Linden, An Sermon, G. Harry van Lenthe
Summary: This study aimed to evaluate the accuracy of a finite element model in predicting bone fracture in cancer patients with proximal femoral bone metastases and to assess the effectiveness of femoroplasty in reducing fracture risk. The results suggest that femoroplasty can effectively reduce the risk of fracture in osteolytic lesions located in the femoral head/neck.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Amelie Sas, An Sermon, G. Harry van Lenthe
Summary: This study validated a voxel-based finite element model against experimental data and found that the model accurately predicted the femoral strength in both defective and augmented femurs. Despite some limitations, the finite element models can provide useful guidance for clinicians in assessing the need for femoroplasty and identifying suitable patients.
SCIENTIFIC REPORTS
(2022)
Review
Engineering, Biomedical
Maria Rocchi, Marcus Ingram, Piet Claus, Jan D'hooge, Bart Meyns, Libera Fresiello
Summary: This review provides an overview of mock circulatory loops (MCLs) and the recent developments of 3D anatomical models for testing cardiovascular medical devices. The review analyzes different techniques to develop 3D anatomical models and discusses the applications of MCLs with 3D models for testing various medical devices. The addition of 3D anatomical models enhances the testing capabilities of MCLs and personalized MCLs are being developed for testing devices in patient-specific scenarios.
Article
Engineering, Biomedical
Annette Caenen, Stephanie Bezy, Aniela Petrescu, Annegret Werner, Jens-Uwe Voigt, Jan D'hooge, Patrick Segers
Summary: Shear wave elastography (SWE) is a promising technique for assessing myocardial stiffness non-invasively. The study found that the transmural wave speed gradient can distinguish between intrinsic myocardial stiffening and stiffening caused by increased pressure. This gradient may have potential as a new diagnostic parameter for future clinical studies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Letter
Cardiac & Cardiovascular Systems
Laurine Wouters, Jurgen Duchenne, Stephanie Bezy, Konstantina Papangelopoulou, Alexis Puvrez, Boudewijn Klop, Lennert Minten, Jan Bogaert, Rik Willems, Gabor Voros, Jan D'hooge, Jens-Uwe Voigt
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Debbie Zhao, Edward Ferdian, Gonzalo D. Maso D. Talou, Gina M. Quill, Kathleen Gilbert, Vicky Y. Wang, Thiranja P. Babarenda P. Gamage, Joao Pedrosa, Jan D'hooge, Timothy M. Sutton, Boris S. Lowe, Malcolm E. Legget, Peter N. Ruygrok, Robert N. Doughty, Oscar Camara, Alistair A. Young, Martyn P. Nash
Summary: Segmentation of the left ventricle in echocardiography is important for volume and mass quantification in heart disease. Analyzing 3D echocardiography poses challenges due to limited resolution, poor contrast, complex noise, and image anisotropy. To address the lack of labeled data, the researchers used high-resolution cardiac magnetic resonance imaging to provide ground truth labels and created a dataset of 536 3DE images. A deep learning network trained on this dataset achieved better accuracy and reproducibility compared to manual analysis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Engineering, Biomedical
Alexandra Tits, Stephane Blouin, Maximilian Rummler, Jean-Francois Kaux, Pierre Drion, G. Harry van Lenthe, Richard Weinkamer, Markus A. Hartmann, Davide Ruffoni
Summary: The attachment of tendon to bone at entheses is a demanding task for the musculoskeletal system. We analyzed mineralized fibrocartilage (FC) and subchondral bone at the Achilles tendon-bone insertion of rats and found that FC had lower mineralization but higher stiffness and hardness compared to bone. The different structure-property relationships of enthesis FC and periosteal FC demonstrate the versatility of FC in providing strength and compliance.
ACTA BIOMATERIALIA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gonzalo Collado-Lara, Sophie Heymans, Marta Rovituso, Edmond Sterpin, Jan D'hooge, Hendrik J. Vos, Koen Van Den Abeele, Nico de Jong
Summary: The goal of this study is to estimate the range estimation precision of a technique that combines ultrasound imaging with radiation-sensitive nanodroplets for in vivo range verification of proton therapy. A model was developed and validated to predict the number of vaporizations of nanodroplets, and the results showed good agreement with experiments. Monte Carlo simulations predicted promising range verification performances for realistic concentrations of nanodroplets.
Article
Multidisciplinary Sciences
Debbie Zhao, Charlene A. Mauger, Kathleen Gilbert, Vicky Y. Wang, Gina M. Quill, Timothy M. Sutton, Boris S. Lowe, Malcolm E. Legget, Peter N. Ruygrok, Robert N. Doughty, Joao Pedrosa, Jan D'hooge, Alistair A. Young, Martyn P. Nash
Summary: Cardiovascular imaging studies provide structural and functional data for understanding disease mechanisms. Comparing data from different acquisition or analysis methods is problematic due to measurement biases specific to each protocol. We demonstrate how mapping techniques can effectively align left ventricular geometries obtained from different modalities, resulting in better agreement and reduced errors between cardiac indices and shape measurements.
SCIENTIFIC REPORTS
(2023)
Article
Biophysics
Stephanie L. Kahmann, Amelie Sas, Nils Grose Hokam, G. Harry van Lenthe, Lars-Peter Mueller, Kilian Wegmann
Summary: Elbow trauma can lead to a loss of independence in daily self-care activities and have a negative impact on patients' quality of life. Finite element models provide valuable insights into native joint mechanics and play a crucial role in restoring joint functionality after severe injuries. This study aimed to develop a finite element model of the elbow, including both the radio-capitellar and ulno-trochlear joints, and subjected to loads representative of daily activities.
JOURNAL OF BIOMECHANICS
(2023)
Article
Biology
Andrea Benova, Michaela Ferencakova, Kristina Bardova, Jiri Funda, Jan Prochazka, Frantisek Spoutil, Tomas Cajka, Martina Dzubanova, Tim Balcaen, Greet Kerckhofs, Wouter Willekens, G. Harry van Lenthe, Arzuv Charyyeva, Glenda Alquicer, Alena Pecinova, Tomas Mracek, Olga Horakova, Roman Coupeau, Morten Svarer Hansen, Martin Rossmeisl, Jan Kopecky, Michaela Tencerova
Summary: This study demonstrates that supplementation of omega-3 PUFAs can improve bone health, reduce bone marrow adipose tissue formation, and promote osteoblast differentiation in obese mice.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Karim Taha, Rutger R. van de Leur, Melle Vessies, Thomas P. Mast, Maarten J. Cramer, Nicholas Cauwenberghs, Tom E. Verstraelen, Remco de Brouwer, Pieter A. Doevendans, Arthur Wilde, Folkert W. Asselbergs, Maarten P. van den Berg, Jan D'hooge, Tatiana Kuznetsova, Arco J. Teske, Rene van Es
Summary: Deep neural networks can automatically detect and visualize disease features in echocardiographic deformation curves, improving clinical assessment. Applying an explainable DNN-based pipeline allows for automated detection and visualization of disease features in phospholamban variant carriers. Novel disease features were identified, which may enhance individual risk stratification.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Cell & Tissue Engineering
W. Colyn, F. Azari, J. Bellemans, G. Harry van Lenthe, L. Scheys
Summary: Recent studies have shown the important role of subchondral bone in the development of OA. However, limited data is available on the relationship between cartilage morphology, subchondral bone plate (SBP) structure, and subchondral trabecular bone (STB). This study aimed to visualize and quantify the microstructure of cartilage and subchondral bone in the medial tibial plateau. The results suggest that region-specific adaptations in subchondral bone are related to the severity of varus deformity, with subchondral sclerosis being most pronounced closer to the mechanical axis of the knee.
EUROPEAN CELLS & MATERIALS
(2023)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)