Article
Engineering, Biomedical
Lisha Meng, Yajin Li, Yu Wang, Jingshu Zhang, Yubiao Zhang, Yadong Chen, Tianxing Gong
Summary: This study developed a novel injectable bone cement for repairing bone fractures under osteoporotic conditions. LA-CPSC bone cement was found to enhance bone regeneration and reduce osteoclast activities, showing potential as a viable solution for bone fracture repair in osteoporotic patients.
BIOMEDICAL MATERIALS
(2021)
Article
Surgery
Suochao Fu, Yu Zhang, Renkai Wang, Xiaobao Zou, Fuzhi Ai, Jianhua Wang, Xiangyang Ma, Hong Xia, Wei Lei
Summary: This study aimed to compare the stability of osteoporotic lumbar pedicle screw with different enhancer-injecters and calcium phosphate cement (CPC). Results showed that the 8-hole group had a smaller pull-out force and was more prone to leakage, while the local reinforcement of 4-hole and 6-hole sheath had a similar effect as the total nail tunnel reinforcement. The combination of enhancer syringes and CPC injection significantly increased the maximum screw pull-out force.
Article
Engineering, Biomedical
Yanan Zhao, Honglei Kang, Xiaopei Wu, Pengzhen Zhuang, Rong Tu, Takashi Goto, Feng Li, Honglian Dai
Summary: A drug carrier system composed of gelatin-coated hollow mesoporous silica nanoparticles loaded with pro-osteogenic parathyroid (PTH) and anti-osteoclastogenic alendronate (ALN) is constructed and compounded into calcium magnesium phosphate cement (MCPC). It enhances osteoporotic bone regeneration in ovariectomized rats by promoting osteogenic differentiation, inhibiting osteoclastogenesis, and accelerating vascularization. The MCPC/HMSNs@ALN-PTH/GM demonstrates a synergistic effect on osteogenesis, osteoclastogenesis, and angiogenesis, holding potential for other biomaterials design and clinical management.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Ceramics
Manqi Yan, Yanan Zhao, Yue Dai, Xiaokang Yao, Honglian Dai
Summary: In this study, modified calcium magnesium phosphate bone cement (MCPC) composites were constructed by introducing gelatin solutions. The modified MCPC composites exhibited improved microenvironment, enhanced osteogenic differentiation and biomineralization. When incorporated with 1% and 5% of gelatin, the MCPC composites showed higher mechanical properties and osteogenic ability of BMSCs.
CERAMICS INTERNATIONAL
(2022)
Review
Engineering, Multidisciplinary
Muhammad Aqib, Aneela Anwar, Humayun Ajaz, Samina Akbar, Ahsan Manzoor, Maham Abid, Zohaib Waheed, Qudsia Kanwal
Summary: In recent years, calcium phosphate cement has been widely used in biomedical applications due to its excellent biocompatibility, bioactivity, self-setting qualities, minimal setting degree, suitable toughness, and versatility in shape. Brushite, a type of calcium phosphate, is particularly attractive for bone repair and can also potentially serve as a drug delivery device. The addition of metal ions, such as magnesium, zinc, and strontium, into the calcium phosphate structure has become a major research focus. This paper provides a comprehensive analysis of the advancements and prospects of metal-doped brushite cement, including its impact on physical and chemical properties, as well as its potential applications in regenerative medicine.
JOURNAL OF BIONIC ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Jianquan Chen, Xinyuan Lin, Zhouming Lv, Maoshui Chen, Taosheng Huang
Summary: This study compared the clinical effects and safety of traditional PVP and PVP aided by 3D-printed body-surface guide plates for treating OVCFs. The results showed that the 3D group had shorter operation times, improved pain and disability scores, and lower incidence of complications compared to the traditional group.
Article
Medicine, General & Internal
Kui Sun, Fuli Huang, Biru Liang
Summary: This article describes a case of a 71-year-old female patient who developed chest tightness and decreased blood oxygen saturation following posterior decompression and cement-enhanced pedicle screw fixation. Diagnosis revealed the presence of foreign bodies in the heart, which were successfully removed during surgery and the patient recovered well.
Article
Engineering, Biomedical
Philipp Heilig, Martin Cornelius Jordan, Mila Marie Paul, Eva Kupczyk, Rainer Heribert Meffert, Uwe Gbureck, Stefanie Hoelscher-Doht
Summary: The study shows that the pullout strength and stiffness of suture anchors can be significantly increased in bone by filling it with magnesium phosphate cement. SwiveLock C anchors perform better when reinforced with additional FibreWire.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Materials Science, Ceramics
Zepeng Cai, Zhiwen Wu, Yi Wan, Tao Yu, Changren Zhou
Summary: The study prepared micronano calcium phosphate (MNC) with different Ca/P ratio and added it to CPC and CSC, showing significant improvements in mechanical properties and setting time of the cement. MNC promoted hydration reaction, affected crystal growth, and reduced porosity in the cement, delaying degradation.
CERAMICS INTERNATIONAL
(2021)
Article
Oncology
Zhou-Shan Tao, Wan-Shu Zhou, Rou-Tian Zhang, Yang Li, Hong-Guang Xu, Shan Wei, Zheng-Yu Wang, Min Yang
Summary: Local application of lithium or aspirin with biological scaffold has been shown to improve bone formation. In this study, Asp-Li/CPC was prepared and confirmed to have better ability in promoting osteoblast differentiation and mineralization. In vivo and in vitro experiments demonstrated that Asp-Li/CPC can rapidly repair bone defects by inhibiting local inflammation and activating specific signaling pathways.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Polymer Science
Ioana Lacan, Marioara Moldovan, Codruta Sarosi, Ioan Ardelean
Summary: Calcium phosphate cements can be improved by adding additives such as chitosan. This study used nuclear magnetic resonance (NMR) to investigate the effect of chitosan on the hardening process of the cement and found that chitosan accelerates the hardening dynamics and reduces the amount of unreacted monomers.
Article
Orthopedics
Ludwig Oberkircher, Adrian Masaeli, Juliana Hack, Jens Figiel, Christopher Bliemel, Steffen Ruchholtz, Antonio Krueger
Summary: This study compared the effects of different cement augmentation options on iliac screw fixation. The results showed that cement augmentation significantly increased the pull-out strength, especially when used before screw placement. Further biomechanical studies are needed to confirm these findings.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jennifer Blankenburg, Johannes Vinke, Bianca Riedel, Sergej Zankovic, Hagen Schmal, Michael Seidenstuecker
Summary: In this study, the adaptation of biological shapes in 3D printing of ceramic-based scaffolds was investigated. By adjusting the layer rotation angle, sample shapes with a rotation angle of only 1 degree were successfully printed. The maximum failure load of the samples was increased by changing the strand diameter and arrangement.
Article
Materials Science, Ceramics
Min Wei, Yufei Tang, Lei Chen, Bo Zhang, Shitong Zhang, Kang Zhao, Zixiang Wu
Summary: This study successfully introduced montmorillonite (MMT) into calcium phosphate cement (CPC) to prepare CPC/MMT composite bone cement. The compressive strength of the composite cement was significantly enhanced, and the anti-washout ability was improved as well. The composite bone cement also exhibited outstanding cell adhesion and proliferation abilities.
CERAMICS INTERNATIONAL
(2022)
Article
Engineering, Multidisciplinary
Wenjuan Liu, Zhiguang Huan, Chengtie Wu, Zhihua Zhou, Jiang Chang
Summary: This study developed a composite bone cement with high compressive strength and desirable bioactivity by incorporating calcium silicate bioceramic into magnesium phosphate bone cement. The composite bone cement showed significantly higher compressive strength compared to traditional bone cements and demonstrated apatite mineralization ability and moderate degradation behavior.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Critical Care Medicine
Alicja J. Bojan, Vincent A. Stadelmann, Dan Wu, Michael Pujari-Palmer, Gerard Insley, Daniel Sundh, Cecilia Persson, Hakan Engqvist, Philip Procter
Summary: This study evaluated the feasibility of bonding human trabecular bone with OsStic(R), a novel phosphoserine modified cement, and compared it with a commercial fibrin tissue adhesive. The results showed that OsStic(R) demonstrated good performance in bonding wet and fatty tissue, with high tensile strength.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Orthopedics
Pezhman Eghbali, Fabio Becce, Patrick Goetti, Frederic Vauclair, Alain Farron, Philippe Buchler, Dominique Pioletti, Alexandre Terrier
Summary: The objective of this study was to determine the normative bone mineral density (BMD) of cortical and trabecular bone regions in the adult glenoid and its dependence on the subject's age and sex. The study found that glenoid BMD was higher in males than females and declined with age. These findings are clinically relevant in the diagnosis and management of shoulder disorders and related research.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Biology
Naser Nasrollahzadeh, Peyman Karami, Jian Wang, Lida Bagheri, Yanheng Guo, Philippe Abdel-Sayed, Lee Laurent-Applegate, Dominique P. Pioletti
Summary: This study focused on cartilage self-heating and investigated the impact of its coupling with mechanical stimuli on cell behavior. The findings suggest that the co-existence of thermo-mechanical cues has a superior effect on chondrogenic gene expression compared to either signal alone, with the TRPV4 channel identified as a key mediator of the thermo-mechanotransduction process.
Article
Rheumatology
Alexandre Terrier, Olivier Fakih, Mickael Chouk, Clement Prati, Daniel Wendling, Sebastien Aubry, Frank Verhoeven
Summary: This study aimed to compare the SBAC-SI differences in AS, OCI, and DISH. The results showed that SBAC-SI was significantly higher in the OCI group compared to the AS group, which could help distinguish between these two diseases. In AS, the disease duration was negatively correlated with SBAC-SI, and HLA B27 was associated with lower SBAC-SI.
Review
Engineering, Biomedical
Peyman Karami, Theofanis Stampoultzis, Yanheng Guo, Dominique P. Pioletti
Summary: The drive to develop cartilage implants for major defects in the musculoskeletal system has led to an increased focus on developing biomaterial devices for cartilage repair. However, there has been limited attention on the preclinical validation process and approval procedures for these devices. This review paper aims to highlight the various considerations regarding preclinical validation of hydrogel devices for cartilage repair, including regulatory requirements, implantation strategies, device performance aspects, and characterizations.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Peyman Karami, Vijay Kumar Rana, Qianyi Zhang, Antoine Boniface, Yanheng Guo, Christophe Moser, Dominique P. Pioletti
Summary: The use of low viscosity photopolymerizable hydrogels for surgical treatment of injured soft tissues can reduce the severity of iatrogenic injury. In this study, near-infrared light was used to cure the hydrogel located behind biological tissues, achieving a minimally invasive approach. The mechanical and adhesive properties of the hydrogel can be modulated by adjusting parameters such as NIR light power and UCNP concentration.
Article
Materials Science, Biomaterials
Theofanis Stampoultzis, Yanheng Guo, Naser Nasrollahzadeh, Peyman Karami, Dominique P. Pioletti
Summary: Articular cartilage is a mechanically sensitive tissue where chondrocytes perceive and react to physical cues. This study explores the role of temperature as a regulatory signal for chondrocyte function and evaluates the effects of thermal and/or mechanical stimulation on chondrocytes in different types of scaffolds. The results suggest that the combination of dynamic thermal and mechanical stimuli has superior effects on chondrogenic genes and proteoglycan accumulation.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Orthopedics
Antoine Dewarrat, Alexandre Terrier, Bardia Barimani, Frederic Vauclair
Summary: This study compared the clinical outcomes and complications of two surgical techniques for proximal humeral fracture. It found that patients treated with ALPS system had better shoulder range of motion and lower complication rates.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Chemistry, Multidisciplinary
Vijay K. Rana, Peyman Karami, Naser Nasrollahzadeh, Dominique P. Pioletti
Summary: Incorporating nanoparticles into polymer matrices can improve the properties of composite materials, but the impact of nanoparticle surface heterostructures on composite systems is not fully understood. By comparing the properties of composite hydrogels containing smooth-surfaced particles and rough-surfaced particles, it is found that the surface roughness of nanoparticles significantly affects the macroscopic properties of the hydrogels.
ADVANCED MATERIALS INTERFACES
(2023)
Review
Orthopedics
G. Dietrich, A. Terrier, M. Favre, J. Elmers, L. Stockton, D. Soppelsa, S. Cherix, F. Vauclair
Summary: Smoking increases the risk of nonunion in patients with conservatively treated clavicle fractures. It is important to inform patients about the higher risks of nonunion associated with smoking and provide smoking cessation support. Surgery should be considered for smokers with this type of fracture.
BONE & JOINT JOURNAL
(2023)
Meeting Abstract
Medicine, General & Internal
Patrick Goetti, Xavier Lannes, Fabio Becce, Alain Farron, Alexandre Terrier
SWISS MEDICAL WEEKLY
(2022)
Meeting Abstract
Cell & Tissue Engineering
Naser Nasrollahzadeh, Lee A. Applegate, Dominique Pioletti
TISSUE ENGINEERING PART A
(2022)
Article
Orthopedics
V. A. Stadelmann, H. A. Rudiger, S. Nauer, M. Leunig
Summary: This study compared the outcome and revision rate of total hip arthroplasty with preservation or resection of the anterolateral capsule. The results showed that there was no significant difference in revision rate between the two groups, but the preserved group had worse patient-reported outcome measures. However, these differences were smaller than the clinically important thresholds.
BONE & JOINT JOURNAL
(2022)
Meeting Abstract
Endocrinology & Metabolism
Ulrike Kettenberger, Arne Vogel, Dominique Pioletti
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)