Review
Cardiac & Cardiovascular Systems
Paul Wong, Andrew D. Wisneski, Amitoj Sandhu, Zhongjie Wang, Vaikom S. Mahadevan, Tom C. Nguyen, Julius M. Guccione
Summary: Severe mitral valve regurgitation (MR) can lead to congestive heart failure and death if not treated. Surgical repair or replacement of the mitral valve is currently the standard treatment, but some patients may not be eligible for surgery. Transcatheter MV repair (TMVR) is emerging as an alternative, but its long-term effectiveness and comparison to surgery are still unknown. Computational modeling using techniques like finite element method and fluid structure interactions can provide insights and help guide clinicians in choosing the optimal intervention. This review discusses the relevance of computational modeling in MV repair and its future applications in treating MR.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Sergio Raposeiras-Roubin, Marianna Adamo, Xavier Freixa, Dabit Arzamendi, Tomas Benito-Gonzalez, Antonio Montefusco, Isaac Pascual, Luis Nombela-Franco, Josep Rodes-Cabau, Mony Shuvy, Antonio Portoles-Hernandez, Cosmo Godino, Berenice Caneiro-Queija, Laura Lupi, Ander Regueiro, Chin Hion Li, Felipe Fernandez-Vazquez, Simone Frea, Pablo Avanzas, Gabriela Tirado-Conte, Jean-Michel Paradis, Alona Peretz, Vanessa Monivas, Jose A. Baz, Michele Galasso, Luca Branca, Laura Sanchis, Lluis Asmarats, Carmen Garrote-Coloma, Filippo Angelini, Victor Leon, Eduardo Pozo, Alberto Alperi, Ronen Beeri, Dario Cani, Manel Sabate, Estefania Fernandez-Peregrina, Javier Gualis, Pier Paolo Bocchino, Salvatore Curello, Emad Abu-Assi, Andres Iniguez-Romo, Francesco Bedogni, Antonio Popolo Rubbio, Luca Testa, Carmelo Grasso, Rodrigo Estevez-Loureiro
Summary: This study aimed to create and validate a user-friendly score (MitraScore) to predict the risk of mortality in patients undergoing transcatheter edge-to-edge mitral valve repair (TEER). The MitraScore, derived from 8 independent predictors, showed better discrimination and calibration in predicting mortality compared to existing scores. It also demonstrated predictive value for heart failure rehospitalization and correlated with the probability of clinical improvement.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Trevor Simard, Sreek Vemulapalli, Richard G. Jung, Andrew Vekstein, Amanda Stebbins, David R. Holmes, Andrew Czarnecki, Benjamin Hibbert, Mohamad Alkhouli
Summary: This study investigated the characteristics and outcomes of patients with significant mitral regurgitation and cardiogenic shock who underwent transcatheter edge-to-edge repair (TEER). The results showed that successful reduction of mitral regurgitation in most patients was associated with lower mortality and heart failure hospitalization.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Raj R. Makkar, Joanna Chikwe, Tarun Chakravarty, Qiudong Chen, Patrick T. O'Gara, Marc Gillinov, Michael J. Mack, Andrew Vekstein, Dhairya Patel, Amanda Lee Stebbins, Annetine C. Gelijns, Moody Makar, Deepak L. Bhatt, Samir Kapadia, Sreekanth Vemulapalli, Martin B. Leon
Summary: A cohort study evaluated the outcomes of transcatheter mitral valve repair for degenerative mitral regurgitation, finding a success rate of 88.9%. Among patients with successful repair, those with mild or less residual regurgitation and low mitral gradients had the lowest mortality.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Medicine, General & Internal
Breda Hennessey, Nestor Sabatovicz Jr, Maria Del Trigo
Summary: Acute ischaemic mitral regurgitation (IMR) is a rare and challenging complication following acute myocardial infarction. Despite advancements in surgical and percutaneous interventions, prognosis for patients with acute IMR is often poor. This review focuses on diagnosis, echocardiographic features, and current treatment options for patients with acute IMR.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Guisela Flores, Dolores Mesa, Soledad Ojeda, Javier Suarez de Lezo, Rafael Gonzalez-Manzanares, Guillermo Duenas, Manuel Pan
Summary: The use of transcatheter edge-to-edge repair for mitral regurgitation has increased in recent years. Knowledge of the potential complications related to the procedure is crucial due to its growing popularity. Transesophageal echocardiography plays a key role in guiding the intervention and preventing and diagnosing these complications early.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sung-Han Yoon, Moody Makar, Saibal Kar, Tarun Chakravarty, Luke Oakley, Navjot Sekhon, Keita Koseki, Mamoo Nakamura, Michele Hamilton, Jignesh K. Patel, Siddharth Singh, Sabah Skaf, Robert J. Siegel, Jeroen J. Bax, Raj R. Makkar
Summary: This study evaluated the clinical outcomes of transcatheter edge-to-edge repair (TEER) in patients with mitral regurgitation (MR) of different etiology and left ventricular and left atrial remodeling. The results showed that despite favorable procedural outcomes, patients with atrial FMR and ventricular FMR had worse clinical outcomes compared to those with degenerative MR.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Philipp M. Doldi, Lukas Stolz, Daniel Kalbacher, Benedikt Koell, Martin Geyer, Sebastian Ludwig, Mathias Orban, Daniel Braun, Ludwig T. Weckbach, Thomas J. Stocker, Michael Naebauer, Satoshi Higuchi, Tobias Ruf, Jaqueline Da Rocha e Silva, Mirjam Wild, Noemie Tence, Matthias Unterhuber, Niklas Schofer, Aniela Petrescu, Holger Thiele, Philipp Lurz, Edith Lubos, Stephan von Bardeleben, Nicole Karam, Daryoush Samim, Jean-Michel Paradis, Christos Iliadis, Erion Xhepa, Christian Hagl, Steffen Massberg, Joerg Hausleiter
Summary: This study aimed to define right ventricular dysfunction (RVD) in patients undergoing mitral valve edge-to-edge repair (M-TEER) for primary MR and evaluate its impact on procedural MR reduction, symptomatic development, and 2-year all-cause mortality.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Luigi Biasco, Catherine Klersy, Giovanni Benfari, Patric Biaggi, Roberto Corti, Moreno Curti, Oliver Gaemperli, Raban Jeger, Francesco Maisano, Olivier Mueller, Barbara Naegeli, Stephane Noble, Fabien Praz, Gregorio Tersalvi, Stefan Toggweiler, Marco Valgimigli, Maurice Enriquez-Sarano, Giovanni Pedrazzini
Summary: This study aimed to evaluate the impact of mitral transcatheter edge-to-edge repair (TEER) on postprocedural life expectancy. The results showed that TEER can restore predicted life expectancy in patients aged 80-89, and sustained procedural success can improve survival rates.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Sung-Han Yoon, Moody Makar, Saibal Kar, Tarun Chakravarty, Luke Oakley, Navjot Sekhon, Keita Koseki, Yusuke Enta, Mamoo Nakamura, Michele Hamilton, Jignesh K. Patel, Siddharth Singh, Sabah Skaf, Robert J. Siegel, Jeroen J. Bax, Raj R. Makkar
Summary: This study aimed to evaluate the prognostic value of an increased mean MVG in patients with primary MR after TEER. The results showed that increased mean MVG was not independently associated with adverse events after TEER.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Medicine, General & Internal
Doron Sudarsky, Fabio Kusniec, Liza Grosman-Rimon, Ala Lubovich, Wadia Kinany, Evgeni Hazanov, Michael Gelbstein, Edo Y. Birati, Shemy Carasso
Summary: The study revealed that moderate or less residual mitral regurgitation (rMR) at transcatheter edge-to-edge mitral valve repair (TEEMr) completion was associated with improved survival, while mild or less rMR was not. Patients with rMR grade 1 at discharge demonstrated longer survival and time to first heart failure hospitalization. The correlation between rMR grade or mitral valve pressure gradient (MVPG) at TEEMr completion and discharge was moderate, with higher MVPG not being associated with adverse events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Engineering, Multidisciplinary
Narendra S. Nanal, Scott T. Miller, Jesse D. Thomas, Lucy T. Zhang
Summary: This study presents a computational framework for simulating shell structures interacting with fluids using the immersed approach. The approach captures the complex movement and motion of thin structures and allows non-intrusive coupling of independent fluid and shell finite element solvers. The method projects the shell structure to create a volumetric structure, enabling accurate and realistic loading and geometry.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Ahmed El Shaer, Alejandra Chavez Ponce, Piotr Mazur, Kevin Greason, Arman Arghami, Mackram F. Eleid, Mayra Guerrero, Charanjit S. Rihal, Juan A. Crestanello, Mohamad Alkhouli
Summary: Mitral surgery is associated with lower mortality in patients with severe persistent or recurrent MR after TEER, compared to medical therapy. Despite the high-risk profile of these patients, they should be referred to a referral mitral surgical center for surgery.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Joerg Hausleiter, Thomas J. Stocker, Marianna Adamo, Nicole Karam, Martin J. Swaans, Fabien Praz
Summary: Mitral regurgitation (MR) is a common valvular heart disease with significant consequences if left untreated. Mitral valve transcatheter edge-to-edge repair (M-TEER) has emerged as an important therapeutic strategy for severe and symptomatic MR.
Review
Medicine, General & Internal
Kaveh Hosseini, Hamidreza Soleimani, Amir Nasrollahizadeh, Yaser Jenab, Angelos Karlas, Dimitrios V. Avgerinos, Alexandros Briasoulis, Toshiki Kuno, Ilias Doulamis, Polydoros N. Kampaktsis
Summary: A comparison of the PASCAL and MitraClip devices showed similar success rates and complication rates for transcatheter edge-to-edge repair (TEER) of the mitral valve. PASCAL was not inferior to MitraClip in reducing the mitral regurgitation (MR) level at discharge.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Danila Vella, Alessandra Monteleone, Giulio Musotto, Giorgia Maria Bosi, Gaetano Burriesci
Summary: Atrial fibrillation is a common arrhythmia affecting mainly the elderly population, leading to serious complications like stroke. This study uses computational fluid dynamic analysis to investigate how physiological changes associated with AF can promote thrombus formation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Peripheral Vascular Disease
Daniyal J. Jafree, David A. Long, Peter J. Scambler, Christiana Ruhrberg
Summary: Lymphatic vessels play critical roles in both health and disease, and research in this field is rapidly evolving. Recent studies have revealed new cellular mechanisms and diverse cell lineages involved in the formation of organ lymphatic vasculature.
Article
Engineering, Mechanical
Anna Maria Tango, Andrea Ducci, Gaetano Burriesci
Summary: The study on aortic valve shows that changes such as tissue stiffening and aortic root dilation with ageing can result in substantial alterations in the haemodynamics and mechanical efficiency of the valve, indicating the importance of considering these factors in evaluating aortic valve diseases in aged patients.
JOURNAL OF FLUIDS AND STRUCTURES
(2021)
Article
Engineering, Biomedical
Giacomo Annio, Ryo Torii, Andrea Ducci, Vivek Muthurangu, Victor Tsang, Gaetano Burriesci
Summary: The integration of four-dimensional flow-sensitive cardiovascular magnetic resonance imaging (4D Flow CMR) with computational fluid dynamics (CFD) in Enhanced 4D Flow CMR (EMRI) overcomes spatial resolution limitations, enabling accurate flow quantification and showing better agreement with experimental results compared to traditional techniques.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Cardiac & Cardiovascular Systems
Marwa Mahmoud, Ian Evans, Laura Wisniewski, Yuen Tam, Claire Walsh, Simon Walker-Samuel, Paul Frankel, Peter Scambler, Ian Zachary
Summary: Research indicates a specific requirement for Bcar1 in neural crest cells, early myogenic and cardiac cells, essential for outflow tract septation, myocardialization, epithelial-to-mesenchymal transformation/cell cycle regulation, and differentiation into myogenic lineages. On the other hand, conditional knockouts of Bcar1 in differentiated smooth muscle, endothelial cells, and second heart field cells survived to term and were phenotypically normal at birth and postnatally.
CARDIOVASCULAR RESEARCH
(2022)
Article
Developmental Biology
Michelle Yu-Qing Cheung, Catherine Roberts, Peter Scambler, Athanasia Stathopoulou
Summary: Congenital heart defects are often associated with genetic haploinsufficiency syndromes and involve network interactions at the gene or protein level. This study identified Setd5 as a potentially haploinsufficient gene associated with cardiovascular defects, particularly in the development of the heart tube. Conditional mutagenesis revealed the requirement of Setd5 in cardiopharyngeal mesoderm for the formation of a four-chambered heart.
Article
Cardiac & Cardiovascular Systems
Christopher McGregor, Jacob Salmonsmith, Gaetano Burriesci, Guerard Byrne
Summary: This study demonstrates the biological equivalence between GalKO and standard pig pericardium in sheep, with similar low tissue calcium levels after 90-day implantation. There were no differences in valve haemodynamic performance and adverse valve-related events between the two groups.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2022)
Article
Engineering, Multidisciplinary
Alessandra Monteleone, Guido Borino, Enrico Napoli, Gaetano Burriesci
Summary: This paper presents a novel three-dimensional fluid-structure interaction (FSI) approach, where the meshless smoothed particle hydrodynamics (SPH) method is used to simulate the motion of incompressible fluid flows, whilst structures are represented by a simplified approach based on particle-spring systems. The proposed FSI technique allows for independent spatial-temporal resolutions for the fluid and structural computational domains, and interfaces made of triangular elements are used to separate the two domains.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Sofia Di Leonardo, Giuseppe Pitarresi, Gaetano Burriesci
Summary: Thanks to its unique superelastic response, Nitinol has become the preferred material in many critical applications, especially in the medical implant field. However, the reversible phase transformation that gives rise to its exceptional behavior also makes its mechanical characterization complex, hindering the assumptions underlying common uniaxial tensile testing. This study analyzes the spurious effects introduced by the unconventional material behavior during uniaxial tensile testing using digital image correlation (DIC), and proposes a more accurate and systematic testing approach.
MATERIALS & DESIGN
(2022)
Article
Multidisciplinary Sciences
Alessandra Monteleone, Alessia Viola, Enrico Napoli, Gaetano Burriesci
Summary: In this paper, a novel model based on the smoothed particle hydrodynamics (SPH) method is proposed to simulate thrombus formation. The model describes the main phases of the coagulative cascade by balancing biochemical species and platelets. SPH particles can transition from fluid to solid phase based on specific biochemical and physical conditions. The interaction between blood and the forming blood clot is handled using an innovative monolithic fluid-structure interaction (FSI) approach.
Review
Materials Science, Multidisciplinary
Ebba Montgomery-Liljeroth, Silvia Schievano, Gaetano Burriesci
Summary: The field of auxetics, which focuses on materials or structures with a negative Poisson's ratio, has gained attention due to their advantageous properties including high indentation and shear resistance. Significant progress has been made in understanding the factors contributing to auxetic behavior, resulting in a wide variety of designed structures. This review provides an overview of identified and designed auxetic structures, discussing their mechanical behavior, structural properties, limitations, and potential applications, with a focus on important works and complementary research.
APPLIED MATERIALS TODAY
(2023)
Article
Cardiac & Cardiovascular Systems
Athanasia Stathopoulou, Ping Wang, Charlotte Thellier, Robert G. Kelly, Deyou Zheng, Peter J. Scambler
Summary: This study investigates the role of CHD7 protein in cardiac development. The results show that CHD7 is necessary for the correct expression of genes involved in cardiac development, particularly in the second heart field. The study also reveals the interaction between CHD7 and ISL1, and their involvement in the regulation of cardiac enhancers during heart morphogenesis.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Sofia Di Leonardo, Danila Vella, Carmelo Savio Grillo, Carla Martorana, Salvatore Torre, Vincenzo Argano, Gaetano Burriesci
Summary: Valve-sparing procedures are surgical techniques aimed at restoring adequate function of the native aortic valve. The use of conduits with Valsalva sinuses can improve the valve function after valve-sparing surgery. The performance of different valve-sparing techniques was evaluated and it was found that using conduits with Valsalva sinuses exhibited better performance in terms of systolic function and dynamics similar to the native case.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Engineering, Biomedical
Junke Yao, Giorgia Maria Bosi, Andrea Palombi, Gaetano Burriesci, Helge Wurdemann
Summary: This study proposes an intra-operative method for improving the sizing of compliant aortic annuli with complex geometry using balloon catheters. Experimental results confirm the accurate measurement of the aortic annular diameter using the sizing algorithm with pressure-volume data.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Meeting Abstract
Medicine, Research & Experimental
Christopher McGregor, Jacob Salmonsmith, Gaetano Burriesci, Guerard W. Byrne
XENOTRANSPLANTATION
(2021)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)
